Pecan-medicinal crops intercropping improved soil fertility and promoted interactions between soil microorganisms and metabolites by Ruyuan Wang, Chenyang Liu, Xuesong Bie, Yan Dai, Xu Feng, Ren Wang, Ming Wang, Shu Xu, Yu Chen

“…A combined analysis of soil microbiomes and metabolomes was performed to discover the effects of intercropping on bulk and rhizosphere soils. …”
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Distinct mRNA expression profiles and miRNA regulators of the PI3K/AKT/mTOR pathway in breast cancer: insights into tumor progression and therapeutic targets by Tomasz Sirek, Tomasz Sirek, Katarzyna Król-Jatręga, Katarzyna Król-Jatręga, Przemysław Borawski, Nikola Zmarzły, Dariusz Boroń, Dariusz Boroń, Dariusz Boroń, Dariusz Boroń, Piotr Ossowski, Olga Nowotny-Czupryna, Kacper Boroń, Dominika Janiszewska-Bil, Elżbieta Mitka-Krysiak, Beniamin Oskar Grabarek, Beniamin Oskar Grabarek

“…For instance, reduced expression of miR-190a-3p may contribute to the overexpression of PIK3CA and other pathway components, enhancing metastatic potential.ConclusionOur findings suggest that the PI3K/AKT/mTOR pathway and its miRNA regulators play crucial roles in breast cancer progression, particularly in aggressive subtypes like TNBC. The identified miRNAs and mRNAs hold potential as biomarkers for diagnosis and treatment, but further validation in functional studies is required. …”
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Identification of novel MYO19 variants in neonatal hypertrophic cardiomyopathy: a familial analysis revealing oligogenic contributors to disease severity by Hye-Won Cho, Hyeseon Kim, Jeong-Min Kim, Dong Mun Shin, Oc-Hee Kim, Misun Yang, Heui Seung Jo, Mi-Ae Jang, Ja-Hyun Jang, Hyun-Young Park, Yun Sil Chang, Mi-Hyun Park

“…All three genes are associated with mitochondrial function, and in silico prediction tools suggest that these variants are likely damaging. …”
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Evaluating the potential of graphene oxide to promote skeletal muscle complex regeneration by Yulu Chen, Zeyu Zhu, Yian Shen, Xuling Liu, Yushi He, Chengqi Lyu, Jiayu Lu

“…Increased GO conductivity played a crucial role in supporting MyoD expression and promoting myocyte differentiation, likely by modulating membrane electrical activity and facilitating intercellular signaling. …”
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Comparative Efficacy of Different Exercise Therapies for Cardiorespiratory Fitness in Breast Cancer Survivors: A Systematic Review and Bayesian Network Meta-analysis by Xue Zhou, Yao Yang, Liwen Zhai, Jianing Gan, Conghui Li, Yi Zhu

“…Conclusions This NMA suggests MICT, M–V, HIIT, and M–V + RE as available options for improving CRF in breast cancer survivors, and M–V + RE is likely to be the optimal choice for improving CRF. …”
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COMPARISON OF CRUSTAL DEFORMATION RATES ESTIMATED FROM SEISMIC AND GPS DATA ON THE BISHKEK GEODYNAMIC POLYGON by N. A. Sycheva, A. N. Mansurov

“…The modern crustal movements were estimated from the geodetic measurements performed on the Central Asian GPS Network. Using the crustal movement velocities for 90 sites in the study area, the deformation processes in the crust were modeled based on the linear part of the Taylorexpansion of the point's-velocity-versus-its-radius-vector function. …”
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Additively manufactured injection mould tooling incorporating gradient density lattice structures for mass and energy reduction by Rokas Šakalys, Christopher O'Hara, Mandana Kariminejad, Albert Weinert, Mohammadreza Kadivar, Bruno Zluhan, Karl Costello, Marion McAfee, Gerard McGranaghan, Ramesh Raghavendra, David Tormey

“…Therefore, this research exploits the combination of lattice structure design and AM to make functional IM tooling. A tooling design with solid infill was initially modified with a lattice structure of uniform strut thickness, and then Finite Element (FE) Structural Analysis was performed to estimate the stress field typical of an injection mould cycle. …”
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Associations of sociodemographic, clinical factors and HLA-B alleles with enthesitis and peripheral arthritis in patients with ankylosing spondylitis by Michael H Weisman, John D Reveille, MinJae Lee, Matthew A Brown, Michael Ward, Lianne Gensler, Mariko Ishimori, Amirali Tahanan, Mohammad Hossein Rahbar, Mark Hwang, Benjamin Sornrung Naovarat

