EPHX2 overexpression deters the advancement of clear cell renal cell carcinoma via lipid metabolism reprogramming by Bo Guan, Cong Huang, Cong Huang, Cong Huang, Jun He, Jun He, Jun He, Weimin Shan, Di Cui, Xiaowei Li, Chaozhao Liang, Chaozhao Liang, Chaozhao Liang, Zongyao Hao, Zongyao Hao, Zongyao Hao

“…Subsequently, EPHX2 was stably overexpressed in the 786-O and ACHN cell lines via lentiviral transfection technology, and its functional effects were validated through in vitro experiments. …”
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Psychoeducation for Relatives of Young Adults with First-Episode Psychosis: A Qualitative Exploration of Needs and Experiences by S. A. Kuipers, C. A. Elzinga-Hut, B. S. Rosema, S. Sanches, D. Boertien, B. Stavenuiter, S. K. Spoelstra, G. H. M. Pijnenborg, N. Boonstra

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Libraries of the world during the pandemic: a new experience and the first conclusions by Asuman Akdemir, Aglaé Achechova, Benjamin Guichard, Andrey E. Guskov, Assel Lakhayeva, Anna Rakityanskaya, Natalya S. Redkina, Alla Roylance, Galina N. Serbina, Olga Einasto, Inna Yuryk

“…It is concluded that librarians need to continue learning digital etiquette and gaining new skills and competencies for telecommuting.…”
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Mutation of the histone demethylase Gasc1 causes ASD-like symptoms in mice by Tetsushi Kagawa, Yuhei Yamaguchi, Yasuhiro Kokubu, Genki Sudo, Aoi Ebisawa, Satoko Hattori, Keizo Takao, Kohtarou Konno, Naomi Nakagata, Takafumi Inoue, Masahiko Watanabe, Johji Inazawa, Tsuyoshi Miyakawa, Tetsuya Taga

“…Conclusion Taken together, our data suggest that histone demethylation plays a pivotal role in normal brain development and higher-order brain functions in both mice and humans.…”
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Behavioral moderators of In-utero superstorm sandy exposure and fronto-limbic cortical development—potential role of adaptiveness in clinical intervention strategies, a pilot study... by A. Duke Shereen, Donato DeIngeniis, Donato DeIngeniis, Tingting Wu, Md. Shafiur Rahman, Md. Shafiur Rahman, Melissa Blum, Jeffrey H. Newcorn, Yoko Nomura, Yoko Nomura, Yoko Nomura, Yoko Nomura

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Regulation of cortical neurogenesis by MED13L via transcriptional priming and its implications for MED13L syndrome by Jia Li, Yu-zhu Hao, Jia Cui, Xiao-xiao Cao, Nan Wu, Ji Ma, Shuang-yi Xie, Yi-Hsuan Pan, Xue-lian He, Yu-lan Zhao, Xiao-Bing Yuan

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The Effects of High-Dose Probiotic Supplementation on Immune Activation and Neurocognitive Disorders in People Living with HIV Undergoing Successful Antiretroviral Treatment: The P... by Matteo Vassallo, Margaux Zerlini, Roxane Fabre, Heloise Joly, Jacques Durant, Alain Makinson, Amandine Mauries, Jacqueline Capeau, Soraya Fellahi, Jean-Philippe Bastard, Christian Pradier, Christine Lebrun-Frenay

“…Neuropsychological testing assessed learning, episodic memory, attention/concentration, executive functions, language, information processing speed, and motor skills. …”
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Responsiveness of the mini-balance evaluation systems test, dynamic gait index, Berg balance scale, and performance-oriented mobility assessment in parkinson’s disease by Maryam Mehdizadeh, Seyed-Mohammad Fereshtehnejad, Merrill R. Landers, Parvaneh Taghavi Azar Sharabiani, Mohsen Shati, Seyede Salehe Mortazavi, Sayed Amir Hasan Habibi, Korosh Mansoori, Mahsa Meimandi, Zahra Nodehi, Zakieh Sadat Saberi, Ghorban Taghizadeh

“…The intervention consisted of task-oriented exercises focused on motor re-learning to improve functional balance. Anchor and distribution methods were used to determine the MID (the receiver-operating characteristic(ROC)-based (MIDROC), the predictive modeling method (MIDpred), and the MIDpred-based method adjusted by the rate of improvement (MIDadj)) and MDC. …”
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Cellular hierarchy framework based on single-cell/multi-patient sample sequencing reveals metabolic biomarker PYGL as a therapeutic target for HNSCC by Jiezhong Guan, Xi Xu, Guo Qiu, Chong He, Xiaoyue Lu, Kang Wang, Xinyu Liu, Yuanyuan Li, Zihang Ling, Xuan Tang, Yujie Liang, Xiaoan Tao, Bin Cheng, Bo Yang

“…The functions of the genes screened out in tumor progression, metastasis and chemotherapy resistance were validated in vitro by cellular functional experiments and in vivo by xenograft tumor mouse model. …”
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Using Landscape Metrics of Pixel Scale Land Cover Extracted from High Spatial Resolution Images to Classify Block-Level Urban Land Use by Haofeng Luo, Xiaomei Yang, Zhihua Wang, Yueming Liu, Huifang Zhang, Ku Gao, Qingyang Zhang

