Dissecting the role of single nucleotide polymorphism of lymphotoxin beta gene during pig domestication using bioinformatic and experimental approaches by R. B. Aitnazarov, E. V. Ignatieva, N. E. Bazarova, V. G. Levitsky, S. P. Knyazev, Y. Gon, N. S. Yudin

“…Studies of wild and laboratory animals have revealed a trade-off between reproductive success and immunity. Therefore, it is likely that domestication favored selection of individuals with high reproductive performance but low immunity. …”
Get full text

The effect of the administration form of antibiotic therapy on the gut microbiome in patients with infected diabetic foot ulcers - DFIATIM trial by Chahrazed Mekadim, Jakub Mrazek, Kateřina Olša Fliegerová, Hana Sechovcová, Tiziana Maria Mahayri, Radka Jarošíková, Jitka Husáková, Veronika Wosková, Petr Tůma, Jan Polák, Dominika Sojáková, Andrea Němcová, Michal Dubský, Vladimíra Fejfarová

“…Diabetic patients without iDFUs were used as a control group. 16 S ribosomal RNA gene amplicon sequencing was performed on stool samples collected from participants. …”
Get full text

Isolation andfunctional characterization of HO-hMSCs as NK-supportive cells derived from hematopoietic organoids by TANG Shili, LIN Bixuan, HUANG Enxia, HE Ying, XUE Yuan, ZHANG Yonggang

“…Flow-cytometric phenotyping and bulk RNA-sequencing were performed to compare HO-hMSCs with umbilical cord-derived MSCs (UC-hMSCs). …”
Get full text

LOCAL APPLICATION OF RECOMBINANT INTERFERON-ALFA2 FOR TREATMENT OF RECURRENT RESPIRATORY PAPILLOMATOSIS by M. Plouzhnikov, E. Katinas, M. Ryabova, S. Karpishenko, K. Syssoev, A. Chukhlovin, A. Totolian

“…In all cases, we revealed an initially decreased functional activity of Т-lymphocytes, as well as low contents of Т-killer and NK-cells. …”
Get full text

Towards the mechanical stability of biocrusts in drylands: Insights from inorganic ions and organic compounds and their interactions by Xingxing Yu, Bo Xiao, Yousong Cao, Stephen R. Hoon, Giora J. Kidron

“…Biocrusts are an important component of dryland ecosystems as they perform crucial ecological functions like stabilizing soils, mediating the hydrological cycle, and improving nutrient availability. …”
Get full text

ASPM mediates nuclear entrapment of FOXM1 via liquid-liquid phase separation to promote progression of hepatocarcinoma by Xunliang Jiang, Jun Liu, Ke Wang, Jianyong Sun, Huilong Yin, Yu Jiang, Yongkang Liu, Ningbo Wang, Xiaochen Ding, Pu Gao, Lin Li, Xiang Zhang, Jipeng Li, Rui Zhang

“…Results Abnormal spindle-like microcephaly associated (ASPM) is identified to interact with FOXM1 protein via LLPS and enhance its stability by preventing proteasome-mediated degradation. …”
Get full text

Transthyretin cardiac amyloid: Broad heart failure phenotypic spectrum and implications for diagnosis by Mileydis Alonso, Radhika K. Neicheril, Yosef Manla, Malcolm L. McDonald, Alejandro Sanchez, Gabrielle Lafave, Yelenis Seijo De Armas, Antonio Lewis Camargo, Dipan Uppal, David Wolinsky, Nina Thakkar‐Rivera, Mauricio Velez, David A. Baran, Jerry D. Estep, David Snipelisky

“…Those presenting with HFrEF or HFmrEF were more likely to be African American and had significantly worse New York Heart Association (NYHA) functional class, higher N‐terminal pro‐brain natriuretic peptide (NT‐proBNP) and higher serum creatinine levels as compared with those with HFpEF. …”
Get full text

Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways by Qingshan Tang, Jiachen Dong, Feng Zhang, Dan Zhao, Qi Yang, Jiayu Wen, Yuhao Sun, Jifu Wei, Zhixian Liu

“…Gene ontology (GO), kyoto encyclopedia of genes and genomes (KEGG) analysis and gene set enrichment analysis (GSEA) were applied to predict the potential functions of DEGs. Quantitative real time polymerase chain reaction (qRT-PCR) and Western blotting assays were performed to measure the expressions of thrombospondin-1 (THBS1), TGF-β1, PI3K, AKT and phosphorylated AKT (p-AKT) in the entrectinib-treated nerve cells. …”
Get full text

Unveiling Palmitoyl Thymidine Derivatives as Antimicrobial/Antiviral Inhibitors: Synthesis, Molecular Docking, Dynamic Simulations, ADMET, and Assessment of Protein–Ligand Interact... by Sarkar M. A. Kawsar, Samiah Hamad Al-mijalli, Gassoumi Bouzid, Emad M. Abdallah, Noimul H. Siddiquee, Mohammed A. Hosen, Mabrouk Horchani, Houcine Ghalla, Hichem B. Jannet, Yuki Fujii, Yasuhiro Ozeki

