Intranasal administration of Ganoderma lucidum-derived exosome-like nanovesicles ameliorates cognitive impairment by reducing inflammation in a mouse model of Alzheimer’s disease by Xue Mi, Xue Mi, Xinglin Ruan, Renyi Lin, Shuxin Huang, Ping Cai, Xiaochun Chen, Xiaochun Chen, Jiangfeng Liao, Xiaoman Dai, Xiaoman Dai

“…Moreover, GLENVs exerted no adverse effects on liver and kidney function.ConclusionGLENVs may be a promising candidate for AD treatment.…”
Get full text

Palmitoylation regulators drive the progression of clear cell renal cell carcinoma through Inhibition of cuproptosis: insights into the role of ZDHHC18 by Wei Xu, Xiao-chao Chen, Yang Wang, Jian-chun Chen, Zhi-jun Cao, Ru Huang, Chao Chen, Dao-rong Hou, Min-jun Jiang, Chen Xu

“…A total of 101 different machine learning methods were used to develop predictive models. …”
Get full text

Robust Data-Driven State of Health Estimation of Lithium-Ion Batteries Based on Reconstructed Signals by Byron Alejandro Acuña Acurio, Diana Estefanía Chérrez Barragán, Juan Carlos Rodríguez, Felipe Grijalva, Luiz Carlos Pereira da Silva

“…In this work, we demonstrate that robustness in SoH estimation for lithium-ion batteries is influenced by the choice of machine learning architecture, loss function, feature selection, and signal reconstruction technique. …”
Get full text

Association between long-term exposure to PM2.5 and thyroid nodules in school-aged children and adolescents: a cross-sectional study in Eastern China by Mao Liu, Pei-hua Wang, Yun-jie Ye, Li Shang, Yu-ting Xia, Yang Wang, Zhen Ding, Yan Xu

“…The concentration-response (C-R) curves were smoothed using a restricted cubic spline function. Stratified analyses were performed to evaluate the modification effects of covariates on associations. …”
Get full text

Ultrasound Evaluation of Internal Jugular Venous Insufficiency and Its Association with Cognitive Decline by Jiu-Haw Yin, Nai-Fang Chi, Wen-Yung Sheng, Pei-Ning Wang, Yueh-Feng Sung, Giia-Sheun Peng, Han-Hwa Hu

“…This study evaluates the relationship between impaired IJV drainage and cognitive function. <b>Methods</b>: We recruited a prospective sample of 106 participants with subjective memory complaints. …”
Get full text

MSFA-YOLO: A Multi-Scale SAR Ship Detection Algorithm Based on Fused Attention by Zhao Liangjun, Ning Feng, Xi Yubin, Liang Gang, He Zhongliang, Zhang Yuanyang

“…Leveraging the excellent feature representation capabilities of neural networks, deep learning methods have been widely adopted for object detection in synthetic aperture radar (SAR) images. …”
Get full text

SCIENTIFIC AND PRACTICAL APPROACHES TO THE FORMATION OF READINESS OF FUTURE SPECIALISTS IN THE SOCIONOMIC SPHERE FOR THE SOCIAL SUPPORT FOR PARENTS OF CHILDREN WITH SPECIAL NEEDS by Sapozhnykov Stanislav, Teplytska Alina

“…It has been emphasized that today in higher education there is an approach that orients future specialists to the transfer of this function to other social institutions. This situation does not contribute to the formation of the appropriate level of motivation and ability to energetically engage in their own professional activities, and the capacity to adequately self-assess professional actions in future specialists in the socionomic sphere. …”
Get full text

Pitolisant alleviates brain network dysfunction and cognitive deficits in a mouse model of Alzheimer’s disease by Yang Zou, Linhan Yang, Jiahui Zhu, Jihua Fan, Hanrun Zheng, Xiang Liao, Zhiqi Yang, Kuan Zhang, Hongbo Jia, Arthur Konnerth, Yan-jiang Wang, Chunqing Zhang, Yun Zhang, Sunny C. Li, Xiaowei Chen

“…Abstract Histamine H3 receptor (H3R) antagonists regulate histamine release that modulates neuronal activity and cognitive function. Although H3R is elevated in Alzheimer’s disease (AD) patients, whether H3R antagonists can rescue AD-associated neural impairments and cognitive deficits remains unknown. …”
Get full text

Dysregulated C1q and CD47 in the aging monkey brain: association with myelin damage, microglia reactivity, and cognitive decline by Sarah A. DeVries, Christina Dimovasili, Maria Medalla, Maria Medalla, Tara L. Moore, Tara L. Moore, Douglas L. Rosene, Douglas L. Rosene

“…Normal aging, though lacking widespread neurodegeneration, is nevertheless characterized by cognitive impairment in learning, memory, and executive function. The aged brain is spared from neuron loss, but white matter is lost and damage to myelin sheaths accumulates. …”
Get full text

Effects of modifying the pulse width on cognitive side effects with electroconvulsive therapy for schizophrenia by Qi Si, Yingbo Dong, Yuting Li, Guoxin Xu, Yilin Tang, Peiyu Cao, Congxin Chen, Fangfang Ren, Runda Li, Yuxiu Sui

