Construction and immunohistochemical validation of a necroptosis-related prognostic signature in bladder cancer and its association with tumor immune infiltration by Tao Wang, Fei Ding, Kai Sun

“…Through the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway annotation, we curated 159 NRGs and subsequently identified 25 differentially expressed genes functionally implicated in necrotic cell death and extrinsic apoptotic pathways, specifically including influenza A signaling, NOD-like receptor cascades, and related biological processes. …”
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Positive selection analyses identify a single WWE domain residue that shapes ZAP into a more potent restriction factor against alphaviruses. by Serina Huang, Juliana Girdner, LeAnn P Nguyen, Carina Sandoval, Oliver I Fregoso, David Enard, Melody M H Li

“…Many of them block a diverse range of viruses, suggesting that their antiviral functions might have been shaped by multiple viral families during evolution. …”
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The human Dicer helicase domain is capable of ATP hydrolysis and single-stranded nucleic acid binding by Kinga Ciechanowska, Agnieszka Szczepanska, Kamil Szpotkowski, Klaudia Wojcik, Anna Urbanowicz, Anna Kurzynska-Kokorniak

“…Abstract Background Vertebrates have one Dicer ortholog that generates both microRNAs (miRNAs) and small interfering RNAs (siRNAs), in contrast to the multiple Dicer-like proteins found in flies and plants. Here, we focus on the functions of the human Dicer (hDicer) helicase domain. …”
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Revealing common differential mRNAs, signaling pathways, and immune cells in blood, glomeruli, and tubulointerstitium of lupus nephritis patients based on transcriptomic data by Haifang Zhao, Dongxia Zheng

“…Common DEmRNAs in the three datasets were taken. Subsequently, functional enrichment analysis, immune correlation analysis, receiver operating characteristic (ROC) curve analysis and real-time polymerase chain reaction (RT-PCR) verification were performed. …”
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Differential roles of ERα and ERβ in normal and neoplastic development in the mouse mammary gland. by Rajendra G Mehta, Michael Hawthorne, Rajeshwari R Mehta, Karen E O Torres, Xinjian Peng, David L McCormick, Levy Kopelovich

“…The present experiments were performed to determine the roles of estrogen receptors α and β (ERα and ERβ) in normal and neoplastic development in the mouse mammary gland. …”
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Ivacaftor–tezacaftor–elexacaftor, tezacaftor–ivacaftor and lumacaftor–ivacaftor for treating cystic fibrosis: a systematic review and economic evaluation by Steven J Edwards, Benjamin G Farrar, Kate Ennis, Nicole Downes, Victoria Wakefield, Isaac Mackenzie, Archie Walters, Tracey Jhita

“…This project also assessed whether these treatments are likely to be considered good value for money for the National Health Service. …”
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Constitutive Parliament and its speakers by Algis Kasperavičius

“…The most important task of the Constitutive Parliament was to prepare a permanent Constitution of the Lithuanian Republic, but it performed other rules' publishing functions too. It performed the control of executive government institutions of all levels. …”
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Modifications of a Distal Shoe Space Maintainer for Preserving Arch Integrity in Children: A Review of Published Literature by Mrunmayee Soman, Ashwin Jawdekar

“…In cases where the primary second molars are indicated for extraction, the distal shoe space maintainer (DSSM) has been considered to perform dual functions of space maintenance while acting as a guide for the eruption of the permanent first molar. …”
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Empirical Analysis of Data Sampling-Based Decision Forest Classifiers for Software Defect Prediction by Fatima Enehezei Usman-Hamza, Abdullateef Oluwagbemiga Balogun, Hussaini Mamman, Luiz Fernando Capretz, Shuib Basri, Rafiat Ajibade Oyekunle, Hammed Adeleye Mojeed, Abimbola Ganiyat Akintola

“…Specifically, this study evaluates the cost-sensitive forest (CS-Forest), forest penalizing attributes (FPA), and functional trees (FT) as DF models. These models were further enhanced using homogeneous ensemble techniques, such as bagging and boosting techniques. …”
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Usefulness of Intraoperative Computed Tomography in Complication Management after Spine Surgery by Johannes Kerschbaumer, Christian Franz Freyschlag, Marcel Seiz-Rosenhagen, Claudius Thomé

“…Shortly after surgery the patient developed a rapid loss of motor function in the upper and lower limbs, followed by a rising sensory deficit. …”
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The relationship between agility and lower extremity strength in female basketball players by Ali Kerim Yılmaz, Soner Akgün, Esra Korkmaz Salkılıç, Berna Anıl, Enes Akdemir, Burcu Aktaş, Emre Karaduman, Menderes Kabadayı

