TiO2-ZnPc nanoparticles functionalized with folic acid as a target photosensitizer for photodynamic therapy against glioblastoma cells by Gustavo Jardón-Guadarrama, Ma Elena Manríquez-Ramírez, Citlali E. Rodríguez-Pérez, Araceli Díaz-Ruiz, María de los Ángeles Martínez-Cárdenas, Alfonso Mata-Bermudez, Camilo Ríos, Emma Ortiz-Islas

“…An in vitro toxicity test was performed using the MTT assay and the C6 cellular line. …”
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Hydrodynamic Modeling of Unstretched Length Variations in Nonlinear Catenary Mooring Systems for Floating PV Installations in Small Indonesian Islands by Mohammad Izzuddin Jifaturrohman, I Ketut Aria Pria Utama, Teguh Putranto, Dony Setyawan, I Ketut Suastika, Septia Hardy Sujiatanti, Dendy Satrio, Noorlaila Hayati, Luofeng Huang

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tRF-5028c disrupts trophoblast function in recurrent spontaneous abortion by inhibiting CRKL-mediated Rap1 signaling pathway by Jialyu Huang, Jiawei Wang, Shuang Wang, Xiangpeng Xiong, Ruiyin Jiang, Chaoyi Xiong, Lu Wang, Lingling Huang, Yan Zhao, Zheng Fang, Xiaoyan Ai, Jiaying Lin

“…CCK-8, transwell assay, and flow cytometry were performed to detect the effects of tRF-5028c on proliferation, migration, invasion, and apoptosis of human extravillous trophoblast cell line HTR-8/SVneo. …”
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Dynamic Programming as a Method of Spline Approximation in the CAD Systems of Linear Constructions by D. A. Karpov, V. I. Struchenkov

“…On the second stage it is used to determine the initial approximation of the desired line, which is optimized at the last stage. The required line consists of a given type elements and it is a spline with a number of features:- In contrast to the polynomial elements considered in the theory of splines, when designing roads unknown spline is a sequence of elements: straight, clothoid, circle, clothoid, straight and so on.- In this task, the spline does not have to be a single-valued function.- The parameters of the elements of the desired spline must satisfy the constraints in the form of inequalities.These features of the task do not allow the use of non-linear programming methods to solve it. …”
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Comprehensive prognostic gene identification and functional characterization of GRAMD1A in Wilms tumor: development of risk prediction models and therapeutic implications by Qiang Zeng, Junfeng Tao, Lilu Qin, Yong Zeng, Zhong Liu, Mingxian Xu, Linshan Zeng

“…External validation confirmed key hub genes, while functional assays in WT cell lines (WiT-49) assessed the role of GRAMD1A in tumor behavior.ResultsA total of 3,395 DEGs were identified, with 1,564 upregulated and 1,831 downregulated genes. …”
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Synergistic Effect of Nitrogen Fertilizer Management on Rice Productivity and Quality by Yongkang Teng, Rongjie Chen, Meng Guo, Xianguan Chen, Min Jiang

“…The experiments analyzed changes in rice nitrogen uptake and transport efficiency, yield and its components, and quality and its components under different nitrogen application treatments, and fitted a function based on the effect of total nitrogen fertilizer on quality. …”
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Local Outlier Detection Method Based on Improved K-means by Yu ZHOU, Hao XIA, Xuezhen YUE, Peichong WANG

“…The changes in the cost function value with the number of clusters are recorded and plotted as a line graph. …”
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Short communication: Estimation of the dietary standardized ileal digestible valine to lysine ratio required for 40 to 130 kg pigs during the finisher periods by Zijuan Wu, Wenli Li, Yali Li

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SETD2 loss-of-function uniquely sensitizes cells to epigenetic targeting of NSD1-directed H3K36 methylation by Ryan T. Wagner, Ryan A. Hlady, Xiaoyu Pan, Liguo Wang, Sungho Kim, Xia Zhao, Louis Y. El Khoury, Shafiq Shaikh, Jian Zhong, Jeong-Heon Lee, Jolanta Grembecka, Tomasz Cierpicki, Thai H. Ho, Keith D. Robertson

“…Confirmation of this synthetic lethal interaction is performed in isogenic clear cell renal cell carcinoma and immortalized renal epithelial cell lines, in mouse and human backgrounds. …”
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Genome-wide identification of ARID-HMG related genes in citrus and functional analysis of FhARID1 in apomixis and axillary bud development by Xietian Song, Yin Zhou, Zhen Cao, Nan Wang, Xiaoyu Tian, Lijun Chai, Zongzhou Xie, Junli Ye, Xiuxin Deng

“…Yeast two-hybrid and MS/MS spectra further indicated that FhARID1 function requires casein kinase II-mediated post-transcriptional phosphorylation. …”
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Cloning and Functional Analysis of <i>BraTSD2</i> Associated with Root Swelling in Turnip (<i>Brassica rapa</i> L.) by Wenyue Huang, Shifan Zhang, Fei Li, Hui Zhang, Rifei Sun, Guoliang Li, Shujiang Zhang

