The role of Seladelpar in primary biliary cholangitis: a systematic review and meta-analysis by Taimoor Ashraf, Omar Abunada, Nandlal Seerani, Kashif Ali, Areej Muhammad, Syeda Lamiya Mir, Syed Adil Mir Shah, Muhammad Hassaan, Vikash Kumar, Waseem Abbas, Simran Bajaj, Asfia Qammar, F. N. U. Deepak, Salih Abdella Yusuf

“…Although ursodeoxycholic acid (UDCA) remains the first-line treatment, many patients exhibit an inadequate response, necessitating alternative therapeutic options. …”
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Effect and Mechanism of Action of Pushing Method on Rats with Skeletal Muscle Overuse Injury based on Wnt/β-catenin Signaling Pathway by DUAN Miaomiao, HUANG Bo, RUAN Lei, MU Pangpang, CHEN Yiming, PENG Liang

“…Catenin protein expression levels.Results(1) Comparison of motor function：compared with the blank group, the time of passing through the balance beam and the number of times of sliding paw were significantly increased in the model group and intervention group after intervention, and the difference was statistically significant (<italic>P</italic>&lt;0.05); compared with the model group, the time of passing through the paw and the number of times of sliding paw were significantly decreased in the intervention group after intervention, and the difference was statistically significant (<italic>P</italic>&lt;0.05). (2) Gastrocnemius muscle histopathological changes：the model group can be seen in the gastrocnemius muscle a large number of myocytes can be seen within the cracks, myogenic fibers fracture; compared with the model group, the degree of damage to the gastrocnemius muscle tissues in the intervention group to reduce the degree of damage, can be seen in the form of myofibers is regular, neatly arranged. (3) Ultrastructural changes in gastrocnemius muscle tissue：local myogenic fiber bundles were broken and dissolved, and a small amount of Z-line structure was dissolved and blurred; compared with the model group, the gastrocnemius muscle cells in the intervention group were slightly edematous, and the structure of the myogenic fiber bundles was clear; part of the myogenic fiber bundles were broken, and the structure of the Z-lines was clear and more neatly arranged. (4) Gastrocnemius muscle tissue MyoD, MyoG and Pax7 mRNA transcript levels：compared with the blank group, MyoD, MyoG and Pax7 mRNA transcript levels were significantly higher in both the model group and the intervention group (<italic>P</italic>&lt;0.05); compared with the model group, MyoD, MyoG and Pax7 mRNA transcript levels were significantly higher in the intervention group (<italic>P</italic>&lt;0.05). (5) Gastrocnemius muscle tissue MyoD, MyoG and Pax7 protein expression level：compared with the blank group, MyoD, MyoG and Pax7 protein expression water were significantly higher in both the model group and the intervention group (<italic>P</italic>&lt;0.05); compared with the model group, MyoD, MyoG and Pax7 protein expression level was significantly higher in the intervention group (<italic>P</italic>&lt;0.05). (6) Wnt3a, Axin2 and β-catenin protein expression levels in gastrocnemius muscle tissues：compared with the blank group, Wnt3a, Axin2 and β-catenin protein expression levels were significantly higher in both the model group and the intervention group (<italic>P</italic>&lt;0.05); compared with the model group, Wnt3a, Axin2 and β-catenin protein expression levels were significantly higher in the intervention group (<italic>P</italic>&lt;0.05).ConclusionPushing method can improve the gastrocnemius muscle injury and motor function in rats with overuse injury model, and its mechanism may be related to the activation of Wnt/β-catenin signaling pathway.…”
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Dose-dependent response of metformin in enhancing motor performance and dopamine release in C57BL/6 mice afflicted by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) by Daha Umar Ishaq, Binta Garba Kurfi, Solomon Ojodemi Oguche

“…This in substance, has always indicated a functional part of metformin in employing the motor functions and DA release in the Parkinson’s disease (PD) mode.…”
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Integrated and Functional Genomics Analysis Validates the Relevance of the Nuclear Variant ErbB380kDa in Prostate Cancer Progression. by Mahmoud El Maassarani, Alice Barbarin, Gaëlle Fromont, Ouafae Kaissi, Margot Lebbe, Brigitte Vannier, Ahmed Moussa, Paule Séité

“…The nuclear localization of ErbB3 has been reported in various cancer tissues and cell lines but the nuclear functions and the putative correlation with tumour progression and resistance to therapy remain unclear. …”
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Investigation of the functional impact of CHED- and FECD4-associated SLC4A11 mutations in human corneal endothelial cells. by Doug D Chung, Angela C Chen, Charlene H Choo, Wenlin Zhang, Dominic Williams, Christopher G Griffis, Paul Bonezzi, Kavya Jatavallabhula, Alapakkam P Sampath, Anthony J Aldave

“…Functional assays were performed to assess cell barrier, proliferation, viability, migration, and NH3-induced membrane conductance. …”
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Analysis of the Operational Impact of the Interconnected Wind Power Plant Selac on Enhancing the Quality of Supply and Operational Functionality of the Kosovo Power System by Gazmend Pula, Kadri Kadriu, Petrit Kastrati, Qendrim J. Nika, Nuri Berisha

