Analysis of Long Noncoding RNAs-Related Regulatory Mechanisms in Duchenne Muscular Dystrophy Using a Disease-Related lncRNA-mRNA Pathway Network by Bing Xu, Chunlei Zheng

“…Then, protein-protein interaction (PPI), coexpression network of lncRNA-mRNA, and DMD-related lncRNA-mRNA pathway networks were constructed, and functional analyses of the genes in the network were performed. …”
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Integrated Serum Metabolomics and Network Pharmacology to Reveal the Interventional Effects of Quzhi Decoction against Osteoarthritis Pain by Xiaoqing Shi, Peng Wu, Lishi Jie, Li Zhang, Jun Mao, Songjiang Yin

“…An anterior cruciate ligament transection (ACLT) rat model was established, and pain-like behavior was evaluated. Metabolomics analysis of serum samples was performed to identify differential metabolites, and network pharmacology was used to identify potential targets of Quzhi decoction for the treatment of OA. …”
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Efficacy of suspension exercise training in spinal cord injury: a systematic review and meta-analysis by Yuntao Li, Minmin Wu, Jiguang Pan, Luwen Zhu

“…Significant improvements were observed in all of the aforementioned outcome indicators, suggesting that SET is likely to be effective in restoring function in patients with SCI. …”
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Multi-omics analysis unveils the predictive value of IGF2BP3/SPHK1 signaling in cancer stem cells for prognosis and immunotherapeutic response in muscle-invasive bladder cancer by Yaobang Wang, Wuyue Song, Chao Feng, Shulin Wu, Zezu Qin, Tao Liu, Yu Ye, Rong Huang, Yuanliang Xie, Zhong Tang, Qiuyan Wang, Tianyu Li

“…Methods We performed single-cell mass cytometry (CyTOF) analysis of 179,483 single cells to characterize potential immunotherapy-related cancer stem cells (CSCs)-like populations in the tumor microenvironment of 38 MIBC tissues. …”
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Artificial plasticenta: how polystyrene nanoplastics affect in-vitro cultured human trophoblast cells by Antonio Ragusa, Loredana Cristiano, Pierluigi Di Vinci, Giuseppe Familiari, Stefania Annarita Nottola, Guido Macchiarelli, Alessandro Svelato, Caterina De Luca, Denise Rinaldo, Isabella Neri, Fabio Facchinetti

“…In addition, PS-NPs alter the ultrastructure of some organelles in the surviving cells, like those we have already described in vivo. We found that NPs enter the cells, affecting the endoplasmic reticulum and mitochondria morphology, accumulating as aggregates within lysosome-like organelles. …”
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Whole Cells of Microorganisms—A Powerful Bioanalytical Tool for Measuring Integral Parameters of Pollution: A Review by Maxim Cheliukanov, George Gurkin, Roman Perchikov, Anastasia Medvedeva, Tatyana Lavrova, Tatyana Belousova, Aleksandra Titova, Yulia Plekhanova, Sergei Tarasov, Anna Kharkova, Vyacheslav Arlyapov, Philippe Mandin, Hideaki Nakamura, Anatoly Reshetilov

“…However, practical challenges, such as sensitivity to environmental factors like pH, salinity, and the presence of competing substances, continue to hinder their broader application and long-term stability. …”
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Microstructural analysis does not support altered interhemispheric wiring of the human anterior commissure in corpus callosum dysgenesis by Timothy J. Edwards, Ryan J. Dean, Gail A. Robinson, Jacquelyn Knight, Simone A. Mandelstam, Linda J. Richards

“…Consequently, other, presently unknown, compensatory mechanisms are likely involved in supporting this function.…”
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IGF1 receptor inhibition amplifies the effects of cancer drugs by autophagy and immune-dependent mechanisms by Qi Wu, Shuai Zhang, Peng Liu, Wei Xie, Guido Kroemer, Oliver Kepp, Bei Li, Pan Hui, Ai-Ling Tian, Marion Leduc, Sabrina Forveille, Peter Hamley, Warren Galloway, Liwei Zhao, Frank Madeo, Yi Tu

