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  1. 5881

    Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis by Meng Wang, Xing Huang, Tingbo Liang, Tianyu Tang, Gang Zhang, Minghao Lu, Zhengtao Hong, Junming Huang, Xiao Zhi

    Published 2022-03-01
    “…As regards the mechanism, ATP11B interacted with PD-L1 in a CKLF-like MARVEL transmembrane domain containing 6 (CMTM6)-dependent manner. The depletion of ATP11B promoted CMTM6-mediated lysosomal degradation of PD-L1, thus reactivating the immune microenvironment and inducing an antitumor immune response. …”
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  2. 5882

    Characterizing immune biomarkers and effector CD8+ T-cell exhaustion in pancreatic adenocarcinoma via single-cell RNA sequencing profiling by Rawaa AlChalabi, Raghda Makia, Semaa A. Shaban, Ahmed AbdulJabbar Suleiman

    Published 2025-01-01
    “…Mutational analysis of IL7R revealed a likely pathogenic mutation (K110N) located in the IL-7Ralpha fibronectin type III domain. Drug repurposing of oxaprozin and celecoxib showed favorable binding interactions with both wild and mutant IL7R proteins. …”
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  3. 5883

    Spatial and temporal variation of Antarctic microbial interactions: a study around the west Antarctic Peninsula by Swan L. S. Sow, Willem H. van de Poll, Rachel Eveleth, Jeremy J. Rich, Hugh W. Ducklow, Patrick D. Rozema, Catherine M. Luria, Henk Bolhuis, Michael P. Meredith, Linda A. Amaral-Zettler, Julia C. Engelmann

    Published 2025-02-01
    “…Results We report on the seasonal diversity, taxonomic overview, as well as predicted inter-and intra-domain causal effects (interactions) of the bacterial and microbial eukaryotic communities close to the Palmer station and at the Rothera time-series site between July 2013 and April 2014. …”
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  4. 5884

    Patients with Age-related Macular Degeneration Have Increased Susceptibility to Valvular Heart Disease by Natan Lishinsky-Fischer, Itay Chowers, MD, PhD, Yahel Shwartz, MSc, Jaime Levy, MD

    Published 2025-03-01
    “…Methods: All patients with AMD underwent spectral-domain OCT (SD-OCT). The SD-OCT scans were annotated by 2 experienced graders. …”
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  5. 5885

    Exosomes from LPS-Stimulated hDPSCs Activated the Angiogenic Potential of HUVECs In Vitro by Xiangyu Huang, Wei Qiu, Yuhua Pan, Jianjia Li, Zhao Chen, Kaiying Zhang, Yifei Luo, Buling Wu, Wenan Xu

    Published 2021-01-01
    “…The mRNA expression levels of vascular endothelial growth factor (VEGF) and kinase-insert domain-containing receptor (KDR) in the LPS-EXO group were significantly higher than those in the N-EXO group. …”
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  6. 5886

    PER3 suppresses tumor metastasis of oral squamous cell carcinoma by promoting HIF-1α degradation by Yaoxu Li, Bing Li, Kai Yang, Lihua Zhu, Hong Tang, Yinpei Huang, Jinhai Deng, Jun Duan

    Published 2025-02-01
    “…Mechanistically, PER3 bound to HIF-1α via the Per-ARNT-Sim 1 domain and promoted its ubiquitination degradation. …”
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  7. 5887

    Performances of asphalt mastic incorporating with a home-made sustained-releasing salt storage additive by Wei Du, Qing-liang Wang, Yong-xu Li, Xiao-ning Wang, Xiao-cun Liu, Ya-fei Wang, Yan-min Wang, Jin Li

    Published 2025-07-01
    “…However, in our study the DSR experimental design was constrained to temperature scanning, neglecting frequency and time domain scanning, which precluded a comprehensive assessment of mid-temperature fatigue performance. …”
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  8. 5888