“…Univariable and multivariable analyses of the association of peripheral arthritis and enthesitis with clinical, sociodemographic factors were performed. Human leucocyte antigen (HLA)-B alleles were analysed by single-stranded conformational polymorphism analysis.Results Those with peripheral arthritis on examination were more likely to have psoriasis (p=0.001, OR=1.68; CI, 1.11, 2.54), greater functional impairment (p<0.001 OR=1.72; CI, 1.31, 2.27), higher erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) levels (p<0.001), greater tumour necrosis factor (TNF) inhibitor (p<0.001, OR=1.50; CI, 1.14, 1.97) and use methotrexate/sulfasalazine (p<0.001, OR=2.25, CI [1.57, 3.23]). …”
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LLT1 overexpression renders allogeneic-NK resistance and facilitates the generation of enhanced universal CAR-T cells by Shuxian Zhu, Shiyu Zuo, Chuo Li, Xingjie You, Erlie Jiang, Xiaoming Feng, Yuechen Luo

“…T cells were subjected to CD38, TCR, HLA-I, and HLA-II gene knockdown using CRISPR/Cas9, followed by lentiviral transduction. We performed cytotoxicity, proliferation, and cytokine assays to evaluate the functionality of universal chimeric antigen receptor-T cell (UCAR-T) cells and conducted in vitro and in vivo assays, including allogeneic responses and RNA sequencing, to assess their resistance to allogeneic T and NK cells, anti-leukemia efficacy, and persistence in treating hematologic malignancies. …”
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Significant differences in knee kinematics of healthy subjects with high and low anterior tibial laxity by Shiyang Chen, Shaohua Chen, Qingyang Kang, Fangzheng Lin, Fangzheng Lin, Fangzheng Lin, Shuting Zheng, Xixi Liu, Chunhong Guo, Chunhong Guo, Yongjin Li, Yongjin Li, Dingkun Lin, Dingkun Lin, Xiaolong Zeng

“…High anterior tibial laxity resulted in dynamic instability of knees during motions, especially in high-demanding activities like upslope or vertical jumping. However, further research is needed to explore the clinical functional effects of knee laxity.…”
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Sex-Specific Inflammatory Profiles Affect Neuropsychiatric Issues in COVID-19 Survivors by Mariagrazia Palladini, Mario Gennaro Mazza, Beatrice Bravi, Margherita Bessi, Maria Cristina Lorenzi, Sara Spadini, Rebecca De Lorenzo, Patrizia Rovere-Querini, Roberto Furlan, Francesco Benedetti

“…In females, a lingering imbalance between pro- and anti-inflammatory responses—likely reflecting the long-lasting immune alterations triggered by COVID-19—significantly affects cognitive functioning and shows a marginal, though not statistically significant, association with depressive symptoms. …”
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THE ROLE OF MAGNETIC RESONANCE RESEARCH IN THE TREATMENT OF DYSFUNCTION OF THE TEMPOROMANDIBULAR JOINT by V.M. Novikov, M.A. Korostashova, V.I. Dodatko, O.S. Svyryda, Ya.O. Yushchenko

“…All patients were prescribed a Michigan-splint occlusal splint in combination with a sling-like head cap at night. The results of the selected treatment were interpreted after 3-6 months. …”
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Zagociguat prevented stressor-induced neuromuscular dysfunction, improved mitochondrial physiology, and increased exercise capacity in diverse mitochondrial respiratory chain disea... by Leonard Burg, Heeyong Yoon, Min Peng, Peter Germano, Emily Reesey Gretzmacher, Rui Xiao, Vernon E. Anderson, Eiko Nakamaru-Ogiso, Eiko Nakamaru-Ogiso, Marni J. Falk, Marni J. Falk

“…BackgroundZagociguat (zag) is a CNS-penetrant, soluble guanylate cyclase (sGC) stimulator that has been evaluated in phase 2a, with phase 2b ongoing, clinical studies of primary mitochondrial disease (PMD) subjects with mitochondrial encephalomyopathy, lactic acidosis, and stroke-like episodes syndrome (MELAS). To explore its utility in a broader array of PMDs and secondary mitochondrial disorders, we performed prfeclinical modeling of zag across larval and adult zebrafish models with biochemical deficiencies in diverse respiratory chain (RC) complexes or dihydrolipoamide dehydrogenase (Dldh).MethodsZag was evaluated for tissue uptake, gross toxicity, protection from RC toxin-induced brain death, neuromuscular dysfunction, heartbeat loss, and biochemical dysfunction in transgenic or toxin-exposed zebrafish with mitochondrial enzyme deficiencies in complex I (ndufs2−/− or rotenone-exposed wild type (WT)), complex IV (surf1−/− or azide-exposed WT), multiple RC complexes (fbxl4−/−), or pyruvate dehydrogenase complex (dldh−/−). …”
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Measuring the Effective Factors in the Non-Development of the Sustainable Smart City of Tabriz by Ali Zeynali Azim, Mehri Fadaei Haghi, Amin Alizadeh, Mohammad Jodeiri Abbasi, Reza Fathipour, Mohammadali Sharifi

“…Introduction: Tabriz city, like most big cities in the world, is facing complex problems in terms of population density, air and noise pollution, providing transportation services, social, economic housing and other issues. …”
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Brain-based Criteria of Human Death. Study of the Issue by Jacek Norkowski

