Exploring virulence and stress response in Entamoeba histolytica: insights from clinical strains by Yasuaki Yanagawa, Manu Sharma, Shinji Izumiyama, Upinder Singh

“…We collected clinical isolates from asymptomatic individuals and patients with amoebic liver abscesses to perform RNA sequencing and compare their gene expression profiles. …”
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Gene expression analysis reveals mir-29 as a linker regulatory molecule among rheumatoid arthritis, inflammatory bowel disease, and dementia: Insights from systems biology approach... by Devi Soorya Narayana S, Vino Sundararajan

“…Subsequently, topology analysis for hub gene identification, cluster and functional enrichment, and regulatory network analysis were performed. …”
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Features of Progress and Treatment of Postprimary Refractory Glaucoma in a Patient with Progressive Mesodermal Iris Atrophy by A. D. Chuprov, L. I. Popova, V. I. Lapochkin, A. V. Lapochkin, D. V. Lapochkin, L. V. Demakova

“…Correct diagnosis helped to choose the proper individual tactics of combined treatment that allowed to compensate glaucomatous process and save the visual functions for restore an active lifestyle of the patient.…”
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Vitronectin, a Novel Urinary Proteomic Biomarker, Promotes Cell Pyroptosis in Juvenile Systemic Lupus Erythematosus by Song Zhang, Wenxu Pan, Hongli Wang, Cheng Zhi, Yanhao Lin, Ping Wu, Qi Ren, Ping Wei, Rui Chen, Feng Li, Ying Xie, Chun Kwok Wong, Hong Tang, Zhe Cai, Wanfu Xu, Huasong Zeng

“…These proteins were involved in several important biological processes, including acute phase inflammatory responses, complement activation, hemostasis, and immune system regulation through Gene Ontology and functional enrichment analysis. Interestingly, urinary ephrin type-A receptor 4 (EPHA4) and VTN were significantly reduced in both inactive and active JSLE patients, and VTN treatment in THP-1 derived macrophages led to a significant increased cell pyroptosis by activation of Nod-like receptor family protein 3 (NLRP3) inflammasomes, resulting in caspase-1 activation, cleaved gasdermin D (GSDMD), and IL-18 secretion. …”
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TLR2 promotes the progression of diabetes mellitus with atherosclerosis via activating NLRP3 inflammasome and MyD88/NF-κB signaling pathway by Sisi Chen, Min Xie, Yong Liu

“…Abstract Atherosclerosis, a critical vascular complication frequently associated with diabetes mellitus, develops due to the synergistic effects of multiple pathological mechanisms. Toll-like receptor-2 (TLR2) has been identified as a key contributor to the progression of a wide range of disorders. …”
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Prevalence and Pattern of Chronic Musculoskeletal Pain among Older Adults and its Sociodemographic and Pain Intervention Correlates in a Tertiary Hospital in North Central Nigeria by Oluwatoyin A. Abolarin, Samuel A. Adefemi, Adetutu Babalola, Mustapha Mamman, Philip N. Gara, Ezekiel U. Sheshi, Yusuf Ibrahim

“…BackgroundChronic musculoskeletal pain (CMP) is a prevalent condition among older adults globally, contributing significantly to reduced quality of life, functional limitations, and healthcare burden. In low- and middle-income countries like Nigeria, the complexity of managing chronic pain is exacerbated by sociocultural factors, underreporting, and limited access to healthcare services. …”
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Quantum Dot‐Based Immunolabelling of Extracellular Vesicles and Detection Using Fluorescence‐Based Nanoparticle Tracking Analysis by Eunyong Ha, Yewon Han, Minseop Kim, Zayakhuu Gerelkhuu, Sook Jin Kwon, Tae Hyun Yoon

“…They can interact with target cells to perform various functions, offering potential for therapeutic applications like drug delivery and diagnosis. …”
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Multi-omics integration reveals the role of N6-methyladenosine in epilepsy, ischemic stroke, and vascular dementia by Xudong Zhang, Yuhao Xu, Hai Hu, Zhenhua Liao, Changli Lou, Xiang Zou

“…PPI analysis revealed interactions involving critical proteins like PARP1, MCL1, and CD40, underscoring their role in neuroinflammation and apoptosis. …”
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Evaluation of branch-level green banking in Bangladesh through life cycle assessment approach by Kishwar Jahan Chowdhury, Papon Roy, Gias Uddin Ahmed, Mohammad Mosharraf Hossain

“…Abstract Green banking is becoming an everyday practice around the globe, similar to developing nations like Bangladesh. This study aims to assess the banking system's environmental burden by leveraging Life Cycle Assessment (LCA), a methodology widely used for environmental footprint assessment. …”
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Psychosocial challenges among Asian adolescents and young adults with cancer: a scoping review by Yihui Wei, Panpan Xiao, Weishang Deng, Cho Lee Wong, Chun-Kit Ngan, Winnie Wan-Yee Tso, Alex Wing-Kwan Leung, Herbert Ho-Fung Loong, Chi Kong Li, Alexandre Chan, Yin Ting Cheung

“…We found Asian studies have focused more on family relationships than peers, likely due to sociocultural nuances when compared with Western societies. …”
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Developing a Multisensor-Based Machine Learning Technology (Aidar Decompensation Index) for Real-Time Automated Detection of Post–COVID-19 Condition: Protocol for an Observational... by Jenny Mathew, Jaclyn A Pagliaro, Sathyanarayanan Elumalai, Lauren K Wash, Ka Ly, Alison J Leibowitz, Varsha G Vimalananda