“…The DigSilent Power Factory software package was used to perform simulations and obtain the results. All simulations were performed using accurate factory-provided data for wind generators, cables, transformers, and lines.…”
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Effects of deoxynivalenol contaminated corn distiller's dried grains with solubles on growth performance, body composition, immunological response, and gastrointestinal health in y... by Deependra Paneru, Milan K. Sharma, Hanyi Shi, Doyun Goo, Venkata S.R. Choppa, Ishwari Gyawali, Revathi Shanmugasundaram, Woo K. Kim

“…In conclusion, feeding DON-contaminated DDGS at higher inclusion levels (15% and 20%) with final diet DON concentrations exceeding 8.9 ppm over 28 days adversely affects growth performance, immune function, and gut integrity in young pullets.…”
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Natural SEL1L variants rescue a model of NGLY1 deficiency and modify ERAD function and proteasome sensitivity. by Travis K Tu'ifua, Clement Y Chow

“…We found that the SEL1LS780P and SEL1LΔ806-809 variants improve resistance to ER stress, with enhanced ERAD function as a likely contributing mechanism. This effect depends on NGLY1 activity, further implicating NGLY1 in general ERAD function. …”
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Bridging Financial Forecasting and Budget Management: New Approaches for Modern Enterprises by Mikhail Lipelis

“… The study aims at uncovering the linkages between financial forecasting accuracy and budget performance in modern enterprises, pointing at the crucial role of integration, managerial and economic conditions, on both suggesting the possible causes and prognosis of budgeting performance decline. …”
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A novel CARD11 heterozygous missense variant in a CADINS patient by Randa S. AlYafie, PhD, Mehdi Adeli, MD, Dinesh Velayutham, PhD, Salim Bougarn, PhD, Manar Ata, MSc, Fatima Al-Ali, MRes, Evonne Chin-Smith, PhD, Bradly M. Bauman, PhD, Andrew L. Snow, PhD, Bertrand Boisson, PhD, Nico Marr, PhD, Nicholas van Panhuys, PhD, Andrea Guennoun, PhD, Puthen Veettil Jithesh, PhD

“…Expression of CARD11 variant–stimulated constitutive NF-κB activity in T-cell lines demonstrated both loss-of-function and dominant-negative activity. …”
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Identification of Alzheimer’s disease brain networks based on EEG phase synchronization by Jiayi Cao, Bin Li, Xiaoou Li

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Research on Highway Lane Change Control Strategy Considering Driving Styles by Yi Ren, Lei Zhang, Xiyao Liu

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NetStart 2.0: prediction of eukaryotic translation initiation sites using a protein language model by Line Sandvad Nielsen, Anders Gorm Pedersen, Ole Winther, Henrik Nielsen

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Exploration of Commonly Used Tests to Assess Physical Qualities in Male, Adolescent Rugby League Players: Discriminative Validity Analyses and Correlations with Match Performance M... by Michael A. Carron, Aaron T. Scanlan, Thomas M. Doering

“…Tests assessing physical qualities are regularly used in youth rugby league teams for various functions. However, the utility of such tests is under-explored in this population. …”
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Hydra Radio Access Network (H-RAN): Multi-Functional Communications and Sensing Networks, Initial Access Implementation, and Task-2 Approach by Rafid I. Abd, Daniel J. Findley, Kwang Soon Kim

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MULTI-OBJECTIVE OPTIMIZATION DESIGN FOR CUTTING MECHANISM OF ROADHEADER BASED ON IMPROVED GENETIC ALGORITHM by MAO Jun, PAN DeWen, XIE Miao, ZHENG GuangHui

“…This paper takes motion parameters and structure parameters of cutting mechanism for design variables and optimizes multi-objective function of comprehensive performance of cutting mechanism based on the improved genetic algorithm. …”
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Distributed Improved RILOS Guidance-Based Formation Control of Underactuated ASVs for Cooperative Maritime Search by Weili Guo, Cheng Liu, Feng Xu, Ting Sun

“…A distributed improved robust integral line-of-sight (RILOS) guidance-based sliding mode controller is designed for multiple underactuated autonomous surface vessels (ASVs) to perform cooperative maritime search operations. …”
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Research on the Local Dynamic Trajectory Planning Method Based on Relative Positioning by LUO Jiaxiang, YUAN Xiwen, HUANG Qiang

“…Advanced driving assistance system (ADAS) in autonomous driving vehicles usually obtains local relative positioning information only by identifying lane lines, and how to avoid collisions when there are jumps in lane lines and encountering obstacles is a key technology that ADAS needs to solve urgently. …”
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Linear broadband interference suppression circuit based on GaN monolithic microwave integrated circuits by Megan C. Robinson, Zoya Popović, Gregor Lasser

“…The circuit accomplishes the function of a tunable frequency notch through an interferometer architecture. …”
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Collapse Potential of an Existing Reinforced Concrete Bridge Structure by Zeynep Yılmaz, Murat Serdar Kirçil

“…Turkey is a country located on active fault lines and has experienced devastating earthquakes in the past. …”
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