Uncovering injury-specific proteomic signatures and neurodegenerative risks in single and repetitive traumatic brain injury by Sarah Mantash, Soulaimane Aboulouard, Hassan Dakik, Yanis Zirem, Lydia Ziane-Chaouche, Ali Nehme, Khalil Mallah, Marya El-Kurdi, Naify Ramadan, Isabelle Fournier, Kazem Zibara, Firas Kobeissy, Michel Salzet

“…Behavioral assessments indicated that repetitive TBI significantly impaired motor and cognitive functions, with recovery in motor function by day 30, whereas cognitive deficits persisted. …”
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Lecithin Alleviates Memory Deficits and Muscle Attenuation in Chinese Older Adults and SAMP8 Mice by Xianyun Wang, Dajun Li, Xiao Ying Li, Weizhao Lu, Huini Ding, Chengyan Qi, Xuan Wang, Jing Shen, Yafei Chi, Tiantian Li, Michelle M. Dunk, Yu An, Hongmei Huang, Kang Yu, Weili Xu, Rong Xiao, Yuandi Xi

“…Erythrocyte lipid analysis and RCT study indicate the protective function of lecithin and the potential involvement of irisin in that process. …”
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Ventricular volume adjustment of brain regions depicts brain changes associated with HIV infection and aging better than intracranial volume adjustment by Benedictor Alexander Nguchu, Benedictor Alexander Nguchu, Jing Zhao, Jiajun Fan, Yifei Han, Yu Lu, Han Jin, Yanming Wang, Hongjun Li, Peter Shaw

“…The analyses of LV-adjusted metrics also show that atrophic patterns observed in the hippocampus, thalamus and pallidum were strongly correlated with HAND(especially dysfunction in executive function) and clinical markers (i.e., CD4/CD8 ratio).ConclusionWe conclude that models that control for individual variability in intracranial and ventricular volumes have the potential to minimize discrepancies and variations in structural reports of HIV, improving the diagnostic power of identified patterns and fostering greater consistency across research studies. …”
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Mitochondrial Pathway Signature (MitoPS) predicts immunotherapy response and reveals NDUFB10 as a key immune regulator in lung adenocarcinoma by Peng Luo, Zhenfa Zhang, Lianmin Zhang, Pengpeng Zhang, Mengzhe Zhang, Jianlan Liu, Zhaokai Zhou

“…Immune microenvironment analysis revealed that low MitoPS scores correlated with higher immune cell infiltration and active immune function. Mechanistic studies identified mitochondria-related gene NDUFB10 as a core gene of MitoPS (r=0.38, p<0.05), where its high expression was significantly associated with immune desert phenotype and worse prognosis. …”
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Integrating single-cell sequencing and transcriptome analysis to unravel the mechanistic role of sialylation-related genes in sepsis-induced acute respiratory distress syndrome by Xiaobing Liu, Yake Huang, Hao Zhang, Xia Yang, Quanxing Liu, Jigang Dai

“…Subsequently, further selection by machine learning and expression assessment confirmed the key genes related to sialylation in sepsis-induced ARDS. …”
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Prophylactic IL-23 blockade uncouples efficacy and toxicity in dual CTLA-4 and PD-1 immunotherapy by Ting Chen, Lin Zhao, Jiaojiao Zhang, Mingyi Ju, Zhuoyuan Deng, Minjie Wei, Lianghua Ma

“…Human melanoma cells were xenografted into these mice concomitantly.Results Here we show that IL-23 was upregulated in the serum of patients suffering from irAEs after dual anti-CTLA-4 and anti-PD-1 treatment, and increased as a function of irAEs severity. Additionally, Augmented CD4+ Tems may preferentially underlie irAEs onset. …”
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Improved detection of decreased glucose handling capacities via continuous glucose monitoring-derived indices by Hikaru Sugimoto, Ken-ichi Hironaka, Tomoaki Nakamura, Tomoko Yamada, Hiroshi Miura, Natsu Otowa-Suematsu, Masashi Fujii, Yushi Hirota, Kazuhiko Sakaguchi, Wataru Ogawa, Shinya Kuroda

“…Multivariate and machine learning models indicate AC_Var’s contribution to predicting clamp-derived DI independent from other CGM-derived indices. …”
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Multiple patterns of EEG parameters and their role in the prediction of patients with prolonged disorders of consciousness by Hui Li, Hui Li, Hui Li, Linghui Dong, Linghui Dong, Linghui Dong, Wenlong Su, Wenlong Su, Ying Liu, Ying Liu, Zhiqing Tang, Zhiqing Tang, Xingxing Liao, Xingxing Liao, Junzi Long, Junzi Long, Xiaonian Zhang, Xinting Sun, Hao Zhang, Hao Zhang, Hao Zhang, Hao Zhang

