Bearberry in the treatment of acute uncomplicated cystitis (BRUMI): protocol of a multicentre, randomised double-blind clinical trial by Péter Hegyi, Noémi Gede, Szilárd Váncsa, Barbara Tóth, András Jávorházy, Péter Nyirády, Boglárka Csupor-Löffler, Péter Birinyi, George Zhanel, Kurt Naber, Reinhard Länger, Nóra Vörhendi, Dezső Csupor

“…Eligible patients will be premenopausal women with a sum score of ≥6 for the typical acute uncomplicated cystitis symptoms (frequency, urgency, painful urination, incomplete emptying, suprapubic pain and visible haematuria) reported on the Acute Cystitis Symptom Score (ACSS) typical domain and pyuria. Patients will be randomly assigned to receive 3 g single dose of fosfomycin powder and two placebo tablets three times a day for 7 days or B a single dose of placebo powder and two tablets containing a dry extract of Uvae ursi folium. …”
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A multicenter, cross‐sectional analysis to assess the safety and usage pattern of brivaracetam in the management of partial‐onset seizure with BAEs—BREEZE study: A post‐hoc analysi... by Arvind Sharma, Krishnaprasad Korukonda, Amit Haldar, Usha Kant Misra, R. V. Anand, Yakshdeep Dave, Girish Kulkarni

“…Abstract Objective Brivaracetam (BRV), a third‐generation anti‐seizure medication (ASM) offers strong conformational receptor domain binding, faster blood brain barrier (BBB) permeability and better tolerability making it potential therapeutic option as an initial line or initial line add‐on strategy for focal onset seizure (FoS). …”
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Molecular Phylogenetic Analysis of 16S rRNA Sequences Identified Two Lineages of Helicobacter pylori Strains Detected from Different Regions in Sudan Suggestive of Differential Evo... by Abeer Babiker Idris, Hadeel Gassim Hassan, Maryam Atif Salaheldin Ali, Sulafa Mohamed Eltaher, Leena Babiker Idris, Hisham N. Altayb, Amin Mohamed Abass, Mustafa Mohammed Ahmed Ibrahim, El-Amin Mohamed Ibrahim, Mohamed A. Hassan

“…These six mutations were detected in regions of the 16S rRNA not closely associated with either tetracycline or tRNA binding sites; 66.67% of them were located in the central domain of 16S rRNA. The phylogenetic analysis of 16S rRNA sequences identified two lineages of H. pylori strains detected from different regions in Sudan. …”
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Low Frequency of MKRN3 and DLK1 Variants in Chinese Children with Central Precocious Puberty by Ting Chen, Linqi Chen, Haiying Wu, Rongrong Xie, Fengyun Wang, Xiuli Chen, Hui Sun, Fei Xiao

“…We also performed bioinformatic analysis to evaluate the impact of variants on MKRN3 protein structures, which showed that Ile357Met locates at the zinc-binding region (C3HC4 RING finger motif), while Glu380Lys is spatially extremely close to the C3HC4 RING finger, MKRN-specific Cys-His domain, and the third C3H1 zinc-finger motif region. …”
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Self-Examination Low-Cost Full-Field Optical Coherence Tomography (SELFF-OCT) for neovascular age-related macular degeneration: a cross-sectional diagnostic accuracy study by Peter Koch, Inke König, Johann Roider, Jan Tode, Konstantine Purtskhvanidze, Claus von der Burchard, Helge Sudkamp, Cristoph Ehlken, Moritz Moltmann, Britta Heimes, Michael Münst, Malte vom Endt, Timo Kepp, Dirk Theisen-Kunde, Gereon Hüttmann

“…This trial investigates an improved prototype for patients with AMD and focusses on device operability and diagnostic accuracy compared with established spectral-domain OCT (SD-OCT).Design Prospective single-arm diagnostic accuracy study.Setting Tertiary care centre (University Eye Clinic).Participants 46 patients with age-related macular degeneration.Interventions Patients received short training in device handling and then performed multiple self-scans with the SELFF-OCT according to a predefined protocol. …”
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Low-cost phone-based LiDAR scanning technology provides sub-centimeter accuracy when measuring the main dimensions of motor-manual tree felling cuts by Stelian Alexandru Borz, Andrea Rosario Proto