    Assessment of the Distributed Ledger Technology for Energy Sector Industrial and Operational Applications Using the MITRE ATT&CK® ICS Matrix by Annabelle Lee, Sri Nikhil Gupta Gourisetti, David Jonathan Sebastian-Cardenas, Kent Lambert, Vicente Navarro, Marco Pasetti, Umit Cali, Kateryna Isirova, Ramesh Reddi, Puica Nitu, Md. Touhiduzzaman, Michael Mylrea, Philip Huff, Farrokh Rahimi, Shammya Shananda Saha

    Published 2023-01-01
    “…The MITRE ATT&CK® for Industrial Control Systems (ICS) matrix was created to provide knowledge about adversary behavior in the ICS technology domain. This study analyzes the relevance of various tactics and techniques across a seven-layer DLT engineering and cybersecurity stack, known as the DLT stack, designed by the Cybersecurity Taskforce under IEEE P2418.5 - Standard for Blockchain in Energy working group sponsored by Power and Energy Systems - Smart Buildings, Loads and Customer Systems (PES/SBLC) Technical Committee. …”
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  9. 5889

    Using satellite-based Sun-induced chlorophyll fluorescence and spectral reflectance for improving terrestrial CO2 flux estimates of India by Aparnna Ravi, Dhanyalekshmi Pillai, Christoph Gerbig, Stephen Sitch, Sönke Zaehle, Vishnu Thilakan, Chandra Sekhar Jha, Thara Anna Mathew

    Published 2025-01-01
    “…We improve these model predictions by additionally using satellite-based solar-induced chlorophyll fluorescence (SIF), soil temperature , and soil moisture specific to the vegetation classes of the domain. Different model refinements were performed to present the improved hourly distributions of terrestrial biospheric CO _2 fluxes on a $0.1^{\circ}\times0.1^{\circ}$ grid from 2012 to 2020. …”
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  10. 5890

    Lipid-encapsulated gold nanoparticles: an advanced strategy for attenuating the inflammatory response in SARS-CoV-2 infection by Sanjeevram Dhandapani, Yujeong Ha, Rongbo Wang, Tae Woo Kwon, Ik-Hyun Cho, Yeon-Ju Kim

    Published 2025-01-01
    “…KGS-NE oral administration facilitated the recovery of mice induced with the receptor binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, as confirmed by inflammatory markers expression in lung tissue. …”
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  11. 5891

    Improved magnetostriction of Tb-Dy-Fe/Dy–Cu multilayer films by introducing interfacial stress due to the semi coherent interface by Yuze Zhao, Jiheng Li, Xiaoqian Bao, Xuexu Gao

    Published 2025-01-01
    “…By tailoring the anisotropy and magnetic domain structure through internal interface stress, it is expected to become an effective way to control the magnetic properties of magnetic thin films.…”
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  12. 5892

    Meta-analysis on Studies of Deviant Marketing Behaviors: Past, Present and Future by Zahra Ahmadi Alvar, Davood Feiz, Meysam Modarresi

    Published 2023-12-01
    “…The observed trend underscores the prevalence of deviant behaviors within the marketing domain. This trend has evolved from initially introducing consumer behavior in marketing, shifting towards customer orientation and service orientation, and ultimately making its most significant contribution to the understanding of sales states and behaviors. …”
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  13. 5893
  14. 5894

    PDZRN3 regulates adipogenesis of mesenchymal progenitors in muscle by Hiroki Iida, Minako Kawai-Takaishi, Yoshihiro Miyagawa, Yasuhiko Takegami, Akiyoshi Uezumi, Takeshi Honda, Shiro Imagama, Tohru Hosoyama

    Published 2025-03-01
    “…Recently, we found that PDZ domain-containing ring finger 3 (PDZRN3), an E3-ubiquitin ligase, was highly expressed in MPs. …”
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  15. 5895

