mRNA vaccines with RBD mutations have broad-spectrum activity against SARS-CoV-2 variants in mice by Xiaoming Liang, Yuxia Yuan, Junbin Wang, Cong Tang, Yun Yang, Yanan Zhou, Hao Yang, Qing Huang, Wenhai Yu, Haixuan Wang, Yuhuan Yan, Dongdong Lin, Yanwen Li, Xuena Du, Longhai Yuan, Wenqi Quan, Daoju Wu, Shuaiyao Lu

“…In this study, we designed new mRNA vaccines, BSCoV05 and BSCoV06, and generated point mutations in the receptor-binding domain (RBD) of the original Wuhan strain to increase their broad-spectrum antiviral activity. …”
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Automatic GPR detection of grouting defects behind the tunnel shield segments based on wavelet coherence analysis combined with modified Res-RCNN by Dengyi Wang, Ming Peng, Liu Liu, Xiongyao Xie, Zhenming Shi, Yaoying Liang, Jian Shen, Qiyu Wu

“…The results show that wavelet coherence analysis improves the visibility of weak signals in (GPR) profiles, enabling their identification in the time-frequency domain by leveraging local coherence between adjacent signals and using phase information. …”
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Research on time–frequency characteristics of electromagnetic signals from coal and rock blasting based on DBO-VMD filtering by Litao WANG, Liming QIU, Menghan WEI, Dazhao SONG, Rentao GOU, Lin LIU, Shiqiang ZHONG, Tianyi XIE

“…Finally, we conducted a statistical analysis of the entropy, energy, bispectrum, and time–frequency domain characteristics of pure electromagnetic signals associated with coal–rock ruptures. …”
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Measúnú ar Ionphlandú Téarmaí Teicneolaíochta Faisnéise agus Cumarsáide sa Ghaeilge: Cur chuige corpasbhunaithe [Assessing the Implantation of ITC Terms in Irish: A corpus-based ap... by Gearóid Ó Cleircín, Jamie Murphy

“…The field of information technology was chosen because it was presumed that there were enough digital texts available in that domain to compile a corpus that would satisfy the criteria set out in the Quirion protocol. …”
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Roles of Rufy3 in experimental subarachnoid hemorrhage-induced early brain injury via accelerating neuronal axon repair and synaptic plasticity by Yang Wang, Jianguo Xu, Wanchun You, Haitao Shen, Xiang Li, Zhengquan Yu, Haiying Li, Gang Chen

“…Abstract RUN and FYVE domain-containing 3 (Rufy3) is a well-known adapter protein of a small GTPase protein family and is bound to the activated Ras family protein to maintain neuronal polarity. …”
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Health-Related Quality of Life in Long COVID: Mapping the Condition-Specific C19-YRSm Measure Onto the EQ-5D-5L by Smith AB, Greenwood DC, Williams P, Kwon J, Petrou S, Horton M, Osborne T, Milne R, Sivan M

“…Responsiveness (standardised response mean; SRM) of the mapped utilities was investigated on a subset of participants with repeat assessments.Results: There was a strong level of association between 8 items and one domain on the C19-YRSm with the EQ-5D single-item dimensions. …”
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Exogenous cystine increases susceptibility of drug-resistant Salmonella to gentamicin by promoting oxidation of glutathione metabolism and imbalance of intracellular redox levels by Junyuan Du, Junyuan Du, Zhiyi Wu, Zhiyi Wu, Chunyang Zhu, Chunyang Zhu, Heng Yang, Heng Yang, Feike Zhao, Feike Zhao, Binghu Fang, Binghu Fang

“…Through the application of metabolomics, the underlying metabolic mechanisms by which cystine exerts its effects on Salmonella have been elucidated, offering a novel perspective in the domain of metabolic reprogramming aimed at counteracting drug resistance. …”
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Ruthenium(II) Lipid‐Mimics Drive Lipid Phase Separation to Arouse Autophagy‐Ferroptosis Cascade for Photoimmunotherapy by Yue Zheng, Wen‐Jin Wang, Jing‐Xin Chen, Kun Peng, Xiao‐Xiao Chen, Qing‐Hua Shen, Bing‐Bing Liang, Zong‐Wan Mao, Cai‐Ping Tan

“…Abstract Lipid‐mediated phase separation is crucial for the formation of lipophilic spontaneous domain to regulate lipid metabolism and homeostasis, furtherly contributing to multiple cell death pathways. …”
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Mfsd2a suppresses colorectal cancer progression and liver metastasis via the S100A14/STAT3 axis by Linfeng Sun, Xiangdong Li, Yuhao Xiao, Wenjie Yu, Xuyang Chen, Ziyi Wang, Nan Xia, Xuejiao Chen, Minhao Chen, Haoliang Zhu, Jie Li, Jie Wei, Sheng Han, Liyong Pu

