Specific gene expression signatures induced by the multiple oncogenic alterations that occur within the PTEN/PI3K/AKT pathway in lung cancer. by Carmela De Marco, Carmelo Laudanna, Nicola Rinaldo, Duarte Mendes Oliveira, Maria Ravo, Alessandro Weisz, Michele Ceccarelli, Elvira Caira, Antonia Rizzuto, Pietro Zoppoli, Donatella Malanga, Giuseppe Viglietto

“…Expectedly, the analysis of the DEGs common to all three alterations highlighted a group of BioFunctions that included Cell Proliferation of tumor cell lines (14 DEGs), Invasion of cells (10 DEGs) and Migration of tumour cell lines (10 DEGs), with a common core of 5 genes (ATF3, CDKN1A, GDF15, HBEGF and LCN2) that likely represent downstream effectors of the pro-oncogenic activities of PI3K/AKT signalling. …”
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Abstract 043: Intra‐cranial Rescue stenting in patients with incomplete perfusion following mechanical thrombectomy;a systemic review and meta‐analysis. by Muhammad K. Ahmed, Muhammad Tayyab M. Chaychi, Ahmad Danial, Muhammad M. Shafiq, Rahimeen, Muhammad S. Khan, Haris Kamal

“…Introduction Incomplete reperfusion following Mechanical Thrombectomy (MT) ranges from 12–34% and patients with Intracranial atherosclerotic (ICAS) occlusions are disproportionally affected.(1, 2)These patients are also more likely to experience poor functional outcomes. (3) Rescue stenting (RS) in these patients has shown promising rates of recanalization and better outcomes in preliminary studies. …”
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Transplacental Transfer of Oxytocin and Its Impact on Neonatal Cord Blood and In Vitro Retinal Cell Activity by Claudette O. Adegboro, Wenxiang Luo, Meha Kabra, Ryan M. McAdams, Nathaniel W. York, Ruwandi I. Wijenayake, Kiana M. Suchla, De-Ann M. Pillers, Bikash R. Pattnaik

“…To validate these differentially expressed genes (DEGs), hfRPE cells were exposed to OXT (0.01, 0.1, 1, or 10 µM) for 12 h, followed by RNA analysis via real-time PCR. Functional, enrichment, and network analyses (Gene Ontology term, FunRich, Cytoscape) were performed to predict the affected pathways. …”
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An Adiabatic-Expansion-Induced Perturbation Study on Gas–Aerosol Partitioning in Ambient Air—Formation of NH₄NO₃ and Microdroplet Nitrogen Fixation (2) by Yating Gao, Qinchu Fan, Yujiao Zhu, Hengqing Shen, Qi Yuan, Yang Gao, Huiwang Gao, Xiaohong Yao

“…We investigate these questions based on adiabatic-expansion-induced perturbation observations performed in various atmospheres over the last decade. …”
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Exploring the Potential of a New Nickel(II):Phenanthroline Complex with L-isoleucine as an Antitumor Agent: Design, Crystal Structure, Spectroscopic Characterization, and Theoretic... by Jayson C. dos Santos, João G. de Oliveira Neto, Ana B. N. Moreira, Luzeli M. da Silva, Alejandro P. Ayala, Mateus R. Lage, Rossano Lang, Francisco F. de Sousa, Fernando Mendes, Adenilson O. dos Santos

“…Supporting the experimental data, we performed computational modeling to examine the pharmacokinetic profile, with particular focus on the absorption, distribution, metabolism, and excretion properties and drug-likeness potential.…”
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Changes in the structure and properties of graphene oxide surfaces during reduction and modification by M. T. Kartel, K. V. Voitko, Y. Grebelna, S. V. Zhuravskyi, K. Ivanenko, T. V. Kulyk, S. M. Makhno, Yu. I. Sementsov

