Warning Function of Frank’s Sign in Pre-Existing Cardiac Disease Patients: A Case Report by Mingzhe Wang, Yujing Zhang, Jiang Huang, Geping Liao, Wei Qian, Yaofu Zheng, Xiaoping Peng, Jianbing Zhu

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Functional and Evolutionary Characterization of the NSP6 Protein in SARS-CoV-2 Omicron Variants by Joyhare Barbosa Souza, Samir Mansour Moraes Casseb

“…Phylogenetic analysis was performed with IQ-TREE software. Analysis of 161 NSP6 protein sequences revealed significant divergence from the reference sequence, with mutations proximal to conserved regions indicating potential functional and structural changes. …”
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The C-terminal domain of CENP-C displays multiple and critical functions for mammalian centromere formation. by Stefania Trazzi, Giovanni Perini, Roberto Bernardoni, Monica Zoli, Joseph C Reese, Andrea Musacchio, Giuliano Della Valle

“…The activity of these two domains in human CENP-C is not well defined. In this study we performed a functional dissection of C-terminal CENP-C region analyzing the role of single Mif2p homology domains through in vivo and in vitro assays. …”
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mTanh: A Low-Cost Inkjet-Printed Vanishing Gradient Tolerant Activation Function by Shahrin Akter, Mohammad Rafiqul Haider

“…To address this, alternative functions like ReLU and Leaky ReLU have been explored, yet these also introduce challenges such as the dying ReLU issue, bias shifting, and noise sensitivity. …”
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Real-world therapeutic performance of pirfenidone for connective tissue disease-associated interstitial lung diseases by Xueting Yuan, Chen Yu, Shengyun Liu, Qiang Shu, Xinwang Duan, Lin Tang, Liying Peng, Shuang Zhou, Chanyuan Wu, Jiuliang Zhao, Dong Xu, Lan Song, Hui Huang, Mengtao Li, Yanhong Wang, Qian Wang, Xiaofeng Zeng

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Effects of exercise interventions on cognitive function in patients with cognitive dysfunction: an umbrella review of meta-analyses by Guangyao Sun, Xingyi Ding, Zhong Zheng, Hongtao Ma

“…ObjectiveThis umbrella review assessed the quality, potential biases, and effects of exercise interventions on cognitive function in individuals with cognitive impairments.MethodsA comprehensive umbrella review of meta-analyses of randomized controlled trials (RCTs) was performed to evaluate the effects of exercise on cognitive function in individuals with cognitive impairments. …”
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The Long-Term Effects of Silicone Hydrogel Contact Lenses on the Ocular Surface and Tear Function Tests by Yelda Yıldız Taşcı, Canan Gürdal, Özge Saraç, Şenay Aşık Nacaroğlu

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Critical structural and functional roles for the N-terminal insertion sequence in surfactant protein B analogs. by Frans J Walther, Alan J Waring, Jose M Hernandez-Juviel, Larry M Gordon, Zhengdong Wang, Chun-Ling Jung, Piotr Ruchala, Andrew P Clark, Wesley M Smith, Shantanu Sharma, Robert H Notter

“…Earlier structural studies with Mini-B, a disulfide-linked construct based on the N- and C-terminal regions of SP-B (i.e., approximately residues 8-25 and 63-78), confirmed that these neighboring domains are helical; moreover, Mini-B retains critical in vitro and in vivo surfactant functions of the native protein. Here, we perform similar analyses on a Super Mini-B construct that has native SP-B residues (1-7) attached to the N-terminus of Mini-B, to test whether the N-terminal sequence is also involved in surfactant activity.…”
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Computational analysis and molecular dynamics of natural anthelmintic compounds from Algerian herbal sources by Farouk BOUDOU, Amal BELAKREDAR, Alaeddine BERKANE, Mohammed RASHEED

“…In silico screening for drug-likeness prediction, toxicity risk assessment (mutagenic, tumorigenic, irritant, or effects on reproduction), molecular docking, and molecular dynamics targeting β-tubulin, a key protein in the cellular functions of helminths, has been performed on 33 phytochemical compounds belonging to 20 different plants used in Algerian folk medicine to treat gastrointestinal disorders. …”
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Multiomics reveal biomolecular shifts and ER stress in sleep-restricted women affecting NSC functions by Vikas Malik, Xin Huang, Hongwei Zhou, Rebecca Bojar, Rajesh Kumar Soni, Donald W. Landry, Sanja Jelic, Jianlong Wang

“…Summary: Adequate sleep (AS) is vital for physiological functions, yet a third of US adults sleep less than recommended. …”
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A Novel Case of Functional Gastric Neuroendocrine Carcinoma Occurred after Endoscopic Submucosal Dissection by Yoshiaki Shibata, Yuji Ito, Hiroko Fujita, Yume Okada, Toshihiko Nagai, Hirohito Sano, Kumiko Ito

