Pathways-driven sparse regression identifies pathways and genes associated with high-density lipoprotein cholesterol in two Asian cohorts. by Matt Silver, Peng Chen, Ruoying Li, Ching-Yu Cheng, Tien-Yin Wong, E-Shyong Tai, Yik-Ying Teo, Giovanni Montana

“…Standard approaches to data analysis in genome-wide association studies (GWAS) ignore any potential functional relationships between gene variants. In contrast gene pathways analysis uses prior information on functional structure within the genome to identify pathways associated with a trait of interest. …”
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Ancient restorations: computer-based structural approach for the identification and reinterpretation of the Medracen’s constructive sequence by Lamia Amokrane, Tsouria Kassab, Juan Monjo-Carrio

“…Besides, this same action was a means for the Numidian elite to transform an ancient monumental burial (sepulchrum) into a monument (monumentum) with cultural significance likely to convey socio-political messages relating to power and sovereignty. …”
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Enhanced sensitivity, robust p21 activation, and sustained DNA repair responses to interstrand crosslinks in elephant cells compared to humans by Taisuke Kitano, Zida Zhu, Naoya Minami, Koichi Orino, Yasunaga Yoshikawa

“…We found that elephant fibroblasts exhibited higher sensitivity to ICL-inducing treatments, such as mitomycin C and trimethylpsoralen plus UVA (PUVA), than human fibroblasts, while showing comparable or reduced sensitivity to other DNA-damaging agents, such as doxorubicin and bleomycin. Functional analyses revealed that elephant and human FANCL performed similarly in mediating FANCD2 monoubiquitylation and cell viability following mitomycin C treatment. …”
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Resilient electrified freight transport: Disruptions and mitigation strategies by Maria Björklund, Henrik Gillström, Fredrik Stahre

“…This transition puts new types of challenges on the freight systems, while also likely making them more vulnerable to disruptions. …”
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Spectroscopic, DFT, anti-bacterial, and in-silico investigations of novel semicarbazone and thiosemicarbazone synthesised from asymmetrical chalcones by Nikita Sharma, Har Lal Singh

“…Thus, synthesized compounds may function as a potential target for bacterial agents. …”
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Inhibition of c-Abl suppresses the proliferation, invasion and migration of glioma cells by Fengqi Zhang, Xianzhi Liu

“…Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses were used to explore the biological pathways involved. Functional assays, including MTS for cell viability, Transwell assays for invasion and migration, and immunofluorescence (IF), were performed to evaluate cellular behavior in vitro. …”
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Assessment of the Prevalence of the Use of Nasal Decongestants Among Hail Population by Farida Habib Khan, Abdullah D Alotaibi, Amal Daher Alshammari, Mohammed Alateeq, Muath Alshmmari, Read Alharbi, Rakhi Issrani

“…Background: Nasal decongestants are widely used to relieve nasal congestion caused by conditions such as allergic rhinitis, sinusitis, and the common cold. These medications function by constricting nasal blood vessels, reducing swelling, and improving airflow. …”
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Cis and trans effects of human genomic variants on gene expression. by Julien Bryois, Alfonso Buil, David M Evans, John P Kemp, Stephen B Montgomery, Donald F Conrad, Karen M Ho, Susan Ring, Matthew Hurles, Panos Deloukas, George Davey Smith, Emmanouil T Dermitzakis

“…Gene expression is a heritable cellular phenotype that defines the function of a cell and can lead to diseases in case of misregulation. …”
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BATF alleviates ox-LDL-induced HCAEC injury by regulating SIRT1 expression in coronary heart disease. by Bei Tian, Jingyu Ji, Can Jin

“…<h4>Conclusion</h4>The research findings suggested a prospective protective function of BATF in HCAEC injury induced by ox-LDL, likely through the mediation of SIRT1 regulation. …”
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Frequency of insulin resistance among non-diabetic patients with non-alcoholic fatty liver disease using HOMA-IR: an experience of a tertiary care hospital in Karachi, Pakistan by Lubna Kamani, Moneeba Siddiqui, Adeel Rahat

“…Clinical history, physical examination, laboratory tests (fasting lipid profile, fasting glucose, insulin, liver function tests) and abdominal ultrasound with fibroscan for liver steatosis assessment were performed. …”
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Variational quantum classifier-based early identification and classification of chronic kidney disease using sparse autoencoder and LASSO shrinkage by P. Parthasarathi, Haya Mesfer Alshahrani, K. Venkatachalam, Jaehyuk Cho