“…However, at present, the extraction of quantitative features from HSRRSIs for BLULUC primarily relies on computer vision or deep learning methods based on image signal characteristics rather than land cover patterns, like vegetation, water, or buildings, thus disconnecting existing knowledge between the landscape patterns and their functions as well as greatly hindering BLULUC by HSRRSIs. …”
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Effects of generative artificial intelligence on cognitive effort and task performance: study protocol for a randomized controlled experiment among college students by Youjie Chen, Yingying Wang, Torsten Wüstenberg, Rene F. Kizilcec, Yiwen Fan, Yanfei Li, Bin Lu, Meng Yuan, Junlai Zhang, Ziyue Zhang, Pascal Geldsetzer, Simiao Chen, Till Bärnighausen

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MOCVD-grown ε(κ)-Ga2O3 with highly preferred orientation for memristor applications by Po-Kai Kung, Hsin-Yu Chou, Wei-Hsiang Chiang, Anoop Kumar Singh, Wen-Hao Lee, Tung-Han Wu, Ray-Hua Horng, Dong-Sing Wuu

“…Furthermore, under pulsed voltage stimulation, the devices exhibit key synaptic plasticity functions, including excitatory postsynaptic currents, spike-voltage-dependent plasticity, and spike-number-dependent plasticity. …”
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Clinical and cost evaluation of intensive support team (IST) models for adults with intellectual disabilities who display challenging behaviour: a comparative cohort study protocol by Angela Hassiotis, Rebecca Jones, Brynmor Lloyd-Evans, Renee Romeo, Nicola Morant, Ken Courtenay, Ian Hall, Athanasia Kouroupa, Vicky Crossey, Laurence Taggart, Peter Langdon, Victoria Ratti, Vincent Kirchner

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Construction of a novel radioresistance-related signature for prediction of prognosis, immune microenvironment and anti-tumour drug sensitivity in non-small cell lung cancer by Yanliang Chen, Chan Zhou, Xiaoqiao Zhang, Min Chen, Meifang Wang, Lisha Zhang, Yanhui Chen, Litao Huang, Junjun Sun, Dandan Wang, Yong Chen

“…Then, Immune landscape and drug sensitivity were evaluated. The biological functions exerted by the key gene LBH were verified by in vitro experiments.Results Ninety-nine RRRGs were screened by intersecting the results of DEGs and WGCNA, then 11 hub RRRGs associated with survival were identified using machine learning algorithms (LASSO and RSF). …”
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TelescopeML. II. Convolutional Neural Networks for Predicting Brown Dwarf Atmospheric Parameters by Ehsan (Sam) Gharib-Nezhad, Hamed Valizadegan, Natasha E. Batalha, Miguel J. S. Martinho, Ben W.P. Lew

“…Concurrently, all modules and functions used to train, develop, and deploy the CNNs and process the spectra are consolidated into a Python PyPI package named TelescopeML , which is publicly available along with a thoroughly documented tutorial covering installation, deployment, and core concepts.…”
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Factors affecting the design of the management dashboard framework with an emphasis on the components of human resources productivity by Hassan Barmaki, Farshad Faezy Razi, Ehtesham Rashidi

“…It collects information gathered from all departments of the organization, which contains various sources related to various business functions. This information is combined and replicated by providing a user interface in the form of graphs, reports, visual indicators and alerting mechanisms. …”
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A Bayesian analysis of birth pulse effects on the probability of detecting Ebola virus in fruit bats by Pleydell, David R.J., Ndong Bass, Innocent, Mba Djondzo, Flaubert Auguste, Meta Djomsi, Dowbiss, Kouanfack, Charles, Peeters, Martine, Cappelle, Julien

“…Bats have long been hypothesised to function as important hosts for ebolavirus maintenance, however the transmission ecology for these viruses remains poorly understood. …”
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New Insights Into the Correlation Between Necroptotic Activation and Neutrophil Infiltration in Pulpitis by Xiaolan Guo, Xinyan Ma, Peng Liu, Xiaoxin Chen, Sitong Liu, Longrui Dang, Buling Wu, Zhao Chen

“…Transcriptome datasets GSE92681 and GSE77459 from GEO identified necroptosis-related differentially expressed genes (NRDEGs) via bioinformatics analysis. Functional enrichment identified 6 hub NRDEGs based on diagnostic capability through machine learning and immune infiltration. …”
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Gut-Microbiome Signatures Predicting Response to Neoadjuvant Chemoradiotherapy in Locally Advanced Rectal Cancer: A Systematic Review by Ielmina Domilescu, Bogdan Miutescu, Florin George Horhat, Alina Popescu, Camelia Nica, Ana Maria Ghiuchici, Eyad Gadour, Ioan Sîrbu, Delia Hutanu

“…Conclusions: Despite heterogeneity, convergent functional and taxonomic signals underpin a microbiome-based radiosensitivity axis in LARC. …”
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The interplay between homeostatic synaptic scaling and homeostatic structural plasticity maintains the robust firing rate of neural networks by Han Lu, Sandra Diaz-Pier, Maximilian Lenz, Andreas Vlachos

“…Critical network states and neural plasticity enable adaptive behavior in dynamic environments, supporting efficient information processing and experience-dependent learning. Synaptic-weight-based Hebbian plasticity and homeostatic synaptic scaling are key mechanisms that enable memory while stabilizing network dynamics. …”
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