Ethyl acetate extract of Knoxia roxburghii (Rubiaceae) down-regulates ECHDC1, CAMK2D, DDB1, UBA6, BIRC6, and HK1 proteins and ameliorates the symptoms of diabetes mellitus by Xinge Wang, Xinge Wang, Xiaoqiao Tian, Yang Xu, Rong Li, Gusha Qumo, Jingping Li, Niman Bao, Maoru Li, Bin Qiu

“…Proteomics and metabolomics analyses were performed using pancreatic proteins and serum samples, and the proteomics findings were validated via parallel reaction monitoring (PRM).ResultsCompared with the model group, rats in the treatment group showed improved diabetic symptoms. …”
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Maternal and neonatal pregnancy outcomes in ankylosing spondylitis by O. A. Krichevskaya, Z. M. Gandaloeva, N. I. Klimenchenko, A. B. Dyomina, T. V. Dubinina

“…Indications for elective CS included severe hip joints involvement with altered function, and scar on the uterus. Emergency C-section was performed in cases of uterine inertia and preterm discharge of amniotic fluid. …”
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The Effect of Liv.52 DS in Metabolic Dysfunction-Associated Fatty Liver Disease (MAFLD): A Pilot, Randomized, Double-Blind, Placebo-Controlled, Clinical Study by Jalihal U, Nanda RA, Katariya K, Ramanathan B, Kumawat R

“…Considering the preliminary trend of hepatoprotective function of Liv.52 DS, the present study was conducted to explore its role in MAFLD.Patients and Methods: This randomized, double-blind, placebo-controlled, prospective, multicenter study was performed at four tertiary care hospitals in India. …”
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Hydroxysafflor yellow A alleviates oxidative stress and inflammatory damage in the livers of mice with nonalcoholic fatty liver disease and modulates gut microbiota by Liang Wu, Liang Wu, Xueyun Dong, Wen Sun, Tan Jiajun, Asmaa Ali, Jiayuan He, Pingping Wang

“…Histopathological examination of liver tissues was performed using hematoxylin and eosin (H&E) staining to evaluate structural damage. …”
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Dysbiosis of Gut Microbiota in Ankylosing Spondylitis Patients by Yang L, Wang K, Liu B, Chen T, Ma T, Cui Z, Zhang D, Zhang S, Liu X, Shen J, Lu H

“…Bioinformatic processing and statistical analysis were performed to assess the microbial community structure, diversity, and function.Results: The study revealed significant differences in gut microbiota composition between AS patients and healthy controls. …”
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The Bordetella effector protein BteA induces host cell death by disruption of calcium homeostasis by Martin Zmuda, Eliska Sedlackova, Barbora Pravdova, Monika Cizkova, Marketa Dalecka, Ondrej Cerny, Tania Romero Allsop, Tomas Grousl, Ivana Malcova, Jana Kamanova

“…We demonstrate that BteA-induced cell death is characterized by the fragmentation of the cellular endoplasmic reticulum and mitochondria, the formation of necrotic balloon-like protrusions, and plasma membrane permeabilization. …”
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Whole-transcriptome sequencing reveals the effects of acupuncture on early embryos post-IVF-ET in poor ovarian response by Jianheng Hao, Yuemeng Zhao, Xuan Liu, Huichao Xu, Liying Liu, Haijun Wang, Ying Lan, Laixi Ji

“…The circ/lncRNA-miRNA-mRNA network was constructed to analyze the biological functions and potential mechanisms of acupuncture on early embryo development post-IVF-ET in POR mice. …”
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Comparative transcriptomics reveal stage-dependent parasitic adaptations in the myxozoan Sphaerospora molnari by Monika M. Wiśniewska, Jiří Kyslík, Gema Alama-Bermejo, Alena Lövy, Martin Kolísko, Astrid S. Holzer, Anush Kosakyan

“…We discovered several apparent innovations in the S. molnari transcriptome, including proteins that are likely to function in the uptake of previously unknown key nutrients, immune evasion factors that may contribute to long-term survival in hosts, and proteins that likely improve adhesion to host cells that may have arisen from horizontal gene transfer. …”
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Integration of Hybrid Machine Learning and Multi-Objective Optimization for Enhanced Turning Parameters of EN-GJL-250 Cast Iron by Yacine Karmi, Haithem Boumediri, Omar Reffas, Yazid Chetbani, Sabbah Ataya, Rashid Khan, Mohamed Athmane Yallese, Aissa Laouissi

“…The results showed that the coated Si₃N₄ tool achieved the best surface finish, with minimal cutting force and power consumption, while the uncoated Si₃N₄ and CBN tools performed slightly worse. Advanced optimization models including improved grey wolf optimizer–deep neural networks (DNN-IGWOs), genetic algorithm–deep neural networks (DNN-GAs), and deep neural network–extended Kalman filters (DNN-EKF) were compared with traditional methods like Support Vector Machines (SVMs), Decision Trees (DTs), and Levenberg–Marquardt (LM). …”
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Protein arginine methyltransferase 6 enhances immune checkpoint blockade efficacy via the STING pathway in MMR-proficient colorectal cancer by Tao Chen, Yu Zhang, Yang Sun, Ling Gao, Ting Lu, Jinlin Duan, Qiwei Li, Junyan Xue, Yonglong Zhang

