Quantitative analysis of amino acid excretion by Methanothermobacter marburgensis under N2-fixing conditions by Barbara Reischl, Benjamin Schupp, Hayk Palabikyan, Barbara Steger-Mähnert, Christian Fink, Simon K.-M. R. Rittmann

“…To quantify N2-fixation rates in a mass balance setting a novel method has been established. The method utilizes the pressure drop below a certain threshold pressure in closed batch cultivation mode – the threshold pressure for N 2 -fixation (THpN2fix). …”
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Safety, Tolerability and Pharmacokinetic-Pharmacodynamic Relationship of NX210c Peptide in Healthy Elderly Volunteers: Randomized, Placebo-Controlled, Double-Blind, Multiple Ascend... by Annette Janus, Daniël Dumas, Juliette Le Douce, Sébastien Marie, Giuseppe Pasculli, Pauline Bambury, Sighild Lemarchant, Philip Kremer, Yann Godfrin

“…In silico data modelling revealed salient pharmacokinetic-pharmacodynamic relationships, including reduction of claudin-5, neurofilament light chain, and SPARC-like protein 1 release, and degradation of homocysteine. …”
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Exploring the paradigm shift towards sustainability: A systematic literature review on circular economy and eco-innovation by Ruchira R N Ghormare, Sana Fatima, Priya Grover, Nidhi Phutela, Vinay Kandpal, Ernesto D. R. Santibanez Gonzalez

“…Therefore, this research is novel, and we explored the role of circular economy and eco-innovation towards sustainability through a systematic literature review. …”
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GTPase GPN3 facilitates cell proliferation and migration in non-small cell lung cancer by impeding clathrin-mediated endocytosis of EGFR by Linlin Xu, Jiankun Guo, Xinsheng Xie, Hailong Wang, Alan Jiang, Changhua Huang, Hua Yang, Shiwen Luo, Limin Chen

“…These results suggest that targeting GPN3 could serve as a novel prognostic biomarker and therapeutic strategy for NSCLC treatment.…”
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A data driven approach for soft tissue biomarker identification linked to Chiari-like malformation and syringomyelia by Jake Cumber, Jake Cumber, Emma Scales-Theobald, Emma Scales-Theobald, Clare Rusbridge, Clare Rusbridge, Clare Rusbridge, Kevin Wells, Kevin Wells

“…Overall, these findings shed light on the distinct morphologies related to CM-P and SM, offering the potential for more accurate and objective diagnoses in affected dogs using MRI. …”
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Redo Aortic Valve Replacement After Prior Transcatheter versus Surgical Aortic Valve Replacement: Insights from Western Experience by Arber Aliu, Klodiana Durici, Ira Lazo, Altin Veshti

“…This article presents a novel perspective on the risks associated with surgical aortic valve replacement (SAVR) after prior TAVR or SAVR. …”
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Improving remote sensing dehazing quality through local hybrid correction and optimization of atmospheric attenuation model based on wavelength by Daihong Zhao, Kun Shi, Zheng Li, Zheng Li, Meixiang Chen

“…To address these limitations, we propose a novel hybrid correction method, local hybrid correction (LHC), which integrates gamma correction for high-contrast regions and logarithmic correction for low-contrast regions within a dehazed image. …”
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Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…Novel engineered IL-2 agonists strive to increase the therapeutic window of aldesleukin (human IL-2) by increasing selectivity toward effector over regulatory T cells and reducing dose-limiting toxicities. …”
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Autoantibodies in systemic sclerosis: From disease bystanders to pathogenic players by Aurélien Chepy, Aurore Collet, David Launay, Sylvain Dubucquoi, Vincent Sobanski

“…Newly discovered antibodies shed light on SSc cases where Aab had previously gone unidentified. …”
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Cell-Based Therapies for the Treatment of Shoulder and Elbow Tendinopathies: A Scoping Review by Berardo Di Matteo, Riccardo Ranieri, Angelo Manca, Simone Cappato, Maurilio Marcacci, Elizaveta Kon, Alessandro Castagna