“…In this study, we cloned the turnip root swelling-related gene <i>BraTSD2</i> (<i>TUMOROUS SHOOT DEVELOPMENT 2</i>) and performed a preliminary functional analysis. The bioinformatics analysis of <i>BraTSD2</i> indicated that the protein is likely to possess a transmembrane feature. …”
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Optimizing Conservative Treatment for Femoroacetabular Impingement Syndrome: A Scoping Review of Rehabilitation Strategies by Federica Giorgi, Daniela Platano, Lisa Berti, Danilo Donati, Roberto Tedeschi

“…While surgery is generally not performed in individuals under 18 due to skeletal immaturity, it remains a standard treatment option for adults presenting with persistent symptoms and functional limitations. …”
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Therapeutic efficacy and mechanism of artesunate for mouse model of polycystic ovary syndrome by WANG Xueling, WANG Xueling, ZHONG Peiling, ZHONG Peiling, ZHAO Zhipeng

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Presenting a simple method to estimate ground deformations in building-tunnel interaction by Yazdan Shams Maleki

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EFFECT OF FUROSTANOL GLYCOSIDES FROM CULTURED DIOSCOREA DELTOIDEA CELLS ON REGULATORY FUNCTION OF ENDOTHELIUM IN A RAT MODEL OF HYPOESTROGEN-INDUCED ENDOTHELIAL DYSFUNCTION by E. B. Artyushkova, N. G. Gumanova, V. A. Metelskaya, T. G. Pokrovskaya, V. I. Kochkarov, M. V. Korokin, M. V. Pokrovsky, L. V. Korokina, A. M. Nosov, M. M. Korneev

“…To study the effects of furostanol glycosides from cultured Dioscorea Deltoidea cells (DM-05, Institute of Plant Physiology, RAS) on physiological and biochemical markers of endothelial function in rats with hypoestrogen-induced endothelial dysfunction.Material and methods. 10 female rats of Wistar line, with body mass 200-300 g have been included in the experiment. …”
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Effects of dietary Bacillus coagulans on the productive performance, egg quality, serum parameters, and intestinal morphology of laying hens during the late laying period by Xiaoming Wang, Huafeng Jian, Wenyan Zhao, Jiankui Li, Xiaoting Zou, Xinyang Dong

“…The aim of this study was to investigate the effects of Bacillus coagulans (B. coagulans) on the productive performance, egg quality, blood biochemistry, antioxidant capacity, reproductive hormones, immune function, and intestinal morphology of laying hens (86 weeks old) during the late laying period. …”
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Demographic, socioeconomic and functional health-related factors in the selection of vaginal pessaries used for the conservative treatment of pelvic organ prolapse: a retrospective... by Orsolya Oláh, Miklós Romics, Nándor Ács, Richárd Cseh, Péter Nyirády, Attila Majoros

“…According to several national guidelines, pessary therapy should be used as a first-line treatment for pelvic organ prolapse. A distinction is made between pessaries that can be worn permanently or require daily control. …”
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Design and Application of Algorithm Intensive Environment for CMA Big Data and Cloud Platform by Huo Qing, He Wenchun, He Lin, Gao Feng, Chen Shiwang, Xu Yongjun

“…Since its operation in 2021, the processing assembly line has facilitated the real-time operation of 202 business systems nationwide, resulting in a performance improvement of 1-10 times and a significant increase in efficiency. …”
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Inhibition of TGF-β-receptor signaling augments the antitumor function of ROR1-specific CAR T-cells against triple-negative breast cancer by Michael Hudecek, Achim Wöckel, Jörg Wischhusen, Tanja Stüber, Razieh Monjezi, Lars Wallstabe, Johanna Kühnemundt, Sarah Louise Nietzer, Gudrun Dandekar, Hermann Einsele

“…Here, we analyzed whether CAR T-cells specific for the receptor tyrosine kinase-like orphan receptor 1 (ROR1) antigen, that is frequently expressed in triple-negative breast cancer (TNBC), are susceptible to inhibition by TGF-β and evaluated TGF-β-receptor signaling blockade as a way of neutralizing the inhibitory effect of this cytokine.Methods CD8+ and CD4+ ROR1-CAR T-cells were prepared from healthy donors and their antitumor function analyzed using the TNBC cell line MDA-MB-231 in vitro and in a microphysiologic 3D tumor model. …”
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Automated fluorine-18 radiolabeling via an alkyne–azide cycloaddition reaction on a dual peptide-functionalized liposome surface for in vivo PET imaging by Marco Iannone, Marcelo Kravicz, Paolo Rainone, Paolo Rainone, Paolo Rainone, Antonia I. Antoniou, Stefano Stucchi, Stefano Stucchi, Silvia Valtorta, Silvia Valtorta, Silvia Valtorta, Silvia Valtorta, Arianna Amenta, Elia Anna Turolla, Elia Anna Turolla, Sara Pellegrino, Sara Pellegrino, Daniele Passarella, Elisa Vino, Sergio Todde, Sergio Todde, Sergio Todde, Francesca Re, Francesca Re, Pierfausto Seneci, Rosa Maria Moresco, Rosa Maria Moresco, Rosa Maria Moresco, Rosa Maria Moresco

“…In addition, radiolabeling is also performed on liposome formulations functionalized with 1) a peptide derived from the receptor-binding domain of apolipoprotein E (mApoE) and 2) a metalloproteinase (MMP)-sensitive lipopeptide (MSLP). …”
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