Exploring the binding pathways of the 14-3-3ζ protein: Structural and free-energy profiles revealed by Hamiltonian replica exchange molecular dynamics with distancefield distance r... by Gabor Nagy, Chris Oostenbrink, Jozef Hritz

“…The 14-3-3 protein family performs regulatory functions in eukaryotic organisms by binding to a large number of phosphorylated protein partners. …”
Get full text

The Effects of Proprioceptive Exercises on Postural Control in Handball Players with Chronic Ankle Instability—A Non-Randomized Control Trial by Bogdan-Alexandru Antohe, Elena-Adelina Panaet

“…Chronic ankle instability was diagnosed using the Identification of Functional Ankle Instability (IdFAI) questionnaire, while postural control was evaluated with the Iso-Shift stabilometric platform. …”
Get full text

Computational analysis of lupenone derivatives as potential inhibitor of human papillomavirus oncoprotein E6 associated cervical cancer by Saurav Kumar Mishra, Mir Md. Shaheen, Sharifa Sultana, Al-Anood M. Al-Dies, Jehad Zuhair Tayyeb, Taha Alqahtani, Yewulsew Kebede Tiruneh, Gabriel Christian de Farias Morais, Jonas Ivan Nobre Oliveira, Magdi E. A. Zaki

“…Initially, lupenone was modified with different functional groups, and each derivative was screened for drug-likeness via ADMET analysis to confirm pharmacological viability. …”
Get full text

Disrupted care during the COVID-19 state of emergency and productivity loss attributed to presenteeism in workers: a nationwide cross-sectional study by Yoshihisa Fujino, Kanami Tsuno, Ai Hori, Tomohiro Ishimaru, Makoto Okawara, Yoshino Yasuda

“…We aimed to investigate whether disrupted care during the COVID-19 state of emergency was associated with health status and productivity loss.Methods We used data from a nationwide, cross-sectional, Internet-based, self-administered survey. We performed multiple logistic regression analysis on data from 14 545 participants to investigate the associations among variables related to disrupted care, health status and the Work Functioning Impairment Scale, with a cut-off of 21 points.Results Participants who experienced exacerbation of underlying disease (adjusted OR (aOR) 2.84; 95% CI 2.28 to 3.53) or any type of disrupted care were more likely to show low productivity at work. …”
Get full text

Single-cell RNA-sequencing reveals cellular heterogeneity and immune microenvironment characteristics between ocular adnexal mucosa-associated lymphoid lymphoma and IgG4−related op... by Yu Yang, Yu Yang, Yujiao Wang, Xuelian Jin, Weimin He

“…This study aimed to investigate the differences between these two diseases based on their cellular composition, transcriptional heterogeneity, and the immune microenvironment using single-cell RNA transcriptional sequencing (scRNA-seq) technology.MethodsWe collected orbital lacrimal gland region tissue samples from three patients with MALT lymphoma and another three with IgG4-ROD and performed single-cell sequencing experiments. Subsequently, we conducted bioinformatics analyses, including cell subpopulation segmentation and inter-group comparison, tumor cell identification, functional enrichment analysis, and pseudotime trajectory analysis. …”
Get full text

Effects of combined aerobic-resistance training on health-related quality of life and stress in sedentary adults by Fernanda M. Silva, Fernanda M. Silva, José P. Ferreira, Ana M. Teixeira, Alain Massart, Pedro Duarte-Mendes, Pedro Duarte-Mendes

“…Intra- and inter-group analysis were performed using a mixed ANOVA or Friedman’s test.ResultsIn relation to SF-36 results, a significant improvement in the mental component summary (p = 0.047, Kendall’s W = 0.170 (small effect)) and social functioning subdomain (p = 0.040, Kendall’s W = 0.179 (small effect)) was found for the exercise group after the intervention. …”
Get full text

Cell differentiation controls iron assimilation in the choanoflagellate Salpingoeca rosetta by Fredrick Leon, Jesus M. Espinoza-Esparza, Vicki Deng, Maxwell C. Coyle, Sarah Espinoza, David S. Booth

“…Overall, our findings provide insight into the ecological roles choanoflagellates perform and inform reconstructions of early animal evolution where functionally distinct cell types became an integrated whole at the origin of animal multicellularity.IMPORTANCEThis study examines how cell differentiation in a choanoflagellate enables the uptake of iron, an essential nutrient. …”
Get full text

Admission glucose is a significant outcome predictor in anterior circulation stroke: approaching the sweet spot by Alexandra Filipov, Martin Andermann, Guilherme Lepski, Analía Arévalo, Tim Hilgenfeld, Silvia Schönenberger, Christoph Gumbinger, Markus Möhlenbruch, Peter Arthur Ringleb, Jessica Jesser

“…We performed a multiple logistic regression analysis to assess the association between admission glucose levels and functional outcome, including for well-established outcome predictors, i.e. age, NIHSS, Alberta Stroke Program Early CT Score (ASPECTS), time to reperfusion, unsuccessful recanalization, presence of bleeding, and diabetes. …”
Get full text

Nomogram for predicting postoperative clinical remission of hypertension in patients with adrenal tumors by YuanJian Liao, MingShun Zuo, YongPan Zhu, Te Xu, JiaJia Tang, LongMei Fan, Neng Zhang

“…Results In patients with non-functioning adrenal tumors, lower age, body mass index, and hypertension grade were considered independent predictors of postoperative clinical remission of hypertension. …”
Get full text

