Amplification of Higher-Order Salivary Gland Volume Effects from External Beam Radiotherapy in Normal Tissue Complication Probability Modeling of Radiopharmaceutical Therapy by Chunming Gu, Robert F. Hobbs, Ana P. Kiess, Junghoon Lee, Todd McNutt, Harry Quon, Zhuoyao Xin, Tahir I. Yusufaly

“…In EBRT, salivary glands are usually assumed to be parallel organs, with QUANTEC guidelines based on <inline-formula><math xmlns="http://www.w3.org/1998/Math/MathML" display="inline"><semantics><msub><mi>D</mi><mrow><mi>m</mi><mi>e</mi><mi>a</mi><mi>n</mi></mrow></msub></semantics></math></inline-formula>, but this is known to be a gross over-simplification of the full complexity of the underlying functional organization. The goal of this work is to combine machine learning of EBRT dose–outcome data with stylized small-scale RPT dosimetry to discover more reliable normal tissue complication probability (NTCP) models of xerostomia across both modalities. …”
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How Do Particles with Complex Interactions Self-Assemble? by Lara Koehler, Pierre Ronceray, Martin Lenz

“…In living cells, proteins self-assemble into large functional structures based on specific interactions between molecularly complex patches. …”
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A general framework for governing marketed AI/ML medical devices by Boris Babic, I. Glenn Cohen, Ariel Dora Stern, Yiwen Li, Melissa Ouellet

“…In particular, we evaluate the data pertaining to adverse events associated with approximately 950 medical devices incorporating AI/ML functions for devices approved between 2010 through 2023, and we find that the existing system is insufficient for properly assessing the safety and effectiveness of AI/ML devices. …”
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Integrity, Confidentiality, and Equity: Using Inquiry-Based Labs to help students understand AI and Cybersecurity by Richard C. Alexander, Liran Ma, Ze-Li Dou, Zhipeng Cai, Yan Huang

“…Despite its functionality and promise, AI has inherent security risks that users should understand and programmers must be trained to address. …”
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Digitalization of the Accounts Chamber of the Russian Federation by A. O. Buryakova, A. V. Varnavskii

“…On the other hand, the article focuses on the prospects for analysing information in real time, using machine learning. The theoretical and practical significance of the study is to justify the necessity for development a common vision of the functional architecture of solutions proposed by the internal and external financial control authorities.…”
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Design thinking: catalysing change in the educational ecosystem – a framework for future challenges by Anders Berglund

“…Few studies have combined a systems perspective with a functional operational level. This research embeds design thinking to structure to isolated actions. …”
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We have to change mind. Neural Plausibility and the Crisis of Cognitive Explanations by Francesco Galofaro

“…The crisis regards three points:(1) When shifted from a psychological context to the neuroscience, the meaning of cognitive metalanguage does not refer any more to mental functions but moreover to brain anatomical regions and their metabolism.(2) The criterion of psychological plausibility is not sufficient to choose between alternative models;(3) Both the innatist and the experience-based explanations are not in grade to express the relation between “mental” functions, cortical anatomy and its biological morphogenesis and phylogenesis.Showing a series of examples referred to vision and space representation in language, the article aims to a different model of explanation, based on the criterion of neural plausibility, focused on learning and cortical plasticity, in which a central role is played by phylogenesis and morphogenesis, allowing feedback relationships between nature and culture.…”
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Design and Construction of Simple Periscope. by Nuwahereza, Emmanuel

“…This research study focused on the construction and functionality of a periscope, designed to provide clear visibility of objects not in the direct line of sight. …”
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Design and Construction of Simple Periscope. by Nuwahereza, Emmanuel

“…This research study focuses on the construction and functionality of a periscope, designed to provide clear visibility of objects not in the direct line of sight. …”
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Exploration of common pathogenic genes between cerebral amyloid angiopathy and insomnia based on bioinformatics and experimental validation by Xin-Yu Li, Kun Li, Yi-Han Wei, Wen-Kai Yu, Jing-Hao Wu, Kai Gao, Wen-Jun He, Peng-Peng Niu, Chan Zhang, Yu-Nan Cheng, Yu-Sheng Li

