Anxiolytic and Antidepressant Effects of Organic Polysulfide, Dimethyl Trisulfide Are Partly Mediated by the Transient Receptor Potential Ankyrin 1 Ion Channel in Mice by Kitti Göntér, Viktória Kormos, Erika Pintér, Gábor Pozsgai

“…Various behavioural assessments—including the open field, marble burying, tail suspension, forced swim, and sucrose preference tests—were performed to evaluate anxiety and depression-like behaviour. …”
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Spectrum of Visual Dysfunction Detected by a Novel Testing Protocol Within a Special School Eye Care Service by Mohammud Musleh, Alison Green, Aleks Mankowska, Catherine Viner, Rachel Pilling

“…This article reports on the feasibility and outcomes of visual function testing performed during in-school visual assessments. …”
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Comprehensive analysis of scRNA-seq and bulk RNA-seq reveals the non-cardiomyocytes heterogeneity and novel cell populations in dilated cardiomyopathy by Siyu He, Chunyu Li, Mingxin Lu, Fang Lin, Sangyu Hu, Junfang Zhang, Luying Peng, Li Li

“…Additionally, two subpopulations of M2 macrophages, M2-like1 and M2-like2, were identified with distinct features. …”
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Long-lasting sex-specific alteration in left ventricular cardiac transcriptome following gamma and simGCRsim radiation by Roksana Zakharyan, Siras Hakobyan, Agnieszka Brojakowska, Suren Davitavyan, Ani Stepanyan, Tamara Sirunyan, Gisane Khachatryan, Mary K. Khlgatian, Malik Bisserier, Shihong Zhang, Susmita Sahoo, Lahouaria Hadri, Venkata Naga Srikanth Garikipati, Arsen Arakelyan, David A. Goukassian

“…We reported heart failure with preserved ejection fraction like cardiac phenotype 660-days following exposure to a single-dose of a simplified galactic cosmic ray simulation (simGCRsim) only in males with functional and structural impairment in left ventricular (LV) function. …”
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Genome-Wide Identification and Expression Analysis of the <i>SPL</i> Gene Family in <i>Solanum melongena</i> (Eggplant) by Hefen Cheng, Zhiliang Li, Baojuan Sun, Wei Zhao, Songyuan Zhang, Tao Li, Qian You, Dinggang Zhou

“…The SPL (SQUAMOSA promoter-binding protein-like) transcription factor gene family plays a crucial role in the growth of plants, including fruit development. …”
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Leveraging dendritic complexity for neuromorphic computing by Suma G Cardwell, Mark Plagge, Luke Parker, Claire E Plunkett, David Munkvold, Paloma T Gonzalez-Bellido, Scott Koziol, Conrad James, Frances S Chance

“…Current neuromorphic systems are focused primarily on scalability, namely, increasing the number of computational units (neurons) and connections between units (synapses). However, for brain-like cognition and efficiency in next-generation computing hardware, we need increased complexity in function, as well as improved connection density for scalability. …”
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CADD based designing and biological evaluation of novel triazole based thiazolidinedione coumarin hybrids as antidiabetic agent by Anchal Sharma, Anmol Narang, Nitish Kumar, Rupali Rana, Megha, Pooja, Muskan Dhir, Harmandeep Kaur Gulati, Jyoti, Aanchal Khanna, Jatinder Vir Singh, Sukhraj Kaur, Preet Mohinder Singh Bedi

“…Pharmacokinetic properties were evaluated through drug-likeness and ADMET studies. Additionally, density functional theory (DFT) analyses were performed to assess the stability and reactivity of potential diabetes mellitus drug candidates. …”
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Efficacy and safety of Qishen granule for treating heart failure with preserved ejection fraction: a study protocol for a multicenter, randomized, double-blind, placebo-controlled... by Huiqi Chen, Zhibo Li, Meiyi Su, Guanghui Song, Sien Guo, Wenwei Feng, Wensheng Chen, Chun Li, Lei Wang, Wei Wang

“…Secondary outcomes include changes in echocardiography parameters, serum soluble human growth stimulation expressed gene 2 (ST2) protein levels, TCM syndrome integral scale score, quality of life and other indicators in CPET. Safety indicators like blood tests of liver and renal function and adverse events are used to assess the safety of QSG. …”
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Unraveling anoikis in glioblastoma: insights from single-cell sequencing and prognostic modeling by Qikai Tang, Chenfeng Ma, Jiaheng Xie, Qixiang Zhang, Bingtao Zhang, Weiqi Bian, Qingyu Lu, Zeyu Wan, Wei Wu

“…Methods Utilizing single-cell sequencing and bulk-transcriptome sequencing data from TCGA, GEO, and CGGA databases, we performed comprehensive bioinformatics analyses. We identified anoikis-related genes, constructed a prognostic model using 101 machine learning algorithms, and validated its clinical utility across multiple cohorts.Finally, we also verified the expression of model genes and the function of key gene in clinical samples and cell lines. …”
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Crude Radix Aconiti Lateralis Preparata (Fuzi) with Glycyrrhiza Reduces Inflammation and Ventricular Remodeling in Mice through the TLR4/NF-κB Pathway by Ping Yan, Wen Mao, Lushuai Jin, Mingsun Fang, Xia Liu, Jiali Lang, Lu Jin, Beibei Cao, Qiyang Shou, Huiying Fu