In Silico Prioritization of STAT1 3′ UTR SNPs Identifies rs190542524 as a miRNA-Linked Variant with Potential Oncogenic Impact by Ebtihal Kamal

“…Using miRNAs’ target genes enrichment analysis, this study indicated that the miRNA target genes were more likely to be involved in cancer-related pathways. …”
Get full text

Acylated glucopyranosides: FTIR, NMR, FMO, MEP, molecular docking, dynamics simulation, ADMET and antimicrobial activity against bacterial and fungal pathogens by Nasrin Akter, Supriyo Saha, Md. Ahad Hossain, Kabir M. Uddin, Ajmal R. Bhat, Sumeer Ahmed, Sarkar M.A. Kawsar

“…Carbohydrates, among the most abundant and widespread biomolecules in nature, play indispensable roles in diverse biological functions and represent a treasure trove of untapped potential for pharmaceutical applications. …”
Get full text

PCK1 and SLC22A2 gene variants associated with response to metformin treatment in type 2 diabetes. by Sophie St-Amour, Laurence Tessier, Janie Harnois, Catherine Allard, Alexandre Lavoie, Philippe Caron, Luigi Bouchard, Patrice Perron, Karine Tremblay

“…Additional genetic and functional studies are necessary to elucidate the variants' impact in metformin's pharmacological mechanisms.…”
Get full text

COMORBIDITIES IN PATIENTS WITH ULCERATIVE COLITIS by T. E. Chernyshova, E. Yu. Varenik, A. A. Valinurov, S. N. Styazhkina

“…The assessment of the basic component was performed using the method of morphofunctional index [Kurnikova I. …”
Get full text

POT1 genetic testing in melanoma-prone families in Sweden: germline variant prevalence and tumor spectrum in identified carriers by Konstantinos Papadakis, Francesca Portelli, Karina Schultz, Hedvig Olsson Sterky, Ismini Vassilaki, Jan Lapins, Michael R. Sargen, Sofia Obolenski, David J. Adams, Muyi Yang, Veronica Höiom, Hildur Helgadottir

“…The population frequency of pathogenic variants (PVs) was assessed using the SweGen and the gnomAD databases. Functional evaluation was performed using a saturation genome editing (SGE) assay. …”
Get full text

Evaluation of the efficacy and safety of injectable glycosaminoglycan-peptide complex (GPC) in patients with osteoarthritis: a multicenter observational study GLADIOLUS (GPC in the... by L. I. Alekseeva, A. E. Karateev, E. Yu. Pogozheva, V. N. Amirdzanova, E. S. Filatova, V. A. Nesterenko

“…The therapy decreased the intensity of pain at rest from 4 [3; 5] to 1 [0; 2] and during movement from 6 [5; 7] to 2 [1; 3] and reduced the severity of functional disorders from 5 [4; 6] to 1 [0; 3]. The number of patients with a good response to therapy (a≥50% decrease in symptom severity) for pain at rest and during movement was 55.6 and 53.5%, respectively; and for functional disorders was 50.8%. 68.1% of patients stopped taking NSAIDs. …”
Get full text

A Comparison of Geminid Models with the PSP/WISPR-observed Phaethon Dust Trail by Karl Battams, Galina O. Ryabova, Angel J. Gutarra-Leon, Jamey R. Szalay, Brendan M. Gallagher, Wolf Cukier

“…Trends in model trail width and offset from Phaethon’s orbit, both as functions of true anomaly, agree with observations to varying extents. …”
Get full text

Organic Dyes Containing Coplanar Dihexyl-Substituted Dithienosilole Groups for Efficient Dye-Sensitised Solar Cells by Ciaran Lyons, Neelima Rathi, Pratibha Dev, Owen Byrne, Praveen K. Surolia, Pathik Maji, J. M. D. MacElroy, Aswani Yella, Michael Grätzel, Edmond Magner, Niall J. English, K. Ravindranathan Thampi

“…Time-dependent density functional theory studies were performed to ascertain the absorption spectrum of the dye and assess the contribution of various transitions to optical excitation, which showed good agreement with experimental results.…”
Get full text

Mesopancreas—Anatomical Insights and Its Implications for Diagnosis and Clinical and Surgical Practice by Florin-Mihail Filipoiu, Georgian-Theodor Badea, Mihaly Enyedi, Ștefan Oprea, Zoran-Florin Filipoiu, Daniela-Elena Gheoca Mutu

“…These components likely contribute to regional metastasis in pancreatic head cancer. …”
Get full text

Serum level of laminin in rats fed with a high-fat diet with sulodexide administration by O. G. Gileva, E. G. Butolin, M. V. Tereshchenko

“…In addition, synthesis of extracellular matrix components was activated with an increase in the serum level of laminin, which performs important structural and regulatory functions.Conclusion. …”
Get full text

Global trends and frontiers in iNKT cells: a bibliometric and visualized analysis by Dan Zhang, Dan Zhang, Jun Lu, Jun Lu

“…BackgroundInvariant natural killer T (iNKT) cells are an unconventional lymphocyte subset that has garnered increasing attention due to their shared features with both natural killer cells and conventional T cells, as well as their unique dual immunological functions. In this study, we conducted a comprehensive bibliometric analysis to trace the evolution of research in the iNKT cell field, identify emerging trends, and highlight current research hotspots and frontier directions.MethodsWe performed a literature search in the Web of Science Core Collection database to retrieve all publications related to iNKT cells published to December 31, 2024. …”
Get full text