Approaches to modulate buffalo gut microbiome for efficient feed utilization and reduced environmental pollution by Vijit Dey, Puran C. Lailer, Tirtha K. Datta

“… Buffaloes are excellent converters of highly fibrous feeds into edible products like milk and meat due to the rumen microbiome structure and their functionality. …”
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PPIH Expression Correlates with Tumor Aggressiveness and Immune Dysregulation in Hepatocellular Carcinoma by Bei J, Sun Z, Fu R, Huang X, Huang J, Luo Y, Li Y, Chen Y, Wei Z

“…Immune infiltration was analyzed via CIBERSORT and ssGSEA, while DNA methylation and somatic mutation analyses were performed using MExpress and “maftools”, respectively, alongside in vitro and in vivo experiments to assess PPIH’s functional roles.Results: Our findings indicated that PPIH is significantly upregulated in various cancer types, correlating with poor patient prognosis, increased somatic mutations, and altered gene methylation patterns. …”
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The Effect of Plasma-β on the Heating Mechanisms during Magnetic Reconnection in Partially Ionized Low Solar Atmosphere by Abdullah Zafar, Lei Ni, Kaifeng Kang, Guanchong Cheng, Jing Ye, Jun Lin, Ahmad Ali, Nadia Imtiaz

“…We performed numerical simulations of magnetic reconnection with different strengths of magnetic fields from the solar photosphere to the upper chromosphere. …”
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Diagnostic and prognostic implications of family history of fibrotic interstitial lung diseases by D. Duminy-Luppi, A. Alcaide-Aldeano, L. Planas-Cerezales, G. Bermudo, V. Vicens-Zygmunt, P. Luburich, B. Del Río-Carrero, R. Llatjós, L. Pijuan, I. Escobar, F. Rivas, A. Montes-Worboys, Y. Gutiérrez-Rodríguez, D. Rodríguez-Plaza, A. Padró-Miquel, A. Esteve-Garcia, B. Fernández-Varas, C. Flores, M. Fuentes, J. Dorca, S. Santos, R. Perona, A. Günther, J. Shull, M. Molina-Molina

“…Clinical, radiological, pulmonary functional tests (PFT), and histological evaluations were performed at diagnosis and follow-up. …”
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The Nutritional Phenotyping of Idiopathic Pulmonary Fibrosis Through Morphofunctional Assessment: A Bicentric Cross-Sectional Case–Control Study by Alicia Sanmartín-Sánchez, Rocío Fernández-Jiménez, Eva Cabrera-César, Francisco Espíldora-Hernández, Isabel Vegas-Aguilar, María del Mar Amaya-Campos, Fiorella Ximena Palmas-Candia, Josefina Olivares-Alcolea, Víctor José Simón-Frapolli, Isabel Cornejo-Pareja, Ana Sánchez-García, Mora Murri, Patricia Guirado-Peláez, Álvaro Vidal-Suárez, Lourdes Garrido-Sánchez, Francisco J. Tinahones, Jose Luis Velasco-Garrido, Jose Manuel García-Almeida

“…Bioelectrical impedance analysis (BIVA), nutritional ultrasound^® (NU) and computed tomography (CT) are included, along with functional tests like the Timed Up and Go test (TUG). …”
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From gut to joint: the protective impact of Eubacterium rectale on rheumatoid arthritis by Xiaoyang Liu, Xiaoyang Liu, Xiaoyang Liu, Ruihe Wu, Ruihe Wu, Ruihe Wu, Yuxin Fan, Yuxin Fan, Yuxin Fan, Kaili Qin, Kaili Qin, Kaili Qin, Baochen Li, Baochen Li, Baochen Li, Xiaofeng Li, Xiaofeng Li, Xiaofeng Li, Chong Gao, Caihong Wang, Caihong Wang, Caihong Wang