“…Conclusions As a result, we found a negative relationship between agility and lower extremity functional performance tests in female basketball players. …”
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Practice and Predictors of Do-Not-Resuscitate Orders in a Tertiary-Care Intensive Care Unit in Saudi Arabia by Abdulrahman Asiri, Farhan Zayed Alenezi, Hani Tamim, Musharaf Sadat, Felwa Bin Humaid, Wedyan AlWehaibi, Hasan M. Al-Dorzi, Yasir Adnan Alzoubi, Samiyah Alrawey Alanazi, Brintha Naidu, Yaseen M. Arabi

“…Compared to patients with “full code,” patients with DNR orders were older (median 67 years [Q1, Q3: 55, 76] versus 57 years [Q1, Q3: 33, 71], p<0.0001), were more likely to be females (43% versus 38%, p<0.0001), had worse premorbid functional status (WHO performance status scores 4-5: 606[18.9%] versus 1894[8.8%], p<0.0001), higher prevalence of comorbid conditions, and higher APACHE II score (median 28 [Q1, Q3: 23, 34] versus 19 [Q1, Q3: 13, 25], p<0.0001) and were more likely to be mechanically ventilated (83% versus 55%, p<0.0001). …”
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Adaptive Top-K Algorithm for Medical Conversational Diagnostic Model by Yiqing Yang, Guoyin Zhang, Yanxia Wu, Zhixiang Zhao, Yan Fu

“…However, doctors typically perform differential diagnoses in real medical practice, considering multiple possible diseases to address diagnostic uncertainty. …”
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The role of bariatric surgery and appetite-related hormones metabolism in obesity treatment: a literature review by A. O. Nykonenko, Ye. I. Haidarzhi, O. S. Nykonenko, M. H. Holovko, A. S. Protsenko

“…The anatomical and physiological changes described in the review are most likely caused by the above-mentioned surgical procedures. …”
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Risk factors, urodynamic characteristics, and distress associated with nocturnal enuresis in overactive bladder -wet women by Kuan Chong Ng, Jeff Shih-Chieh Chueh, Shang-Jen Chang

“…NE was defined as complaint of intermittent incontinence that occurs during the main sleep period. Urodynamics was performed on every patient to assess bladder function. …”
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Preserved Ratio Impaired Spirometry in US Primary Care Patients Diagnosed with Chronic Obstructive Pulmonary Disease by Evans A, Tarabichi Y, Pace WD, Make B, Bushell N, Carter V, Chang KL, Fox C, Han MK, Kaplan A, Kocks JWH, Le Lievre C, Roussos A, Skolnik N, Soriano JB, Yawn BP, Price D

“…Multivariable logistic regression was performed to assess whether PRISm predicts lung function decline.Results: Prevalence of PRISm within a primary care population clinically diagnosed with COPD was 23.6% (678/2866, 95% CI 22.0– 25.1). …”
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Distributionally Robust Variational Quantum Algorithms With Shifted Noise by Zichang He, Bo Peng, Yuri Alexeev, Zheng Zhang

“…A practical issue is that quantum noise is highly unstable and thus it is likely to shift in real time. This presents a critical problem as an optimized VQA ansatz may not perform effectively under a different noise environment. …”
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ST8SIA6 Sialylates CD24 to Enhance Its Membrane Localization in BRCA by Jinxia He, Fengchao Zhang, Baihai Wu, Wengong Yu

“…CD24, a highly sialylated glycosyl-phosphatidyl-inositol (GPI) cell surface protein that interacts with sialic acid-binding immunoglobulin-like lectins (Siglecs), serves as an innate immune checkpoint and plays a crucial role in inflammatory diseases and tumor progression. …”
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Early diagnosis of hereditary angioedema in children: genetic testing should be prioritized by A. Bocquet, A. Pagnier, I. Boccon-Gibod, F. Defendi, C. Dumestre-Perard, G. Hardy, Laurence Bouillet

“…Case presentation A woman with well-documented HAE due to type II C1 INH deficiency gave birth to two children 4 years apart. Functional C1 INH assays performed at 8 and 7 months of age returned normal C1 INH inhibitory activity. …”
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Cranial reconstruction with prefabricated 3D implant after a gunshot injury: A case report by Malivuković Ana, Novaković Nenad, Lepić Milan, Minić Ljubodrag, Stepić Nenad, Đorđević Boban, Rasulić Lukas

“…Materials routinely used for reconstructions like titanium mesh, polymethyl metacrylate (PMMA), and other have numerous disadvantages and limitations. …”
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