የጋብቻ ለውጥ መለማመጃ ሥርዓተ ክዋኔዎች በጃቢ ጠህናን ማኅበረሰብ by Siraye Endalew, Waltenigus Mekonnen, Desta Amare

“…The research also used the functionalism theoretical framework to analyze data. …”
Get full text

Bioinformatics identification and validation of pyroptosis-related gene for ischemic stroke by Xinying Shang, Rui Wei, Di Yang, Bawei Yu, Wei Zhang

“…We screened for LASSO regression to construct a prognostic model of GSE131193 and PRGs and examined by GSE137482. The functional enrichment analysis of Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) were performed on pyroptosis-related differentially expressed genes (PRDEGs) of GSE202659.The key modules for CIRI and pyroptosis were identified by Weight Gene Co-expression Network Analysis (WGCNA). …”
Get full text

Impact of Midfoot Charcot Arthropathy (Brodsky Type 1) on Patient Reported Outcome Scores by Seth J. Tysor BS, Christopher E. Gross MD, Daniel J. Scott MBA, MD, Joshua L. Morningstar BS, Joseph Cutrone BS, Michael Otten MD

“…We will compare these values with PROMs from conditions like ESRD, knee and hip arthritis, highlighting Charcot arthropathy's comparable debilitation. …”
Get full text

COL6A2 in clear cell renal cell carcinoma: a multifaceted driver of tumor progression, immune evasion, and drug sensitivity by Yashuang Yang, Ruixin Fan, Boming Zhang, Kai Liu

“…COL6A2 was also linked to enhanced stem cell-like properties, invasiveness, and metastatic potential. …”
Get full text

Mycochemistry, antioxidant, anticancer activity, and molecular docking of compounds of F12 of ethyl acetate extract of Astraeus asiaticus with BcL2 and Caspase 3 by Swapan Kumar Ghosh, Koushik Pandey, Madhuparna Ghosh, Pradip Kumar Sur

“…The FT-IR study revealed different functional groups in the extracts with different characteristic peak values. …”
Get full text

Increasing cisplatin exposure promotes small-cell lung cancer transformation after a shift from glucose metabolism to fatty acid metabolism by Qiu-yu Zhao, Wen-jun Liu, Jian-guang Wang, He Li, Jia-lu Lv, Yumeng Wang, Chun Wang

“…RNAseq analyses identified TP53 and RB1 gene mutations. Comprehensive functional assays were performed to characterize A549/DDP1 μg/mL and A549/DDP3 μg/mL cells, focusing on proliferation and migratory capabilities. …”
Get full text

Equine Adipose-Derived Mesenchymal Stromal Cells Release Extracellular Vesicles Enclosing Different Subsets of Small RNAs by Stefano Capomaccio, Katia Cappelli, Cinzia Bazzucchi, Mauro Coletti, Rodolfo Gialletti, Franco Moriconi, Fabrizio Passamonti, Marco Pepe, Stefano Petrini, Samanta Mecocci, Maurizio Silvestrelli, Luisa Pascucci

“…Enrichment analyses were performed to infer involved pathways and functional categories. …”
Get full text

Multicriteria Group Decision Making Based on TODIM and PROMETHEE II Approaches with Integrating Quantum Decision Theory and Linguistic Z Number in Renewable Energy Selection by Prasenjit Mandal, Leo Mrsic, Antonios Kalampakas, Tofigh Allahviranloo, Sovan Samanta

Get full text

GM-CSF potentiates macrophages to retain an inflammatory feature from their circulating monocyte precursors in rheumatoid arthritis by Jianing Chen, Minghua Zhan, Yanling Zhao, Honglin Xu, Futai Feng, Zhou Bai, Ke Zhang, Lufan Fu, Fang Wang, Yongjing Cheng, Xuan Zhang, Yudong Liu

“…Transcriptomic analysis, metabolic profiling, flow cytometry, and functional assays were performed. Results Transcriptomic and functional analyses revealed that GM-CSF-differentiated macrophages (GM-DMs) from RA monocytes preserved a proinflammatory M1-like phenotype, whereas M-CSF-differentiated macrophages (M-DMs) lost this phenotype. …”
Get full text

Acoustic features of emotional expression in 5-year-old children with autism spectrum disorder by Daichi Okuizumi, Daichi Okuizumi, Kazunori Terada, Azusa Ishii, Yoshimasa Ohmoto, Hitomi Shimizu, Akira Imamura, Ryoichiro Iwanaga, Hirokazu Kumazaki, Hirokazu Kumazaki

“…Prosody serves important communicative functions not only at grammatical and pragmatic levels but also at the emotional level. …”
Get full text

Blood Progenitor Cell Mobilization Driven by TWEAK Promotes Neovascularization and Reduces Brain Damage in a Rat Model of Intracerebral Hemorrhage by Daniel Romaus-Sanjurjo, Esteban López-Arias, Cristina Rodríguez, Pablo Hervella, Mariña Rodríguez-Arrizabalaga, Manuel Debasa-Mouce, Juan Manuel Pías-Peleteiro, Ramón Iglesias-Rey, Pablo Aguiar, Ángeles Almeida, José Castillo, Alberto Ouro, Tomás Sobrino