“…The aim of this paper is to perform a scoping review of the available clinical evidence on the application of cell-based therapies for the management of elbow and rotator cuff tendinopathies, in order to summarize the current application methods and to shed light on the therapeutic potential and current limitations of these biologic approaches. …”
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Effect of Exogenous Melatonin Administration in Critically Ill Patients on Delirium and Sleep: A Randomized Controlled Trial by Judith Bellapart, Vinesh Appadurai, Melissa Lassig-Smith, Janine Stuart, Christopher Zappala, Rob Boots

“…This study applies a previously published novel regimen of melatonin with proven sustained levels of melatonin during a 12 h period. …”
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Synthesis and evaluation of nitrochromene derivatives as potential antileishmanial therapeutics through biological and computational studies by Niloofar Javid, Ali Asadipour, Ehsan Salarkia, Mohammad Amin Langarizadeh, Fatemeh Sharifi, Mohammad Mahdavi, Bagher Amirheidari, Aida Iraji, Hojjat Rezaiezadeh, Gholamreza Hassanpour, Yaghoub Pourshojaei

“…This study endeavors to address this critical need by focusing on the design and synthesis of a series of novel compounds. Fifteen derivatives incorporating the nitrochromene pharmacophore were meticulously synthesized using the Henry reaction. …”
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Alteration in the Cytokine Secretion of Bone Marrow Stromal Cells from Patients with Chronic Myelomonocytic Leukemia Contribute to Impaired Hematopoietic Supportive Activity by Hui Shi, Yingshao Wang, Rong Li, Wen Xing, Feng-Chun Yang, Jie Bai, Yuan Zhou

“…These results suggested that BMSCs may contribute to the pathogenesis of CMML by altering their cytokine secretion, which will shed light on the further investigation to develop novel therapeutic strategies for CMML patients.…”
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Fractional-order PID feedback synthesis controller including some external influences on insulin and glucose monitoring by Kottakkaran Sooppy Nisar, Muhammad Farman, Khadija Jamil, Saba Jamil, Evren Hincal

“…Numerical simulations, mathematical modeling, and analysis work together to shed light on the dynamics of diabetes mellitus and make important advances in the knowledge and treatment of this common disease.…”
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Tanshinone IIA Sodium Sulfonate Attenuates LPS-Induced Intestinal Injury in Mice by Xin-Jing Yang, Jin-Xian Qian, Yao Wei, Qiang Guo, Jun Jin, Xue Sun, Sheng-Lan Liu, Chun-Fang Xu, Guo-Xing Zhang

“…The present study may provide novel insight into the molecular mechanisms of TSS on the treatment of intestinal injury.…”
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Mechanically robust surface-degradable implant from fiber silk composites demonstrates regenerative potential by Wenhan Tian, Yuzeng Liu, Bo Han, Fengqi Cheng, Kang Yang, Weiyuan Hu, Dongdong Ye, Sujun Wu, Jiping Yang, Qi Chen, Yong Hai, Robert O. Ritchie, Guanping He, Juan Guan

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Circadian clock regulation in soybean senescence: a transcriptome analysis of early and late senescence types by Prakash Basnet, Sevin Lee, Ka Hee Moon, Nam-Il Park, Gang-Seob Lee, Seongkon Lee, Taeyoung Um, Ik-Young Choi

“…Conclusions These findings provide novel insights into the regulation of senescence in soybean plants, which could lead to the development of new strategies to improve agriculture.…”
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Conjugates of Phthalocyanines With Oligonucleotides as Reagents for Sensitized or Catalytic DNA Modification

“…These results suggest the possible use of phthalocyanine-oligonucleotide conjugates as novel artificial regulators of gene expression and therapeutic agents for treatment of cancer.…”
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Chronic restraint stress affects the diurnal rhythms of gut microbial composition and metabolism in a mouse model of depression by Yue Wang, Peijin Cui, Maolin Cao, Ling Ai, Li Zeng, Xue Li, Dan Chen, Fang Gong, Liang Fang, Chanjuan Zhou

“…Rhythmicity in the microbiome may affect the host by regulating distinct metabolic pathways during the light and dark phases. A better combination of microbiota composition and oscillation would help to offer novel insight into key genera and their potential effects on depression.…”
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A modern scientific perspective on the flavor and functional properties of diverse teas in traditional cuisine “tea-flavored fish”: From macroscopic quality to microscopic variatio... by Wenxia Wang, Kun Liu, Chunlong Liu, Bei Yang, Hao Dong, Wenzhen Liao, Xingfen Yang, Qi He

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