PLEK2: a potential biomarker for metastasis and prognostic evaluation in uveal melanoma by Yichong Liu, Haiyue Wang, Qian Zhang, Xiaodi Gao, Yiqing Ji, Yuanzhang Zhu, Jingjing Zhang, Wenjuan Luo

“…A total of 21 miRNAs potentially regulating PLEK2 were predicted.ConclusionPLEK2 is upregulated in UVM and correlates with poor patient prognosis, likely influencing the calcium signaling pathway. …”
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Integrative analysis of bulk and single-cell RNA sequencing data reveals increased arachidonic acid metabolism in osteoarthritic chondrocytes by Kan Wu, Zhaoqian Zhong, Li Chen, Haihua Luo, Aolin Jiang, Linlin Tao, Yong Jiang

“…CellChat analysis was performed to investigate the communication among osteoarthritic chondrocytes. …”
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Abstract 215: A Sweet Indicator: HbA1C and Thrombectomy Outcomes in Hispanics by Zorain M. Khalil, Samantha D. Miller, Yazan D. Abualnadi, Sohum K. Desai, Kaiser O. Sadiq, Wondwossen G. Tekle, Ameer E. Hassan

“…Diabetes is a risk factor for acute ischemic stroke and also a poor predictor of outcome for many interventional surgeries. We performed this retrospective cohort analysis to assess the impact of poorly controlled diabetes, defined as HbA1C of 9.0% or greater, on the functional and procedural outcomes of Hispanic patients with acute ischemic stroke undergoing mechanical thrombectomy. …”
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Minor population of NK lymphocytes with CD19 coexpression by A. A. Kalashnikova, N. V. Bychkova

“…CD56+CD19+dim lymphocytes can reach noticeable values thus altering the results of studies performed by flow cytometry. The errors are most likely to occur upon assessing the minimal residual disease levels in acute B cell leukemias. …”
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Gender Differences in Clinical and Biochemical Variables of Patients Affected by Bipolar Disorder by Luigi Piccirilli, Enrico Capuzzi, Francesca Legnani, Martina Di Paolo, Anna Pan, Alessandro Ceresa, Cecilia Maria Esposito, Luisa Cirella, Teresa Surace, Ilaria Tagliabue, Massimo Clerici, Massimiliano Buoli

“…<b>Introduction:</b> Bipolar disorder (BD) affects over 1% of the global population and significantly impacts psychosocial functioning and life expectancy. This manuscript has the objective of investigating gender differences in the clinical and biochemical parameters of patients affected by BD. …”
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Correlates of avian extinction timing around the world since 1500 CE by Kyle D. Kittelberger, Colby J. Tanner, Amy N. Buxton, Amira Prewett, Çağan Hakkı Şekercioğlu

“…In order to provide a more comprehensive and robust assessment of trait-based drivers of global bird loss in comparison to prior studies, we included extinct species recognized by any of the three major avian taxonomies as well as those birds that lack recent confirmed sightings and are at least functionally extinct. We found that insular, flightless, larger-bodied, ecologically specialized species, as well as those with high aspect ratio wings, were likely to go extinct earlier in time. …”
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The immune-related gene CD5 is a prognostic biomarker associated with the tumor microenvironment of breast cancer by Yi Zhao, Hengheng Zhang, Wenwen Wang, Guoshuang Shen, Miaozhou Wang, Zhen Liu, Jiuda Zhao, Jinming Li

“…The tumor microenvironment (TME) plays an important role in this process, but the functions of immune components and stromal components in the TME require further elucidation. …”
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Extracellular vesicles from different regions of the female reproductive tract promote spermatozoa motility and support capacitation by Camilla Fasoli, Elisa Giacomini, Valentina Pavone, Lisett Solano Narduche, Viviana Bonzi, Laura Privitera, Paolo Giardina, Ludovica Bartiromo, Matteo Schimberni, Luca Pagliardini, Enrico Papaleo, Massimo Candiani, Andrea Salonia, Riccardo Vago

“…Abstract Extracellular vesicles (EVs) have been proven to have a crucial role in intercellular communication and have attracted significant attention in the physiology of reproduction because of their multiple functions in physiological processes essential for reproduction including gametogenesis, fertilization and embryo-endometrial cross-talk. …”
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APOE gene polymorphism as a potential predictor of postoperative cognitive dysfunction in colon cancer surgery under general anesthesia by Bošković Dalibor, Marić Sanja, Lalović Nenad, Mašić Srđan, Elez-Burnjaković Nikolina, Miletić Rade, Spaić Dragan, Krunić Jelena

“…Patients 65 years old or above were more likely to have POCD three months after surgery compared to younger patients (80.0% vs. 52.9%; p = 0.003). …”
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Case Report: Identification of a novel hemizygous CFAP47 variant in a primary ciliary dyskinesia patient with dual ciliary and flagellar defects by Miao He, Wangji Zhou, Yixuan Li, Qiaoling Chen, Yaping Liu, Xinlun Tian, Xue Zhang

“…BackgroundPrimary ciliary dyskinesia (PCD) is a genetically heterogeneous ciliopathy caused by structural and functional abnormalities of motile cilia. Although over 50 PCD-associated genes have been reported, the genetic spectrum remains incomplete. …”
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Transcriptome Analysis of Potato (<i>Solanum tuberosum</i> L.) Seedlings with Varying Resistance Levels Reveals Diverse Molecular Pathways in Early Blight Resistance by Jiangtao Li, Jie Li, Hongfei Shen, Rehemutula Gulimila, Yinghong Jiang, Hui Sun, Yan Wu, Binde Xing, Ruwei Yang, Yi Liu