“…The TNF-like weak inducer of apoptosis (TWEAK), binding to its receptor Fn14, has been suggested as an inducer of EPCs differentiation, viability and migration to the injury site in a model of myocardial infarction. …”
Get full text

A rapid and efficient reverse genetics method for generating RNA viruses by Ms Kavitha Sethumadhavan, Ms JyothiLakshmi Sajimon, Dr Pratyajit Mohapatra, Dr Victor Stalin Raj

“…Results: To construct functional VSV full-length genome and minigenome plasmids, we integrated regulatory elements like leader, trailer, and ribozyme sequences (<200 bp each) into the larger genome via overlap PCR approach, with a 35 bp overlap between fragments. …”
Get full text

Comparative Outcomes of Minimally Invasive Versus Open Hallux Valgus Surgery: A Systematic Review and Meta-Analysis by Abdul-Hadi Kafagi, Abdul-Rhaman Kafagi, Marwan Tahoun, Omar Tariq Al Zareeni, Khaled El Aloul, Mohammad Usman Ahmad, Anand Pillai

“…While MIS offers benefits such as improved DMAA correction, higher functional AOFAS scores, shorter operative times and reduced hospital stays, it also carries risks like increased radiation exposure and a higher rate of hardware removal. …”
Get full text

Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

“…BOO model 3 continuously showed a high discriminative ability, whereas the DU, DO main and DO SA2 models showed moderate discriminative performance. There was large uncertainty around the c-index and calibration slope, likely driven by the smaller sample size of the validation cohort, less than originally targeted, owing to recruitment problems, principally due to the pandemic. …”
Get full text

FBN2 pathogenic mutation in congenital contractural arachnodactyly with severe skeletal manifestations by Yazhou Huang, Xingxin Fang, Linya Ma, Jibo Zhang, Chao Wang, Taoran Gao, Dan Peng

“…Furthermore, DNA multiple sequence alignment indicates that this site is highly evolutionarily conserved. Functional assays and structure prediction indicated that the missense variant located at the edge of exon 26 of FBN2 does not affect RNA splicing, instead, it changes the structure and function of the protein by altering the amino acid sequence. …”
Get full text

The HL-60 clone 15 cell line as a model for leukocyte migration–possibilities and limitations by Lena Griesbaum, Christopher Weusthof, Thorben Sauer, Timo Gemoll, Gregor Weirich, Ludger Klimek, Ludger Klimek, Julie Petry, Ali Bashiri Dezfouli, Ali Bashiri Dezfouli, Maria Shoykhet, Barbara Wollenberg

“…This sets restrictions on many aspects of eosinophilic research. In this study, we performed a thorough characterization and functional assessment of the HL-60 clone 15 (HC15) cell line, which can be differentiated into eosinophil-like cells, to investigate its potential in eosinophil research.MethodsHC15 cells were differentiated with sodium butyrate with or without IL-5 and cells were characterized and compared to primary eosinophils, neutrophils and peripheral blood mononuclear cells. …”
Get full text

Structural tailoring of etoricoxib: A spectrochemical, medicinal and pharmacological study by Bakul Akter, Silvia Aishee, Abdullah Hridoy, Md. Mehedi Hasan Pulok, Mohammad Ariful Islam, Antu Biswas, Aurna Patwary, Majedul Hoque, MD. Sazidul Islam, Md. Nipatul Hasan Nirob, Faisal Islam Chowdhury, Monir Uzzaman

“…A total of 21 derivatives were designed by introducing various functioning sets at the R3, R2, and R1 sites of ETC. …”
Get full text

Bioactive Coatings on 3D Printed Polycaprolactone Scaffolds for Bone Regeneration: A Novel Murine Femur Defect Model for Examination of the Biomaterial Capacity for Repair by Karen M. Marshall, Jonathan P. Wojciechowski, Vineetha Jayawarna, Abshar Hasan, Cécile Echalier, Sebastien J. P. Callens, Tao Yang, Janos M. Kanczler, Jonathan I. Dawson, Alvaro Mata, Manuel Salmeron‐Sanchez, Molly M. Stevens, Richard O. C. Oreffo

“…The PCL‐TMA900 scaffolds are coated with i) elastin‐like polypeptide (ELP), ii) poly(ethyl acrylate) (PEA)/fibronectin (FN)/bone morphogenetic protein‐2 (PEA/FN/BMP‐2), iii) both ELP and PEA/FN/BMP‐2, or iv) Laponite nanoclay binding BMP‐2. …”
Get full text

Identification of EXPA4 as a key gene in cotton salt stress adaptation through transcriptomic and coexpression network analysis of root tip protoplasts by Qiankun Liu, Pengtao Li, Muhammad Jawad Umer, Mubashir Abbas, Yongqing Zhao, Yu Chen, Yanfang Li, Aiming Zhang, Yuling Liu, Yangyang Wei, Quanwei Lu, Mengying Yang, Yiman Liu, Xiaoyan Cai, Zhongli Zhou, Shuxun Yu, Fang Liu, Renhai Peng

“…Conclusion These findings underscore the functional significance of GaEXPA4 in the salt stress response. …”
Get full text

Virtual reconstruction of Tarragona’s amphitheater through the opening procession by Carme Codina-Peñarroja

“…The intention is to improve the current museography of the monument, which poorly performs its main purpose: cultural heritage dissemination. …”
Get full text