“…The onset of RA is closely associated with intestinal flora, which is essential for immune regulation.MethodsFecal samples of 22 healthy controls and 38 patients with newly diagnosed RA were used for performing 16S rRNA sequencing, microbiota diversity assessment, and functional enrichment analysis. …”
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Impact of short-term housing temperature alteration on metabolic parameters and adipose tissue in female mice by Henry A. Paz, Henry A. Paz, C. G. Shashank, C. G. Shashank, Lasya Buddha, Tian Lam, Taylor Zhang, Ying Zhong, James D. Sikes, Craig Porter, Reid D. Landes, Roy Morello, Umesh D. Wankhade, Umesh D. Wankhade

“…Proteomic analysis of iWAT identified 38 differentially expressed proteins, with enrichment of pathways related to mitochondrial function and mTOR signaling.DiscussionShort-term cold exposure induced lasting histological and proteomic changes in iWAT and BAT without sustained effects on energy metabolism, likely due to reversion to RT and limited sample size.ConclusionBrief temperature manipulation around pregnancy can durably alter maternal adipose tissue architecture and molecular signatures, underscoring ambient temperature as an important modulator of maternal metabolic adaptation.…”
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Novel Potent and Selective Dopamine D4 Receptor Piperidine Antagonists as Potential Alternatives for the Treatment of Glioblastoma by Federica Matteucci, Pegi Pavletić, Alessandro Bonifazi, Rian Garland, Hideaki Yano, Consuelo Amantini, Laura Zeppa, Emanuela Sabato, Giulio Vistoli, Valerio Mammoli, Loredana Cappellacci, Fabio Del Bello, Gianfabio Giorgioni, Riccardo Petrelli, Alessia Piergentili, Wilma Quaglia, Alessandro Piergentili

“…<b>Results</b>: Radioligand binding results highlighted that the derivatives bearing a terminal butyl chain showed structure–activity relationships different from those with a benzyl terminal. From functional studies performed on the best derivatives <b>12</b> and <b>16</b>, the response profiles of both compounds were more robust in antagonist mode, with derivative <b>16</b> showing higher antagonist potency than <b>12</b> across all three transducers. …”
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A stable 15-member bacterial SynCom promotes Brachypodium growth under drought stress by Archana Yadav, Mingfei Chen, Shwetha M. Acharya, Grace Kim, Yuguo Yang, Tiffany Z. Zhao, Eunice Tsang, Romy Chakraborty

“…We further observed preferential colonization of SynCom strains around root tips under stress, likely due to active interactions between plant root metabolites and bacteria.DiscussionOur results demonstrate that trait-informed construction of synthetic communities can yield stable, functionally diverse consortia that enhance plant resilience under drought. …”
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Migraine Headache and Its Related Disability Factors Among University Students in Jordan: A Cross-Sectional Study by Almomani MA, Almomani BA, Al-Sawalha NA, Alqudah AA

“…University students, especially, face psychological and academic stressors that may trigger migraine, leading to functional impairment. This can hinder concentration, studying, and academic performance, resulting in disability, reduced productivity, and absenteeism. …”
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Primary failure of eruption: From molecular diagnosis to therapeutic management by Delphine Wagner, Tristan Rey, Marie-Cécile Maniere, Sarah Dubourg, Agnès Bloch-Zupan, Marion Strub

“…Clinical and radiological features were collected, and genetic analyses were performed. Results: The clinical phenotype (type and number of involved teeth, depth of bone inclusions, functional consequences) is variable within the family. …”
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HMGB1 blood levels and neurological outcomes after traumatic brain injury: Insights from an exploratory study by Irma Wati Ngadimon, Devi Mohan, Mohd Farooq Shaikh, Ching Soong Khoo, Hui Jan Tan, Yu Mey Lee, Nor Syazwani Chamhuri, Farizal Fadzil, Nursyazwana Zolkafli, Alina Arulsamy, Jegan Thanabalan, Angel Aledo‐Serrano, Wing Loong Cheong

