-
5881
Oncolytic peptide LTX-315 induces anti-pancreatic cancer immunity by targeting the ATP11B-PD-L1 axis
Published 2022-03-01“…As regards the mechanism, ATP11B interacted with PD-L1 in a CKLF-like MARVEL transmembrane domain containing 6 (CMTM6)-dependent manner. The depletion of ATP11B promoted CMTM6-mediated lysosomal degradation of PD-L1, thus reactivating the immune microenvironment and inducing an antitumor immune response. …”
Get full text
Article -
5882
Characterizing immune biomarkers and effector CD8+ T-cell exhaustion in pancreatic adenocarcinoma via single-cell RNA sequencing profiling
Published 2025-01-01“…Mutational analysis of IL7R revealed a likely pathogenic mutation (K110N) located in the IL-7Ralpha fibronectin type III domain. Drug repurposing of oxaprozin and celecoxib showed favorable binding interactions with both wild and mutant IL7R proteins. …”
Get full text
Article -
5883
Spatial and temporal variation of Antarctic microbial interactions: a study around the west Antarctic Peninsula
Published 2025-02-01“…Results We report on the seasonal diversity, taxonomic overview, as well as predicted inter-and intra-domain causal effects (interactions) of the bacterial and microbial eukaryotic communities close to the Palmer station and at the Rothera time-series site between July 2013 and April 2014. …”
Get full text
Article -
5884
Patients with Age-related Macular Degeneration Have Increased Susceptibility to Valvular Heart Disease
Published 2025-03-01“…Methods: All patients with AMD underwent spectral-domain OCT (SD-OCT). The SD-OCT scans were annotated by 2 experienced graders. …”
Get full text
Article -
5885
Exosomes from LPS-Stimulated hDPSCs Activated the Angiogenic Potential of HUVECs In Vitro
Published 2021-01-01“…The mRNA expression levels of vascular endothelial growth factor (VEGF) and kinase-insert domain-containing receptor (KDR) in the LPS-EXO group were significantly higher than those in the N-EXO group. …”
Get full text
Article -
5886
PER3 suppresses tumor metastasis of oral squamous cell carcinoma by promoting HIF-1α degradation
Published 2025-02-01“…Mechanistically, PER3 bound to HIF-1α via the Per-ARNT-Sim 1 domain and promoted its ubiquitination degradation. …”
Get full text
Article -
5887
Performances of asphalt mastic incorporating with a home-made sustained-releasing salt storage additive
Published 2025-07-01“…However, in our study the DSR experimental design was constrained to temperature scanning, neglecting frequency and time domain scanning, which precluded a comprehensive assessment of mid-temperature fatigue performance. …”
Get full text
Article -
5888
Assessment of the Distributed Ledger Technology for Energy Sector Industrial and Operational Applications Using the MITRE ATT&CK® ICS Matrix
Published 2023-01-01“…The MITRE ATT&CK® for Industrial Control Systems (ICS) matrix was created to provide knowledge about adversary behavior in the ICS technology domain. This study analyzes the relevance of various tactics and techniques across a seven-layer DLT engineering and cybersecurity stack, known as the DLT stack, designed by the Cybersecurity Taskforce under IEEE P2418.5 - Standard for Blockchain in Energy working group sponsored by Power and Energy Systems - Smart Buildings, Loads and Customer Systems (PES/SBLC) Technical Committee. …”
Get full text
Article -
5889
Using satellite-based Sun-induced chlorophyll fluorescence and spectral reflectance for improving terrestrial CO2 flux estimates of India
Published 2025-01-01“…We improve these model predictions by additionally using satellite-based solar-induced chlorophyll fluorescence (SIF), soil temperature , and soil moisture specific to the vegetation classes of the domain. Different model refinements were performed to present the improved hourly distributions of terrestrial biospheric CO _2 fluxes on a $0.1^{\circ}\times0.1^{\circ}$ grid from 2012 to 2020. …”
Get full text
Article -
5890
Lipid-encapsulated gold nanoparticles: an advanced strategy for attenuating the inflammatory response in SARS-CoV-2 infection
Published 2025-01-01“…KGS-NE oral administration facilitated the recovery of mice induced with the receptor binding domain (RBD) of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein, as confirmed by inflammatory markers expression in lung tissue. …”
Get full text
Article -
5891
Improved magnetostriction of Tb-Dy-Fe/Dy–Cu multilayer films by introducing interfacial stress due to the semi coherent interface
Published 2025-01-01“…By tailoring the anisotropy and magnetic domain structure through internal interface stress, it is expected to become an effective way to control the magnetic properties of magnetic thin films.…”
Get full text
Article -
5892
Meta-analysis on Studies of Deviant Marketing Behaviors: Past, Present and Future
Published 2023-12-01“…The observed trend underscores the prevalence of deviant behaviors within the marketing domain. This trend has evolved from initially introducing consumer behavior in marketing, shifting towards customer orientation and service orientation, and ultimately making its most significant contribution to the understanding of sales states and behaviors. …”
Get full text
Article -
5893
Major Depressive Disorder as a Condition Negatively Impacting Both Mental and Physical Functioning. What to Do When There Is Treatment Resistance?