“…This is the novel case of a functional gastric neuroendocrine carcinoma that occurred after ESD and induced a hypoglycemic attack associated with NICTH.…”
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The impact of kidney function on Alzheimer’s disease blood biomarkers: implications for predicting amyloid-β positivity by Burak Arslan, Wagner S. Brum, Ilaria Pola, Joseph Therriault, Nesrine Rahmouni, Jenna Stevenson, Stijn Servaes, Kübra Tan, Paolo Vitali, Maxime Montembeault, Jesse Klostranec, Arthur C. Macedo, Cecile Tissot, Serge Gauthier, Juan Lantero-Rodriguez, Eduardo R. Zimmer, Kaj Blennow, Henrik Zetterberg, Pedro Rosa-Neto, Andrea L. Benedet, Nicholas J. Ashton

“…When evaluating whether accounting for kidney function could lead to improved prediction of Aβ-positivity, we observed no improvements in model fit (Akaike Information Criterion, AIC) or in discriminative performance (AUC) by adding eGFR to a base model including each plasma biomarker, age, and sex. …”
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Heat stress affects the functionality of the ovine cumulus-oocyte complex and subsequent in vitro embryo production by Alicia Martín-Maestro, Irene Sánchez-Ajofrin, María Iniesta-Cuerda, Daniela Medina-Chávez, Carolina Maside, María Rocío Fernández-Santos, Julián Garde, Ana Josefa Soler

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Propranolol and Prazosin Have a Positive Effect on the Sexual Performance of Female Three-Spot Gourami by Marzieh Monemi, Tahereh Naji, Afshin Kheradmand

“…Background: Sexual function is one of the most important aspects of life and is likely to be affected by the side effects of antihypertensive drugs. …”
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Global research on cognitive function for Schizophrenia from 2014 to 2024: a bibliometric and visual analysis by Yansha Gan, Chunyu Dong, Jiaojiao Sun, Danting Yang, Jiajun Yin, Zhenhe Zhou

“…We used bibliometric methods to identify the current research hotspots and emerging trends in this field.Methods We thoroughly searched SCZ cognitive function publications in the WoSCC database (2014-2024). …”
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Integration and functionality of human iPSC-derived microglia in a chimeric mouse retinal model by Chun Tang, Qi-Qi Zhou, Xiu-Feng Huang, Ya-Yi Ju, Bi-Lin Rao, Zhi-Cong Liu, Yi-An Jia, Zhan-Pei Bai, Qing-Yang Lin, Lin Liu, Jia Qu, Jun Zhang, Mei-Ling Gao

“…Our approach achieved over 86% integration of human microglia, which maintained key functions including proliferation, immune responsiveness, and synaptic pruning over a 14-day culture period. scRNA-seq of xMG revealed a shift in microglial signatures compared to monoculture iMG, indicating a transition to a more in vivo-like phenotype. …”
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HOXB4/METTL7B cascade mediates malignant phenotypes of hepatocellular carcinoma through TKT m6A modification by Enshuang Guo, Lei Li, Jiankun Yang, Yongjian Zhou, Lu Bai, Weiwei Zhu, Qiuyue Hu, Huifen Wang, Hongqiang Liu

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Metabolomic Profiling and Functional Characterization of Biochar from Vine Pruning Residues for Applications in Animal Feed by Serena Reggi, Sara Frazzini, Maria Claudia Torresani, Marianna Guagliano, Cinzia Cristiani, Salvatore Roberto Pilu, Martina Ghidoli, Luciana Rossi

“…The aim of this study was to characterize the metabolomic and functional properties of an aqueous biochar extract from vine pruning waste, in order to predict its potential in vivo effects as a functional feed ingredient. …”
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Exposure to elevated relative humidity in laboratory chambers alters fungal gene expression in dust from the International Space Station (ISS) by Neeraja Balasubrahmaniam, Nicholas Nastasi, Bridget Hegarty, John M. Horack, Marit E. Meyer, Sarah R. Haines, Karen C. Dannemiller

“…However, we do not yet understand how exposure of these microbes to excess moisture alters their function. A de novo metatranscriptomic study was performed using dust collected from the US air filtration system of the ISS and incubated in laboratory chambers on Earth at different equilibrium relative humidity (ERH) levels. …”
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Gastrin exerts a protective effect against myocardial infarction via promoting angiogenesis by Jinjuan Fu, Yuanjuan Tang, Zhen Zhang, Lin Tong, Rongchuan Yue, Lin Cai

“…CD31 and VEGF expression were quantified using immunofluorescence staining or/and western blot to assess the angiogenesis in peri-infarct myocardium. Capillary-like tube formation and cell migration assays were performed to detect gastrin-induced angiogenesis. …”
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