“…For the subsequent 8 weeks, hemodynamic indicators, ventricular pressure indices, and mass indices were evaluated, and histopathological imaging was performed. CFZ, CFZ+GC, and PFZ significantly improved left ventricular function and structure and reduced myocardial damage. …”
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In Vitro Activity of Imipenem/Relebactam Alone and in Combination Against Cystic Fibrosis Isolates of <i>Mycobacterium abscessus</i> by Madeline Sanders, Sun Woo Kim, Aditi Shinde, Danielle Fletcher-Williams, Eric Quach, Paul Beringer

“…Background: <i>Mycobacterium abscessus</i> (MABS) is an opportunistic pathogen that causes chronic, difficult-to-treat pulmonary infections, particularly in people with cystic fibrosis (PwCF), leading to rapid lung function decline and increased morbidity and mortality. …”
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Stress-dependent activation of the Listeria monocytogenes virulence program ensures bacterial resilience during infection by Mariya Lobanovska, Ying Feng, Jonathan Zhang, Allison H. Williams, Daniel A. Portnoy

“…The screen identified transposon insertions in a large bacterial sensory organelle known as the stressosome. The absence of functional stressosome components resulted in heterogeneity within bacterial populations, with some bacteria behaving like wild type, while other members of the population exhibited defects in either vacuolar escape and/or cell-to-cell spread. …”
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Hsa-miR-21 promoted the progression of lung adenocarcinoma by regulating LRIG1 expression by Li Liu, Xinhua Liu, Chengpeng Gao, Meijuan Liu, Mengmeng Peng, Leqiang Wang

“…The differential expression analysis and gene set enrichment analysis (GSEA) were performed using “limma” and “clusterProfiler” function package, respectively. …”
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Long-term left atrial adaptations to reduced training load in former elite athletes: a long-term follow-up longitudinal observational study by Ahmad Sajadieh, Robin Christensen, Jens Jakob Thune, Mikkel Aaroee, Susanne Glasius Tischer, Christian Have Dall, Hanne Rasmusen

“…LA contraction strain was increased (change from baseline: 1.4%, 95% CI: 0.4% to 2.5%), while LV filling pressure increased (E/e’ change from baseline: 0.4, 95% CI: 0.1 to 0.7).Conclusions 7 years of reduced training does not reverse exercise-induced LA enlargement in former elite endurance athletes. LA contractile function improved with higher LV filling pressure, suggesting that age-related LV pressure increases may contribute to chronic LA dilation, though irreversible adaptations like fibrosis cannot be ruled out.Trial registration number NCT05555849.…”
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The whole genome analysis of the wild-type and attenuated orf virus reveals that ORF022 facilitates viral replication by Tian Jing, Yunpeng Wang, Yukun Bu, Xi Chen, Shutong Feng, Wenbo Liu, Zhannur Niyazbekova, Dekun Chen, Xiaolong Gao, Wentao Ma

“…Results In this study, we performed whole-genome sequencing of ORFV wild-type and attenuated strains from Shaanxi Province. …”
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Microbial carbonate rocks: composition, structures, textures, mechanisms and environments of formation. Microbiolite formation processes and environments. Article 2 by V. G. Kuznetsov, L. M. Zhuravleva

“…Along with plants, microbial communities perform a similar function.Aim. The paper presents the results of generalization and systematization of accumulated research data on the abovementioned forms.Materials and methods. …”
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Exploration of the Mountainous Urban Rail Transit Resilience Under Extreme Rainfalls: A Case Study in Chongqing, China by Chenhui Liu, Xue Su, Zhichun Wu, Yingjun Zhang, Cuizhu Zhou, Xiangguo Wu, Yong Huang

“…By introducing the metro ridership and topological shortest distances, a network service efficiency function is developed, and the importance of nodes is quantified using service efficiency index and topological importance index. …”
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Deubiquitination of DNM1L by USP3 triggers the development and metastasis of gallbladder carcinoma by Ruopeng Liang, Xiaoxue Zhang, Shitao Wu, Jing Liu, Yunpeng Zhai, Chaojie Lin, Zhenya Wang, Yi Zhang, Hao Chen, Rongtao Zhu

“…Previous studies have indicated that dynamin 1 like (DNM1L) is a key mediator of mitochondrial fission. …”
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Integrating Bulk RNA and Single-Cell Sequencing Data Reveals Genes Related to Energy Metabolism and Efferocytosis in Lumbar Disc Herniation by Lianjun Yang, Jinxiang Li, Zhifei Cui, Lihua Huang, Tao Chen, Xiang Liu, Hai Lu

“…Machine learning approaches were used to identify key genes. Functional enrichment analyses were performed to elucidate the biological roles of these genes. …”
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Impact of COVID-19 on the endocrine system by D. N. Zadumina, V. V. Skvortsov, D. A. Shtonda

“…Under normal conditions, this mission is performed by a complex of ACE/ACE2 enzymes that control the synthesis and physiological activity of angiotensin and kinin peptides in the body. …”
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