Effectively alleviate rheumatoid arthritis via maintaining redox balance, inducing macrophage repolarization and restoring homeostasis of fibroblast-like synoviocytes by metformin-... by Rui Zhang, Xingyu Lin, Rongjie Lin, Zhenbin Chen, Chenfang Miao, Yao Wang, Xiaoqin Deng, Jianlong Lin, Shishui Lin, Shaohuang Weng, Min Chen

“…In addition, MCDs eliminated the cellular ROS in M1 phenotype macrophages in RA microenvironment through the enzyme-like catalytic activity as well as inhibiting NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome signaling pathway, effectively polarizing them into the M2 phenotype to realize the anti-inflammatory effect. …”
Get full text

Topographic correlation of microperimetry with foveal microstructure characteristics in idiopathic epiretinal membrane patients with an ectopic inner foveal layer by Qianqian Wang, Congyao Wang, Yihua Su, Fenfen Yu, Tingting Chen, Xia Dong, Pengxia Wan

“…Quantitative foveal light sensitivity was measured using microperimetry, and foveal microstructure was assessed using spectral-domain optical coherence tomography (SD-OCT) and optical coherence tomography angiography (OCTA). …”
Get full text

Altered expression of miRNA profile in peripheral blood mononuclear cells following the third dose of inactivated COVID-19 vaccine by Guanguan Qiu, Ruoyang Zhang, Huifeng Qian, Ruoqiong Huang, Jie Xia, Ruoxi Zang, Zhenkai Le, Qiang Shu, Jianguo Xu, Guoping Zheng, Jiangmei Wang

“…Our results validated the differential expression of miR-25-5p, miR-34c-3p, and miR-206 post-booster, with a significant correlation to the receptor binding domain (RBD)-specific antibody. Bioinformatic analysis suggested that miR-25-5p, miR-34c-3p, and miR-206 may target multiple pathways involved in immune regulation and inflammation. …”
Get full text

Exploring the antimicrobial and antioxidative potential of Leucas aspera (Willd.) link: Phytochemical screening, molecular docking, and HR-LC/MS profiling against SARS-CoV-2 protei... by Thavasiaanatham Seenivasan Shalini, Ragothaman Prathiviraj, Poomalai Senthilraja

“…Molecular docking of the 19 compounds against the SARS-CoV-2 main protease (3CLPro) protein (PDB ID: 6LU7) and spike protein receptor binding domain (SGp-RBD) protein (PDB ID: 2GHV) revealed Famprofazone and Loxtidine compounds having the highest binding affinity with LibDock scores of 105.53 and 116.70 respectively. …”
Get full text

A note on the global existence and boundedness of an N-dimensional parabolic-elliptic predator-prey system with indirect pursuit-evasion interaction by Liu Ling

“…We investigate the two-species chemotaxis predator-prey system given by the following system: ut=Δu−χ∇⋅(u∇w)+u(λ1−μ1ur1−1+av),x∈Ω,t>0,vt=Δv+ξ∇⋅(v∇z)+v(λ2−μ2vr2−1−bu),x∈Ω,t>0,0=Δw−w+v,x∈Ω,t>0,0=Δz−z+u,x∈Ω,t>0,\left\{\begin{array}{ll}{u}_{t}=\Delta u-\chi \nabla \cdot \left(u\nabla w)+u\left({\lambda }_{1}-{\mu }_{1}{u}^{{r}_{1}-1}+av),& x\in \Omega ,\hspace{0.33em}t\gt 0,\\ {v}_{t}=\Delta v+\xi \nabla \cdot \left(v\nabla z)+v\left({\lambda }_{2}-{\mu }_{2}{v}^{{r}_{2}-1}-bu),& x\in \Omega ,\hspace{0.33em}t\gt 0,\\ 0=\Delta w-w+v,& x\in \Omega ,\hspace{0.33em}t\gt 0,\\ 0=\Delta z-z+u,& x\in \Omega ,\hspace{0.33em}t\gt 0,\end{array}\right. in a bounded domain Ω⊂RN(N≥1)\Omega \subset {{\mathbb{R}}}^{N}\left(N\ge 1) with smooth boundary, where parameters χ,ξ,λi,μi>0\chi ,\xi ,{\lambda }_{i},{\mu }_{i}\gt 0, and ri>1(i=1,2){r}_{i}\gt 1\hspace{0.33em}\left(i=1,2). …”
Get full text