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Unveiling the mechanisms of CEBPD-orchestrated TAM polarization through RGS2/PAR2 pathway and its impact on ICB efficacy in clear cell renal cell carcinoma by Jun Gu, Yifan Liu, Wang Zhou, Shun Zhang, Ke-Qin Dong, Jia-Xin Chen, Wen-Yan Li, Zi-Chang Liu, Yi-Fan Tang, Xiu-Wu Pan, Xin-Gang Cui, Hong-feng Zheng, Mu-chen Li, Tian-yue Yang, Jian-gui Liu, Zi-xuan Gong

“…Background The polarization status and function of tumor-associated macrophages (TAMs) influence tumor progression and patients’ prognosis. …”
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Tannins from <i>Acacia mearnsii</i> De Wild as a Sustainable Alternative for the Development of Latent Fingerprints by Danielle Tapia Bueno, Amanda Fonseca Leitzke, Rayane Braga Martins, Daisa Hakbart Bonemann, Emanuel Gomes Bertizzolo, Gabrielly Quartieri Sejanes, Juliana Porciúncula da Silva, Lucas Minghini Gonçalves, Neftali Lenin Villarreal Carreno, Claudio Martin Pereira de Pereira

“…This study characterized four types of tannins from black wattle, using Fourier Transform Infrared Spectroscopy, revealing key functional groups like C=O, C=C, and O–H. Ultraviolet–visible absorption spectra showed similar behaviors for all tannins, indicating phenolic and benzenoid structures. …”
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Nutritional profiling, phytochemical screening, cytotoxicity, and antioxidant content analysis for different crude extracts of Ulva lactuca from coast of Bangladesh by S.M. Bokhtiar, D. Sarker, Alima Akter, M.A. Salam, K.U. Ahmed, M.M. Anwar, M.F. Hossain, M. Ahmed, M.S. Bhuiyan, R.A. Kanta, A.K.M. Asaduzzaman, Khondoker Shahin Ahmed, Hemayet Hossain, S.M. Rafiquzzaman

“…Phytochemical screening, Fourier transform infrared (FT-IR) and High-performance liquid chromatography (HPLC) analysis confirmed the presence of different secondary metabolites, functional groups and polyphenols. …”
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Validated KASP Markers for drought tolerance in cotton enable efficient trait selection and preliminary mechanism analysis by Wenju Gao, Hu Zhang, Qin Chen, Ning Wang, Jianbin Shi, Yibin Zhang, Qinghua Xu, Jieyin Zhao, Quanjia Chen, Gentu Yan

“…Candidate gene prediction highlighted several drought-responsive genes, such as a Bacillus-like protease and a 14–3–3 protein. Functional exploration of the 14–3–3 gene through RNA sequencing, yeast two-hybrid screening, and Arabidopsis phenotyping supported its potential role in drought resistance. …”
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Molecularly imprinted polymer technology for electrochemical detection of diabetes-related biomarkers by Launa Silky Karenindra Rokhmat, Irkham, Serly Zuliska, Adisyahputra, Yohanes Susanto Ridwan, Retna Putri Fauzia, Putra Rafli Ramdani, Yeni Wahyuni Hartati

“…Furthermore, key factors influencing sensor performance, such as functional monomers, crosslinkers, and initiators, are discussed. …”
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Preclinical pharmacology of alogabat: a novel GABAA-α5 positive allosteric modulator targeting neurodevelopmental disorders with impaired GABAA signaling by Giuseppe Cecere, Theresa M. Ballard, Frederic Knoflach, Michael Honer, Joerg F. Hipp, Pilar Garces, Thomas Mueggler, Basil Künnecke, Andreas Bruns, Eric P. Prinssen, Philipp Schoenenberger, Philipp Janz, Roger Redondo, Barbara Biemans, Henner Knust, Andrés Olivares-Morales, Alessandro Brigo, Jan Michael Schulz, Daniel Bertrand, Michael Saxe, Eoin C. O’Connor, Maria-Clemencia Hernandez