“…Pharmacological inhibition of PRMT6 using EPZ020411 promotes mutagenesis and destabilizes MutSα or MutSβ assembly, and prolonged EPZ020411 exposure maintains an MSI-like phenotype in microsatellite stability (MSS) cells. …”
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Modelación de la Solubilidad de Panela Granulada y Otros Edulcorantes en Agua by Nelly Lara, Alejandra Clavijo, Verónica Barrera

“…No included glucose, the reciprocal-Y model was selected in order to predict the solubility as a function of temperature. Concerning to glucose, the square root-X was selected. …”
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Assessing the causal effect of inflammation‐related genes on myocarditis: A Mendelian randomization study by Huazhen Xiao, Hongkui Chen, Wenjia Liang, Yucheng Liu, Kaiyang Lin, Yansong Guo

“…The results of PPI analysis showed that 20 genes were predicted to be associated with IRF7 function, such as response to type I interferon, pattern recognition receptor signalling pathway, and toll‐like receptor signalling pathway. …”
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Modelación de la Solubilidad de Panela Granulada y Otros Edulcorantes en Agua by Nelly Lara, Alejandra Clavijo, Verónica Barrera

“…No included glucose, the reciprocal-Y model was selected in order to predict the solubility as a function of temperature. Concerning to glucose, the square root-X was selected. …”
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Prostaglandin F2α stimulates the growth of human intermediate hair follicles in ex vivo organ culture with potential clinical relevance by Ben H. Miranda, Ben H. Miranda, Karzan G. Khidhir, Karzan G. Khidhir, Desmond J. Tobin, Desmond J. Tobin, Desmond J. Tobin

“…Current treatments are limited by unwanted side effects and a lack of understanding of hair follicle (HF) regulation, particularly in miniaturised intermediate or vellus-like follicles; the clinical targets in hair loss disorders. …”
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Modelación de la Solubilidad de Panela Granulada y Otros Edulcorantes en Agua by Nelly Lara, Alejandra Clavijo, Verónica Barrera

“…No included glucose, the reciprocal-Y model was selected in order to predict the solubility as a function of temperature. Concerning to glucose, the square root-X was selected. …”
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Influence of Different Synthesis Methods on the Defect Structure, Morphology, and UV-Assisted Ozone Sensing Properties of Zinc Oxide Nanoplates by Pedro P. Ortega, João V. N. Palma, Ana L. Doimo, Laura Líbero, Gabriel F. Yamakawa, Leonnam G. Merízio, Ederson C. Aguiar, Luís F. Silva, Elson Longo

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Axiology and dynamics of contemporary research groups: a systematic review and hermeneutic meta-analysis of knowledge, values, and social elements by Edgar O. Ayala, Edgar O. Ayala, Myriam M. Altamirano-Bustamante, Myriam M. Altamirano-Bustamante, Adalberto de Hoyos-Bermea

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Gut Microbiota Alterations in Alzheimer’s Disease: Relation with Cognitive Impairment and Mediterranean Lifestyle by David Mateo, Nerea Carrión, Cristian Cabrera, Luis Heredia, Montse Marquès, Eva Forcadell-Ferreres, Maria Pino, Josep Zaragoza, Alfons Moral, Lluís Cavallé, José M. González-de-Echávarri, Paloma Vicens, José L. Domingo, Margarita Torrente

“…Dysbiosis involves changes in microbial diversity influenced by environmental factors, like diet or lifestyle. In this study, we investigated the role of GMB parameters in Spanish AD patients, assessing the impact of adherence to the Mediterranean lifestyle (ML), as well as to characterize these parameters in relation to neuropsychological, neuropsychiatric, emotional, and functionality parameters. …”
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Peptidylglycine alpha-amidating monooxygenase is important in mice for beta-cell cilia formation and insulin secretion but promotes diabetes risk through beta-cell independent mech... by Yi-Chun Chen, Nils E. Bäck, Jenicia Zhen, Lena Xiong, Mitsuhiro Komba, Anna L. Gloyn, Patrick E. MacDonald, Richard E. Mains, Betty A. Eipper, C. Bruce Verchere

“…PAM is the only enzyme capable of converting glycine-extended peptide hormones into amidated products. Like neuropeptide Y (NPY), α-melanocyte stimulating hormone (αMSH), and glucagon-like peptide 1 (GLP-1), islet amyloid polypeptide (IAPP), a beta cell peptide that forms islet amyloid in type 2 diabetes, is a PAM substrate. …”
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Providing a Roadmap for the Adaption of Agricultural Sector to Water Scarcity Conditions (Case Study: Selected Crops of Tajan Basin, Iran) by H. Fouladi, H. Amirnejad, S. Shirzadi Laskookalayeh

“…In this model, barley can be removed from the crop composition like the linear pattern or cultivated on a maximum of 2553 hectares. …”
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