    Behavior of SD-OCT Detectable Hyperreflective Foci in Diabetic Macular Edema Patients after Therapy with Anti-VEGF Agents and Dexamethasone Implants by Anne Rübsam, Laura Wernecke, Saskia Rau, Dominika Pohlmann, Bert Müller, Oliver Zeitz, Antonia M. Joussen

    Published 2021-01-01
    “…Diabetic macular edema (DME) is the most common cause of blindness in the working-age population. Spectral-domain optical coherence tomography (SD-OCT) allows detection and monitoring of the edema and a detailed analysis of the retinal structure. …”
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  16. 5896

    The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases by Geordan J. Stukey, Matthew R. Breuer, Natalie Burchat, Ruta Jog, Kollin Schultz, Gil-Soo Han, Matthew S. Sachs, Harini Sampath, Ronen Marmorstein, George M. Carman

    Published 2025-01-01
    “…Consistent with the inhibitory mechanism of sertraline and propranolol, molecular docking of the inhibitors predicts that they interact with non-catalytic residues in the haloacid dehalogenase-like catalytic domain of Pah1. The Pah1-CC (catalytic core) variant, which lacks regulatory sequences, was inhibited by both drugs in accordance with molecular docking data. …”
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  17. 5897

    Clinical evidence of acupuncture for amnestic mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials by Guangyao Lin, Stella Lim Jin Yie, Shanshan Guo, Xuanling Li, Lianwei Xu

    Published 2025-03-01
    “…Methods: We comprehensively searched nine databases on January 09, 2024, to identify relevant articles estimating the effects of acupuncture for aMCI, and then assessed the risk of bias of the included trials utilizing the RoB 2.0 tool which included the domain of randomization process, deviation from intended interventions, missing outcome data, measurement of the outcome, selection of the reported outcome, and overall bias. …”
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  18. 5898

    In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats by Will J. Costain, Arsalan S. Haqqani, Greg Hussack, Henk van Faassen, Etienne Lessard, Binbing Ling, Eric Brunette, Dao Ly, Hung Fang, Jennyfer Bultinck, Steven Geysens, Gwenda Pynaert, Kathleen Piens, Stefan Ryckaert, Franck Fudalej, Wouter Vervecken, Danica Stanimirovic

    Published 2025-01-01
    “…We aimed to enable brain delivery of systemic ERT by using molecular BBB-Trojans targeting endothelial transcytosis receptors. Methods: Single-domain antibody (sdAb)-enzyme fusion protein constructs were prepared in Yarrowia lipolytica. sdAb affinity and BBB permeability were characterized using SPR and an in vitro rodent BBB assay, respectively. …”
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  19. 5899

    HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model by Yi-fu He, Xi-min Hu, Md. Asaduzzaman Khan, Bo-yao Yu, Yi-cun Sheng, Xian-zhong Xiao, Xin-xing Wan, Si-pin Tan, Kun Xiong

    Published 2023-01-01
    “…Objective. NLR family pyrin domain-containing 3 (NLRP3) increased in the procession of sepsis and functioned as the key regulator of pyroptosis. …”
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  20. 5900

    Protective factors, risk factors, and intervention strategies in the prevention and reduction of crime among adolescents and young adults aged 12-24 years: A scoping review protoco... by Rosanna Mary Rooney, Amber Hopkins, Jacob Peckover, Kael Coleman, Rebecca Sampson, Rosa Alati, Sharinaz Hassan, Christina M Pollard, Jaya A R Dantas, Roanna Lobo, Zakia Jeemi, Sharyn Burns, Robert Cunningham, Stephen Monterosso, Lynne Millar, Sender Dovchin, Rhonda Oliver, Ranila Bhoyroo, Getinet Ayano

    Published 2024-01-01
    “…The review is expected to identify effective interventions that address critical factors within each domain, including Multisystemic Therapy (MST) and Multidimensional Treatment Foster Care (MTFC), which have shown promise in reducing youth crime. …”
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