Wharton’s jelly mesenchymal stromal cells derived from preterm umbilical cord reveal a hepatogenic potential by F. Timoneri, M. Lo Iacono, S. Corrao, G. Alberti, G. Amico, T. Corsello, P. G. Conaldi, Eleonora Russo, Eleonora Russo, G. La Rocca

“…A standardized liver differentiation protocol was performed, and the acquisition of the hepatic phenotype was assessed by characterization of hepatic protein expression and functional assays.ResultsWe demonstrated that pWJ-MSCs exhibited mesenchymal characteristics, acquired phenotypical and functional features of hepatocytes when induced to differentiate in a specific medium, and maintained the expression of immunomodulatory molecules.DiscussionThis study showed that even if pregnancy has been interrupted before the 22nd week, p-WJ-MSCs had the same differentiative ability as the counterpart derived from the full-term UC, that we have previously demonstrated, and can be considered a valid cellular population for liver cell therapy.…”
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Coinfection of Herpes Simplex virus 2 and Mycobacterium chelonae in acute hydrops associated with keratoconus: A case report by Pedro Marques-Couto, Ana Gama-Castro, Teresa Carvalho, Rodrigo Vilares-Morgado, João Pinheiro-Costa, Dolores Pinheiro, Ana Maria Cunha

“…The combination of corneal edema, previous viral infection, and prolonged corticosteroid use likely created a “perfect storm” scenario, predisposing the patient to this unusual coinfection. …”
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Implementation and application of an improved phase spectrum determination scheme for Fourier transform spectrometry by F. Hase, P. Castracane, A. Dehn, O. E. García, D. W. T. Griffith, L. Heizmann, N. B. Jones, T. Karppinen, R. Kivi, M. de Mazière, J. Notholt, M. K. Sha

“…<p>Correct determination of the phase spectrum is a highly relevant task in Fourier transform spectrometry for concluding which spectral distribution most likely gave rise to the measured interferogram. We present implementation of an improved scheme for phase determination in the operational Collaborative Carbon Column Observing Network (COCCON) processor. …”
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Toxicological Investigations of Aristolochia longa Root Extracts by Nasreddine El Omari, Omar El Blidi, Abdelhakim Bouyahya, Karima Sayah, Saad Bakrim, Saad Fettach, Rajae Tahri, Khalid Taghzouti, Omar Chokairi, Malika Barkiyou

“…The global analysis of hepatic and renal biomarkers showed a significant increase between control and different doses of the extract, from the first to the third week of treatment, indicating the likely toxic effect of the extract on liver and kidney function. …”
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An automated extraction of spectral-temporal and spatial-temporal features of EEG for emotion detection by Monira Islam, Tan Lee

“…On classifying high versus low states in valence, arousal, dominance, and liking, PLV showed better performance than MHS with 97.61%, 96.09%, 96.75%, and 97.23% accuracy, respectively, for DEAP dataset. …”
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Consumer Qualities and Potential Relevance of Dairy Alternatives from Domestic Beans and Peas by Anna L. Veber, Svetlana A. Leonova, Oksana V. Kondrateva

“…This research featured their prospective market demand, key performance criteria, and market capacity. The research featured functional products based on vegetable dispersion from germinated peas and beans of Russian cultivars, e.g. beverages, ice cream, tofu, bakery products, etc. …”
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Drought-induced transposon expression reveals complex drought response mechanisms in Brassica napus by Manyi Chen, Dan Luo, Hanzhao Kong, Yan Lv, Chunsheng Li, Yongguo Zhao, Qian Huang, Guangyuan Lu, Guangyuan Lu

“…A comprehensive computational pipeline was used to identify and characterize TE-derived transcripts, including protein-coding and long non-coding RNAs (lncRNAs). Functional annotation was performed for protein-coding TE transcripts located in intergenic regions to predict their involvement in biological processes. …”
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Genetic diversity and GWAS analysis of flesh hardness trait in Xinjiang melon germplasm resources by ZHU Wanting, LI Jiangfeng, ZHAN Qianru, SHUA Zhenyang, ZHU Yingchun, GUO Yanxia, LUO Xiang