“…According to the results of IR spectroscopy, also confirmed by TPD-MS, GO has a large number of functional surface groups: (OH), (C=O), (C=C), (C-O-C), (CO-O-CO), (CH). …”
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A genome-wide association study of adults with community-acquired pneumonia by Eva Suarez-Pajes, Itahisa Marcelino-Rodriguez, Elisa Hernández Brito, Silvia Gonzalez-Barbuzano, Melody Ramirez-Falcon, Eva Tosco-Herrera, Luis A. Rubio-Rodríguez, María Luisa Briones, Olga Rajas, Luis Borderías, Jose Ferreres, Antoni Payeras, Leonardo Lorente, Javier Aspa, Jose M. Lorenzo Salazar, José Manuel Valencia-Gallardo, Nieves Carbonell, Jorge L. Freixinet, Felipe Rodríguez de Castro, Jordi Solé Violán, Carlos Flores, Carlos Rodríguez-Gallego

“…Subsequently, we prioritized genes and likely causal variants based on Bayesian fine mapping and functional evidence. …”
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Case Report: The nonsense variation of the cardiac transcription factor NKX2-5 has been identified in a Chinese family with nonsyndromic congenital heart disease by Haixia Zhang, Haixia Zhang, Jing Chen, Jing Chen, He Wang, He Wang, Qinqin Xiang, Qinqin Xiang, Shanling Liu, Shanling Liu

“…As a member of the NK homeobox gene family, NKX2-5 functions as an essential DNA-binding transcriptional activator. …”
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Impact of length of stay on diagnostic yield in the epilepsy monitoring unit: A multi‐center retrospective 12‐year Veterans Health Administration study by Maximillian S. Feygin, Autumn Smith, Sruthi Gopinath Karicheri, Khadar Haroun, Omar Khan, Maria R. Lopez, Stephan Eisenschenk, John Jones, Stephanie Reeder, Alan R. Towne, Christopher Ransom, Karen Medin, James Chen, Tung Tran, Nina I. Garga, Noemi Rincon‐Flores, Marissa Kellogg, Steven Tobochnik, Zulfi Haneef, the Veterans Epilepsy Learning, Collaborative Research, and Operations (VELCRO) investigators

“…Repeat EMU admissions were performed in 10% of patients and were more likely to be diagnostic of ES than PNES or other non‐epileptic events. …”
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Multidimensional bioinformatics analysis reveals the potential carcinogenic role of acrylamide in colorectal cancer by Xiaopeng Yu, Junjie Niu, Jinyang Hu

“…Gene ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were performed to elucidate gene functions, while clinical feature correlation analysis and single-sample gene set enrichment analysis (ssGSEA) were utilized to assess immune infiltration characteristics. …”
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Network pharmacology integrated with molecular docking and experimental validation elucidates the therapeutic potential of Forsythiae Fructus extract against hepatitis B virus-rela... by Fuqing Chen, Yifan Cai, Changzhou Chen, Jianyin Zhou

“…Notably, adenovirus-mediated overexpression experiments showed that ESR1 enhanced FF’s anti-HCC effects, whereas JUN and MMP9 partially counteracted them, confirming their roles as functional targets. In vivo studies further confirmed that FF suppressed tumor growth, reduced serum levels of ALT, AST, TNF-α, and IL-17B in mice, and modulated the expression of core target genes.ConclusionsThe therapeutic potential of FF in HBV-related HCC was demonstrated, with its mechanism likely involving the regulation of multiple components, targets, and pathways. …”
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Clinical characteristics and risk factors for readmission after deep anterior lamellar keratoplasty: a nationwide, cross-sectional, multicenter study by Chenxi Wang, He Xie, Binjia Sun, Kexin Tang, Haiou Wang, Zelin Zhao, Qinxiang Zheng, Jie Wu, Qi Zhang, Baihua Chen, He Dong, Jizhong Yang, Hai Liu, Feng Wen, Tao Sun, Jinsong Xue, Shaozhen Zhao, Limin Chen, Zhirong Liu, Yanning Yang, Xunlun Sheng, Pengcheng Wu, Yuping Han, Wei Qiang, Qi Xie, Yingnan Xu, Hui Liu, Man Yu, Linying Huang, Huiping Li, Ruifen Wei, Minye Wang, Gang Chen, Yan Cheng, Wei Chen

