Proteasome inhibition enhances oncolytic reovirus therapy in multiple myeloma independently of its direct cytotoxic effects by Ada Alice Dona, Theophilus Tandoh, Lokesh Nigam, Mahmoud Singer, Enrico Caserta, Mariam Murtadha, Yinghui Zhu, Milad Moloudizargari, Preeti Sharma, Ottavio Napolitano, Janet Winchester, Arnab Chowdhury, Alex Pozhitkov, James F. Sanchez, Hawa Vahed, Guido Marcucci, Matt Coffey, Gerard Nuovo, Douglas W. Sborov, Flavia Pichiorri, Craig C Hofmeister

“…To validate the importance of PIs in enhancing oncolytic viral therapy independently of their killing activity on cancer cells, we then conducted a phase 1b trial of the reovirus Pelareorep together with the PI carfilzomib in 13 heavily pretreated PI-resistant MM patients. …”
Get full text

ATP-Binding Pocket-Targeted Suppression of Src and Syk by Luteolin Contributes to Its Anti-Inflammatory Action by Jeong-Oog Lee, Deok Jeong, Mi-Yeon Kim, Jae Youl Cho

“…Luteolin dose-dependently inhibited the secretion of nitric oxide (NO) and prostaglandin E2 (PGE2) and diminished the levels of mRNA transcripts of inducible NO synthase (iNOS), tumor necrosis factor- (TNF-) α, and cyclooxygenase-2 (COX-2) in lipopolysaccharide- (LPS-) and pam3CSK-treated macrophage-like RAW264.7 cells without displaying cytotoxicity. …”
Get full text

Ingested house dust mite favors sensitization to egg white in mice independently of its proteinase activity by Sara Benedé, Leticia Pérez-Rodríguez, David Menchén-Martínez, Elena Molina, Rosina López-Fandiño

Subjects: Get full text

A Method for Rapidly Determining the Seismic Performance of Buildings Based on Remote-Sensing Imagery and Its Application by Sihan Yu, Xiaofeng Xie, Peng Du, Xiaoqing Wang, Shun Yang, Chao Liu

“…Examination based on the field survey data collected from at least one sample site in each village and township in all 22 county-level divisions (CLDs) of Ningxia showed an average SP accuracy of 76% for all 22 CLDs and an SP accuracy exceeding 70% for 20 (91%) of the 22 CLDs. …”
Get full text

Effects of Apatinib on the “Stemness” of Non-Small-Cell Lung Cancer Cells In Vivo and Its Related Mechanisms by Bin Yang, Yan Wang, Zhuoying Chen, Yi-Ming Feng, Liang-Liang Shi

“…Tumor tissues were harvested after 2 weeks, and mRNA was extracted to detect changes in stemness-related genes (CD133, EPCAM, CD13, CD90, ALDH1, CD44, CD45, SOX2, NANOG, and OCT4) and Wnt/β-catenin, Hedgehog, and Hippo signal pathways. …”
Get full text

Exploring the role of spiritual leadership among nurse colleagues: an associative analysis of its impact on passion and altruism by Huda Gaber Hamzaa, Mohamed Hussein Ramadan Atta, Heba Mostafa Ali Taha, Mervat Amin Sayed, Asmaa Kamal Ahmed, Ahmed Abdellah Othman, Nadia Mohamed Ibrahim Wahba

“…Results The current study verified that nurse colleagues had high levels of perceived spiritual leadership, passion, and altruism (50.9, 47.6, and 40.2, respectively). The results revealed noteworthy positive correlations between spiritual leadership, passion, and altruism (r = 0.644, 0.519, & 0.509). …”
Get full text

Characterization of PCL and Chitosan Nanoparticles as Carriers of Enoxaparin and Its Antithrombotic Effect in Animal Models of Venous Thrombosis by Lucas Bessa Prado, Stephany Cares Huber, Aline Barnabé, Fernanda Dutra Santiago Bassora, Devanira Souza Paixão, Nelson Duran, Joyce Maria Annichino-Bizzacchi

“…In conclusion, the double emulsion method w/o/w was efficient for enoxaparin encapsulation, producing spherical nanoparticles with high encapsulation efficiency. …”
Get full text

Influence of Aggregate and Asphalt Type on the Bond Strength between Asphalt and Aggregates and Its Self-Healing Properties by Xinli Gan, Wenli Zhang, Jie Li, Hui Tang, Peiyuan Zhong

“…Determining the bond strength between asphalt and the aggregate base material is an intuitive way to ascertain the adhesion. In this study, we determined the bond strength between different types of asphalt and aggregates. …”
Get full text

