Design, synthesis, and in vitro, in vivo, and in silico evaluation of novel substituted 1,3,4-thiadiazole derivatives as anticonvulsant agents by Tulika Anthwal, Swati Pant, Preeti Rana, Sumitra Nain

“…In the present study, a library of ten novel substituted 1,3,4‐thiadiazole derivatives were designed and synthesized using an appropriate synthetic route. …”
Get full text

Availability, accessibility and activation of mental health services among university students in Africa: a protocol of a mixed-methods systematic review with meta-analysis and met... by Hesborn Wao, Melvin A Wao, Ian Muriithi, Paul Seraii, Jackline Syonguvi

Get full text

Screening and identification of host signaling pathways for alleviating influenza-induced production of pro-inflammatory cytokines, IP-10, IL-8, and MCP-1, using a U937 cell-based... by Si Chen, Si Chen, Yang Yu, Yue Su, Xiaoqin Lian, Lefang Jiang, Zhuogang Li, Mingxin Zhang, Yarou Gao, Haonan Zhang, Xingjian Zhu, Jiaxin Ke, Xulin Chen

“…Influenza virus infection initiates an exaggerated inflammatory response, which may culminate in a fatal cytokine storm characterized by the excessive production of pro-inflammatory cytokines. Prior research indicates that IP-10, IL-8, and MCP-1, primarily produced by monocytes and macrophages, play a crucial role in influenza-induced inflammation. …”
Get full text

Competence and safety of digital environment consumption by children and parents by A. B. Neustroeva, L. D. Filippova

Get full text

A prospective, multi-site, cohort study to estimate incidence of infection and disease due to Lassa fever virus in West African countries (the Enable Lassa research programme)-Stud... by Suzanne Penfold, Ayola Akim Adegnika, Danny Asogun, Olufemi Ayodeji, Benedict N Azuogu, William A Fischer, Robert F Garry, Donald Samuel Grant, Christian Happi, Magassouba N'Faly, Adebola Olayinka, Robert Samuels, Jefferson Sibley, David A Wohl, Manfred Accrombessi, Ifedayo Adetifa, Giuditta Annibaldis, Anton Camacho, Chioma Dan-Nwafor, Akpénè Ruth Esperencia Deha, Jean DeMarco, Sophie Duraffour, Augustine Goba, Rebecca Grais, Stephan Günther, Énagnon Junior Juvénal Prince Honvou, Chikwe Ihekweazu, Christine Jacobsen, Lansana Kanneh, Mambu Momoh, Aminata Ndiaye, Robert Nsaibirni, Sylvanus Okogbenin, Chinwe Ochu, Ephraim Ogbaini, Énagnon Parsifal Marie Alexandre Logbo, John Demby Sandi, John S Schieffelin, Thomas Verstraeten, Nathalie J Vielle, Anges Yadouleton, Emmanuel Koffi Yovo, Enable Protocol authorship group

Get full text

Combined blockade of GPX4 and activated EGFR/HER3 bypass pathways inhibits the development of ALK‐inhibitor‐induced tolerant persister cells in ALK‐fusion‐positive lung cancer... by Koh Furugaki, Takaaki Fujimura, Narumi Sakaguchi, Yasutaka Watanabe, Ken Uchibori, Eisaku Miyauchi, Hidetoshi Hayashi, Ryohei Katayama, Shigeki Yoshiura

Get full text

Off-the-shelf CAR-NK cells targeting immunogenic cell death marker ERp57 execute robust antitumor activity and have a synergistic effect with ICD inducer oxaliplatin by Jichao Sun, Dinglan Wu, Liuhai Zheng, Huifang Wang, Jihao Zhou, Guangwei Shi, Jingbo Ma, Yuke Jiang, Zhiyu Dong, Jiexuan Li, Yuan-Qiao He, Chengchao Xu, Zhijie Li, Jigang Wang

Get full text

The PainSMART project: Protocol for a research program on effectiveness, mechanisms of effect and patient-practitioner experiences of the PainSMART-strategy as an adjunct to usual... by Richard Thompson, Maria Fors, Ann-Sofi Kammerlind, Pia Tingström, Allan Abbott, Kajsa Johansson

Get full text

Examining the impact of a community-based exercise intervention on cardiorespiratory fitness, cardiovascular health, strength, flexibility and physical activity among adults living... by Kelly K O'Brien, Aileen M Davis, Soo Chan Carusone, Lisa Avery, Ada Tang, Patricia Solomon, Rachel Aubry, Mehdi Zobeiry, Ivan Ilic, Zoran Pandovski, Ahmed M Bayoumi

Get full text

Bioactive Anti-Aging Substances: Geroprotectors by Anna D. Fokina, Anna D. Vesnina, Anna S. Frolova, Darya Yu. Chekushkina, Larisa A. Proskuryakova, Larisa M. Aksenova