“…This region contained 11 significant associated SNPs, which explained 9.04% of the phenotypic variation. Functional annotation revealed that this region harbored candidate genes related to cell wall biosynthesis and remodeling, like inositol monophosphatase (MELO3C007440.2) and nucleotide-sugar transporter (MELO3C007449.2). …”
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Correlation of Intraoperative Neuromonitoring (IONM) Signal Changes with Clinical Outcomes in Patients with Compressive Cervical Myelopathy: A Prospective Study by Saumyajit Basu, Aditya Vardhan Guduru, Vikas Hanasoge, Piyush Joshi, Trinanjan Sarangi, Suraj Chakroborthy

“…Paired t-tests were used for the comparison of preoperative and postoperative functional scores. One-way Analysis of variance (ANOVA) tests with Bonferroni post hoc analyses were performed for comparison between the three groups. …”
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Alum-anchored IL-12 combined with cytotoxic chemotherapy and immune checkpoint blockade enhanced antitumor immune responses in head and neck cancer models by James W Hodge, Howard Kaufman, Michelle R Padget, Kellsye P Fabian, Sailaja Battula, Wiem Lassoued, Ginette Santiago-Sanchez, Clint Tanner Allen

“…For MOC1, flow cytometry and cytokine array were performed to assess the immune effector functions associated with the combinational treatment. …”
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Rod-shaped microglia represent a morphologically distinct subpopulation of disease-associated microglia by Yukio Matsuba, Kenichi Nagata, Yosuke Kadota, Naruhiko Sahara, Takaomi C. Saido, Shoko Hashimoto

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Single-cell ligand–receptor profiling reveals an immunotherapy-responsive subtype and prognostic signature in triple-negative breast cancer by Chuanzhi Chen, Jiahui Qi, Weichao Lin, Chunlan Fu, Xin Jin

“…The functional impact was assessed through proliferation, colony formation, and wound healing assays.ResultsOne subtype (Clust1) demonstrated strong immune cell infiltration, higher immune scores, and enrichment in pathways such as epithelial–mesenchymal transition, angiogenesis, and KRAS signaling—indicative of a basal-like, immune-active phenotype. …”
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EEG Oscillations as Neuroplastic Markers of Neural Compensation in Spinal Cord Injury Rehabilitation: The Role of Slow-Frequency Bands by Guilherme J. M. Lacerda, Lucas Camargo, Marta Imamura, Lucas M. Marques, Linamara Battistella, Felipe Fregni

“…Based on the potential role of lower-frequency oscillations in exerting a salutogenic compensatory effect, detrimental clinical and neurophysiological markers, such as depression and lower ME, likely induce slow oscillatory rhythms. Alpha oscillations may indicate a more salutogenic state, often associated with various cognitive functions, such as attention and memory processing. …”
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ADME analysis, metabolic prediction, and molecular docking of lipoic acid with SARS-CoV-2 Omicron spike protein by Carlos Alonso Leite dos Santos, Antonia Adeublena de Araújo Monteiro, Adrielle Rodrigues Costa, Luiz Marivando Barros, Abdulaziz Aloufi, Mashal M. Almutairi, Waseem Hassan, Jean Paul Kamdem, Antonia Eliene Duarte, Abid Ali, Mohammad Ibrahim

