Delivery of small interfering RNA through lyophilized natural lipid nanoparticles: effects of natural lipid selection by Hangjie Wang, Wei Li, Junyan Chen, Rong Chen, Yuwei Qi, Linshuang Shen, Kaidi Chen, Lewei Dai, Yuxin Sheng, An Wang, Hong Wang, Chujian Chen, Xiao Cheng, Mancang Gu

“…However, synthetic lipids face issues, such as low lysosomal escape efficiency and high cost.Objective This study aimed to use three natural lipids to construct LNPs, optimize their preparation and freeze-drying processes, and evaluate their siRNA delivery efficiency in vitro.Materials and methods Coix seed lipid [Coix lacryma-jobi L. var. mayuen (Roman.) …”
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Brazilian Academy of Neurology practice guidelines for stroke rehabilitation: part I by Cesar Minelli, Rodrigo Bazan, Marco Túlio Araújo Pedatella, Luciana de Oliveira Neves, Roberta de Oliveira Cacho, Sheila Cristina Sayuri Abe Magalhães, Gustavo José Luvizutto, Carla Heloísa Cabral Moro, Marcos Christiano Lange, Gabriel Pinheiro Modolo, Bruna Correia Lopes, Elisandra Leites Pinheiro, Juli Thomaz de Souza, Guilherme Riccioppo Rodrigues, Soraia Ramos Cabette Fabio, Gilmar Fernandes do Prado, Karla Carlos, Juliana Junqueira Marques Teixeira, Clara Monteiro Antunes Barreira, Rodrigo de Souza Castro, Thalita Dayrell Leite Quinan, Eduardo Damasceno, Kelson James Almeida, Octávio Marques Pontes-Neto, Marina Teixeira Ramalho Pereira Dalio, Millene Rodrigues Camilo, Michelle Hyczy de Siqueira Tosin, Bianca Campos Oliveira, Beatriz Guitton Renaud Baptista de Oliveira, João José Freitas de Carvalho, Sheila Cristina Ouriques Martins

“…ABSTRACT The Guidelines for Stroke Rehabilitation are the result of a joint effort by the Scientific Department of Neurological Rehabilitation of the Brazilian Academy of Neurology aiming to guide professionals involved in the rehabilitation process to reduce functional disability and increase individual autonomy. …”
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The transition from oncology to palliative care: barriers and facilitators explored through an integrative review by Barbara Gonçalves, Tamara Radojičić, Carlos Centeno, Eduardo Garralda, Marina Martínez, Nancy Preston, Jeroen Hasselaar, María Arantzamendi

“…This review aims to explore barriers and facilitators involved in a comprehensive transition process from oncology to palliative care of patients with advanced cancer. …”
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Artificial intelligence analysis of thermal energy for convectively heated ternary nanofluid flow in radiated channel considering viscous dissipations aspects by Hamid Qureshi, Amjad Ali Pasha, Muhammad Asif Zahoor Raja, Zahoor Shah, Salem Algarni, Talal Alqahtani, Waqar Azeem Khan, Moinul Haq

“…A new computational process tools up Python, Mathematica, and MATLAB to solve the transformed system of PDEs a LMNNA. …”
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Design of an improved model using federated learning and LSTM autoencoders for secure and transparent blockchain network transactions by R. Vijay Anand, G. Magesh, I. Alagiri, Madala Guru Brahmam, Balamurugan Balusamy, Chithirai Pon Selvan, Haya Mesfer Alshahrani, Masresha Getahun, Ben Othman Soufiene

“…It includes some such issues as follows: data privacy, centralized vulnerability, inefficiency in fraud detection and much more. …”
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The impact of a hazardous external environment on the quality of life, physical activity, and health of students in Ukraine, Poland, and Romania by Vladimir Potop, Igor Vypasniak, Iryna Ivanyshyn, Vasyl Lutskyi, Iryna Kryventsova, Lyudmila Shesterova, Krzysztof Prusik

“…Background and Study Aim. The issue of quality of life, physical activity, and health of students is becoming increasingly relevant in the context of the ongoing conflict in Ukraine. …”
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Modeling and Exploratory Analysis of Discrete Event Simulations for Optimizing Overhead Hoist Transport Systems and Logistics in Semiconductor Manufacturing by Jin-Hyeon Sung, Seong-Hyeon Ju, Seung-Wan Cho, Hak-Jong Joo, Kyung-Min Seo, Bong-Gu Kang

“…Additionally, by adjusting the amount of equipment based on their utilization rates, we found that reducing the amount of equipment from 12 to five in process E-1 and from seven to three in the OUT process did not degrade performance. …”
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EDITORIAL by Ivan Čuk

“… Dear friends, We are entering into the 7th year of publishing our journal. Up until this issue, 91 original scientific articles and 6 review articles have been published. …”
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Scientific objectives of research on road machines life cycle in modern conditions by S. A. Evtiukov, S. V. Repin, S. M. Grushetskii, G. A. Kаrro