“…We explored the biological functions of these genes through immune cell infiltration, metabolic and Hallmark pathway analyses, and clinical correlation analysis. …”
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Preventing epileptogenesis by interaction between inositol isomers and proteins by Lia Tsverava, Luka Kharkhelauri, Vincenzo Lagani, Giorgi Gamkrelidze, Veriko Bokuchava, Tamar Kiguradze, Merab Kokaia, Revaz Solomonia

“…Myo‐inositol (MI), the most prevalent isomer, functions as an osmolyte and mediates cell signal transduction. …”
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Affective literature, effective literacy: a case of “affect turn” among preservice teachers in Spain10/Literatura afectiva, alfabetización efectiva: un caso de “affect turn” entre... by Elena Guichot-Muñoz, Giulia De Sarlo

“…This study proposes a replicable and functional intervention in the teaching of emotions as a springboard for affective and effective literacy in preservice primary school teachers’ curriculum. …”
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Analysis of Progress in Data Mining of Scientific Literature Using Large Language Models by CAI Yiran, HU Zhengyin, LIU Chunjiang

“…Methodologically, this research introduces dynamic prompt learning frameworks and domain adaptation fine-tuning technologies to address the shortcomings of traditional rule-driven approaches. …”
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Innovative engineering training in a competitive educational environment by N. I. Naumkin, N. N. Shekshaeva, E. V. Zabrodina

“…Methodological support for the functioning of the educational environment has been developed.…”
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Cross-Platform Availability of Smartphone Sensors for Depression Indication Systems: Mixed-Methods Umbrella Review by Johannes Leimhofer, Milica Petrovic, Andreas Dominik, Dominik Heider, Ulrich Hegerl

“… BackgroundA popular trend in depression forecasting research is the development of machine learning models trained with various types of smartphone sensor data and periodic self-ratings to derive early indications of changes in depression severity. …”
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Designing host-associated microbiomes using the consumer/resource model by Germán Plata, Karthik Srinivasan, Madan Krishnamurthy, Lukas Herron, Purushottam Dixit

“…For example, there has been a boom in machine-learning models aiding in the design of proteins with user-specified structures or functions. …”
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Integrative multiomics analysis reveals the subtypes and key mechanisms of platinum resistance in gastric cancer: identification of KLF9 as a promising therapeutic target by Pengcheng Zhang, Lexin Wang, Haonan Lin, Yihui Han, Jingfang Zhou, Hang Song, Peng Wang, Huanhuan Tan, Yajuan Fu

“…Gene expression profiles, prognosis, immune cell infiltration, chemotherapy sensitivity, and immunotherapy responsiveness were comprehensively evaluated for each subtype. Localization and functional evaluation were conducted at the single-cell and spatial transcriptomics levels, and predictive models were developed using machine learning techniques. …”
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PIEZO1 variant implications for biological understanding and human health by Chew W. Cheng, Sophie L. Earle, Oleksandr V. Povstyan, Chloe Randall, Katie A. Smith, Marjolaine Debant, Fraser L. Macrae, Daniel G. Beech, Anna McGrane, Fiona Bartoli, Eulashini Chuntharpursat-Bon, Richard M. Cubbon, Kathryn J. Griffin, Marc A. Bailey, Antreas C. Kalli, Lara C. Morley, Klaus K. Witte, David J. Beech

“…When these channels are activated by force, cell membrane permeability to calcium ions and other ions increases rapidly, coupling force to cell function through ionic control. In humans and other species, PIEZO1 is both widely expressed and functional across major systems that include the cardiovascular, haematological and musculoskeletal systems, thereby serving diverse needs. …”
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Mucosal Immunity: Lessons from the Lower Respiratory and Small Intestinal Epithelia by Kayle B. Dickson, Andrew W. Stadnyk, Juan Zhou, Christian Lehmann

“…Mucosal epithelia represent a diverse group of tissues that function as a barrier against the external environment and exert a wide variety of tissue-specific secondary functions. …”
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On Question of Representation of Intra-company Written Communication in Foreign Language Professionally-Oriented Textbook for Undergraduate Students of Engineering Specialty by E. V. Rybakova

“…The issues associated with the methodological potential of exercises, designed on the basis of this texts, are discussed in terms of the most complete implementation of conditions to ensure the communicative orientation of the textbook and the principles of contextual learning. The possibility of using some of the functions of intra-company communication texts, such as organising and regulatory functions, as a way of structuring communicative activities in the manual is proved. …”
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