“…By the commonly used error metrics such as the bias (−0.73–0.10), mean absolute error (0.51–0.78) and root mean squared error (0.68–0.92), the differences between the two were in the sub-centimeter domain. Taken individually, all the measurements agreed well in a ± 2 cm range, with an obvious dominance in much lower ranges and no evident trends in variance related to the measurement size. …”
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A novel platform for engineered AAV-based vaccines by Sabrina Babutzka, Miranda Gehrke, Anastasia Papadopoulou, Maria Diedrichs-Möhring, Maria Giannaki, Lena Hennis, Bastian Föhr, Cale Kooyman, Andreas Osterman, Evangelia Yannaki, Gerhild Wildner, Hermann Ammer, Stylianos Michalakis

“…Using SARS-CoV-2 as a model pathogen, we introduced ∼200 amino acids of the SARS-CoV-2 receptor-binding domain (RBD) into a surface-exposed variable loop region of AAV2 and AAV9, resulting in AAV2.RBD and AAV9.RBD capsids (AAV.RBDs). …”
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FABLDroid: Malware detection based on hybrid analysis with factor analysis and broad learning methods for android applications by Kazım Kılıç, İsmail Atacak, İbrahim Alper Doğru

“…The Kronodroid dataset is a dataset consisting of malware and benign applications, specifically designed to examine and explore the concept drift and cross-device detection issues in the problem domain. The Kronodroid dataset contains different datasets obtained from both real devices and emulator runtimes. …”
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Piezoelectric-triboelectric hybrid nanogenerator based on tough, stretchable BaTiO3 doped antibacterial hydrogel for self-powered sensors by Runi Hou, Lijian Xu, Maolin Yu, Zengmin Tang, Bin Zhou, Qiao Zhang, Na Li, Jianxiong Xu

“…Overall, this work represents a noteworthy advancement in the domain of self-powered flexible electronics, with the potential for application in a wide range of complex scenarios.…”
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Modeling of historical and future changes in temperature and precipitation in the Panj River Basin in Central Asia under the CMIP5 RCP and CMIP6 SSP scenarios by Aminjon Gulakhmadov, Xi Chen, Nekruz Gulahmadov, Muhammmad Rizwan, Manuchekhr Gulakhmadov, Muhammad Umar Nadeem, Moldir Rakhimova, Tie Liu

“…The performance of Max Plank Institute (MPI) across all variables in CMIP6 models was exceptional. Within the CMIP5 domain, Geophysical Fluid Dynamics (GFDL) demonstrated outstanding skill in reproducing maximum temperature (Tmax) and precipitation (KGE 0.58 and 0.34, respectively), while (Institute for Numerical Mathematics) INMCM excelled in replicating minimum temperature (Tmin) (KGE 0.28). …”
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Development of a Recombinant Omicron BA.1 Subunit Vaccine Candidate in Pichia pastoris by Sibel Kalyoncu, Dogu Sayili, Ayca Zeybek Kuyucu, Hakan Soyturk, Seyda Gullu, Busra Ersayan, Ibrahim Oguzhan Tarman, Mehmet Ender Avci, Olcay Mert, Umut Haskok, Ege Tekin, Huseyin Akinturk, Ridvan Orkut, Aysegul Demirtas, Idil Tilmensagir, Ceren Ulker, Bilgi Gungor, Mehmet Inan

“…The receptor binding domain of Omicron BA.1 spike protein (RBD‐Omicron) was produced at 0.35 g/L in supernatant. …”
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Proceedings of the 14th European immunogenicity platform open symposium on immunogenicity of biopharmaceuticals by Sophie Tourdot, Daniel Baltrunkonis, Sofie Denies, Viswanath Devanarayan, Joanna Grudzinska-Goebel, Arno Kromminga, Gregor P. Lotz, Laurent Malherbe, Lydia Michaut, Karin N. Weldingh, Joao A. Pedras-Vasconcelos, Laura. I. Salazar-Fontana, Sebastian Spindeldreher, Zuben Sauna, Veerle Snoeck, Daniela Verthelyi, Daniel Kramer

“…With the rapid diversification and complexification of biologics, which today include modalities such as multi-domain antibodies, cell-based products, AAV delivery vectors, and nucleic acids, developers are faced with the challenge of establishing a risk assessment strategy sometimes in the absence of specific regulatory guidelines. …”
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Evaluation of Lacrimal Punctal Changes by Anterior Segment Optical Coherence Tomography after Punctal Dilation Versus Punctal Plug Insertion in Cases of Inflammatory Punctual Steno... by Islam Awny, Elshimaa A Mateen Mossa, Tasneem Mohammed Bakheet, Hany Mahmoud, Amr Mounir