“…The review covered five years of Russian research articles and patents on biologically active anti-aging agents indexed in the National Center for Biotechnology Information, ScienceDirect, eLIBRARY.RU, and the database of the Federal Institute of Industrial Property. …”
Get full text

大學教師學術發表影響力之影響因素 Factors Influencing Publication Impact of Faculty by 郭玲玲 Ling-Ling Kueh, 許清芳 Ching-Fan Sheu

“…Consequently, a close connection exists between faculty publication impact and the research environment. A higher graduate student-faculty ratio suggests that faculty members must dedicate more time to teaching activities and student supervision, which may reduce their research productivity (O’Hara et al., 2019; Smeltzer et al., 2016). …”
Get full text

Should the Food and Drug Administration Limit Placebo-Controlled Trials? by Max Goodman, Connor Pedersen

“…Randomized controlled trials: Ethical and scientific issues in the choice of placebo or active control. Ann Afr Med. 2017;16(3):97-100. doi:10.4103/aam.aam_211_16 [10] The Belmont Report Ethical Principles and Guidelines for the Protection of Human Subjects of Research. …”
Get full text

Development of a clinical decision support tool for Primary care Management of lower Urinary tract Symptoms in men: the PriMUS study by Adrian Edwards, Ridhi Agarwal, Janine Bates, Alison Bray, Sarah Milosevic, Emma Thomas-Jones, Michael Drinnan, Marcus Drake, Peter Michell, Bethan Pell, Haroon Ahmed, Natalie Joseph-Williams, Kerenza Hood, Yemisi Takwoingi, Chris Harding

Get full text

Microbial Biomass as a Bioresource of Functional Food Ingredients: A Review by Elena M. Serba, Tatyana V. Yuraskina, Liubov V. Rimareva, Polina Yu. Tadzibova, Elena N. Sokolova, Galina S. Volkova

Get full text

A novel machine learning methodology for the systematic extraction of chronic kidney disease comorbidities from abstracts by Eszter Sághy, Mostafa Elsharkawy, Frank Moriarty, Sándor Kovács, István Wittmann, Antal Zemplényi, Antal Zemplényi

“…A comprehensive understanding of CKD comorbidities could lead to the identification of risk-groups, more effective treatment and improved patient outcomes. Our research presents a two-fold objective: developing an effective machine learning (ML) workflow for text classification and entity relation extraction and assembling a broad list of diseases influencing CKD development and progression.MethodsWe analysed 39,680 abstracts with CKD in the title from the Embase library. …”
Get full text

DOES CANDIDATE OF SCIENCES NEED TO PUBLISH ARTICLES? by Valery A. Gurtov, Lyudmila V. Shchegoleva

“…Only 10% of candidates of science still continue an active research activities including writing articles.…”
Get full text

Satisfaction of Students with the Quality of Educational Services at Technical University by D. V. Maltsev, D. S. Repetskiy

“…The main comments are related to the quality of social and living conditions (catering, living conditions in a hostel).The results of the survey showed the need for further research in order to form a generalized (complex) model for assessing the quality of the University activities.…”
Get full text

Identification of ALEKSIN as a novel multi-IRF inhibitor of IRF- and STAT-mediated transcription in vascular inflammation and atherosclerosis by Aleksandra Antonczyk, Katarzyna Kluzek, Natalia Herbich, Mahdi Eskandarian Boroujeni, Bart Krist, Dorota Wronka, Anna Karlik, Lukasz Przybyl, Adam Plewinski, Joanna Wesoly, Hans A. R. Bluyssen

Get full text

Effect of Soft Rehabilitation Robot Gloves on Upper Limb and Hand Function of Stroke Patients：A Meta-Analysis by YU Tingting, SHEN Yuwei, WAN Guomeng, LI Jianan

“…ObjectiveTo evaluate the effect of soft rehabilitation robot gloves (SRG) on upper limb, hand motor function and activities of daily living of stroke patients by meta-analysis.MethodsData were searched and retrieved from the PubMed, Web of Science, The Cochrane Library, Embase, China National Knowledge Infrastructure (CNKI), Wanfang Data, Chinese Biomedical Literature Service System (CBMdisc), Chinese Science and Technology Periodical Database (VIP). …”
Get full text

DIVERSIFICATION OF STUDENTS' SCIENTIFIC CREATIVITY IN A VIRTUAL ENVIRONMENT by Vera S. Fedotova

“…The paper shows the possibility of diversification of research activities of students in online space by means of Internet technologies using the potential of scientific social networking, blogs, forums, online conferences, online seminars, webinars, chat, email, multimedia technologies, direct contact technology, electronic and hybrid journals, institutional repositories, electronic preprints, personal pages, scientometric databases, electronic library catalogs, scientific electronic library. …”
Get full text