Iron metabolism and preeclampsia: new insights from bioinformatics analysis by Xijiao Guo, Sha Li, Guoping Xiong

“…Lasso-Cox, SVM, and XGboost machine learning methods were utilized to identify hub genes related to iron metabolism in PE, followed by GSEA analysis. …”
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Perfusion Parameter Map Generation from 3 Phases of Computed Tomography Perfusion in Stroke Using Generative Adversarial Networks by Cuidie Zeng, Xiaoling Wu, Fusheng Ouyang, Baoliang Guo, Xiao Zhang, Jianghua Ma, Dong Zeng, Bin Zhang

“…The three phases were chosen based on the multiphase computed tomography angiography scanning protocol: the peak arterial input function phase, the peak venous output function phase, and the delayed venous output function phase. …”
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Enhanced path planning for robot navigation in Gaussian noise environments with YOLO v10 and depth deterministic strategies by Feng Xiao, Shiwei Chu, Xing Guo, Youhai Zhang, Rubing Huang

“…A reward function is designed to motivate the agent to learn. …”
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Myocardial Proteome in Human Heart Failure With Preserved Ejection Fraction by Vivek P. Jani, Edwin J. Yoo, Aleksandra Binek, Alina Guo, Julie S. Kim, Jennifer Aguilan, Mohammad Keykhaei, Sydney R. Jenkin, Simone Sidoli, Kavita Sharma, Jennifer E Van Eyk, David A. Kass, Virginia S. Hahn

“…Ingenuity pathway analysis predicted downregulation of protein translation, mitochondrial function, and glucose and fat metabolism in HFpEF. …”
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Immune-related diagnostic indicators and targeted therapies for COPD combined with NASH were identified and verified via WGCNA and LASSO by Jianwei Hong, Zikai Xu, Fangrui Xu, Haifeng Wu, Jinxia Liu, Lishuai Qu

“…In addition, we further identified the hub genes S100A9 and MYH2 for NAFLD and COPD by machine learning methods. The immune infiltration indicated that these two core genes might be involved in the immunomodulatory process of NASH by regulating the function or recruitment of specific immune cell types. …”
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Integrated metabolomic-lipidomic profiling reveals novel biomarkers and therapeutic targets for alcohol use disorder with cognitive impairment by Li Shi, Li Shi, Li Shi, Xiaofang Chen, Bojie Zhou, Bojie Zhou, Shanghao Yang, Shanghao Yang, Qinglin Ou, Qinglin Ou, Xuhui Zhou, Xuhui Zhou

“…Plasma samples underwent LC-MS/MS-based metabolomic and lipidomic profiling. Cognitive function was assessed using the Repeatable Battery for the Assessment of Neuropsychological Status (RBANS). …”
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Synaptic protein CSF levels relate to memory scores in individuals without dementia by Kirsten E. J. Wesenhagen, Diederick M. de Leeuw, Jori Tomassen, Johan Gobom, Isabelle Bos, Stephanie J. B. Vos, Pablo Martinez-Lage, Mikel Tainta, Julius Popp, Gwendoline Peyratout, Magda Tsolaki, Rik Vandenberghe, Yvonne Freund-Levi, Frans Verhey, Simon Lovestone, Johannes Streffer, Valerija Dobricic, Kaj Blennow, Philip Scheltens, August B. Smit, Lars Bertram, Charlotte E. Teunissen, Henrik Zetterberg, Betty M. Tijms, Pieter Jelle Visser, the Alzheimer’s Disease Neuroimaging Initiative

“…Abstract Background We investigated how cerebrospinal fluid levels of synaptic proteins associate with memory function in normal cognition (CN) and mild cognitive impairment (MCI), and investigated the effect of amyloid positivity on these associations. …”
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Zipper Pattern: An Investigation into Psychotic Criminal Detection Using EEG Signals by Gulay Tasci, Prabal Datta Barua, Dahiru Tanko, Tugce Keles, Suat Tas, Ilknur Sercek, Suheda Kaya, Kubra Yildirim, Yunus Talu, Burak Tasci, Filiz Ozsoy, Nida Gonen, Irem Tasci, Sengul Dogan, Turker Tuncer

“…<b>Background:</b> Electroencephalography (EEG) signal-based machine learning models are among the most cost-effective methods for information retrieval. …”
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Disulfidptosis-Related Genes as Novel Biomarkers and Therapeutic Targets in Dilated Cardiomyopathy by Fan J, Xu S, Zeng Y, Xu A, Wang X, Wang H, Kang P, Fu Y, Fan H, Zhou Y

“…A predictive model was constructed using four machine learning methods, and its performance was validated with independent datasets. …”
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Bromelain prevents Alzheimer's disease progression by suppressing oxidative stress and upregulating apolipoprotein A1 in 5x familial Alzheimer's disease transgenic mice by Julia Chu-Ning Hsu, Po-An Hu, Chia-Hui Chen, Chia-Ju Lee, Hsuan-Yun Hu, Man-Chen Hsu, Wen-Hua Chen, Hsueh-Te Lee, Tzong-Shyuan Lee

