Analysis of Toll-Like Receptors in Human Milk: Detection of Membrane-Bound and Soluble Forms by Chiara Cattaneo, Alice Caramaschi, Elena Uga, Michela Braghin, Gianluca Cosi, Chiara Peila, Maria C. Strozzi, Miriam Sabatini, Diego Gazzolo, Marcello Manfredi, Maria Cavaletto

“…We demonstrated the presence of only TLR2 in the milk fat globule membrane, while the immunoreactivity of TLR1/4/6 was ascribed to crossreaction with some interesting milk proteins sharing leucine-rich repeat domains. These results will provide new insights into the definition of the role of TLRs in intestinal immune regulation of the newborns.…”
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Broad substrate scope C-C oxidation in cyclodipeptides catalysed by a flavin-dependent filament by Emmajay Sutherland, Christopher J. Harding, Tancrède du Monceau de Bergendal, Gordon J. Florence, Katrin Ackermann, Bela E. Bode, Silvia Synowsky, Ramasubramanian Sundaramoorthy, Clarissa Melo Czekster

“…Abstract Cyclic dipeptides are produced by organisms across all domains of life, with many exhibiting anticancer and antimicrobial properties. …”
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MFFTNet: A Novel 3D Point Cloud Segmentation Network Based on Multi-Scale Feature Fusion and Transformer Architecture by Hao Bai, Xiongwei Li, Qing Meng, Shulong Zhuo, Lili Yan

“…Precise segmentation of 3D point clouds is particularly important within these domains; however, it faces several challenges: <xref ref-type="disp-formula" rid="deqn1">(1)</xref> point cloud data inherently lacks structured topological information; <xref ref-type="disp-formula" rid="deqn2">(2)</xref> point cloud shapes are complex and highly variable, making it difficult to utilize semantic priors; and <xref ref-type="disp-formula" rid="deqn3-deqn6">(3)</xref> the sampling process of point clouds may result in sparse and uneven data. …”
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Predominant polarity in bipolar affective disorder and its impact on cognition and quality of life by Shashank Bhardwaj, Deoraj Sinha, Ami Pawar, Astik Mane

“…Manic predominate polarity performed better in the physical and psychological domains of the post hoc test for quality-of-life BREF scale. …”
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SumGPT: A Multimodal Framework for Radiology Report Summarization to Improve Clinical Performance by Tipu Sultan, Mohammad Abu Tareq Rony, Mohammad Shariful Islam, Samah Alshathri, Walid El-Shafai

“…In the future, this approach could pave the way for applications in other medical domains while further optimizing the model for real-time clinical use.…”
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Study on Change of Landscape Pattern Characteristics of Comprehensive Land Improvement Based on Optimal Spatial Scale by Baoping Feng, Hui Yang, Yarong Ren, Shanshan Zheng, Genxiang Feng, Yuwei Huang

“…The results showed that: (1) patch density, largest patch index, area-weighted average shape index, contagion, and division index all showed obvious scale effects, and the suitable first and second scale domains in the study area are 5–7 m and 35–40 m, respectively, and 5 m is the most suitable grain size for the study of landscape pattern change. (2) The block basis ratio of the semi-variogram of the six landscape level indices begins to stabilize at the window radius of 210 m. …”
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Implementation of global health competencies: A scoping review on target audiences, levels, and pedagogy and assessment strategies. by Meike Schleiff, Bhakti Hansoti, Anike Akridge, Caroline Dolive, David Hausner, Anna Kalbarczyk, George Pariyo, Thomas C Quinn, Sharon Rudy, Sara Bennett

“…Substantial effort has gone towards defining competency domains for public health professionals working globally. …”
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Fold-Related Faults Track Progressive Fold Development from Layer-Parallel Shortening to Subsequent Orthogonal Extension within an Appalachian Buckle Fold System: Bear Valley Mine,... by Arlo Brandon Weil, Mary Beth Gray, Kylie G. Cush, Mattathias D. Needle, Juliet G. Crider

“…Although the fault-related extensional linear strain magnitudes are relatively small, LPE faults are present in all fold dip domains, in two contrasting lithologies, and on adjacent open and tight folds, highlighting the importance of minor faulting and LPE strains in the formation of contractional buckle folds in the shallow crust. …”
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Modulation of Cognition: The Role of Gnidia glauca on Spatial Learning and Memory Retention in High-Fat Diet-Induced Obese Rats by Wycliffe Makori Arika, Cromwell Mwiti Kibiti, Joan Murugi Njagi, Mathew Piero Ngugi

“…Learning, memory performance, and executive function are the main domains affected by an obesogenic diet. There are limited effective therapies for addressing cognitive deficits. …”
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Analyse des besoins langagiers des étudiants de français sur objectifs spécifiques à l’Université de Kabale. by Ayebare, Boniface Martial

“…Ces derniers étaient composés de trois ingénieurs et deux acteurs dans le domaine du tourisme. La littérature relative à l’analyse de besoins et au FOS a été étudiée. …”
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Numerical Simulations of the Lunar Penetrating Radar and Investigations of the Geological Structures of the Lunar Regolith Layer at the Chang’E 3 Landing Site by Chunyu Ding, Yan Su, Shuguo Xing, Shun Dai, Yuan Xiao, Jianqing Feng, Danqing Liu, Chunlai Li