“…Recent studies have revealed that the major facilitator superfamily domain containing protein-2a (Mfsd2a) plays a pivotal role in the development and metastasis of various cancers. …”
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Clinical and cost-effectiveness of Knee Arthroplasty versus Joint Distraction for Osteoarthritis (KARDS): protocol for a multicentre, phase III, randomised control trial by Deborah D Stocken, Dennis G McGonagle, David Murray, Catherine Reynolds, Catherine Fernandez, David R Ellard, Andrew Metcalfe, Hemant Sharma, Paul Harwood, Hamish Simpson, Hemant Pandit, Susanne Arnold, Cerys Joyce Tassinari, Ruchi Higham, Isabelle Louise Smith, Ruben Mujica-Mota, Thomas William Hamilton, Julie Croft

“…The primary outcome measure is the Knee Injury and Osteoarthritis Outcomes Score (KOOS) pain domain score at 12 months post-operation. Secondary outcome measures include patient-reported overall KOOS, Pain Visual Analogue Scale and Oxford Knee Scores, knee function assessments, joint space width, complications and further interventions over 24 months post-operation. …”
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Consensus for Operating Room Multimodal Data Management: Identifying Research Priorities for Data-Driven Surgery by Alain Garcia Vazquez, MD, Juan Verde, MD, Ariosto Hernandez Lara, MD, Didier Mutter, MD, Lee Swanstrom, MD, 5G-OR Research Committee, 5G-OR Consensus Panel, Ariosto Hernandez Lara, Barbara Seeliger, Daniel Hashimoto, Deepak Alapatt, Joel Lavanchy, Juan Verde, Lise Lecointre, Pietro Mascagni, Pr.Danail Stoyanov, Didier Mutter, MD, Dirk Willhelm, MD, Pr.Gerald Fried, MD, Gretchen Jackson, MD, PhD, Jean-Paul Mazellier, PhD, Lee Swanstrom, MD, Pr.Lena Maier-Hein, Pr.Nicolas Padoy, PhD, Pr.Sascha Treskatsch, MD, Pr.Silvana Perretta, MD, PhD, Pr.Stefanie Speidel, Pr.Teodor Grantcharov, Annika Mareike Engel, BSc, MEng, Axel Boese, DrIng, Carla M. Pugh, MD, PhD, Cesare Hassan, Fabian Dietrich, PhD, Felix Nickel, MD, MME, Franziska Jurosch, MSc, Guido Beldi, MD, Henriette Hegermann, Dr, Johannes Horsch, Dipl-Ing, Julian Rosenkranz, Ing, MSc, Keno Sponheuer, DrMed, Luca Milone, MD, PhD, FACS, Nariaki Okamoto, MD, PhD, Patrick Seeling, PhD, Pedro Filipe Pereira Gouveia, MD, PhD, Roland Croner, Prof.Dr, Sandra Keller, PhD, Sharona B Ross, Taiga Wakabayashi, MD, Ph.D, Takeaki Ishizawa, MD, PhD, Takeshi Urade, MD, PhD, Thomas Schnelldorfer, MD, PhD, Thorge Lackner, MSc, and MEng

“…These innovations have resulted in operating rooms evolving into data-rich environments, which, in turn, requires a thorough understanding of the data pipeline for improved and more intelligent real-time data usage. As this new domain is vast, it is necessary to identify where efforts should be focused on developing seamless and practical data usage. …”
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Treatment Planning Strategies for Interstitial Ultrasound Ablation of Prostate Cancer by Pragya Gupta, Tamas Heffter, Muhammad Zubair, I-Chow Hsu, E. Clif Burdette, Chris J. Diederich

“…Purpose: To develop patient-specific 3D models using Finite-Difference Time-Domain (FDTD) simulations and pre-treatment planning tools for the selective thermal ablation of prostate cancer with interstitial ultrasound. …”
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The neural activity of auditory conscious perception by Kate L. Christison-Lagay, Aya Khalaf, Noah C. Freedman, Christopher Micek, Sharif I. Kronemer, Mariana M. Gusso, Lauren Kim, Sarit Forman, Julia Ding, Mark Aksen, Ahmad Abdel-Aty, Hunki Kwon, Noah Markowitz, Erin Yeagle, Elizabeth Espinal, Jose Herrero, Stephan Bickel, James Young, Ashesh Mehta, Kun Wu, Jason Gerrard, Eyiyemisi Damisah, Dennis Spencer, Hal Blumenfeld