“…Bromelain treatment significantly improved motor function, spatial learning, and memory in 5xFAD mice. …”
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Longitudinal exploration of cancer-related cognitive impairment in patients with newly diagnosed aggressive lymphoma: protocol for a feasibility study by Vincent Dore, Christopher C Rowe, Meinir Krishnasamy, Haryana Dhillon, Adam K Walker, Karla Gough, Priscilla Gates, Carlene Wilson, Eliza Hawkes, Yuliya Perchyonok, Janette L Vardy, Michiel de Ruiter

“…All patients will be assessed for self-reported cognitive difficulties and objective cognitive function using Stroop Colour and Word, Trail Making Test Part A and B, Hopkins Verbal Learning Test-Revised, Controlled Oral Word Association and Digit Span. …”
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An artificial intelligence-based platform for personalized predictions of Metacognitive Training effectiveness by Caroline König, Pedro Copado, Alfredo Vellido, Àngela Nebot, Cecilio Angulo, Maria Lamarca, Vanessa Acuña, Fabrice Berna, Steffen Moritz, Łukasz Gawęda, Susana Ochoa

“…This study introduces a machine learning (ML)-based platform aimed at predicting the effectiveness of Metacognitive Training (MCT). …”
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DNA‐encoded plasmonic bubbles aggregating dual‐microRNA SERS signals for cancer diagnosis by Yu Yang, Hao Lu, Dan Fang, Yuyuan Zhang, Yuteng Tang, Songsong Zhao, Jun Yan, Xiaojie Qin, Jianlei Shen, Fan Yang

“…Furthermore, DNA‐encoded plasmonic bubbles seamlessly couple with dual‐color catalytic hybridization assembly to amplify the specific miRNA‐responsive Raman signal, and function as both an analyte concentrator and a Raman signal aggregator without external forces. …”
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MONSTROUS: a web-based chemical-transporter interaction profiler by Mohamed Diwan M. AbdulHameed, Mohamed Diwan M. AbdulHameed, Souvik Dey, Souvik Dey, Zhen Xu, Zhen Xu, Ben Clancy, Ben Clancy, Valmik Desai, Valmik Desai, Anders Wallqvist

“…Transporters are membrane proteins that are critical for normal cellular function and mediate the transport of endogenous and exogenous chemicals. …”
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Novel ANKRD17 variants implicate synaptic and mitochondrial disruptions in intellectual disability and autism spectrum disorder by Dan Xia, Yuanyuan Xu, Zhanwen He, Rui Chen, Xiaoqin Xiao, Xiaojuan Li, Kewen Deng, Shuyun Deng, Lina Zhang, Jieming Zhang, Xiaofang Peng, Zhe Meng, Ruohao Wu, Dilong Wang, Zulin Liu, Hui Chen, Lu Li, Liyang Liang

“…Our study highlighted in mouse models an association between Ankrd17 haploinsufficiency and deficits in social behavior, spatial learning and memory, as well as elevated anxiety. Furthermore, our studies suggest dysregulation of synaptic proteins and mitochondrial function, along with impaired neural circuits following Ankrd17 knockdown. …”
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Facilitators and barriers to implementation of early intensive manual therapies for young children with cerebral palsy across Canada by Divya Vurrabindi, Alicia J. Hilderley, Adam Kirton, John Andersen, Christine Cassidy, Shauna Kingsnorth, Sarah Munce, Brenda Agnew, Liz Cambridge, Mia Herrero, Eleanor Leverington, Susan McCoy, Victoria Micek, Keith O. Connor, Kathleen O’ Grady, Sandra Reist-Asencio, Chelsea Tao, Stephen Tao, Darcy Fehlings

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Non-negative connectivity causes bow-tie architecture in neural circuits by Zhaofan Liu, Zhaofan Liu, CongCong Du, KongFatt Wong-Lin, Da-Hui Wang, Da-Hui Wang

“…Our findings offer a mechanistic account of BTA emergence and bridge biological structure with artificial learning principles.…”
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Engineering education on sustainability and the reuse of electronic components: a novel, hands-on educational method that emphasizes student creativity by Nikolaos Nikoloudakis, Maria Rangoussi, Georgia Liarakou, Panagiotis Sinioros

“…An educational intervention of two phases is implemented and evaluated via multiple tools.ResultsResults document student gains of varying degrees across all three domains of learning; an increase in creativity, in particular, is measured between the two phases.DiscussionThe formation of a community of learning is another important outcome that opens directions for future research.…”
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Massive discovery of crystal structures across dimensionalities by leveraging vector quantization by ZiJie Qiu, Luozhijie Jin, Zijian Du, Hongyu Chen, Guanyao Mao, Yan Cen, Siqi Sun, Yongfeng Mei, Hao Zhang

“…Abstract Discovering new functional crystalline materials through computational methods remains a challenge in materials science. …”
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Embolization of a high cervical pial arteriovenous fistula resulting in respiratory insufficiency due to diaphragmatic paralysis: A case report by Jinlu Yu

“…We reported this case to alert neurointerventionists to the lessons learned from experience.…”
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