“…Patients with severe episodes of COVID-19 are significantly more likely to be hospitalized in the following months. …”
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cogsworth: A Gala of COSMIC Proportions Combining Binary Stellar Evolution and Galactic Dynamics by Tom Wagg, Katelyn Breivik, Mathieu Renzo, Adrian M. Price-Whelan

“…Alternatively, several analytic models are available for galactic potentials and star formation histories. cogsworth can also transform the intrinsic simulated population into an observed population using dust maps, bolometric correction functions, and survey selection functions. We provide a detailed explanation of the functionality of cogsworth and demonstrate its capabilities through a series of use cases: (1) we predict the spatial distribution of compact objects and runaways in both dwarf and Milky Way–like galaxies; (2) using a star cluster from a hydrodynamical simulation, we show how supernovae can change the orbits of stars in several ways; and (3) we predict the separation of disrupted binary stellar companions on the sky and create a synthetic Gaia color–magnitude diagram. …”
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Biomechanical Behavior of Bioactive Material in Dental Implant: A Three-Dimensional Finite Element Analysis by Vathsala Patil, Nithesh Naik, Srikanth Gadicherla, Komal Smriti, Adithya Raju, Udit Rathee

“…Dental implants are widely accepted for the rehabilitation of missing teeth due to their aesthetic compliance, functional ability, and great survival rate. The various components in implant design like thread design, thread angle, pitch, and material used for manufacturing play a critical role in its success. …”
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Estradiol Reverses Ovariectomy-Induced Disruption of Hypothalamic Gene Expression and Behavior via Modulation of Gonadotropin Releasing Hormone and Calcium Signaling Pathways by Asim Muhammad, Mubashir Muhammad, Xiaohuan Chao, Chunlei Zhang, Jiahao Chen, Huan Yang, Shuhan Liu, Yuan Ding, Ziming Wang, Hongwei Bi, Wen Guo, Junhong Fan, Bo Zhou

“…This study investigates the transcriptional and behavioral changes induced by ovariectomy (OVX) and estradiol (E2) supplementation in female C57BL/6J mice. RNA sequencing was performed to identify differentially expressed genes (DEGs) across control (CK), E2, OVX, and OVX+E2 groups, followed by functional enrichment and pathway analyses. …”
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Soil Drenching with Wood Distillate Modifies the Nutritional Properties of Chickpea (<i>Cicer arietinum</i> L.) Seeds by Increasing the Protein Content and Inducing Targeted Change... by Rossana De Salvo, Riccardo Fedeli, Alfonso Carleo, Luca Bini, Stefano Loppi, Laura Bianchi

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Effect of interface moisture content on the interlayer bond strength by Gowrikanthan Nishangani, Lees Janet M.

“…For functionally graded members with horizontal concrete layers, the mechanical performance of the interface zones is critical for structural behaviour. …”
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Proteomic compensation by paralogs preserves protein interaction networks after gene loss in cancer by Anjan Venkatesh, Niall Quinn, Swathi Ramachandra Upadhya, Barbara De Kegel, Alfonso Bolado Carrancio, Thomas Lefeivre, Olivier Dennler, Kieran Wynne, Alexander von Kriegsheim, Colm J Ryan

“…Compensation is enriched among paralog pairs that are central in the protein–protein interaction network and whose interaction partners perform essential functions. Compensation is also significantly more likely to be observed between synthetic lethal pairs. …”
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Femtolaser refractive autokeratoplastic: first results and prospects by H. V. Sitnik, A. Yu. Slonimsky, Yu. B. Slonimsky

“…Between 3 to 6 months after surgery, we observed the increasing of visual functions (like UCVA and BCVA). The improvement of BCVA was observed in 94.1 %, and in 76.5 % of cases the increase was more than 3 lines. …”
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Bronchoalveolar lavage cell percentages as diagnostic markers of immune checkpoint inhibitor pneumonitis by Mahnoor Mir, Felipe Soto, Pedro Antonio Amezcua Gomez, Rodrigo Del Rio Arroyo, Adarsh Suresh, Amber Su, Qiong Gan, John Stewart, Roberto Adachi, Diwakar D. Balachandran, Lara Bashoura, Roberto F. Casal, Burton F. Dickey, George A. Eapen, Scott E. Evans, Horiana Grosu, Carlos A. Jimenez, Julie Lin, David E. Ost, Bruce F. Sabath, Vickie R. Shannon, Aung Naing, Jianjun Gao, Jia Wu, Karthik Suresh, Saadia A. Faiz, Mehmet Altan, Ajay Sheshadri

“…BAL immune cell percentages may have prognostic value for 1-year survival, but this likely reflects the morbidity of other pulmonary diseases that require BAL for evaluation.…”
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High-Resolution Fourier Transform Spectra of Atomic Sulfur: Testing of Modified Quantum Defect Theory by Vladislav E. Chernov, Nikolai L. Manakov, Alexei V. Meremianin, Alexander V. Naskidashvili, Svatopluk Civiš, Martin Ferus, Petr Kubelík, Ekaterina M. Zanozina, Oxana V. Zetkina

“…We show that, outside the atomic core domain, the electron radial functions calculated using modified semi-phenomenological QDT agree well with ab initio calculations. …”
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