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Health status and risk profiles for brain aging of rural‐dwelling older adults: Data from the interdisciplinary baseline assessments in MIND‐China by Yongxiang Wang, Xiaolei Han, Xianda Zhang, Zhonglin Zhang, Lin Cong, Shi Tang, Tingting Hou, Cuicui Liu, Xiaojuan Han, Qinghua Zhang, Jianli Feng, Ling Yin, Lin Song, Yi Dong, Rui Liu, Yuanjing Li, Tiia Ngandu, Miia Kivipelto, Heather Snyder, Maria Carrillo, Jonas Persson, Laura Fratiglioni, Lenore J Launer, Jianping Jia, Yifeng Du, Chengxuan Qiu

“…Participants examined for the specific modules were younger, more likely to be women, and more educated than those not examined. …”
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Secretome enriched with small extracellular vesicles derived from human gingiva-derived mesenchymal stem cells enhances rat tongue muscle regeneration by Qunzhou Zhang, Puhan He, Shihong Shi, Qilin Xu, Eric J. Granquist, Beth A. Winkelstein, Rabie M. Shanti, Anh D. Le

“…Abstract Background Accumulating evidence demonstrates that the therapeutic effects of stem cells are most likely attributed to their secretome, composed of a myriad of bioactive factors, including small extracellular vesicles (EVs). …”
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Overactive bladder symptoms profile and related factors among women during the perinatal period: a latent profile analysis by Xiaojiao Wang, Lingling Li, Guoying Zhang, Chunxiang Zhu, Hui Min, Xinli Zhu, Chunyi Gu

“…Abstract Background Women's pelvic floor muscle functions can be impaired during the perinatal period, which not only affects their normal social and other quality of life and physical health, but also causes mental and psychological abnormalities. …”
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The burden and determinants of cognitive impairment among individuals with chronic diseases in Ethiopia: A systematic review and meta-analysis by Addisu Getie, Melaku Bimerew, Mihretie Gedfew, Baye Tsegaye Amlak, Tegene Atamenta Kitaw, Adam Wondmieneh

“…Participants who are unable to read and write were 3.82 times more likely to experience cognitive impairment compared to those who had completed primary education (AOR = 3.82; 95 % CI: 2.97–4.91). …”
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Structural characterization of a purified polysaccharide from Chrysanthemum vestitum and its effects on acute lung injury in mice by Shujuan Xue, Ruixue Li, Jishu Wang, Xiaojun Li, Yuchen Guo, Yisen Qiao, Bao Zhang, Lili Wang, Suiqing Chen

“…Its therapeutic mechanism is likely linked to modulation of gut microbiota composition, promoting beneficial bacteria and suppressing pathogenic taxa. …”
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Challenges in developing a split drive targeting dsx for the genetic control of the invasive malaria vector Anopheles stephensi by Mireia Larrosa-Godall, Joshua X. D. Ang, Philip T. Leftwich, Estela Gonzalez, Lewis Shackleford, Katherine Nevard, Rob Noad, Michelle A. E. Anderson, Luke Alphey

“…Although high homing rates were observed, the fitness defects found in both males and females carrying the transgene would likely prohibit this drive from functioning in the field. …”
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Computer-assisted discovery of natural inhibitors for platelet-derived growth factor alpha as novel therapeutics for thyroid cancer by Hira Khalid, Farah Sattar, Iqra Ahmad, Valdir Ferreira de Paula Junior, Valdir Ferreira de Paula Junior, Umar Nishan, Umar Nishan, Riaz Ullah, Hanna Dib, Khaled W. Omari, Mohibullah Shah, Mohibullah Shah

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Feasibility, classification and potential clinical impact of non-invasive delineation of abdominal lymphatic vessels in patients following TCPC with T2 weighted MRI by Anja Hanser, Michael Hofbeck, Melanie Hofmeister, Petros Martirosian, Andreas Hornung, Michael Esser, Fritz Schick, Thomas Küstner, Renate Kaulitz, Jörg Michel, Konstantin Nikolaou, Jürgen Schäfer, Christian Schlensak, Winfried Baden, Johannes Nordmeyer, Ludger Sieverding

“…Abstract Recent research in patients with functionally univentricular hearts (UVH) is focusing on pathologies of the lymphatic vessels. …”
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