“…In this paper, the random medium theory and Apollo drilling core data are used to construct a modeling method based on discrete heterogeneous random media, and the simulation data are processed and collected by the electromagnetic numerical method FDTD (finite-difference time domain). When comparing the LPR data with the simulated data, the heterogeneous random medium model is more consistent with the actual distribution of the media in the lunar regolith layer. …”
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The Impact of the Coexpression of MET and ESR Genes on Prognosticators and Clinical Outcomes of Breast Cancer: An Analysis for the METABRIC Dataset by Nehad M. Ayoub, Ghaith M. Al-Taani, Amer E. Alkhalifa, Dalia R. Ibrahim, Aymen Shatnawi

“…The METABRIC dataset for breast cancer was obtained from the cBioPortal public domain. Gene expression data for MET, ESR1, and ESR2, as well as the putative copy number alterations (CNAs) for MET were retrieved. …”
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Numerical parametric study of a Kaplan turbine incorporated with a sub runner considering analysis of hydraulic dissipation by Amirhossein Khoddami, Mojtaba Tahani, Fathollah Pourfayaz, Alireza Riasi, Khalil Allah Sajadian

“…For this purpose, it is aimed to extract its underlying passive control logic through investigating the hydrodynamic behavior and flow characteristics within the overall turbine domain numerically, so that the safe and allowable region of the turbine operation is determined. …”
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Multisite Kinetic Modeling of 13C Metabolic MR Using [1-13C]Pyruvate by Pedro A. Gómez Damián, Jonathan I. Sperl, Martin A. Janich, Oleksandr Khegai, Florian Wiesinger, Steffen J. Glaser, Axel Haase, Markus Schwaiger, Rolf F. Schulte, Marion I. Menzel

“…Kinetic modeling parameters were determined by fitting the multisite model to time-domain dynamic metabolite data. The results for different pyruvate doses were compared with those of different two-site models to evaluate the hypothesis that for identical data the uncertainty of a model and the signal-to-noise ratio determine the sensitivity in detecting small physiological differences in the target metabolism. …”
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CLN-978, a novel half-life extended CD19/CD3/HSA-specific T cell-engaging antibody construct with potent activity against B-cell malignancies with low CD19 expression by Agapitos Patakas, Bochong Li, Naveen K Mehta, Kristan Meetze, Patrick A Baeuerle, Jennifer S Michaelson, Hannah M Findlay, Timothy B London

“…A serum albumin binding domain was incorporated to extend serum half-life. …”
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Numerical investigation on structure optimization and heat transfer of a phase change accumulator based on changing eccentricity and fin parameters by Shi Yiting, Zhang Liting, Yang Yongwen, Zhang Tao, Li Qifen

“…In contrast, the cost of heat storage is only one-tenth of that of electricity storage, which endows heat storage with more promising application prospects. Within the domain of heat storage, phase change heat storage has emerged as a prominent research focus due to its unique advantages such as high heat storage density, compact volume, and convenient control and matching capabilities. …”
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Age-Related Physiologic Thinning Rate of the Retinal Nerve Fiber Layer in Different Levels of Myopia by Daun Jeong, Kyung Rim Sung, Youn Hye Jo, Sung-cheol Yun

“…This study analyzed 223 eyes of 141 healthy subjects followed for more than 5 years and underwent at least five serial spectral domain optical coherence tomography (SD-OCT) examinations. …”
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Dynamic Reliability Design of Multicomponent Structure with Improved Weighted Regression Distributed Collaborative Surrogate Model Method by Xiao-Wei Dong, Wei-Kai Li, Chun-Yan Zhu, Chang-Hai Chen, Cheng Lu, Shu-Juan Yi

“…Finally, the radial deformation dynamic probabilistic analysis of an aeroengine turbine blisk assembled by blade and disk is accomplished, in respect of the IWRDCSMM, fluid-thermal-structure interaction, and the randomness of input parameters within the time domain [0, T]. The results illustrate that the reliability degree of turbine blisk radial deformation is 0.9951 when the allowable value uallow is 2.30 × 10−3 m, and all the input parameters affecting the turbine blisk radial deformation are gas temperature, angular speed, inlet velocity, outlet pressure, material density, and inlet pressure, successively. …”
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Serum levels of the Parkinson's disease-linked protein Parkin are specifically elevated in COVID-19 by Nadezhda G. Gumanova, Natalya L. Bogdanova, Alexander Yu. Gorshkov

“…Methods: COVID-19 infection was confirmed by the detection of immunoglobulin G (IgG)-SARS antibodies against SARS-CoV-2 S1 protein receptor-binding domain in serum samples collected in 2019–2021. IgG antibodies to adenovirus (IgG-AdV) were analyzed in serum samples collected in 2016–2018 prior the onset of the COVID-19 pandemic. …”
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Gene Structures, Classification, and Expression Models of the DREB Transcription Factor Subfamily in Populus trichocarpa by Yunlin Chen, Jingli Yang, Zhanchao Wang, Haizhen Zhang, Xuliang Mao, Chenghao Li

“…We analyzed gene structures, phylogenies, domain duplications, genome localizations, and expression profiles. …”
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