The key role of the NUDT3 gene in lung adenocarcinoma progression and its association with the manganese ion metabolism family by Deyong Ge, Xinyu Xu, Liyi Fang, Huihui Tao

“…Results NUDT3 was found to be significantly upregulated in lung adenocarcinoma and highly correlated with tumor mutation burden (TMB) and mutation enrichment (MEs). Single-cell transcriptomic analyses demonstrated elevated NUDT3 expression in lung adenocarcinoma epithelial cells, with expression levels increasing in cells associated with advanced tumor stages. …”
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Joint association of systemic immune-inflammation index and phenotypic age acceleration with chronic respiratory disease: a cross-sectional study by Yuan Zhan, Ruonan Yang, Jie Feng, Genlong Bai, Xiangyun Shi, Jiaheng Zhang, Jingbo Zhang

“…Abstract Background Chronic respiratory diseases (CRD) represents a series of lung disorders and is posing a global health burden. Systemic inflammation and phenotypic ageing have been respectively reported to associate with certain CRD. …”
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Association between gestational weight gain and adverse pregnancy outcomes: cohort analysis from South Asia and Sub-Saharan Africa by Anisur Rahman, Fyezah Jehan, Gary M Shaw, Sunil Sazawal, Salahuddin Ahmed, Abdullah H Baqui, David K Stevenson, Monjur Rahman, Jesmin Pervin, Shaki Aktar, Rasheda Khanam, Sayedur Rahman, Nitya Wadhwa, Ge Zhang, Huan Xu, Usma Mehmood, Shinjini Bhatnagar, Jeffrey S A Stringer, Bellington Vwalika, Waqasuddin Khan, Nabidul Haque Chowdhury, Imran Nisar, Javairia Khalid, Nima Aghaeepour, U Tin Nu, Yuri V Sebastião, Ramachandran Thiruvengadam, Ayushi, Bapu Koundinya Desiraju, Fatma Kabole, Muhammad Farrukh Qazi, Margaret Kasaro, Bihila Abdalla Bakari

“…Introduction Studies of gestational weight gain (GWG) and adverse pregnancy outcomes seldom focus on low-to-middle-income countries (LMICs), despite their high burden of morbidity and mortality. We examined GWG patterns and adverse pregnancy outcomes in a consortium of pregnancy cohorts from LMICs.Methods We analysed data from five observational pregnancy cohorts in Bangladesh (two cohorts), India, Pakistan and Zambia. …”
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Identification of CD8+ T Cell-Related Genes: Correlations with Immune Phenotypes and Outcomes of Liver Cancer by Qi Pan, Ying Cheng, Donghua Cheng

“…We obtained single nucleotide polymorphism (SNP) data to evaluate the tumor mutation burden. The “estimate” package and the CIBERSORT algorithm were used to evaluate tumor purity and the proportion of CD8+ T lymphocytes in the liver cancer cohort. …”
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Predominant polarity in bipolar affective disorder and its impact on cognition and quality of life by Shashank Bhardwaj, Deoraj Sinha, Ami Pawar, Astik Mane

“…The outcome of female bipolar patients may be improved if the clinician is mindful of the burden of depression, risk of misdiagnosis, and variable therapy response. …”
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Upper Quarter Injury Rates and Risk in United States High School Athletes Prior To and During the Prolonged Sport Stoppage by Garrett Bullock, Charles Thigpen, Albert Prats-Uribe, R. Gill Gilliand, Ellen Shanley

“…The COVID-19 pandemic has created an opportunity to evaluate the potential added burden abrupt and prolonged sport stoppage had on upper quarter injury risk…”
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Prevalence of soil-transmitted helminths infection and associated risk factors among residents of Jigjiga town, Somali region, Eastern Ethiopia. by Abdlmenur Alewi Sedo, Ahmed Zeynudin, Tariku Belay, Mekdes Mekonen Belay, Ahmed Mohammed Ibrahim, Mohamed Omar Osman, Ramadan Budul Yusuf, Abdifatah Abdulahi

