Upregulated astrocyte HDAC7 induces Alzheimer-like tau pathologies via deacetylating transcription factor-EB and inhibiting lysosome biogenesis by Jinwang Ye, Suyue Zhong, Huali Wan, Xing Guo, Xuanbao Yao, Qiong Liu, Liming Chen, Jian-Zhi Wang, Shifeng Xiao

“…Specifically, deacetylation of TFEB at K310 site by HDAC7 prevented TFEB nuclear translocation with reduced lysosomal biogenesis and tau clearance in astrocytes, whereas inhibiting HDAC7 restored astrocytic TFEB acetylation level at K310 with improved tau pathology and cognitive functions in PS19 mice. Conclusions Our findings suggest that upregulation of HDAC7 induces AD-like tau pathologies via deacetylating TFEB and inhibiting lysosomal biogenesis in astrocytes, and downregulating HDAC7-TFEB signaling is promising for arresting AD and other tauopathies.…”
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Phytochemical profiling and in silico evaluation of Artemisia absinthium compounds targeting Leishmania N-myristoyltransferase: molecular docking, drug-likeness, and toxicity analy... by Farouk Boudou, Amal Belakredar, Alaeddine Berkane, Ahcen Keziz, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Mikhael Bechelany, Ahmed Barhoum

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Camellia sinensis phytochemical profiling, drug-likeness, and antibacterial activity against gram-positive and gram-negative bacteria: in vitro and in silico insights by Farouk Boudou, Amal Belakredar, Ahcene Keziz, Huda Alsaeedi, David Cornu, Mikhael Bechelany, Mikhael Bechelany, Ahmed Barhoum, Ahmed Barhoum

“…The plant contains bioactive compounds, such as catechins, flavonoids, and phenolic acids, which are associated with various health benefits, including antioxidant, anti-inflammatory, and anticancer activities.AimTo investigate the bioactive potential of a Camellia sinensis extract, particularly its antibacterial activity against Gram-positive and Gram-negative bacteria and its drug-like properties.MethodPhenolic compounds in C. sinensis extract were identified and quantified using high-performance liquid chromatography (HPLC). …”
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Methodology for managing employee performance in modern commercial organizations. by A. T. Samatoev

“…The modeling carried out allows to draw a conclusion about the potential effectiveness of this approach, especially for organizations with one or in the same location and/or employing a large number of people performing similar functions, as it does not require significant financial outlays. …”
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Investigating the electronic structure and adsorption of OCN− and CN− on Si12C12 Fullerene-like cages using DFT and MD simulations by Abdulrahman Sumayli, Saad M. Alshahrani

“…Abstract The adsorption behavior of the toxic molecules OCN− and CN− onto Si12C12 fullerene-like cages was performed using density functional theory (DFT) calculations with the B3LYP and PBE functionals and a 6-311 + G** basis set, in both vacuum and aqueous phases (PCM model). …”
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NR4A3 potentials M1-like macrophage polarization to facilitate anti-tumor immune responses in breast cancer by Yi-yu Qian, Ning Jin, Shan-shan Rao, Ya Wang, Xin Li, Wen Pan, Pu Huang, Si-yuan Wang, Ping-fei Li, Yan-kai Lv, Qing-lei Gao, Yu Xia

“…Abstract Breast cancer (BC) is commonly labeled a “cold tumor” due to its dense population of immunosuppressive cells, particularly M2-like macrophages, which contribute to its resistance to therapy. …”
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Endothelial cells nurture stem cell-like characteristics of osteosarcoma cells in a perivascular niche by CXCL12/CXCR4 pathway by CAO Ya, LIU Yang, WANG Yang

“…Objective‍　‍To investigate the effect of endothelial cells in the perivascular niche on the stem cell-like characteristics of osteosarcoma cells and primarily explore the possible molecular mechanism. …”
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Toll-like receptor 3 activation enhances antitumor immune response in lung adenocarcinoma through NF-κB signaling pathway by Ang Li, Ang Li, Ang Li, Man Luo, Xiyao Liu, Hongjiao Wu, Hongjiao Wu, Hongjiao Wu, Xiaoguang Liu, Zhi Zhang, Xuemei Zhang, Xuemei Zhang, Xuemei Zhang

