NPC1 controls TGFBR1 stability in a cholesterol transport-independent manner and promotes hepatocellular carcinoma progression by Shuangyan Li, Lishan Yan, Chaoying Li, Lijuan Lou, Fengjiao Cui, Xiao Yang, Fuchu He, Ying Jiang

“…Mechanistically, NPC1 significantly promotes HCC progression by modulating the TGF-β pathway, independent of its traditional role in cholesterol transport. We identify that the 692-854 amino acid region of NPC1’s transmembrane domain is critical for its interaction with TGF-β receptor type-1 (TGFBR1). …”
Get full text

Adaptation for Staphylococcus aureus to hosts via insertion mutation in the accessory gene regulator agrC gene: decreased virulence and enhanced persistence capacity by Jiawei Chen, Yun Wu, Ying Zhu, Li Zhang, Yingchun Xu, Yali Liu

“…ABSTRACT Staphylococcus aureus is an important human pathogen due to its vast array of virulence factors regulated by multiple regulatory mechanisms, including the accessory gene regulator. …”
Get full text

Liver Radioembolization: a New Chapter in Russian Oncology by A. D. Kaprin, S. A. Ivanov, V. V. Kucherov, A. P. Petrosyan, K. V. Mayorov, N. V. Markov, L. O. Petrov, G. A. Davydov, M. A. Sigov, N. K. Silantieva, T. P. Berezovskaya, A. Yu. Usacheva, D. B. Sanin

“…To review literature data on the history of radioembolization and its application for liver tumours.Key findings. …”
Get full text

Complications and Mortality Characterization in Acute Ischemic Cerebrovascular Disease by Ricardo Leyva Tornés, Lázaro Ibrahim Romero García, Esther Mayor Guerra, Yordanis Páez Candelaria, Karima Gondres Legró, Pedro Alexei Bacardí Zapata

“…<strong>Background:</strong> ischemic cerebrovascular diseases constitute a neurological emergency. Its prevalence is progressively increasing worldwide, as well as associated morbidity, general and premature mortality. …”
Get full text

Effective in vivo binding energy landscape illustrates kinetic stability of RBPJ-DNA binding by Duyen Huynh, Philipp Hoffmeister, Tobias Friedrich, Kefan Zhang, Marek Bartkuhn, Francesca Ferrante, Benedetto Daniele Giaimo, Rhett A. Kovall, Tilman Borggrefe, Franz Oswald, J. Christof M. Gebhardt

“…Importantly, the search time of RBPJ exceeds its residence time, indicating kinetic rather than thermodynamic binding stability. …”
Get full text

Ossification of the Interosseous Membrane of the Leg in a Football Player: Case Report and Review of the Literature by Roberto Postacchini, Stefano Carbone, Marco Mastantuono, Carlo Della Rocca, Franco Postacchini

Get full text

The effect of carbonate mineral additions on biogeochemical conditions in surface sediments and benthic–pelagic exchange fluxes by K. Biçe, K. Biçe, T. Myers Stewart, T. Myers Stewart, G. G. Waldbusser, C. Meile

“…Model simulations were carried out to delineate the impact of mineral type and amount added, porewater mixing, and organic matter mineralization rates on sediment alkalinity and its flux to the overlying water. Model results showed that the added minerals undergo initial rapid dissolution and generate saturated conditions demonstrating the potential of alkalinity enhancement in mitigating surface sediment acidification. …”
Get full text

Consumer Savings and Digital Remittance in Open Banking: Insights From Bibliometric and Geospatial Econometric Analysis by Ibrahim Niankara, Hassan Ismail Hassan, Rachidatou I. Traoret, Abu Reza Mohammad Islam

“…Despite its growth, there is still a lack of academic studies examining its impact on consumer financial behaviors on a global scale. …”
Get full text

Kinematic Analysis and Trajectory Planning of Redundant Mobile Manipulators by Xia Guangjian, Zeng Qingsheng, Feng Dongyan, Li Shenlin

“…The kinematic analysis was carried out by considering the manipulator and the mobile platform as an integrated system, a generalized form of the geometric Jacobi matrix and its pseudo-inverse were derived. In the trajectory planning process, the trajectory running time and the spatial distance travelled by the end of the mobile manipulator were taken as the optimization objectives, the velocity and acceleration constraints of each joint were also taken into account, and a genetic algorithm was used to optimize the trajectory of the redundant mobile manipulator. …”
Get full text

Critical Conditions and Energy Transfer Characteristics of the Failure Process of Coal-Rock Combination Systems in Deep Mines by Haitao Sun, Linchao Dai, Yanbao Liu, Hongwei Jin

“…When the coal–rock combination structure failed, the rock strain reached its maximum value and the strain rebound phenomenon occurred. …”
Get full text