“…A combination of machine learning and SHapley Additive exPlanations (SHAP) were used to develop predictive model and interpret the results.ResultsThe results indicated significant abnormalities in low-frequency spectral power, microstate parameters, and amplitudes of MMN and P3a in MCS and UWS. …”
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An Antinoise Fault Diagnosis Method Based on Multiscale 1DCNN by Jie Cao, Zhidong He, Jinhua Wang, Ping Yu

“…In the multiscale convolution structure, the ELU activation function is used instead of the ReLU function to improve the antinoise ability of MSK-1DCNN, also by adding pepper noise to the training set data to destroy the input data and forcing the network to learn more representative features to improve the robustness of the network. …”
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Depression Detection and Diagnosis Based on Electroencephalogram (EEG) Analysis: A Systematic Review by Kholoud Elnaggar, Mostafa M. El-Gayar, Mohammed Elmogy

“…<b>Background:</b> Mental disorders are disturbances of brain functions that cause cognitive, affective, volitional, and behavioral functions to be disrupted to varying degrees. …”
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Quantum chaos in Liouville CFT by Julian Sonner, Benjamin Strittmatter

“…However, as we show, the states contributing to the relevant correlation function can be thought of as dressed scramblons. At a technical level we first use the path integral picture in order to derive the Euclidean four-point function in an explicit compact form. …”
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Beyond the screen: The psychological significance of ecophilia in childhood by Asha S, Vineeth Radhakrishnan

“…This research concludes that fostering ecophilia enhances children's cognitive function, environmental awareness, and stewardship, while also promoting ecospirituality. • Human-nature interactions are key learnings for children. • This research aims to integrate ecology and psychology fostering interdisciplinary approach.…”
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Hepatitis C virus p7 protein is crucial for assembly and release of infectious virions. by Eike Steinmann, Francois Penin, Stephanie Kallis, Arvind H Patel, Ralf Bartenschlager, Thomas Pietschmann

“…Although much has been learned about the function of individual viral proteins, the role of the HCV p7 protein in virus replication is not known. …”
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Development of a Decision Support System for Urban Planning by Using K-means ++ Algorithm by Hussein Ali Salih, Ahmed Shihab Ahmed, Jalal Qais Jameel

“…The learning-based framework stores experts_ information and additionally answers for past issues. …”
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Philosophical footprints in the evolution of art: an analysis of the flourishing of Yangliuqing woodblock New Year prints during the Ming dynasty by Baicheng Qi, Minggang Liu

“…The unity of knowledge and action (heart-learning), investigating things to attain knowledge (Neo-Confucianism), and the unity of heaven and humanity (Daoism) guided the thematic choices, application of techniques and social functions of these prints. …”
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Exploration of Algorithms and Heuristics in Puzzle Playing Activities of Early Childhood by Selvia Dwi Lusiana, Thorik Aziz

“…Analysis of the findings indicates that the use of algorithms and heuristics reflects complex cognitive development, involving executive functions, metacognition, and visuospatial abilities. …”
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ADVANCEMENTS AND EMERGING PERSPECTIVES IN MICROSCOPIC IMAGING

“…Illustrative examples that will be presented would include the application of biosensors and optogenetic tools for functional imaging in neural tissues, the integration of deep learning algorithms with high-resolution imaging for analysis of murine organs, and the tracking of colon and breast cancer cells using label-free modalities that bridge histopathology and radiology, to improve diagnosis and therapy. …”
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Gaussian barebone mechanism and wormhole strategy enhanced moth flame optimization for global optimization and medical diagnostics. by Jingjing Ma, Zhifang Zhao, Lin Zhang

“…The scalability of the algorithm is confirmed through benchmark functions. Employing BWEMFO, we optimize the kernel parameters of the kernel-limit learning machine, thereby crafting the BWEMFO-KELM methodology for medical diagnosis and prediction. …”
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Pemberdayaan Tim “Jumantik” (Juru Pemantau Jentik) di SD 14 dan 15 Koto Lalang pada Masa Pandemi by Masrizal Masrizal, Muhammad Alfarezi, Ade Betasril, Trif Vando Rahmalber

“… Schools, apart from functioning as places of learning, can also be a threat of disease transmission if they are not appropriately managed. …”
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