“…This study aims to investigate the role of TLR3 in LUAD by examining its expression levels, prognostic significance, and impact on immune signaling pathways.MethodsWe analyzed the impact of TLR3 expression on the prognosis of lung adenocarcinoma patients using data from the Cancer Genome Atlas (TCGA) database and four additional cohorts (GSE72094, GSE30219, GSE50081 and GSE31210). Functional enrichment analyses were performed to compare molecular features between low and high TLR3 expression groups using gene set variation analysis (GSVA). …”
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Potential therapeutic effects of Ferula gummosa Boiss. Extract on Autistic-like behaviors in maternally separated mice: Role of NMDA receptor gene by Forozan Yaghoubi, Hossein Amini-Khoei, Kamal Solati, Antoni Sureda, Zahra Lorigooini

“…NMDA receptors are crucial in the functioning of the brain, especially in memory and learning, and have been implicated in the development of ASD. …”
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AETHER: An Ultra-High Throughput and Low Energy Authenticated Encryption Scheme by Subhadeep Banik, Andrea Caforio, Tatsuya Ishikawa, Takanori Isobe, Mostafizar Rahman, Kosei Sakamoto

“…While inspired by an AEGIS-like structure, AETHER stands out with a completely redesigned round-update function. …”
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Propofol Induces Postoperative Depression and Inhibits Microglial Function in Mice by Feng Song, Xiao Lv, Jing Meng

“…These above results suggested that propofol treatment might promote the depressive-like behaviours in mice via influencing the microglial cell function. …”
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Method of designing security protocol for remote attestation by YU Rong-wei1, WANG Li-na1, KUANG Bo1

“…By the introduction of the natural law of survival of the fittest,an improved method of automatically designing cryptographic protocols was proposed.This method regards BAN-like logic as a basic tool to describe them,construct a fitness function to assess the performance of individuals systematically in order to reach the best solutions.The result shows the method can assure correctness and security of the designed protocol.Furthermore,it has a strong feasibility and applicability.…”
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Method of designing security protocol for remote attestation by YU Rong-wei1, WANG Li-na1, KUANG Bo1

“…By the introduction of the natural law of survival of the fittest,an improved method of automatically designing cryptographic protocols was proposed.This method regards BAN-like logic as a basic tool to describe them,construct a fitness function to assess the performance of individuals systematically in order to reach the best solutions.The result shows the method can assure correctness and security of the designed protocol.Furthermore,it has a strong feasibility and applicability.…”
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Integration of Security Service Functions Into Network-Level Access Control by Leonard Bradatsch, Frank Kargl

“…Service function chaining is an approach to dynamically steer traffic through different service functions like intrusion prevention systems within a local area network. …”
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Evaluating Image Quality Metrics as Loss Functions for Image Dehazing by Rareș Dobre-Baron, Adrian Savu-Jivanov, Cosmin Ancuți

“…This paper examines the adequacy of ten recent IQA metrics, compared with standard loss functions, within two trained dehazing neural networks, with observed broad improvement in their performance.…”
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Acupuncture Ameliorates Alzheimer’s-Like Cognitive Impairment and Pathological Changes via Regulating the Intestinal Fungal Community in APP/PS1 Mice by Hao X, Ding N, Zhang Y, Wu M, Tao Y, Li Z

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Anti-RANKL Inhibits Thymic Function and Causes DRONJ in Mice by Yusuke Nakamura, Takashi Kikuiri, Takahiro Sugiyama, Ayako Maeda, Daisuke Izumiyama, Daigo Yahata, Yoshitaka Yoshimura, Tetsuo Shirakawa, Yoshimasa Kitagawa

“…Anti-mouse RANKL monoclonal antibody and melphalan were performed to create a mouse model of DRONJ-like lesions in female C57BL/6J mice. …”
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SARE: an optimized method for detection functional regulatory elements in genome by Mohammadjavad Hosseinpoor

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Cognitive function changes and DTI-ALPS index in postmenopausal women by Ningning Liu, Yue Zhang, Weiqing Fu, Huijun Liu

“…These included MANOVA, non-linear correlation analysis, structural equation modeling, and machine learning algorithms.ResultsPostmenopausal women exhibited lower right and mean ALPS indices (P < 0.05) and worse cognitive performance on reaction time tasks (P < 0.05). The mean ALPS index fully mediated the relationship between estrogen and cognitive accuracy (e.g., Stroop: r = 0.588, P < 0.01), with machine learning ranking ALPS index and estrogen as top predictors of cognitive function.ConclusionsReduced brain lymphatic function (lower ALPS index) is associated with cognitive decline in postmenopausal women, and this relationship is mediated by estrogen levels. …”
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Impact of the resection method on the structure–functional changes in pancreatic gland by K. G. Valikhnovska

“…Results. After resection, performed using standard surgical procedure, alternative changes have occurred, which were accompanied by circulatory disorders around foci of destruction in pancreatocytes, and the process progressing in a cascade-like character with formation of the colliquative necrosis foci. …”
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