“…+is does not mean, however, that the brain is so damaged that is has ceased to perform all its functions. On the contrary, these patients usually show many symptoms of brain activity. …”
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Complex Approach to the Diagnosis of Children with Nasal and Nasopharyngeal Pathology. Key Results by Leyla S. Namazova-Baranova, Viktor A. Gankovsky, Irina V. Zelenkova, Svetlana G. Gubanova, Alexander V. Pashkov, George A. Karkashadze, Elena A. Vishneva, Elena V. Kaytukova, Kamilla E. Efendieva

“…The following practical guidelines have been proposed: 1) all patients with complaints on prolonged nasal breathing difficulties require not only otorhinolaryngologist examination, but also diagnostic endoscopy of nasal cavity and nasopharynx; 2) in case of nasal septum deviation and complaints on prolonged nasal breathing difficulties, it is necessary to perform functional methods for nasal breathing evaluating (RRM, RMM) to choose adequate treatment method; 3) the use of RRM, RMM would help to choose the optimal treatment approach in children with complaints on prolonged nasal breathing difficulties and confirmed diagnosis of allergic disease (allergic rhinitis, hay fever, etc.), also associated with adenoid hypertrophy and/or nasal cavity and nasopharynx inflammatory diseases; 4) all patients with confirmed chronic diseases of ENT-organs should be examined by allergist, and, if necessary, should undergo comprehensive allergological examination. …”
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Biosynthesis and activity of Zn-MnO nanocomposite in vitro with molecular docking studies against multidrug resistance bacteria and inflammatory activators by Samy Selim, Tarek M. Abdelghany, Mohammed S. Almuhayawi, Mohammed K. Nagshabandi, Muyassar K. Tarabulsi, Mohammed Yagoub Mohammed Elamir, Asmaa A. Alharbi, Soad K. Al Jaouni

“…Transmission electron microscopy confirmed irregular particles with a spherical-like shape ranging from 25.13 to 36.21 nm. Numerous functional groups were detected on the surface of Zn-MnO nanocomposite via Fourier-transform infrared spectroscopy. …”
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Postoperative Sore Throat After Tracheal Intubation: An Updated Narrative Review and Call for Action by Chen Z, Zuo Z, Zhang L, Gong M, Ye Y, Jin Y, Zhao X

“…Zheping Chen,1,2,* Zhenxiang Zuo,3,4,* Le Zhang,2,4 Moxuan Gong,2,5 Yuyang Ye,2,4 Yanwu Jin,2,4,6 Xin Zhao2,4 1Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Translational Research Institute of Brain and Brain-Like Intelligence, Clinical Research Center for Anesthesiology and Perioperative Medicine, Department of Anesthesiology and Perioperative Medicine, Shanghai Fourth People’s Hospital, School of Medicine, Tongji University, Shanghai, 200434, People’s Republic of China; 2Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, People’s Republic of China; 3Department of Gastroenterology, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, 250033, People’s Republic of China; 4The Second Clinical College, Shandong University, Jinan, Shandong, 250033, People’s Republic of China; 5Department of Pain, Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, 200041, People’s Republic of China; 6Department of Anesthesiology and Perioperative Medicine, Shandong Public Health Clinical Center, Shandong University, Jinan, Shandong, 250100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yanwu Jin; Xin Zhao, Department of Anesthesiology, The Second Hospital, Cheeloo College of Medicine, Shandong University, 247 Bei Yuan Street, Jinan, Shandong, 250033, People’s Republic of China, Tel +86-17660085535 ; +86-17660085551, Email jinyanwu_aa@163.com; lujnzx@sohu.comBackground: Postoperative sore throat (POST) represents a common airway complication closely related to endotracheal tube (ETT), exhibiting a higher incidence following tracheal intubation compared to other airway apparatuses. …”
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Transcranial Direct Current Stimulation (tDCS) for Borderline Personality Disorder (BPD): Why and How? by Lionel Cailhol, Kamilia Soltani, Cécilia Neige, Marine Mondino, Jérôme Brunelin, Martin Blay

“…A PubMed/MEDLINE search was performed using keywords related to transcranial direct current stimulation (tDCS) and BPD, identifying five published randomized controlled trials on the topic. …”
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ANYONE CAN HEAR: RESEARCH POTENTIAL OF CLASSICAL RADIO FORMAT / У ВСЕХ НА СЛУХУ: АНАЛИТИЧЕСКИЙ ПОТЕНЦИАЛ РАДИО ФОРМАТА CLASSICAL by TSVETKOVSKAYA Tatiana A. / ЦВЕТКОВСКАЯ ТАТЬЯНА АНАТОЛЬЕВНА

“…Even though the radio of classical music outlines trends which are specific for academic art in general, there is a number of specialties arising from the nature of mass-media. Duality like this distinguishes the structure of its program too, the quality of which can not be evaluated without taking into account the functional specific of radio. …”
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