Preclinical Polymodal Hallucinations for 13 Years before Dementia with Lewy Bodies by Carlo Abbate, Pietro Davide Trimarchi, Silvia Inglese, Niccolò Viti, Alessandra Cantatore, Lisa De Agostini, Federico Pirri, Lorenza Marino, Renzo Bagarolo, Daniela Mari

“…The neuropsychological evaluation showed a multiple domain without amnesia MCI subtype with prefrontal dysexecutive, visuoperceptual, and visuospatial impairments and simultanagnosia, which has not previously been reported in MCI-DLB. …”
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Ezetimibe Anticancer Activity via the p53/Mdm2 Pathway by Charmy Twala, Sibusiso Malindisa, Chamone Munnik, Selisha Sooklal, Monde Ntwasa

“…Methods and Results: Our in silico studies indicate that Ezetimibe binds to the Tp53 binding domain in Mdm2, forming a more thermodynamically stable complex than nutlin3a. …”
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Improving the N-glycosylation occupancy of plant-produced IgG1 by engineering the amino acid environment at Asn297 by Kathrin Göritzer, Valentina Ruocco, Ulrike Vavra, Shiva Izadi, Omayra C. Bolaños-Martínez, Thareeya Phetphoung, Nuttapat Pisuttinusart, Waranyoo Phoolcharoen, Richard Strasser

“…This was achieved through an amino acid mutation near the conserved glycosylation site in the CH2 domain of the heavy chain. The transient expression of trastuzumab and SARS-CoV-2 neutralizing IgG1 antibody COVA2-15 in N. benthamiana, with mutations such as Y300L, resulted in a notable improvement in glycosylation occupancy. …”
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The effect of tumour necrosis factor-α (TNF-α) muteins on human neutrophils in vitro by H. Tchorzewski, K. Zeman, J. Kantorski, E. Paleolog, M. Kahan, M. Feldmann, M. Kwinkowski, P. Guga, B. Szymanska, P. Parniewski, A. Wilk, J. Jarosz

“…To verify the suggestion that the receptor binding domain includes the region close to the N-terminus of the TNF-α molecule, four TNF-α derivatives termed muteins were constructed, using a synthetic cDNA fragment substituting the N-terminal 3–7 selected hydrophilic or hydrophobic amino acids in the original TNF-α genomic DNA. …”
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Increased Choroidal Thickness in Keratoconus Patients: Perspectives in the Disease Pathophysiology by João Pinheiro-Costa, João Viana Pinto, Sara Perestrelo, João Nuno Beato, Luís Torrão, Elisete Brandão, Ângela Carneiro, Maria Dulce Madeira, Fernando Falcão-Reis

“…Patients with KC followed in Corneal Department of Centro Hospitalar São João, Porto, Portugal, were identified and consecutively included between December 2017 and February 2018. A spectral-domain optical coherence tomography (OCT) using depth enhanced imaging was performed, and choroidal thickness in the center of the fovea and at 500 μm intervals along a horizontal section was measured and compared. …”
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Specifics of Foreign Assistance Allocation under the Trump Administration: From Inauguration to ‘Ukrainegate’ by V. I. Bartenev

“…Foreign assistance has become the domain where these two dimensions overlapped generating a cumulative effect of an extreme scale manifested by the Ukrainegate and its aftermath.…”
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Predicting Solar Energetic Particle Events with Time Series Shapelets by Omar Bahri, Peiyu Li, Soukaïna Filali Boubrahimi, Shah Muhammad Hamdi

“…Our objective is to mitigate the interpretability challenges inherent to most machine learning models and to show that other methods exist that can not only yield accurate forecasts but also facilitate exploration and insight generation within the data domain. For this purpose, we construct a multivariate time series data set consisting of proton flux data recorded by the National Oceanic and Atmospheric Administration's geosynchronous orbit Earth-observing satellite. …”
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Enhanced Immunogenicity and Affinity with A35R-Fc-Based Chimeric Protein Compared to MPXV A35R Protein by Shimeng Bai, Yanxin Cui, Qibin Liao, Hongyang Yi, Zhonghui Liao, Gengwei Zhang, Fenfang Wu, Hongzhou Lu

“…These results support the potential of Fc domain chimeric antigens as a strategy to enhance the efficacy of subunit vaccines targeting the MPXV.…”
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Transcriptomic Analysis of Pathogenicity Genes in Sclerotinia sclerotiorum Affecting Brassica napus by Hengameh Taheri, Mohamad Hamed Ghodoum Parizipour

“…Protein-protein interaction network was drawn and several hub genes were determined and ranked according to the CytoHubba tool among which the genes encoding nitrate reductase, beta-glucosidase, glucanase, PA14 domain-containing protein, carbohydrate-binding module family 1, and acyl-coenzyme A oxidase were found to be associated with the SSR induction. …”
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Cell-free expression and SMA copolymer encapsulation of a functional receptor tyrosine kinase disease variant, FGFR3-TACC3 by Alexander J. D. Snow, Tharushi Wijesiriwardena, Benjamin J. Lane, Brendan Farrell, Polly C. Dowdle, Matilda Katan, Stephen P. Muench, Alexander L. Breeze

“…Functionally, the protein demonstrated significant kinase domain phosphorylation (t < 0.0001). Currently, there is no published, high-resolution structure of any full-length RTK. …”
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Evaluation of Retinal Changes in Women with Different Phenotypes of Polycystic Ovary Syndrome by Fatma Sumer, Beril Gurlek, Elif Yildiz, Feyzahan Uzun, Sabri Colak, Ilknur Merve Ayazoglu