“…Abstract Lipoic acid (ALA), also known as 1,2-dithiolane-3-pentanoic acid, is a natural antioxidant and a critical component of mitochondrial function, where it participates in several key enzymatic processes. …”
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LRH‐1/NR5A2 targets mitochondrial dynamics to reprogram type 1 diabetes macrophages and dendritic cells into an immune tolerance phenotype by Nadia Cobo‐Vuilleumier, Silvia Rodríguez‐Fernandez, Livia López‐Noriega, Petra I. Lorenzo, Jaime M. Franco, Christian C. Lachaud, Eugenia Martin Vazquez, Raquel Araujo Legido, Akaitz Dorronsoro, Raul López‐Férnandez‐Sobrino, Beatriz Fernández‐Santos, Carmen Espejo Serrano, Daniel Salas‐Lloret, Nila vanOverbeek, Mireia Ramos‐Rodriguez, Carmen Mateo‐Rodríguez, Lucia Hidalgo, Sandra Marin‐Canas, Rita Nano, Ana I. Arroba, Antonio Campos Caro, Alfred CO Vertegaal, Alejandro Martín‐Montalvo, Franz Martín, Manuel Aguilar‐Diosdado, Lorenzo Piemonti, Lorenzo Pasquali, Roman González Prieto, Maria Isabel García Sánchez, Decio L. Eizirik, Maria Asuncion Martínez‐Brocca, Marta Vives‐Pi, Benoit R. Gauthier

“…Pharmacological activation of LRH‐1/NR5A2 improves the survival iPSC‐islets‐like organoids co‐cultured with PBMCs from individuals with T1D.…”
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Hantaan virus infection induces human mucosal-associated invariant T cell pyroptosis through IRE1α pathway by Yusi Zhang, He Liu, Dalu Liu, Huiyuan Zhang, Ying Ma, Na Li, Chunmei Zhang, Manling Xue, Fenglan Wang, Xiaozhou Jia, Hui Zhang, Kang Tang, Xiaoyue Xu, Shijia Wang, Yiwen Wei, Xiaojing Yang, Jiajia Zuo, Lihua Chen, Boquan Jin, Yun Zhang

“…Mucosal-associated invariant T (MAIT) cells, categorized as innate-like T lymphocytes, perform crucial functions in the innate host defense mechanism during virus infection. …”
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Metagenomic signatures of extraintestinal bacterial infection in the febrile term infant gut microbiome by Anna L. DeVeaux, Carla Hall-Moore, Nurmohammad Shaikh, Meghan Wallace, Carey-Ann D. Burnham, David Schnadower, Nathan Kuppermann, Prashant Mahajan, Octavio Ramilo, Phillip I. Tarr, Gautam Dantas, Drew J. Schwartz

“…Infants with E. coli infections who were colonized by the putatively isogenic pathogen strain had significantly higher E. coli phylogroup B2 abundance in their gut, and their microbiome was more likely to contain virulence factor loci associated with adherence, exotoxin production, and nutritional/metabolic function. …”
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Mixed Reality Ultrasound-Guided Mini-ECIRS with Apple Vision Pro™ - First Case Report by Roberto Montoro Neto, Fabio C. Vicentini, Ricardo T.S. Ugino, Alexandre Danilovic, Giovanni S. Marchini, Fabio C.M. Torricelli, Carlos A. Batagello, Anderson B. Pellanda, Alexandre Silva, William C. Nahas, Eduardo Mazzucchi

“…ABSTRACT Introduction: Some endourological surgeries require multiple screens to perform combined procedures, which can present ergonomic challenges (1, 2). …”
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Unveiling the green transition and gender disparities in the energy industry: A value-based DEA cluster analysis approach by C.O. Henriques, M.C. Gouveia, C.P. Viseu, S.R. Sousa, V. Moutinho

“…These dimensions were transformed into value functions inspired by Kahneman and Tversky, emphasizing the heightened sensitivity to the negative effects of gender disparities compared to the benefits of gender parity. …”
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Magnification Bias Reveals Severe Contamination in Hubble Frontier Field Photo-z Catalogs by Jiashuo Zhang, Jeremy Lim, Tom Broadhurst, Sung Kei Li, Man Cheung Li, Giorgio Manzoni, Rogier Windhorst

“…Gravitational lensing by massive galaxy clusters enables faint distant galaxies to be more abundantly detected than in blank fields, thereby allowing one to construct galaxy luminosity functions (LFs) to an unprecedented depth at high redshifts. …”
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