Study of Traditional Uses, Extraction Procedures, Phytochemical Constituents, and Pharmacological Properties of Tiliacora triandra by Gitishree Das, Sushanto Gouda, Rout George Kerry, Hernán Cortes, María L. Del Prado-Audelo, Gerardo Leyva-Gómez, Patrick Valere Tsouh Fokou, Erick P. Gutiérrez-Grijalva, J. Basilio Heredia, Han-Seung Shin, Jayanta Kumar Patra

“…Despite the plant species’ abundance of bioactive compounds, there is very little in vivo and clinical proof of its pharmacological significance. The present review focuses on the phytochemical configurations, extraction methods for major bioactive compounds, and pharmacology of T. triandra, in light of its potent medicinal values.…”
Get full text

Symbolic Motif on Sepehri’s Poems by Morteza Ghasemi

“…In line with personification and synesthesia, symbol is a significant characteristic of rhetorical level of Sohrab Sepehri’s style. By means of iteration, some of the symbols have been converted to an important and remarkable characteristic and are considered as motif. …”
Get full text

Sex and APOE genotype modulate neuropsychological profile and depression in temporal lobe epilepsy by Francesco Bruno, Francesco Bruno, Patrizia Spadafora, Ida Veltri, Mario L. Cuconati, Francesca Condino, Annamaria Cerantonio, Selene De Benedittis, Beatrice M. Greco, Beatrice M. Greco, Gemma Di Palma, Olivier Gallo, Luigi Citrigno, Antonio Qualtieri, Maurizio Cundari, Maurizio Cundari, Maurizio Cundari, Francesca Cavalcanti

“…We also performed APOE genotyping to assess its role in the study. The final sample was composed by fifty-four patients (53.7% female). …”
Get full text

Croissance, inégalités et pauvreté au sein des pays émergents : le cas des BRICS by Laila Porras

“…The global economic framework in which a country leads its integration into the world economy can follow various paths. …”
Get full text

Effect of Exercise on Sternoceleidomastoid Muscular Fibrosis after Radiotherapy for Nasopharyngeal Carcinoma Patients Analyzed by Shear-Wave Elastography by HE Cui, YI Wenhong, LUO Baolong, WEN Yuanyuan, CAO Junyan, GUO Libing

“…Cervical spine range of movement (ROM), the thicknesses, widths and Young's module values of sternoceleidomastoid muscles were assessed before and after treatment.ResultsThe thickness of right and left sternoceleidomastoid muscles was significant different before and after treatment (<italic>P</italic>&lt;0.05). The widths of right and left sternoceleidomastoid muscles were significant different before and after treatment (<italic>P</italic>&lt;0.05). …”
Get full text

De los candires a Kandire. La invención de un mito chiriguano by Isabelle Combès

“…The analysis of colonial texts, however, reveals that the first mention of the term designates a concrete people called « the Candires », who can easily be associated with the Incas; the second « Candire » is assimilated to the idea of Paytiti; and, finally, the third use of the term relates to the « Candire » god of the Itatin Chiriguano. The assimilation of « Kandire » to a « land without evil », or at least its inclusion in a religious complex of representations, can only be attested among the Itatin branch of the Chiriguano and not among the ethnic groups that gave birth to the current Bolivian Chiriguano. …”
Get full text

PPIH is a novel diagnostic biomarker associated with immune infiltration in cholangiocarcinoma by Jun Ye, Zhitao Chen, Chuan Zhang, Rui Xie, Haini Chen, Peng Ren

“…Moreover, PPIH may influence tumor progression through its involvement in cell cycle regulation and spliceosome pathways, and is associated with immune cell infiltration levels. …”
Get full text

Characteristics of Biodegradable Polylactide/Thermoplastic Starch/Nanosilica Composites: Effects of Plasticizer and Nanosilica Functionality by Regina Jeziorska, Agnieszka Szadkowska, Ewa Spasowka, Aneta Lukomska, Michal Chmielarek

“…From SEM, it is clear that plasticized PLA/MPLA/TPS blend continuous porous structure is highly related to the silica content and its functionality. The results indicate that polydimethylsiloxanol enhances ductility and the initial thermal stability of the plasticized blend. …”
Get full text

The role of 5G in enhancing IOT connectivity: a systematic review on applications, challenges, and future prospects by Shankha Goswami, Surajit Mondal

“…This review article examines the transformative role of 5G in enhancing IoT connectivity, discussing its applications across multiple sectors, the challenges faced in implementation—such as infrastructure demands and regulatory issues—and its promising future prospects. …”
Get full text

Artificial Intelligence in Manipulation: The Significance and Strategies for Prevention by Kavoliūnaitė-Ragauskienė Eglė

“…Manipulation has always been a persistent aspect of society, but the rise of artificial intelligence has significantly amplified its scope and impact. AI’s ability to access and process vast amounts of personal data has revolutionized the way individuals can be targeted with specific information. …”
Get full text