Published 2025-01-01“…Additionally, the review identifies potential avenues for future research within this domain. The article compares the results of selected studies. …”
Get full text
Article -
5894
PDZRN3 regulates adipogenesis of mesenchymal progenitors in muscle
Published 2025-03-01“…Recently, we found that PDZ domain-containing ring finger 3 (PDZRN3), an E3-ubiquitin ligase, was highly expressed in MPs. …”
Get full text
Article -
5895
Behavior of SD-OCT Detectable Hyperreflective Foci in Diabetic Macular Edema Patients after Therapy with Anti-VEGF Agents and Dexamethasone Implants
Published 2021-01-01“…Diabetic macular edema (DME) is the most common cause of blindness in the working-age population. Spectral-domain optical coherence tomography (SD-OCT) allows detection and monitoring of the edema and a detailed analysis of the retinal structure. …”
Get full text
Article -
5896
The antidepressant drug sertraline is a novel inhibitor of yeast Pah1 and human lipin 1 phosphatidic acid phosphatases
Published 2025-01-01“…Consistent with the inhibitory mechanism of sertraline and propranolol, molecular docking of the inhibitors predicts that they interact with non-catalytic residues in the haloacid dehalogenase-like catalytic domain of Pah1. The Pah1-CC (catalytic core) variant, which lacks regulatory sequences, was inhibited by both drugs in accordance with molecular docking data. …”
Get full text
Article -
5897
Clinical evidence of acupuncture for amnestic mild cognitive impairment: A systematic review and meta-analysis of randomized controlled trials
Published 2025-03-01“…Methods: We comprehensively searched nine databases on January 09, 2024, to identify relevant articles estimating the effects of acupuncture for aMCI, and then assessed the risk of bias of the included trials utilizing the RoB 2.0 tool which included the domain of randomization process, deviation from intended interventions, missing outcome data, measurement of the outcome, selection of the reported outcome, and overall bias. …”
Get full text
Article -
5898
In vivo brain delivery of BBB-enabled iduronate 2-sulfatase in rats
Published 2025-01-01“…We aimed to enable brain delivery of systemic ERT by using molecular BBB-Trojans targeting endothelial transcytosis receptors. Methods: Single-domain antibody (sdAb)-enzyme fusion protein constructs were prepared in Yarrowia lipolytica. sdAb affinity and BBB permeability were characterized using SPR and an in vitro rodent BBB assay, respectively. …”
Get full text
Article -
5899
HSF1 Alleviates Brain Injury by Inhibiting NLRP3-Induced Pyroptosis in a Sepsis Model
Published 2023-01-01“…Objective. NLR family pyrin domain-containing 3 (NLRP3) increased in the procession of sepsis and functioned as the key regulator of pyroptosis. …”
Get full text
Article -
5900
Protective factors, risk factors, and intervention strategies in the prevention and reduction of crime among adolescents and young adults aged 12-24 years: A scoping review protoco...
Published 2024-01-01“…The review is expected to identify effective interventions that address critical factors within each domain, including Multisystemic Therapy (MST) and Multidimensional Treatment Foster Care (MTFC), which have shown promise in reducing youth crime. …”
Get full text
Article