“…Weighted Gene Co-expression Network Analysis (WGCNA) and pathway enrichment analyses were performed to explore resistance-associated pathways and hub genes. …”
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Genetic heterogeneity in familial forms of genetic generalized epilepsy: from mono- to oligogenism by Maha Dahawi, Jean-Madeleine de Sainte Agathe, Mohamed S. Elmagzoub, Elhami A. Ahmed, Julien Buratti, Thomas Courtin, Eric Noé, Julie Bogoin, Bruno Copin, Fatima A. Elmugadam, Wasma A. Abdelgadir, Ahmed K. M. A. Ahmed, Mohamed A. Daldoum, Rayan Mamoon Ibrahim Altayeb, Mohamed Bashir, Leena Mohamed Khalid, Sahar Gamil, Sara Baldassari, Liena Elsayed, Boris Keren, Gregory Nuel, Ammar E. Ahmed, Eric Leguern

“…Standard genetic filters and Endeavour algorithm for functional prioritization of genes selected likely susceptibility variants in FAT1, DCHS1 or ASTN2 genes. …”
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Monitoring terrestrial rewilding with environmental DNA metabarcoding: a systematic review of current trends and recommendations by Clare Cowgill, James D. J. Gilbert, Ian Convery, Lori Lawson Handley, Lori Lawson Handley

“…Most studies focused on measuring species richness, and few included analyzes of functional diversity. Greater species richness was found when using multiple substrates, but few studies took this approach. …”
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Exome-wide association study reveals novel susceptibility genes to sporadic dilated cardiomyopathy. by Ulrike Esslinger, Sophie Garnier, Agathe Korniat, Carole Proust, Georgios Kararigas, Martina Müller-Nurasyid, Jean-Philippe Empana, Michael P Morley, Claire Perret, Klaus Stark, Alexander G Bick, Sanjay K Prasad, Jennifer Kriebel, Jin Li, Laurence Tiret, Konstantin Strauch, Declan P O'Regan, Kenneth B Marguiles, Jonathan G Seidman, Pierre Boutouyrie, Patrick Lacolley, Xavier Jouven, Christian Hengstenberg, Michel Komajda, Hakon Hakonarson, Richard Isnard, Eloisa Arbustini, Harald Grallert, Stuart A Cook, Christine E Seidman, Vera Regitz-Zagrosek, Thomas P Cappola, Philippe Charron, François Cambien, Eric Villard

“…In silico fine mapping identified HSPB7 as the most likely candidate at the ZBTB17 locus. Rare variant analysis (MAF<0.01) demonstrated significant association for TTN variants only (P = 0.0085). …”
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Dementia and patient outcomes after hip surgery in older patients: A retrospective observational study using nationwide administrative data in Japan. by Noriko Morioka, Mutsuko Moriwaki, Jun Tomio, Kiyohide Fushimi, Yasuko Ogata

“…<h4>Design and setting</h4>Retrospective observational study using the linked data between the Japanese Diagnosis Procedure Combination database and the reports of the medical functions of hospital beds database in Japan (April 2016-March 2017).…”
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Development and Sensory Evaluation of Omega-3-Rich Nile Perch Fish Oil-Fortified Yogurt by Margaret W. Murage, Edward K. Muge, Betty N. Mbatia, Mercy W. Mwaniki

“…This study is aimed at developing an omega-3-rich functional yoghurt and evaluating its quality and acceptability. …”
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Assessment of Hidden Hearing Loss in Tinnitus patients with Normal hearing by Yomna Magdy Zoghba, Wessam Mostafa Essawy, Mona Ahmed Kotait, Afaf Ahmed Emara

“…This basic neuronal degeneration doesn't influence hearing thresholds but likely adds to difficulties in comprehending speech in challenging auditory settings and might have a significant impact in the onset of tinnitus and/or hyperacusis. …”
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Understanding the selectivity in silico of colistin and daptomycin toward gram-negative and gram-positive bacteria, respectively, from the interaction with membrane phospholipids by Yesid Aristizabal, Yamil Liscano, José Oñate-Garzón

“…However, daptomycin displayed strong interactions with several POPG functional groups of the S. aureus membrane model, which favored the insertion of the fatty acid tail into the bilayer. …”
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Demographic and professional risk factors of SARS-CoV-2 infections among physicians in low- and middle-income settings: Findings from a representative survey in two Brazilian state... by Giuliano Russo, Alex Cassenote, Bruno Luciano Carneiro Alves De Oliveira, Mário Scheffer

“…Conversely, working with diagnostic services [95% CI 0.53-0.96], in administrative functions [95% CI 0.42-0.80], or in teaching and research [95% CI 0.48-0.91] were negatively associated. …”
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Effects and predictors of intravenous lidocaine infusion for patients with fibromyalgia. by Min Liu, Stephany Harris, Anna P Andreou, Adnan Al-Kaisy, David Pang, Xuenong Bo

“…IV lidocaine infusion is the most performed procedure in the UK that is offered after conventional therapy has failed. …”
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