Ultrahigh piezoelectric performances of (K,Na)NbO3 based ceramics enabled by structural flexibility and grain orientation by Li-Feng Zhu, Dong Liu, Xiaoming Shi, Shiqing Deng, Jiecheng Liu, Li-Yu Wei, Zi-Qi Yang, Qi Wang, Bo-Ping Zhang, Houbing Huang, Shujun Zhang, Jing-Feng Li

“…Phenomenological models, phase field simulations and high-angle annular dark-field scanning transmission electron microscopy reveal that the structural flexibility originates from the high Coulomb force between K+/Na+ ions and Sb ions in the KNN-xSb system, while the grain orientation promotes the displacement of B-site cations leveraging the engineered domain configuration. As a result of its excellent comprehensive piezoelectric properties, the textured KNN-5Sb/epoxy 1-3 piezoelectric composite is found to possess a broader bandwidth BW = 60% and higher amplitude output voltage than commercial PZT-5 and other KNN counterparts. …”
Get full text

On the potential of using nature-based technologies to improve the efficiency of blade hydro-machines by G. A. Kromm, A. V. Volkov, A. V. Ryzhenkov, V. Yu. Lyapin, E. S. Trushin

“…Examples of a number of the most interesting, according to the authors, works that are in the public domain are given. Some features of the presented studies are noted. …”
Get full text

Analysis of Changes in Retinal Thickness in Type 2 Diabetes without Diabetic Retinopathy by Jing Jiang, Yan Liu, Yingchao Chen, Bo Ma, Yiwen Qian, Zhenzhen Zhang, Dongqing Zhu, Zhiliang Wang, Xiaofang Xu

“…Full retinal thicknesses of ten areas were assessed using spectral domain optical coherence tomography. Confounding variables, such as age, gender, and glycated haemoglobin (HbA1c) level, were assessed by regression analysis. …”
Get full text

Real-World Parkinson’s Hand Tremor Detection Using Ensemble Learning Techniques by Sungwook Hur, Jieming Zhang, Moon-Hyun Kim, Tai-Myoung Chung

“…We then exploit walking periodicity to combine time and frequency domain features, and design two new accelerometer-based features, Average Peak Interval Time (APIT) and Average Peak Frequency (APF), which capture the characteristic amplitude and frequency patterns of PD tremors during natural walking movements. …”
Get full text

Association between Optical Coherence Tomography Measurements and Clinical Parameters in Idiopathic Intracranial Hypertension by Priscilla Fernandes Nogueira, Gustavo Coelho Caiado, Carolina P. B. Gracitelli, Fernando Meister Martins, Felipe Chaves Duarte Barros, Sandro Luis De Andrade Matas, Sérgio Henrique Teixeira, Luciana da Cruz Noia, Danilo Andriatti Paulo

“…All participants underwent comprehensive ophthalmological examination followed by spectral-domain OCT (SD-OCT) and standard automated perimetry using the 30–2 program of the Humphrey visual field analyzer. …”
Get full text

HACE1 protects against myocardial ischemia–reperfusion injury via inhibition of mitochondrial fission in mice by Bang-Xia Liu, Juan Zheng, Zhan-Wei Tang, Lei Gao, Meng Wang, Ying Sun, Chen Chen, Heng-Chen Yao

“…Abstract Background HECT domain and Ankyrin repeat Containing E3 ubiquitin-protein ligase 1 (HACE1) has been found to be associated with mitochondrial protection. …”
Get full text

Discovery and development of ANV419, an IL-2/anti-IL-2 antibody fusion protein with potent CD8+ T and natural killer cell-stimulating capacity for cancer immunotherapy by Patrizia Murer, Barbara Brannetti, Jean-Michel Rondeau, Laetitia Petersen, Nicole Egli, Simone Popp, Catherine Regnier, Kirsten Richter, Andreas Katopodis, Christoph Huber

“…The fusion protein has an IL-2 connected to the light chain complementarity-determining region (CDR) domain of a humanized antibody that binds to IL-2 at the same epitope as IL-2 Rα. …”
Get full text

Quantitative Assessment of Deep Gray Matter Susceptibility and Correlation With Cognition in Patients With Liver Cirrhosis by Wenjun Wu, Yu Su, Ziji Qin, Jiamin Kang, Dongqiao Xiang, Dingxi Liu, Chuansheng Zheng, E. Mark Haacke, Lixia Wang

