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5081
A temporal knowledge graph reasoning model based on recurrent encoding and contrastive learning
Published 2025-01-01“…Temporal knowledge graphs (TKGs) are critical tools for capturing the dynamic nature of facts that evolve over time, making them highly valuable in a broad spectrum of intelligent applications. In the domain of temporal knowledge graph extrapolation reasoning, the prediction of future occurrences is of great significance and presents considerable obstacles. …”
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5082
Highly Expressing SCARA5 Promotes Proliferation and Migration of Esophageal Squamous Cell Carcinoma
Published 2022-01-01“…Thrombospondin type 1 domain-containing 7A (THSD7A) was reported to play a procancer role in esophageal squamous cell carcinoma (ESCC). …”
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5083
HVSR Analysis of Rockslide Seismic Signals to Assess the Subsoil Conditions and the Site Seismic Response
Published 2018-01-01“…This can be related to the indirect effect of temperature on rock mass conditions and further extensive studies (also in the time frequency domain) are required to better comprehend this dependency. …”
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5084
Improved Continuous Wavelet Transform for Modal Parameter Identification of Long-Span Bridges
Published 2020-01-01“…Wavelet analysis is one of the most advantageous methods for identification because of its good localization characteristics in both time and frequency domain. In recent years, the wavelet method has been applied more frequently in parameter identification of linear and nonlinear systems. …”
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5085
ML-AMPSIT: Machine Learning-based Automated Multi-method Parameter Sensitivity and Importance analysis Tool
Published 2025-01-01“…Through a detailed case study with the Weather Research and Forecasting (WRF) model coupled with the Noah-MP land surface model, ML-AMPSIT is demonstrated to efficiently predict the effects of varying the values of Noah-MP model parameters with a relatively small number of model runs by simulating a sea breeze circulation over an idealised flat domain. This paper points out how ML-AMPSIT can be an efficient tool for performing sensitivity and importance analysis for complex models, guiding the user through the different steps and allowing for a simplification and automatisation of the process.…”
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5086
Urban Dealing with Pandemic: Comparative Responses on Spanish Flu and the Covid-19 Era in Indonesia
Published 2022-06-01“…The action taken by the government in tackling the Spanish flu and Covid-19 pandemic in Indonesia is to issue regulations to reduce activities in the public domain. This regulation has proven successful in reducing the spread of the Spanish flu pandemic in the past and Covid-19 in the present. …”
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5087
CD22 modulation alleviates amyloid β-induced neuroinflammation
Published 2025-02-01“…Moreover, sCD22 activated microglia via sialic acid binding domain and 2,6 linked sialic acid glycan on sCD22. …”
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5088
The Film-Forming Characterization and Structural Analysis of Pectin from Sunflower Heads
Published 2021-01-01“…Due to the high content of the HG domain, low DM and high molecular weights, AHP had excellent gelling properties induced by Ca2+ and was added to improve the film-forming properties of HPMC and to develop plant hollow capsules.…”
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5089
Transcriptional Activity of PGC-1α and NT-PGC-1α Is Differentially Regulated by Twist-1 in Brown Fat Metabolism
Published 2012-01-01“…Thus, the absence of the corresponding C-terminal domain in NT-PGC-1α allows NT-PGC-1α to be free from Twist-1-mediated inhibition. …”
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5090
Some Novel Concepts of Bipolar Picture Fuzzy Influence Graphs Models With Application Toward MADM
Published 2025-01-01“…Following this, several characteristics of these terms in the domain of bipolar picture fuzzy influence graphs are explored. …”
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5091
Improved Insulin Resistance and Lipid Metabolism by Cinnamon Extract through Activation of Peroxisome Proliferator-Activated Receptors
Published 2008-01-01“…The transactivities of both full length and ligand-binding domain (LBD) of PPARγ and PPARα are activated by cinnamon as evidenced by reporter gene assays. …”
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5092
Retargeting Clostridium difficile Toxin B to Neuronal Cells as a Potential Vehicle for Cytosolic Delivery of Therapeutic Biomolecules to Treat Botulism
Published 2012-01-01“…For AGT-TcdB-BoNT/A-Hc, the receptor-binding domain (RBD) of TcdB was replaced by the equivalent RBD from BoNT/A (BoNT/A-Hc). …”
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5093
Replication-transcription complex of coronaviruses: functions of individual viral non-structural subunits, properties and architecture of their complexes
Published 2022-04-01“…This review will encompass current, modern studies on the properties and complexes of individual non-structural subunits of the RTC, the structures of individual coronavirus RTC subunits, domain organization and functions of subunits, protein-protein interactions, properties and architectures of subunit complexes, the effect of mutations, and the identif ication of mutations affecting the viability of the virus in cell culture.…”
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5094
Challenging Gender Norms: Male Physicians' Perspectives on Family Planning in Rural Islamabad
Published 2025-02-01“… Objective: To explore male physicians' perceptions of how family planning (FP) training, supportive supervision, and access to educational materials impact their knowledge, confidence, and ability to provide FP services in rural areas of Islamabad, Pakistan, where FP is traditionally considered a female domain. Methodology: This qualitative study involved 12 in-depth interviews with male family physicians practicing in rural communities of the Islamabad Capital Territory (ICT). …”
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5095
Solution Structures of PPARγ2/RXRα Complexes
Published 2012-01-01“…To understand how coactivators are recognized by the functional heterodimer PPARγ/RXRα and to determine the topological organization of the complexes, we performed a structural study using small angle X-ray scattering of PPARγ/RXRα in complex with DNA from regulated gene and the TIF2 receptor interacting domain (RID). The solution structures reveal an asymmetry of the overall structure due to the crucial role of the DNA in positioning the heterodimer and indicate asymmetrical binding of TIF2 to the heterodimer.…”
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5096
The Role of Big Data Analytics in Revolutionizing Diabetes Management and Healthcare Decision-Making
Published 2025-01-01“…The evolving healthcare domain necessitates an upgrade through digitization, integrating patient data, and advanced medical results. …”
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5097
Rotting Sounds . Artistic Research Practice in Experimental Sound Art
Published 2022-12-01“…The majority of today’s media is produced in the digital domain. Although digital data are adorned by a myth of perfection, everyday experience does provide evidence for the existence of degradation and, ultimately, data loss in various forms. …”
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5098
Effects of Delta-Like Noncanonical Notch Ligand 1 Expression of Human Fetal Liver Hepatoblasts on Hematopoietic Progenitors
Published 2019-01-01“…Hepatoblasts express delta-like noncanonical Notch ligand 1 (Dlk1), whose cleaved extracellular domain can become a soluble protein. We assessed the effects of DLK1 gene expression knockdown in cultures of total fetal liver cells. …”
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5099
Curcumin Relieves Chronic Unpredictable Mild Stress-Induced Depression-Like Behavior through the PGC-1α/FNDC5/BDNF Pathway
Published 2021-01-01“…Increasing evidence suggests that the peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α)/fibronectin type III domain-containing 5 (FNDC5)/brain-derived neurotrophic factor (BDNF) pathway might be critical for neuroprotection. …”
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5100
Hydrogen-Rich Saline Inhibits NLRP3 Inflammasome Activation and Attenuates Experimental Acute Pancreatitis in Mice
Published 2014-01-01“…Recent findings have indicated that the NOD-like receptor family, pyrin domain-containing 3 (NLRP3) inflammasome, an intracellular multiprotein complex required for the maturation of interleukin- (IL-) 1β, may probably be a potential target of HRS in the treatment of AP. …”
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