A U-Net-based denoising method for semi-airborne transient electromagnetic data and its application by Dong LIU, Hao FENG, Yongxin WANG, Xiaosheng ZHOU, Yuhong YAO, Huaifeng SUN

Subjects: Get full text

Case report: Tongue metastasis as an initial sign of clear cell renal cell carcinoma and its prognosis by Shuo Liu, Hongyun Liu, Bowen Weng, Sichuan Hou

“…Immunohistochemistry showed positivity for vimentin, CD10, PAX-8, and epithelial membrane antigen (EMA), but negativity for PAX-2, calponin, S-100 protein, periodic acid-Schiff with diastase (PAS-D), P63, P40, and CK7, confirming the diagnosis of ccRCC metastasis to the tongue. …”
Get full text

Flow Mediated Dilation and Its Correlation with Coronary and Systemic Atherosclerosis in Patients Scheduled for Surgical Myocardial Revascularization by Boieriu AM, Luca CD, Tint D

Subjects: Get full text

Neuro-linguistic Programming and Its Relationship with Psychological Flexibility Among Secondary School Students in Najran Region by Ahmed Mohamed Bani Ismail, Faisal Jaber Al-Ajmi

“…The NLP scale by Abu-Ruman [1] and the PF scale by Singh and Nan yu [2] were utilized after ensuring their validity and reliability. …”
Get full text

Provincial Climate Action Index and Its Use for Assessing Dual Carbon Policy of 31 Provinces in China by Jing Xu, Fengqiao Mei, Chuntian Lu, Bin Zhang, Min Wang

“…We calculate the index scores of 31 Chinese provinces and identify 3 clusters: leaders, followers, and laggards in dual carbon policy, demonstrating both differences and similarities in provincial‐level actions to achieve climate goals. …”
Get full text

Resveratrol and its derivates improve inflammatory bowel disease by targeting gut microbiota and inflammatory signaling pathways by Ming Li, Ping Li, Rongxue Tang, Hui Lu

Subjects: Get full text

Development and Validation of UPLC-MS/MS Method for Determination of Enasidenib in Rat Plasma and Its Pharmacokinetic Application by Shuang-long Li, Yong-liang Zhu, Yi Zhang, Shu-han Liu, Xiang-die Wang, Xiang-jun Qiu

“…Besides, the values of intraday and interday precision were 2.25–8.40% and 3.94–5.46%, respectively, and the range of the accuracy values varied from −1.44 to 2.34%. …”
Get full text

Environmental behavior of per- and polyfluoroalkyl substances (PFASs) and the potential role of biochar for its remediation: a review by Haiyan Wang, Haiyan Zhang, Lizhi He, Jie Wang, Shuo Wang, Xiaoyu Shi, Xiaokai Zhang, Hailong Wang, Feng He

“…Furthermore, this review discusses the ability of biochar to reduce the likelihood of PFASs entering the food chain through water and soil and evaluates the feasibility and limitations of using biochar for PFASs removal. Finally, we identify future research directions to support the safe and effective use of biochar for PFASs remediation, so as to promote the advancement of green remediation technologies. …”
Get full text

Expression of CSTF2 in oral squamous cell carcinoma and its relationship with immune infiltration and poor prognosis by Zumulaiti Aierken, Muertiza Muhetaer, Zhang Lei, Ainiwaerjiang Abudourousuli, Ainiwaerjiang Abudourousuli

Subjects: Get full text

Anxiety due to Dental Treatment and Procedures among University Students and Its Correlation with Their Gender and Field of Study by Mohd G. Sghaireen, Abdalwhab M. A. Zwiri, Ibrahim A. Alzoubi, Sadeq M. Qodceih, Mahmoud K. AL-Omiri

“…Patients were considered to suffer from high dental anxiety if they scored 13 to 20 points. Statistical analysis significance was set at P≤0.05. …”
Get full text

Gray-Related Support Vector Machine Optimization Strategy and Its Implementation in Forecasting Photovoltaic Output Power by Bo Xiao, Hai Zhu, Sujun Zhang, Zi OuYang, Tandong Wang, Saeed Sarvazizi

“…The results of this analysis showed that the air temperature parameter has a greater effect on the target parameter than the solar irradiance intensity parameter (relevancy factor equal to 0.75 compared to 0.49, respectively). …”
Get full text

Retracted: Enhancing Orthopedic Surgery and Treatment Using Artificial Intelligence and Its Application in Health and Dietary Welfare by Journal of Food Quality

Get full text