“…The NCT‐A, DST, MoCA, and sub‐domain scores were correlated with susceptibility values of RN, DN, SN, and CN, respectively. …”
Get full text

Effect of EOG Signal Filtering on the Removal of Ocular Artifacts and EEG-Based Brain-Computer Interface: A Comprehensive Study by Malik M. Naeem Mannan, M. Ahmad Kamran, Shinil Kang, Myung Yung Jeong

“…Results from statistical testing of time and frequency domain metrics suggested that a low-pass frequency between 6 and 8 Hz could be used as the most optimal filtering frequency of EOG signals, both to maximally overcome/minimize the effect of bidirectional contamination and to achieve good results from artifact removal algorithms. …”
Get full text

Long-Term Safety of Transplanting Human Bone Marrow Stromal Cells into the Extravascular Spaces of the Choroid of Rabbits by Adi Tzameret, Sapir E. Kalish, Ifat Sher, Lea Twito, Amilia Meir, Itay Levy, Shlomo Margel, Iris Moroz, Mordechai Rosner, Avraham J. Treves, Arnon Nagler, Michael Belkin, Ygal Rotenstreich

“…Cells were retained in the EVSC compartment 10 weeks following transplantation. Spectral domain optical coherence tomography (SD-OCT) and histopathology analysis demonstrated no choroidal hemorrhages, retinal detachment, inflammation, or any untoward pathological reactions in any of transplanted eyes or in the control noninjected contralateral eyes. …”
Get full text

PENGARUH PEMBELAJARAN DENGAN MODEL PROBLEM SOLVING FISIKA TERHADAP HASIL BELAJAR KOGNITIF DAN KEMAMPUAN BERPIKIR KRITIS SISWA by Yenni Novita Lestari, Eko Swistoro, Andik Purwanto

“…Kata kunci: Model Problem Solving Fisika, Hasil Belajar Kognitif, Kemampuan Berpikir Kritis   The aims of this research were to examine the effect of learning with the Problem Solving Fisika (PSF) model on learning outcomes in the cognitive domain and critical thinking abilities. This research used nonequivalent control group design to examine the effect of the PSF model on cognitive learning outcomes and one group pretest posttest design to examine the effect of the PSF model on critical thinking ability. …”
Get full text

Optical Coherence Tomography May Help Distinguish Glaucoma from Suprasellar Tumor-Associated Optic Disc by Michael Mimouni, Hadas Stiebel-Kalish, Irena Serov, Gabriel Chodick, Mohammad Zbedat, Dan D. Gaton

“…In this retrospective cross-sectional study, we collected data from the eyes of 25 patients with suprasellar craniopharyngioma or pituitary macroadenomas (group 1) and 35 patients with primary open-angle glaucoma (POAG) (group 2), seen between 2001 and 2015, all with a visual acuity of ≥20/40, for whom Stratus Time-Domain (TD) optic nerve OCT scans were available. …”
Get full text

Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling by Ying Cheng, Man Zhang, Chenguang Li, Long Su, Lingli Fu, Shi Wu, Chaofei Xu, Bei Sun, Liming Chen

“…Here, we confirm that angiogenic factor 1 with a G patch and FHA domain (AGGF1) is elevated in the diabetics and induces retinal angiogenesis. …”
Get full text

Social Structure Analysis in Management of South Sumatra Inland Waters by Fevi Rahma Dwi Putri, Arif Satria, Rilus A. Kinseng, Taryono Taryono

“…The participants in this social landscape strived to accumulate capital to enhance their competitiveness within the L3S domain. A patronage system was implemented with middlemen assuming the role of patron and the fishermen acting as their clients. …”
Get full text

Promoting Computational Access to Digital Collections in the Nordic and Baltic Countries: An Icelandic Use Case by Gustavo Candela, Olga Holownia, Max Odsbjerg, Mirjam Cuper, Nele Gabriëls, Katrine Hofmann, Edward J. Gray, Sally Chambers, Mahendra Mahey

“…The main contributions of this work are: (a) a framework for creating a collection of Jupyter Notebooks in the GLAM domain, (b) the reproducible code and examples of use, and (c) the results obtained after its application. …”
Get full text