“…To determine whether there are shared mechanisms for perceptual consciousness across sensory modalities, here we test within the auditory domain. Participants completed an auditory threshold task while undergoing intracranial electroencephalography. …”
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Multi-cancer early detection tests for general population screening: a systematic literature review by Ros Wade, Sarah Nevitt, Yiwen Liu, Melissa Harden, Claire Khouja, Gary Raine, Rachel Churchill, Sofia Dias

“…Most studies were case-control, so had a high risk of bias in the ‘patient selection’ domain of QUADAS-2. Most studies also had a high risk of bias in the ‘index test’ and/or ‘flow and timing’ domains. …”
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POVEIKIS IR ATSAKAS BIOLOGINIUOSE VYKSMUOSE by Jonas Rubikas

“…Biologinių vyksmų poveikio - atsako priklausomybė gali būti vertinama dviem lygiais: pirmas - molekulių sąveikų, atomų ir jungčių mainų lygis, antras - ląstelės-individo-organizmo lygis. …”
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Functional assessment of the glycoproteins of a novel Hendra virus variant reveals contrasting fusogenic capacities of the receptor-binding and fusion glycoproteins by Andrew Z. Ma, Yao Yu Yeo, Jean F. Lee, Colin M. Kim, Shahrzad Ezzatpour, Carolina Menchaca, Viraj Upadhye, Edward J. Annand, John-Sebastian Eden, Raina K. Plowright, Alison J. Peel, David W. Buchholz, Hector C. Aguilar

“…Further investigation using HeV-g1 and HeV-g2 glycoprotein chimeras revealed that multiple domains may play roles in modulating these fusion phenotypes. …”
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Exposure of wild mammals to glyphosate, AMPA, and glufosinate: a case for “emerging organic contaminants”? by Fritsch, Clémentine, Appenzeller, Brice M. R., Bertrand, Colette, Coeurdassier, Michael, Driget, Vincent, Hardy, Emilie M, Palazzi, Paul, Schaeffer, Charline, Goydadin, Anne-Claude, Gaba, Sabrina, Bretagnolle, Vincent, Pelosi, Céline

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A semantic strength and neural correlates in developmental dyslexia by Sladjana Lukic, Sladjana Lukic, Sladjana Lukic, Fei Jiang, Maria Luisa Mandelli, Maria Luisa Mandelli, Ting Qi, Sarah M. Inkelis, Sarah M. Inkelis, Emily Rosenthal, Emily Rosenthal, Zachary Miller, Zachary Miller, Emma Wellman, Emma Wellman, Silvia A. Bunge, Silvia A. Bunge, Silvia A. Bunge, Maria Luisa Gorno-Tempini, Maria Luisa Gorno-Tempini, Christa Watson Pereira, Christa Watson Pereira

“…IntroductionMost studies of dyslexia focus on domains of impairment (e.g., reading and phonology, among others), but few examine possible strengths. …”
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Development, implementation, and evaluation of an innovative clinical trial operations training program for Africa (ClinOps) by Dawit Asmamaw Ejigu, Abebaw Fekadu, Jeremy Whitty, Tsegahun Manyazewal, Pamela Nebeta, Almari Conradie, Brenda Okech, Alice Neequaye, Sinéad Whitty, Jennifer Lehrman, Renee Holt, Rahel Birhane, Mahnaz Vahedi, Helen Demarest, Eyasu Makonnen

“…The pre- and post-surveys measured changes in trainees’ confidence in clinical trial domains and leadership and coordination skills. End-course evaluations gathered feedback on the course content, organization, technology, and instructional methods. …”
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Moderate regular physical exercise can help in alleviating the systemic impact of schistosomiasis infection on brain cognitive function by Inssaf Berkiks, Inssaf Berkiks, Nada Abdel Aziz, Nada Abdel Aziz, Nada Abdel Aziz, Blessing Moses, Blessing Moses, Tiroyaone Brombacher, Tiroyaone Brombacher, Frank Brombacher, Frank Brombacher

“…Our aims were multifaceted: to pinpoint the specific cognitive domains affected during the infection in adult mice, to unravel the complex interplay between glial and immune cells within the central nervous system (CNS), and crucially, to explore the potential therapeutic role of regular physical exercise in counteracting the deleterious effects of schistosomiasis on the CNS. …”
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