“…ADMET predictions were performed to assess drug-likeness and pharmacokinetic properties. …”
Get full text

Study on assessment of water system health in Heihe River Basin based on the game theory by Jiayu Du, Hairong Gao, Ran Liu, Yu Han, Runzhi Hu

“…Maintaining river health holds significant implications for guaranteeing the proper functioning of water systems and promoting social development. …”
Get full text

Improvement in genomic prediction of maize with prior gene ontology information depends on traits and environmental conditions by Baber Ali, Tristan Mary‐Huard, Alain Charcosset, Laurence Moreau, Renaud Rincent

“…Gene ontology (GO) terms can be used for this purpose, and the information can be integrated into genomic prediction models through marker categorization. It allows likely causal markers to account for a certain portion of genetic variance independently from the remaining markers. …”
Get full text

Feasibility of Group Telerehabilitation for Older Adults: A Quality Improvement Project by Emily M. Hudson, Stephanie P. Bazal, Michelle R. Rauzi, Hillari S. N. Olson, Melissa J. Ludescher, Christine Interrante, Molly Lahn, Estee Berg, Howard A. Fink, Jennifer P. Wisdom, Allison M. Gustavson

“…Eligible Veterans lived in the community and were at risk for falls or hospitalization per functional performance measures. We used convergent parallel mixed methods approach in the evaluation. …”
Get full text

Is competitive body-building pathological? Survey of 984 male strength trainers by Ian Steele, Harrison Pope, Eric J Ip, Mitchell J Barnett, Gen Kanayama

“…AAS-using competitors were more likely than AAS-using recreationals to have disclosed their AAS use to a physician (31 (50.8%) vs 107 (30.0%), p=0.003). …”
Get full text

Seismic Vulnerability Assessment of Residential RC Buildings in Yemen Using Incremental Dynamic Analysis (IDA) by Amr Ahmed Radman Ahmed, Linfeng Lu, Bo Li, Wei Bi, Fawziah Mohammed Abdullah Al-Dhubai

“…Based on these results, cumulative distribution functions (CDFs) were calculated to derive the seismic fragility curves. …”
Get full text

Linking gas production to microbial fuel cell output: a novel approach to assess soybean processing and selenium bioavailability by Vahid Vegari, Akbar Taghizadeh, Ali Hosseinkhani, Maghsoud Besharati, Kasim Sakran Abass, Maximilian Lackner

“…Gas production kinetics showed microwaved soybeans yielded the highest cumulative GP (312.75 mL/g DM at 96 h), surpassing roasted and raw treatments, likely due to structural modifications improving microbial accessibility. …”
Get full text

Comparative study of intelligent sensory technologies combined multiple metabolomics in evaluating sensory attributes and health profiles across different grades and varieties of g... by Junhui Lin, Zhangchang Yang, Qian Li, Weifei Wang, Sentai Liao, Dongxu Xing, Ruohong Chen, Daorui Pang, Yuxiao Zou

Get full text

Single‐cell landscape of the intrahepatic ecosystem in alcohol‐related liver disease by Xiaofang Zhao, Senyan Wang, Qi Liu, Wenjuan Wei, Xiaoyan Sun, Hao Song, Jing Xu, Shuijun Zhang, Hongyang Wang, Jing Fu

“…The ALB+ KRT7+ epithelium were enriched in ALD patients, and the function of this epithelial population varied significantly across ALD stages. …”
Get full text

ADAR1 Promotes Myogenic Proliferation and Differentiation of Goat Skeletal Muscle Satellite Cells by Zihao Zhao, Miao Xiao, Xiaoli Xu, Meijun Song, Dinghui Dai, Siyuan Zhan, Jiaxue Cao, Jiazhong Guo, Tao Zhong, Linjie Wang, Li Li, Hongping Zhang

“…Here, we explored the functions of ADAR1 in the myogenic process of goat skeletal muscle satellite cells (MuSCs). …”
Get full text

Supercharged NK cells, unlike primary activated NK cells, effectively target ovarian cancer cells irrespective of MHC-class I expression by Sara Huerta-Yepez, Thomas G Graeber, Neda A Moatamed, Po-Chun Chen, Sanaz Memarzadeh, Subramaniam Malarkannan, Ao Mei, Kawaljit Kaur, Yash Jain, Tanya Singh, Favour Esedebe, Yi Jou Liao, Gabriella DiBernardo, Anahid Jewett

“…MHC-class gene expression assessments of ovarian tumours were performed using gene set enrichment analysis (GSEA). …”
Get full text

Identifying a prognostic signature for clear cell renal cell carcinoma: the convergence of single-cell and bulk sequencing with machine learning by Yude Hong, Xiao Hu, Libo Chen, Mingyong Li, Mingxiao Zhang, Weiming Deng

“…Single-cell RNA sequencing analysis, qRT-PCR, and a CCK-8 assay were used to clarify the biological functions of the hub gene.ResultsMLRS demonstrated outstanding performance in predicting prognosis compared with the other published signatures, and the high-MLRS group had a favorable outcome in four independent datasets. …”
Get full text