“…Health education on handwashing, regular deworming, improved access to clean water and sanitation facilities to reduce the burden of STH effectively.…”
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Risk of hemorrhagic fever with renal syndrome associated with meteorological factors in diverse epidemic regions: a nationwide longitudinal study in China by Nan Chang, Wenzhong Huang, Yanlin Niu, Zhihu Xu, Yuan Gao, Tingting Ye, Zihao Wang, Xiaohui Wei, Yuming Guo, Qiyong Liu

“…Targeted preventive measures should be taken during cold and dry spring days in Rattus-dominant regions, and during warm and moderately humid winter days in Apodemus-dominant regions. …”
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Assessment of hand hygiene practices among nurses at a regional hospital in Kandahar, Afghanistan: A cross-sectional study based on the World Health Organization (WHO) ‘Your 5 Mome... by Abdul Qadeer Baseer, Asmatullah Usmani, Shafiqullah Mushfiq, Mohammad Hassan Hassand, Bilal Ahmad Rahimi, Abdul Wahid Monib, Mohammad Salim Daqiq, Parwiz Niazi

“…Conclusion: While overall compliance was relatively high, significant gaps persist, particularly among younger, less educated, and male nurses, as well as those in high-burden wards. Enhanced training programs, tailored strategies, and regular audits are essential for improving hand hygiene practices and strengthening infection prevention and control efforts, ultimately enhancing patient safety in resource-limited settings. …”
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Estimating the Health-Related Quality of Life Benefit of Prophylactic Treatment for COVID-19 in Immunocompromised People: A Multimethod Valuation Study by Katy Gallop, Rebekah Hall, Michael Watt, Daniel Squirrell, Neil Branscombe, Sofie Arnetop, Andrew Lloyd

“…**Conclusion:** This study quantified the expected health state utility benefit of reduced psychosocial burden and behavioral restriction. PrEP would potentially result in a utility gain between 0.082 and 0.326, dependent on valuation approach and expected change in behavioral restrictions, leading to improvements in daily activities and emotional well-being.…”
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Prognostic Value of Endothelial Progenitor Cells in Acute Myocardial Infarction Patients by Gongjie Ye, Xiaodan Chen, Yinchao Zhou, Jianqing Zhou, Yongfei Song, Xiaoyong Yang, Lei Yang

“…Among these patients, 23 (25.3%) died from various causes during the follow-up period. The counts of EPCs were found to be significantly higher in the survival group compared to the death group (P<0.05). …”
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Clinical and Economic Outcomes in Low-risk Pulmonary Embolism Patients Treated with Rivaroxaban versus Standard of Care by W. Frank Peacock, Craig I. Coleman, Phil Wells, Gregory J. Fermann, Li Wang, Onur Baser, Jeff Schein, Concetta Crivera

“…# Study Design Adult patients with continuous health plan enrollment for ≥12 months pre- and 3 months post-inpatient PE diagnosis (index date=discharge date) between October 1, 2011- June 30, 2015 and an anticoagulant claim during the index hospitalization were included…”
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Confronting needlestick and sharp injuries in healthcare: a decade of struggle and progress in a university teaching hospital by Shuk-Ching Wong, Lithia Lai-Ha Yuen, Germaine Kit-Ming Lam, Monica Oi-Tung Kwok, Crystal Yuen-Ki Siu, Bella Hong-Yan Li, Jonathan Hon-Kwan Chen, Simon Yung-Chun So, Kelvin Hei-Yeung Chiu, Vincent Chi-Chung Cheng

“…This study analyzes the incidence and characteristics of NSIs at Queen Mary Hospital and assesses the effectiveness of targeted training programs for interns. …”
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Partial Replacement of Cement with Ceramic Waste Powder in the Stabilization of Laterite Soils for Interlocking Earth Blocks. by Iteba, Maurice Victor

“…This brick eliminates the kiln firing stage in its production, the stage with the highest environmental burden. Not only because of emission of air pollutants, which increase the greenhouse effect, but also because of the consumption of non-renewable resources in the production of the intensive amounts of energy necessary for the process. …”
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Utilizing A Multi-Stage Transition Model for Analysing Child Stunting in Two Urban Slum Settlements of Nairobi: A Longitudinal Analysis, 2011-2014. by Oduro, Michael S., IddiI, Samuel, Asiedu, Louis, Asiki, Gershim, Kadengye, DamazoT.