“…A total of 114 patients with schizophrenia (SCZ) were enrolled and received BP ECT (63 participants) or UBP ECT (51 participants). Cognitive function was assessed before and after treatment, with peripheral blood biomarkers and hippocampal magnetic resonance spectroscopy (MRS) data collected concurrently. …”
Get full text

Protocol for the RoboSling Trial: A Randomised Study Assessing Urinary Continence Following Robotic Radical Prostatectomy with or without an Intraoperative Retropubic Vascularised... by Amandeep Virk, Patrick-Julien Treacy, Wenjie Zhong, Stuart Robert Jackson, Nariman Ahmadi, Nicola Nadia Jeffery, Lewis Chan, Paul Sved, Arthur Vasilaras, Ruban Thanigasalam, Scott Leslie

“…Four surgeons will take part in the study, all of whom are beyond their learning curve. Patients will be blinded as to whether the RoboSling procedure is performed for them, as will be the research officers collecting the post-operative data on urinary function. …”
Get full text

Identification and validation of biomarkers, construction of diagnostic models, and investigation of immunological infiltration characteristics for idiopathic frozen shoulder by Han-tao Jiang, Li-ping Shen, Meng-Qi Pang, Min-jiao Wu, Jiang Li, Wei-jie Gong, Gang Jin, Rang-teng Zhu

“…Early diagnosis and treatment can help alleviate symptoms and restore shoulder function. Therefore, we aimed to explore the diagnostic biomarkers and potential mechanisms of FS from a transcriptomics perspective.MethodsTotal RNA was extracted from tissue samples of 15 FS and 11 controls. …”
Get full text

iKids study protocol: a longitudinal study to understand the impact of interactive electronic devices on the development and health of young children in England by Jenny Retzler, Daniel Jones, John J Reilly, John Stephenson, Stuart Fairclough, Christine Smith, Amy Hughes, Tony Okely, Liane Beretta De Azevedo, João Paulo de Aguiar Greca, Colette Marr

“…Consultations with early years practitioners, parents and policy makers recognise IEDs as a valuable resource for early-year learning. However, concerns exist regarding their potential negative impacts on children’s self-regulation, parent-child interaction and physical activity.The primary aim of this study is to understand the longitudinal impact of IED use, in particular duration (hours per day) and mode (educational vs non-educational; age-appropriate vs non-age-appropriate), on emerging abilities (ie, self-regulation, social development, executive function, language and numeracy) in 3-year-old to 5-year-old children. …”
Get full text

Association of genetic variants, protein domains, and phenotypes in the ZMIZ1 syndromic neurodevelopmental disorder by Kendall E. Cormier, Belle L. Kantor, Rajan K C, Xabier Blanco-Fernandez, Maria J. Galazo, Maria J. Galazo

Get full text

Physically Guided Estimation of Vehicle Loading-Induced Low-Frequency Bridge Responses with BP-ANN by Xuzhao Lu, Guang Qu, Limin Sun, Ye Xia, Haibin Sun, Wei Zhang

“…The intersectional relationship in bridge health monitoring refers to the mapping function that correlates bridge responses across different locations. …”
Get full text

A statistical framework for modelling migration corridors by Tristan A. Nuñez, Mark A. Hurley, Tabitha A. Graves, Anna C. Ortega, Hall Sawyer, Julien Fattebert, Jerod A. Merkle, Matthew J. Kauffman

“…We then used GPS data from three migrating mule deer Odocoileus hemionus herds in Idaho and Wyoming to model corridors as a function of elevation, slope, aspect, percent shrub, date of peak green‐up, snow‐off date and human footprint. …”
Get full text

Regression models for the prediction of the influence of magnesium ions on primary endothelial cell (HUVEC) proliferation and migration by Heike Helmholz, Redon Resuli, Marius Tacke, Jalil Nourisa, Sven Tomforde, Roland Aydin, Regine Willumeit-Römer, Berit Zeller-Plumhoff

“…Therefore, numerous studies evaluating the effect of Mg as a promising degradable, metallic biomaterial on the proliferation and function of endothelial cells have been performed. …”
Get full text

NDVI estimation using Sentinel-1 data over wheat fields in a semiarid Mediterranean region by Emna Ayari, Zeineb Kassouk, Zohra Lili-Chabaane, Nadia Ouaadi, Nicolas Baghdadi, Mehrez Zribi

“…To estimate the NDVI values, different methods are used: curve-fitting equations and machine learning regressors such as the random forest (RF) and the support vector regressor (SVR). …”
Get full text

From Clinical Presentation to Genetic Confirmation: A Case of L2HGDH-Related Leukodystrophy in an 11-Year-Old by Negareh Poursalehi, Mojtaba Movahedinia, Mohammad Hossein Mohammadi, Mohamammad Ebrahim Ghanei, Mohammad Yahya Vahidi Mehrjerdi, Seyed Mehdi Kalantar

“…Leukodystrophies cause a progressive loss of neurological function in infants, children, and sometimes adults. …”
Get full text

Intratentacular budding and zooid-dynamics in two coral genera by Matan Yuval, Amit Peleg, Elvan Ceyhan, Dan Tchernov, Yossi Loya, Avi Bar-Massada, Tali Treibitz

“…The patterns of addition of zooids (budding mechanics) determine much of the colony’s shape and function. Yet because zooids are small in size and large in numbers, ecological studies often focus on coral colonies as unitary organisms and little is known about how zooids vary within and between colonies and species. …”
Get full text