“…Abstract Objective Posttraumatic epilepsy (PTE) and cognitive impairment are severe complications following traumatic brain injury (TBI). Neuroinflammation likely contributes, but the role of specific inflammatory mediators requires clarification. …”
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Biogenic Zinc nanoparticles: green approach to synthesis, characterization, and antimicrobial applications by Myada S. M. Ouf, Mahmoud E. A. Duab, Dina I. Abdel-Meguid, Ebaa E. EL-Sharouny, Nadia A. Soliman

“…Antimicrobial dose-response testing showed that single-phase ZnS NPs inhibited Klebsiella pneumoniae, while mixed-phase ZnS-ZnO NPs were effective against Staphylococcus epidermidis at 100 µg/ml based on inhibition zone measurements.Furthermore, the mixed-phase ZnS-ZnO NPs at 25 µg/ml demonstrated superior inhibition of microbial growth in sludge samples, likely due to a synergistic effect. Conclusion The study demonstrates the successful biogenic synthesis of ZnS NPs, and ZnS-ZnO NPs using two bacterial strains, with distinct morphological and functional properties. …”
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Sex-related Anthropometrics in a Lower-Body Mobility Assessment Among Professional Soccer Athletes by Corbin A. Hedt, Jessica T. Le, Tyler Heimdal, Justin Vickery, Erin Orozco, Patrick C. McCulloch, Bradley S. Lambert

“…Thus, these anatomical factors likely need to be taken into account when assessing baseline performance and risk of injury to improve screening efficacy…”
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Complementary interventions for cognitive rehabilitation in patients with cerebral palsy: a single-center study by Ammara Rafique

“…One-way ANOVA and Tukey’s post hoc analysis showed significant differences among the control and intervention groups at baseline in information processing, selective attention, and spatial fluency. These cognitive functions are likely attributable to increased neuronal activity in the prefrontal cortex and elevated serotonin levels. …”
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Time-coexpress: temporal trajectory modeling of dynamic gene co-expression patterns using single-cell transcriptomics data by Shuyi Yang, Anderson Bussing, Giampiero Marra, Michelle L. Brinkmeier, Sally A. Camper, Shannon W. Davis, Yen-Yi Ho

“…Results We propose a copula-based framework, TIME-CoExpress, with proper data-driven smoothing functions to model non-linear changes in gene co-expression along cellular temporal trajectories. …”
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Scaling Relationships and Sexual Size Dimorphism Among the Body Parts of Holotrichia oblita (Coleoptera: Scarabaeidae) by Mengmeng Zhu, Karl J. Niklas, Long Chen, Lin Wang, Yabing Jiao, Peijian Shi

“…By integrating allometry with functional ecology, we reveal how trade‐offs between protection (elytra mass), mobility (wing area), and reproduction (female‐biased size) drive non‐isometric growth, potentially advancing predictions of insect performance under selective pressures.…”
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Concurrent Validity and Inter-Rater Reliability of Hand-Held Measurements of Maximal Sprint Speed by Bartosz Zając, Paulina Gaj, Jakub Zięba

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Flavonoids and anthocyanins in seagrasses: implications for climate change adaptation and resilience by Jana Botes, Jana Botes, Xiao Ma, Xiao Ma, Jiyang Chang, Jiyang Chang, Yves Van de Peer, Yves Van de Peer, Yves Van de Peer, Yves Van de Peer, Dave Kenneth Berger, Dave Kenneth Berger

“…However, ocean warming will likely lead to a decrease in anthocyanin content, which may impact the performance of intertidal seagrasses. …”
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ISG15 as a Potent Immune Adjuvant in MVA-Based Vaccines Against Zika Virus and SARS-CoV-2 by Juan García-Arriaza, Michela Falqui, Patricia Pérez, Rocío Coloma, Beatriz Perdiguero, Enrique Álvarez, Laura Marcos-Villar, David Astorgano, Irene Campaña-Gómez, Carlos Óscar S. Sorzano, Mariano Esteban, Carmen Elena Gómez, Susana Guerra

“…To elucidate the underlying mechanism of action of ISG15, in vitro co-infection studies were performed in macrophages. Finally, we evaluated the magnitude and functional quality of the elicited antigen-specific cellular immune responses in vivo. …”
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