“…Conclusion These findings reveal a high burden of stunting and transitions in urban slums. …”
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Prevalence of and Risk factors associated with hypertension: a community based- cross sectional study in Ndorwa West Health Sub District, Kabale district, southwestern Uganda. by Munezero,Tamu John Bosco, Mfitumukiza, Valence, Okafor, Christiana Nkiru, Mandera, Immaculate, Kabami, Jane, Arineitwe, Edward Bwengye, Namuyibwa, Lydia, Izo, Herbert, Baikaitwoha, Everd M., Okonkwo, Uchenna Prosper

“…Hence, the considerable risk and burden of HT and related CVDs that require a dire need to adopt strategies to prevent and control hypertension based on the identified associated risk factors in Ndorwa HSD…”
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Adherence to First-Line Intravesical Bacillus Calmette-Guérin Therapy in the Context of Guideline Recommendations for US Patients With High-Risk Non-muscle Invasive Bladder Cancer by Franklin D. Gaylis, Bruno Emond, Ameur M. Manceur, Anabelle Tardif-Samson, Laura Morrison, Dominic Pilon, Patrick Lefebvre, Lorie A. Ellis, Hiremagalur Balaji, Andrea Ireland

“…**Background:** Bacillus Calmette-Guérin (BCG) can reduce recurrence and delay progression among patients with high-risk non–muscle invasive bladder cancer (NMIBC), but is associated with a substantial emotional, physical, and social burden. **Objectives:** This study evaluated the adequacy of first-line intravesical BCG treatment among high-risk NMIBC patients in the United States, including the subgroup with carcinoma in situ (CIS) of the bladder. …”
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Chronic Myeloid Leukemia: Part II—Cost of Care Among Patients in Advanced Phases or Later Lines of Therapy in Chronic Phase in the United States from a Commercial Perspective by Ehab L. Atallah, Rodrigo Maegawa, Dominick Latremouille-Viau, Carmine Rossi, Annie Guérin

“…**Methods:** Adult CML patients from administrative claims data (January 1, 2000–June 30, 2019) were classified by health state: on third-line (CML-CP On Treatment), on fourth or later lines (CML-CP Post-Discontinuation), or progressed to AP/BC (CML-AP/BC). …”
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Predictors of specialist care referrals (SCR) following emergency department review or hospital admission in adults with previous acute COVID-19: a prospective UK cohort study by Anita Saigal, Songyuan Xiao, Owais Siddique, Prasheena Naran, Heba M Bintalib, Camila Nagoda Niklewicz, George Seligmann, Sindhu Bhaarrati Naidu, Amar J Shah, Chibueze Ogbonnaya, John R Hurst, Marc Ci Lipman, Swapna Mandal

“…Conclusions We demonstrate greater specialist care referrals to mental health and physiotherapy services in patients attending the ED and discharged with acute COVID-19, compared to those admitted, despite lower ongoing COVID-19 symptom burden. Total number of symptoms, pre-existing co-morbidity such as smoking status, cardiac co-morbidities, and mental health illnesses may predict those requiring healthcare input. …”
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Implementing a Care Model for Bedridden Stroke Survivors: A Qualitative Study in Northeastern Thailand by Panpanit L, Jongudomkarn D, Doungmungkorn A, Boontoch K, Neelasmith S, Manorat M, Maneerat T

“…Data collection involved focus group discussions, in-depth interviews, and participant observations, with content analysis used for data interpretation.Results: Key themes emerged: SSs experienced “Feeling Isolation & Powerlessness” and “Hopelessness & Being Burden to Family”, FCGs expressed “Sorrow & Gratitude”, and CVCGs identified “Inadequate Capacity & Need for Training”. …”
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