Impact of Race and Social Determinants on Operative Management of Distal Radius Fractures in Medicare Patients by Nicole J. Newman-Hung, MD, Amil R. Agarwal, BA, Ambika E. Paulson, MD, Uma Srikumaran, MD, MBA, MPH, Dawn Laporte, MD, Lauren E. Wessel, MD

“…Operative fixation of distal radius fractures (DRFs) in high-demand patients may provide functional benefit, particularly in the setting of significant displacement. …”
Get full text

Suppressed Accretion onto Massive Black Hole Binaries Surrounded by Thin Disks by Christopher Tiede, Jonathan Zrake, Andrew MacFadyen, Zoltán Haiman

“…We present new grid-based hydrodynamics simulations, performed with the binary on the grid and a locally isothermal equation of state, in which the binary is seen to functionally “stop accreting” if the orbital Mach number in the disk exceeds a threshold value of about 40. …”
Get full text

ACE2 and TMPRSS2 genetic polymorphisms as potential predictors of COVID−19 severity and outcome in females by Sanja Matic, Dragan Milovanovic, Dragan Milovanovic, Zeljko Mijailovic, Zeljko Mijailovic, Predrag Djurdjevic, Predrag Djurdjevic, Srdjan Stefanovic, Danijela Todorovic, Katarina Vitosevic, Katarina Vitosevic, Vanja Canovic, Suzana Popovic, Nevena Milivojevic Dimitrijevic, Nevena Milivojevic Dimitrijevic, Marko Zivanovic, Marko Zivanovic, Dragana Seklic, Sanja Aleksic, Nemanja Djordjevic, Nemanja Djordjevic, Milena Vukic, Nenad Vukovic, Nenad Filipovic, Nenad Filipovic, Dejan Baskic, Dejan Baskic, Natasa Djordjevic

“…Genotyping for single nucleotide polymorphisms of ACE2 (rs2106809 and rs2074192) and TMPRSS2 (rs2070788 and rs4818239) was performed using the Real-Time PCR method with TaqMan assays.ResultsControlling for other factors of influence, such as CCI, N/L ratio, LDH level, and pO2, we showed that females with TMPRSS2 rs2070788 A/A genotype were less likely to develop severe COVID-19 (odds ratio [OR] [95% confidence interval (95% CI)]: 0.030 [0.001; 0.862]). …”
Get full text

Genetic and clinical insights into MAST4-related neurodevelopmental disorders by Xiaohong Zheng, Foyang Fan, Bin Lei, Yao Xu, Min Peng, Youfeng Zhou

“…The absence of infantile spasms in our case suggests variable expressivity, necessitating further functional studies to assess the variant's pathogenicity and MAST4's neurobiological mechanisms.…”
Get full text

Pharmacological modulation of MRAP2 protein on murine melatonin receptor signaling by Wenqi Song, Yanchuan Li, Hongtao Xu, Yaqun Zhang, Liu Liu, Yihao Li, Xinran Wang, Yueming Du, Yining Chen, Jianjun Lyu, Lingjing Jin, Chao Zhang, Yuchen Xiao

“…Bulk RNA-seq was then employed to analyze the expression distribution of these genes. Next, we performed co-immunoprecipitation and Bimolecular Fluorescence Complementation (BiFC) assays to investigate the interaction of MRAP2 with melatonin receptors. …”
Get full text

Simultaneous adsorptive removal of Pb2+, Cd2+, Cu2+, and Zn2+ using raw Norway Spruce biomass: a low-cost and eco-friendly solution for wastewater treatment by Ibrahim G. Al-Labadi, Márk Horváth, Ayah T. Alkilani, Alaa M. Al-Ma'abreh, Mohammed J. K. Bashir, Basem E. Keshta, Basem E. Keshta, Ghadir Hanbali, Wail Al Zoubi, Mostafa R. Abukhadra, Mostafa R. Abukhadra, Haifa A. Alqhtani, Mohamed Hamdy Eid, Mohamed Hamdy Eid

“…The Langmuir model provided an excellent fit to the data (R2 ≈ 0.99), indicating favorable monolayer chemisorption, likely driven by a combination of cation exchange supported by EDS and interactions with surface functional groups. …”
Get full text

Insights into genetic and clinical profiles of triple A syndrome in Sudanese children by Salwa A. Musa, Salwa A. Musa, Mohamed A. Abdullah, Mohamed A. Abdullah, Samar S. Hassan, Eliane Streiff, Franziska Lange, Omer O. Babiker, Areej A. Ibrahim, Hiba A. Elshafie, Angela Huebner, Katrin Koehler, Friederike Quitter

“…IntroductionTriple A syndrome (OMIM*231550) is a rare autosomal recessive disorder characterized by achalasia, alacrima, adrenal insufficiency, and neurological features. It is caused by functional impairment of the nucleoporin ALADIN due to mutations in the AAAS gene. …”
Get full text

Association Between Depressive Symptoms and Comorbidities Among Elderly Diabetic Individuals in China by Luyao Qiao, Xin Pan, Tianpei Li, Shouqin Yi, Zhenyu Tang

“…Logistic regression analyses were performed, adjusting for potential demographic factors, and health status and functioning factors. …”
Get full text