“…Researchers worldwide utilize the rate of globular filtration and kidney inflammation biomarkers to identify chronic kidney disease that gradually reduces renal function. The mortality rate for CKD is high, and thus, a person with this illness is more likely to pass away at a younger age. …”
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Network Pharmacology Integrated Docking Studies on Molecular Targets of Achyranthes aspera in the Treatment of Rheumatoid Arthritis by Sivasankari Marimuthu, Arul Jayanthi Antonisamy, Janani Palpandi, Sankar Malayandi

“…Results: Phytochemicals such as oleanolic acid, inokosterone, and ecdysone were listed as active phytochemicals with respect to the drug likeness score ≥0.18. Out of the active compounds selected, oleanolic acid was found to have higher binding affinity when docked with all the proteins. …”
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Beyond coincidence: a case series on the clinical course of coinciding cluster headache and short-lasting unilateral neuralgiform headache attacks by Julia J. Jansen, Job Scheurink, Tijmen Balvers, Rolf Fronczek, Wim M. Mulleners

“…The observed co-occurrence of these headache types could suggest a pathophysiological relationship between the 2, which might be explained by a bidirectional interaction between posterior hypothalamic function and trigeminal root demyelination. The role of a trigeminal neurovascular conflict seems likely in this context, with dedicated magnetic resonance imaging being the optimal method for its identification. …”
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Common genetic origins for EEG, alcoholism and anxiety: the role of CRH-BP. by Mary-Anne Enoch, Pei-Hong Shen, Francesca Ducci, Qiaoping Yuan, Jixia Liu, Kenneth V White, Bernard Albaugh, Colin A Hodgkinson, David Goldman

“…The resting EEG is a dynamic index of cortical activation, cognitive function and consciousness and is therefore an intermediate phenotype for many behaviors in which arousal is implicated such as anxiety and alcoholism. …”
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Association between cardiometabolic index and overactive bladder in adult American women: A cross-sectional study. by Junhua Li, Min He, Yu Zhou

“…When compared to the lowest CMI quartile (Q1), women in the highest CMI quartile were 70% more likely to have OAB (OR = 1.70, 95% CI: 1.42-2.04). …”
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Transcriptomic Characterization of Phototransduction Genes of the Asian Citrus Psyllid <i>Diaphorina citri</i> Kuwayama by Shao-Ping Chen, Xue-Mei Chu, Mei-Xiang Chi, Jian Zhao, Rong-Zhou Qiu

“…Opsin plays a regulatory role in phototaxis of <i>Diaphorina citri</i>, functioning as the initial station in the phototransduction cascade. …”
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Tumor associated macrophages: current research and perspectives of clinical use by A. N. Gratchev, D. V. Samoilova, M. A. Rashidova, A. A. Petrenko, O. V. Kovaleva

“…Numerous clinical studies have shown that the amount of TAM is often correlated with a poor prognosis of the disease. TAM perform a large number of functions necessary to maintain tumor progression. …”
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In vitro protein expression profile of cultivated muscle cells from Labeo rohita by B. S. Yashwanth, Nevil Pinto, A. Sathiyanarayanan, Kiran D. Rasal, S. Sanjeeva, Michael Saad, Reza Ovissipour, David L. Kaplan, Mukunda Goswami

“…Comparative proteome analysis was performed for LR muscle cells at different passages (1, 15 and 25) using label free quantitative proteomics. …”
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Concept design, application and optimization of operational parameters for new forced safety injection tank system [version 2; peer review: 2 approved] by Hyun Gook Kang, Asad Ullah Amin Shah, Ali Mansoor, Junyung Kim

“…Failure of any one of these functions can result in severe accident conditions. …”
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Key gene screening and diagnostic model establishment for acute type a aortic dissection by Yue Pan, Zhiming Yu, Xiaoyu Qian, Xuesong Zhang, Qun Xue, Weizhang Xiao

“…Recent studies highlight the role of immune dysregulation, vascular smooth muscle cell (VSMC) apoptosis, and metabolic-epigenetic interactions in AD pathogenesis, underscoring the need for novel biomarkers and therapeutic targets.ObjectiveThis study aims to identify critical genes and molecular pathways associated with ATAAD, develop a multi-omics diagnostic model, and evaluate potential therapeutic interventions to improve clinical outcomes.MethodsTranscriptome datasets from the Gene Expression Omnibus (GEO) database were analyzed using differential expression analysis, weighted gene co-expression network analysis (WGCNA), and machine learning algorithms (SVM, Random Forest, LASSO regression). Functional enrichment and immunoinfiltration analyses were performed to explore biological pathways and immune cell interactions. …”
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