“…The second epiphora group (EG2 20 eyes) who managed by punctal dilatation augmented with an application of perforated punctal plugs for two months. Spectral Domain Anterior Segment-OCT Image Acquisition. AS-OCT for lower puncti was performed using RTVue (Optovue Inc., Fermont, CA). …”
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Low Thermal Resistance of Diamond‐AlGaN Interfaces Achieved Using Carbide Interlayers by Henry T. Aller, Thomas W. Pfeifer, Abdullah Mamun, Kenny Huynh, Marko Tadjer, Tatyana Feygelson, Karl Hobart, Travis Anderson, Bradford Pate, Alan Jacobs, James Spencer Lundh, Mark Goorsky, Asif Khan, Patrick Hopkins, Samuel Graham

“…In order to accurately measure the thermal boundary resistance we develop a hybrid technique, combining time‐domain thermoreflectance and steady‐state thermoreflectance fitting, offering superior sensitivity to buried thermal resistances. …”
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THE RECEPTION OF THE PHILOSOPHICAL TRADITION AS A WAY OF FORMING AMERICAN PERSONALISM: THE POST-SECULAR VIEW by V. O. Patsan

“…Conclusions define the resource of Bowne's idea of the “personal interpretation of experience” which inspired the subsequent “personalized” ontological constructions in the personalistic domain established on the North American continent. …”
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Aurora kinase as a putative target to tick control by Bruno Moraes, Helga Gomes, Luiz Saramago, Valdir Braz, Luís Fernando Parizi, Gloria Braz, Itabajara da Silva Vaz, Carlos Logullo, Jorge Moraes, Ala Tabor

“…Two aurora kinase coding sequences have been identified in the transcriptome of the cattle tick Rhipicephalus microplus (Rm-AURKA and Rm-AURKB) containing the aurora kinase-specific domain. For both isoforms, the highest number of AURK coding transcripts is found in ovaries. …”
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Association of Serum Irisin With Severity and Prognosis in Patients With Coronavirus Disease 2019: A Prospective Cohort Study by Zhang X, Wang W, Li Y, Liu X, Zhang L, Cheng Z, Liu M, Wang Y, Fu L, Yang J

“…Xinli Zhang,1,2,* Wennan Wang,1,3,* Ye Li,2 Xiaoning Liu,2 Liangzhu Zhang,2 Zhenyu Cheng,1,4 Mingyan Liu,1,4 Yu Wang,1,4 Lin Fu,1,4 Jin Yang1,4,5 1Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China; 2The First Department of Tuberculosis, Anhui Chest Hospital, Hefei, Anhui Province, People’s Republic of China; 3The Fifth Department of Tuberculosis, Anhui Chest Hospital, Hefei, Anhui Province, People’s Republic of China; 4Institute of Respiratory Diseases, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China; 5Information Management Center, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin Fu; Jin Yang, Department of Respiratory and Critical Care Medicine, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, People’s Republic of China, Email fulindev@126.com; yangqj1015@foxmail.comBackground: Irisin is the cleaved form of fibronectin type III domain-containing protein 5 (FNDC5), which can confer antioxidant and anti-inflammatory effects. …”
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ϵ-Confidence Approximately Correct (ϵ-CoAC) Learnability and Hyperparameter Selection in Linear Regression Modeling by Soosan Beheshti, Mahdi Shamsi

“…In a data based learning process, training data set is utilized to provide a hypothesis that can be generalized to explain all data points from a domain set. The hypothesis is chosen from classes with potentially different complexities. …”
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Critical biomarkers for responsive deep brain stimulation and responsive focal cortex stimulation in epilepsy field by Zhikai Yu, Binghao Yang, Penghu Wei, Hang Xu, Yongzhi Shan, Xiaotong Fan, Huaqiang Zhang, Changming Wang, Jingjing Wang, Shan Yu, Guoguang Zhao

“…The resultant model possesses the capability to function as a feedback trigger program for electrical stimulation systems of the feedback variety, specifically within the domain of neural modulation in epilepsy.…”
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The Legionella pneumophila effector PieF modulates mRNA stability through association with eukaryotic CCR4−NOT by Harley O'Connor Mount, Malene L. Urbanus, Francesco Zangari, Anne-Claude Gingras, Alexander W. Ensminger

“…Adding to the complexities of PieF activity in vivo, we identified a separate domain of PieF responsible for binding to eukaryotic kinases. …”
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