“…In addition, the active implementation of CALS-technologies; modern monitoring systems for road machines; the commitment to automate and robotic work processes; change in the volume and pace of road construction; increasing requirements for the quality of work performed; extension of the warranty period of road service; the existence of mega road organizations; the absence to date of generally accepted criteria for evaluating the effectiveness of one form or another of organizing maintenance and repair work (unscheduled repairs) of road machines; active development of a network of toll roads, etc. they require a radical review and systematization of issues related to the formulation of scientific problems in the study of the life cycle system of road vehicles in modern conditions.Materials and methods. …”
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Current research and future prospects of air pollutant and CO2 emission inventories in the iron and steel industry by Xin XU, Wanyue SHAN, Zheng ZHANG, Qing WANG, Xin BO

“…This study highlights several critical issues in China’s iron and steel industry, including challenges related to the diversity and quality of emission inventory data, the construction of an unorganized emission accounting system, deficiencies in CO2 accounting systems and methodologies, challenges in characterizing component spectra of volatile organic compounds (VOCs) and particulate matter profiles for key processes, obstacles in developing detailed time series for steel enterprises using continuous emission monitoring system (CEMS), and concerns in the practical application of emission inventories. …”
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THE MOTIVE OF CATASTROPHISM IN THE DYSTOPIAN GENRE POETICS: KAZUO ISHIGURO AND YAROSLAV MELNIK by Olena A. Andreichykova

“…Once again, modern dystopian literature shows that “common issue” as a social slogan cannot satisfy individual human needs. …”
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INTERNATIONAL TECHNICAL AID IN POST-CONFLICT RECOVERY: LESSONS FROM GLOBAL PRACTICES FOR DE-OCCUPIED AREAS by Viktoriia Zalizniuk, Anton Plaksun

“…Special attention is paid to transparency and accountability issues in the implementation of technical support projects in countries with post-conflict status. …”
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From knowledge silos to integrated insights: building a cardiovascular medication knowledge graph for enhanced medication knowledge retrieval, relationship discovery, and reasoning by Hongzhen Cui, Xiaoyue Zhu, Wei Zhang, Wei Zhang, Meihua Piao, Yunfeng Peng

“…Taking beta-blockers (β) as an example demonstrates the complete process of ontology to knowledge graph construction and application, encompassing 41 AMTs, 1,197 entity nodes, and 1,351 relationships. …”
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Reducing Methamphetamine Use in Aboriginal and Torres Strait Islander Communities With the “We Can Do This” Web App: Qualitative Evaluation of Acceptability and Feasibility by Leda Sivak, Rachel Reilly, Shani Crumpen, Carla Treloar, Rebecca McKetin, Julia Butt, Yvette Roe, Nadine Ezard, Brendan Quinn, Jack Nagle, Wade Longbottom, Clifford Warrior, James Ward

“…Barriers to using the web application for clients included a lack of internet connectivity and personal issues such as scheduling. ConclusionsProcess evaluation is often under-valued. …”
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Application of sensitive quality indicators of assembly for medical instruments in quality management of Central Sterile Supply Department (器械装配质量敏感指标在消毒供应中心质量管理中的应用)... by ZHANG Ying (张颖), ZHANG Xiaorong (张晓蓉), CAO Lixia (曹丽霞)

“…Methods The error rate of assembly was set as an sensitive quality indicator, and root-cause analysis was made to find influencing factors in issues of human resource, instruments, process and methods. …”
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DEFINITION OF PATIENTS GENETIC PREDISPOSITION TO INCREASED WEAR OF DENTAL HARD TISSUES by I.M. Tkachenko

“… In literature the information about research issues that the morphology of the teeth mainly caused by hereditary factors and the process of dentinogenesis regulated by many genes is not found. …”
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Methods for Applying Matrices when Creating Models of Group Pursuit by A. A. Dubanov

“…It is obvious that in the near future, the issues of equipping moving robotic systems with autonomous control elements will remain relevant. …”
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Improving Large Language Models’ Summarization Accuracy by Adding Highlights to Discharge Notes: Comparative Evaluation by Mahshad Koohi Habibi Dehkordi, Yehoshua Perl, Fadi P Deek, Zhe He, Vipina K Keloth, Hao Liu, Gai Elhanan, Andrew J Einstein

“…Our approach to achieving the simplification of discharge notes involves a process of incremental simplification steps to achieve the ideal note. …”
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Analysis of crack evolution in large-volume concrete based on thermal mechanical coupling finite element method by Anbing QIU

“…With the continuous increase in large-scale engineering projects, large-volume structures are encountering quality control issues during the concrete pouring process. To ensure the quality of construction, higher requirements are often placed on the design strength, setting time, and other related properties of concrete. …”
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Temperature control strategy and simulation analysis of a walking beam reheating furnace by Xiaobo Qu, Ruowei Li, Caiyi Liu, Silvia Barella, Zhihao Ni, Yang Liu, Shuo Guo, Shicheng Liang, Sunrui Tao, Yan Peng, De Li, Andrea Gruttadauria, Marco Belfi, Pietro Cetto, Marawan Abdelwahed, Carlo Mapelli

“…To address issues such as uneven billet temperature distribution during heating, which leads to non-uniform deformation resistance in the rolling process, causing bending deformation, excessive thermal stress, and the initiation of microcracks and propagation of inherited casting cracks, this study uses 20CrNiMoA steel billets as the research object. …”
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