Urinary continence outcomes during the transition from laparoscopic to robotic assisted radical prostatectomy: A single surgeon’s Australian regional centre experience by Basil Razi, Dane Cole-Clark, Duncan Self, Mark Louie-Johnsun

“…Postoperative continence significantly impacts patients’ quality of life, making functional outcomes a critical focus in the evolution of surgical techniques. …”
Get full text

Comparative Analysis of Survival in Pulmonary Arterial Hypertension for Patients Treated with Selexipag in Clinical Practice (EXPOSURE Study) by Stefan Söderberg, Pilar Escribano-Subias, Ciara Archey, Audrey Muller, Martina Fontana, Tobias J. Lange, Sean Gaine

“…Prior to applying propensity score weighting, patients in the selexipag cohort were more likely to have longer time from diagnosis, less functional impairment, and treatment with combination background therapy versus the other PAH therapy cohort. …”
Get full text

Analysis of the Effect of D-Limonene on the Viscosity Reduction of Heavy Crude Oils Using FTIR-ATR Spectroscopy by Julian Sanabria, Cristian Gonzalez, Jose Reyes, Juan Orozco-Agamez, Emiliano Ariza, Adan Leon-Bermudez

“…Notably, crude C4 demonstrated a higher affinity with D-Limonene, likely due to its higher resin/asphaltene content and the presence of -C=C functional groups.…”
Get full text

Exon level machine learning analyses elucidate novel candidate miRNA targets in an avian model of fetal alcohol spectrum disorder. by Abrar E Al-Shaer, George R Flentke, Mark E Berres, Ana Garic, Susan M Smith

“…We address these limitations with a novel approach and implemented an unsupervised machine learning model, which we applied to an exon-level analysis to reduce data complexity to the most likely functionally relevant exons, without loss of novel information. …”
Get full text

Very Early Treatment of Recurrent Strokes with Mechanical Thrombectomy in a Patient with Severe Anemia by Katja Lovoković, Vjekoslav Kopačin, Mihael Mišir, Jasna Hanižjar-Berlančić, Tajana Turk

“…Severe anemia and PRCA likely contributed to hypercoagulability and increased stroke risk. …”
Get full text

Models for analyzing the complexity of English words in the text on the scale from A1 to C2 by М. Бєліков, Т. Ліхоузова, Ю. Олійник

“…For example, it is possible to find a list of likely unknown and difficult words for the end user in any text depending on his level of English language proficiency. …”
Get full text

Impact of ethinylestradiol and levonorgestrel on memory, neurochemical indicators, and neuron density in the hippocampus of Wistar rats by Nathaniel Ohiemi Amedu, Blessing Ifelola

“…Conclusion: Prolonged EE/LNG treatment enhances cognitive flexibility in rats, likely mediated by neurochemical and structural changes in the hippocampus. …”
Get full text

Whole-Genome Characterization of <i>Inonotus hispidus</i> from <i>Ulmus macrocarpa</i> and Its Comparative Genomics with Strains from <i>Morus alba</i> and <i>Acer truncatum</i> by Ruxue Bai, Qingchun Wang, Haiying Bao

“…Phenotypic assays demonstrated distinct mycelial growth dynamics and antagonistic behaviors, which likely reflect host-related environmental adaptation. …”
Get full text

The minor allele rs2295613(A), protective against systemic lupus erythematosus, makes a differential contribution to the activity of the <i>SLAMF1</i> gene promoter in T helpers an... by A. N. Uvarova, L. V. Putlyaeva, E. A. Zheremyan, E. M. Stasevich, M. M. Murashko, E. A. Bogomolova, K. V. Korneev, D. E. Demin, A. M. Schwartz, D. V. Kuprash

“…In the present work, we performed a functional analysis of single nucleotide promoter polymorphisms rs2295614(A&gt;T) and rs2295613(G&gt;A) of the SLAMF1 gene in the models of T-regulatory lymphocytes (MT-2 cell line) and T helpers (Jurkat cell line). …”
Get full text

A novel intronic variant in the ASAH1 gene enhances aberrant splicing, causing spinal muscular atrophy with progressive myoclonic epilepsy by Jinli Bai, Ping Li, Hui Jiao, Yuwei Jin, Hong Wang, Qinglin Jiang, Fang Song, Xiaoyin Peng, Yujin Qu

“…However, the c.264 + 11A > G variant in intron 3 was reported for the first time, and its functional impact has not yet been fully elucidated. …”
Get full text

Proximity Proteomics Reveals USP44 Forms a Complex with BRCA2 in Neuroblastoma Cells and Is Required to Prevent Chromosome Breakage by Asma Ali, Sajjad Hussain, Tibor Bedekovics, Raymond H. Jeon, Danielle G. May, Kyle J. Roux, Paul J. Galardy

“…We found that high <i>BRCA2</i> transcript was correlated with poor survival in neuroblastoma, likely due to its tight association with proliferation in these tumors. …”
Get full text

Dehydrotanshinone II A alleviates osteoarthritis via activating PPARγ to inhibit ferroptosis in chondrocytes by Wenli Guan, Fahu Yuan, Xin Wang

“…Potential therapeutic targets of Simiao Powder were identified through the TCMSP and GEO databases, and their potential biological functions were evaluated using GO enrichment, ROC curve analysis, molecular docking, and immune infiltration assessment via CIBERSORTx. …”
Get full text