“…All participants underwent comprehensive ophthalmologic examinations, and RNFL thickness, macular thickness (MT), and choroidal thickness (CT) in each eye were measured via spectral-domain optical coherence tomography. The body mass index (BMI) of the patients was recorded and compared with the retinal changes. …”
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Computational analysis of congenital heart disease associated SNPs: unveiling their impact on the gene regulatory system by Shikha Vashisht, Costantino Parisi, Cecilia L. Winata

“…Concurrently, coding CHD-SNPs were represented as a protein interaction network and its subsequent binding energy analysis focused on a pair of proteins within this network, pinpointed a deleterious coding CHD-SNP, rs770030288, located in C2 domain of MYBPC3 protein. Overall, our findings demonstrate that SNPs have the potential to disrupt gene regulatory systems, either by affecting enhancer sequences or modulating protein-protein interactions, which can lead to abnormal developmental processes contributing to CHD pathogenesis.…”
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The Estimates of Retinal Ganglion Cell Counts Performed Better than Isolated Structure and Functional Tests for Glaucoma Diagnosis by Bruno L. B. Esporcatte, Andrea C. Kara-José, Luiz Alberto S. Melo, Luciano M. Pinto, Ivan M. Tavares

“…To evaluate the diagnostic accuracy of retinal ganglion cell (RGC) counts as estimated by combining data from standard automated perimetry (SAP) and spectral domain optical coherence tomography (SD-OCT). Methods. …”
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Novel Speech-Based Emotion Climate Recognition in Peers&#x2019; Conversations Incorporating Affect Dynamics and Temporal Convolutional Neural Networks by Ghada Alhussein, Mohanad Alkhodari, Ahsan H. Khandoker, Leontios J. Hadjileontiadis

“…Peers&#x2019; conversation provides a domain of rich emotional information. The latter, apart from facial and gestural expressions, it is also naturally conveyed via peers&#x2019; speech, contributing to the establishment of a dynamic emotion climate (EC) during their conversational interaction. …”
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Time-Varying Total Stiffness Matrix of a Rigid Machine Spindle-Angular Contact Ball Bearings Assembly: Theory and Analytical/Experimental Verifications by Fawzi M.A. El-Saeidy

“…For a machine spindle-ACBBs assembly under mass unbalnce and a horizontal force at the spindle cutting nose when the bearing time-varying stiffness matrix (bearing cage rotation is considered) is used, the peak-to-valley variation in time domain of the stiffness matrix elements becomes significant compared to its counterpart when the bearing standard stiffness matrix (bearing cage rotation is neglected) is used. …”
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Mechanical Properties of Bump-Prone Coal with Different Porosities and Its Acoustic Emission-Charge Induction Characteristics under Uniaxial Compression by Xin Ding, Xiaochun Xiao, Xiangfeng Lv, Di Wu, Jun Xu

“…The frequency of AE waveform is dominated in three bands (1∼50 kHz, 100∼150 kHz, and 175∼200 kHz) and that of charge induction had one frequency band 1∼100 Hz, and the amplitudes of time domain and main frequency components increased with stress improved. …”
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Hierarchical graph-based integration network for propaganda detection in textual news articles on social media by Pir Noman Ahmad, Jiequn Guo, Nagwa M. AboElenein, Qazi Mazhar ul Haq, Sadique Ahmad, Abeer D. Algarni, Abdelhamied A. Ateya

“…In this study, we propose a Hierarchical Graph-based Integration Network (H-GIN) designed for detecting propaganda in text within a defined domain using multilabel classification. H-GIN is extracted to build a bi-layer graph inter-intra-channel, such as Residual-driven Enhancement and Processing (RDEP) and Attention-driven Multichannel feature Fusing (ADMF) with suitable labels at two distinct classification levels. …”
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Coordinated frequency modulation strategy considering source–load uncertainty by Xiaohong Dong, Shuo Wang, Dengxin Ai, Yang Ma, Xiaodan Yu

“…The adjustable capacity of WTGs is determined based on the wind speed prediction error and the operation strategy of load reduction; Secondly, based on the controllable domain model of an EV considering the off-grid time uncertainty, the adjustable capacity of EV clusters is determined by state grouping of the state of charge (SOC) according to its charging urgency. …”
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INFLUENCE OF INTEGRATED FINANCIAL MANAGEMENT INFORMATION SYSTEM (IFMIS) ON THE PERFORMANCE OF GOVERNMENT ENTITIES IN NIGERIA by Salaudeen Ibrahim, Abdul-Hakeem Shuaib, Muhammed Basiru Mustapha, Benuh Adama Idris, Tunde Saka Abdulsalam

“…Despite the formidable regulatory and institutional frameworks put in place to strengthen public sector finance management in Nigeria, the domain continues to struggle with huge financial management infractions that are not in tune with the norms as well as international best practices thereby resulting to performance failure. …”
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Epsin3 promotes non-small cell lung cancer progression via modulating EGFR stability by Huiling Su, Jie Shen, Chenzi Gao, Yue Zhao, Wanyu Deng, Bo Qin, Xin Zhang, Juan Lai, Qian Wang, Jie Dou, Min Guo

“…Notably, mutations in the EGFR tyrosine kinase domain, which typically confer resistance to TKIs, did not alter the regulatory effect of EPN3. …”
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