“…Alogabat was evaluated for its effects on the repetitive behavior phenotype in BTBR and contactin-associated protein-like 2 (Cntnap2−/−) knockout mice, seizure models, cognitive performance in rats, and rotarod performance following combination treatment with diazepam.ResultsAlogabat is a potent positive allosteric modulator of GABAA-α5 receptors, with binding and functional selectivity. …”
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IGF2/IGFBP4 reduces apoptosis and increases free cholesterol of chicken granulosa cells in vitro by Wenhui Zhang, Xuejiao Chen, Axiu Guo, Zongyi Zhao, Bo Zhang, Fuwei Li, Hao Zhang

“…In addition, our study contributes to understanding follicular development and improves the egg-laying performance of chickens.…”
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Alleviating small sample problem in continuous forest monitoring with remote sensing-assisted Copulas by Xinjie Cheng, Zhengyang Hou, Annika Kangas, Jean-Pierre Renaud, Hao Tang, Weisheng Zeng, Qing Xu

“…Consequently, this study aims to (1) develop and demonstrate estimation using Copulas modeling; (2) propose a sample size optimization procedure for MA estimators in the context of continuous forest monitoring; and (3) compare survey precisions of the estimators using Copulas and Weighted Least Squares regression (WLS) as a function of sample sizes. Four main conclusions are relevant: for both Burkina Faso (BF) and Genhe (GH) study area, (1) Copulas outperforms WLS in modeling and prediction, both in terms of mean values and maximum/minimum values; (2) Copulas consistently demonstrates superior performance and precision across varying sample sizes compared to the WLS with MA estimators; (3) a straightforward sample size optimization approach reveals that variance estimates of Copulas remain lower than those of WLS as the sample size decreases in monitoring surveys; (4) Copulas requires about 20% smaller sample size than WLS does when achieving a specified precision, suggesting enhanced efficiency. …”
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Identification and validation of mitophagy-related genes in acute myocardial infarction and ischemic cardiomyopathy and study of immune mechanisms across different risk groups by Ying Hao, Ying Hao, RuiLin Li, RuiLin Li, ChengHui Fan, ChengHui Fan, Yang Gao, Xia Hou, Wei wen, YunLi Shen

“…We analyzed AMI and ICM datasets from GEO, identifying mitophagy-related differentially expressed genes (MRDEGs) through databases like GeneCards and Molecular Signatures Database, followed by functional enrichment and Protein-Protein Interaction analyses. …”
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Integrated analysis of electrical stimulation effects on Pseudomonas aeruginosa PAO1 inoculated denitrifying community: targeted and untargeted metabolomic analysis of phenazine bi... by Li Wu, Li Wu, Yong Liu, Yong Liu, Jianping Deng, Jianping Deng, Shuanglin Gui, Shuanglin Gui, Hanbing Nie, Hanbing Nie

“…Among these, indole, a signaling molecule with QS-like functionality, exhibited the highest VIP score as an upregulated metabolite, and another indole derivative, brassicanal A, was also elevated. …”
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Predictive Value of Inflammation Markers for Frailty in Older Patients with CVD by Hu S, Lai X, Shi Y, Chai H, Guo Z, Liu D, Cui C

“…Patients in the non-frailty group were generally younger, more likely to have normal kidney function, and better blood pressure control. …”
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Impact of prenatal Di(2-ethylhexyl) phthalate exposure on pubertal development in female offspring rats: A focus on ERα-Mediated IGF-1/NKB crosstalk in the hypothalamus by Xiuying Li, Chunyan Li, Qingjie Li, Yuzhuo Wang, Modi Yang, Zhongsheng Zhou, Bo Zhang, Hang Li, Yingying Xu, Te Liu

“…Consequently, our research posits that prenatal exposure to DEHP is likely transmitted from the mother to the embryo, precipitating developmental anomalies and the onset of precocious puberty in offspring. …”
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