The increasing doses of methotrexate pharmacokinetics after intravenous administration in rats - model selection by Rajšić Ivana, Pavlović Nebojša, Milijašević Boris, Vukmirović Saša, Spasić Dragan, Žigić Miodrag, Grahovac Nenad, Goločorbin-Kon Svetlana, Mikov Momir

“…Methotrexate (MTX) plays a significant role in the treatment of various diseases, but the toxicity remains the main issue of its use, especially when administered in high doses. …”
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Two-dimensional QSAR-driven virtual screening for potential therapeutics against Trypanosoma cruzi by Naseer Maliyakkal, Sunil Kumar, Ratul Bhowmik, Harish Chandra Vishwakarma, Prabha Yadav, Bijo Mathew

“…Trypanosoma cruzi is the cause of Chagas disease (CD), a major health issue that affects 6–7 million individuals globally. …”
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Cross-scale observation of riparian vegetation: Testing the potential of satellite-UAV-Field integrated observations for large-scale herbaceous species by Weiwei Jiang, Chenyu Li, Henglin Xiao

“…In response to the dual challenges of global change and human activities, riverine ecological management urgently requires a deep understanding of the large-scale ecological processes of dominant vegetation populations along riverbanks. …”
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A weakly-supervised follicle segmentation method in ultrasound images by Guanyu Liu, Weihong Huang, Yanping Li, Qiong Zhang, Jing Fu, Hongying Tang, Jia Huang, Zhongteng Zhang, Lei Zhang, Yu Wang, Jianzhong Hu

“…By leveraging Multiple Instance Learning (MIL), we formulated the learning process in a weakly supervised manner and developed an end-to-end trainable model that efficiently addresses the issue of annotation scarcity. …”
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Interparental violence and school bullying among Nigerian adolescents: Moderating role of psychological resilience by Wisdom Chidiebere Obioha, Chisom JohnVictor Obi, Kenechukwu Emmanuel Nnamani, Uzochukwu Emmanuel Chima, Philip Chukwuemeka Mefoh, Kanayochukwu Michael Okoye, Emmanuella U. Anozie

“…Background: Despite the widespread prevalence of bullying, a public health issue, there is limited understanding of factors that propel or reduce bullying behaviors among adolescents in Sub-Saharan Africa. …”
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A novel MPDENet model and efficient combined loss function for real-time pixel-level segmentation detection of tunnel lining cracks by Ningyu Zhao, Yi Song, Hao Liu, Ailin Yang, Haifei Jiang, Haihong Tan

“…In this study, an efficient combined loss function was proposed to address the sample imbalance issue, and a novel lightweight model, MPDENet, was introduced for real-time pixel-level segmentation detection of tunnel lining cracks of interference backgrounds. …”
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Grain Size Effects on Visible and Near-infrared (0.35–2.5 μm) Laboratory Spectra of Rare Meteorite Classes by K. I. Ridenhour, V. Reddy, A. Battle, D. Cantillo, N. C. Pearson, J. A. Sanchez

“…Linking near-Earth asteroids to associated meteorites can be a challenging process for many reasons, one being grain size differences. …”
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Estimating food availability and self-reliance in island territories: Puerto Rico as a case study by Nayla Bezares, Chad Fisher, Carol E. Ramos-Gerena, William Suarez-Gomez, Sean B. Cash, Thomas Nemecek, Nicole Tichenor Blackstone

“…For island territories, this issue is more pronounced as food production data are disaggregated, inconsistent, and scarce. …”
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Construction and Analysis of Slope Plane Deformation of High CFRD Based on Statistical Analysis of Multi‐Points Monitoring Data by Xiongxiong Zhou, Wenjun Cai, Qiujiang He, Jing Zhou, Bingqian Zhou

“…However, with the increasing of dam height, the issue of deformation control is becoming increasingly prominent, especially the panel deformation control which closely related to the internal rockfill deformation. …”
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Influence of NaCl on Phase Development and Corrosion Resistance of Portland Cement by Byung-Hyun Shin, Miyoung You, Jinyong Park, Junghyun Cho, Seongjun Kim, Jung-Woo Ok, Jonggi Hong, Taekyu Lee, Jong-Seong Bae, Pungkeun Song, Jang-Hee Yoon

“…Although various materials are often added during production to enhance their performance, NaCl can be introduced in the process for various reasons. Despite this issue, existing studies lack sufficient quantitative data on the effects of NaCl on cement properties. …”
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M. caprae in northern Italy: a comprehensive analysis through whole-genome sequencing on the genetic variability in bovine herds by Cristina Bertasio, Valentina Carta, Giovanni Parisio, Mariagrazia Zanoni, Marco Tamba, Laura Mazzera, Erika Scaltriti, Maria Lodovica Pacciarini, Giovanni Loris Alborali, Daniel Polzer, Annette Nigsch, Romana Steinparzer, Maria Beatrice Boniotti

“…Starting from spoligotyping and the MIRU-VNTR profile specifically associated with the Lechtal subgroup we decided to process a selection of Italian M. caprae isolates using whole genome sequencing (WGS) to define the phylogenetic relationships between isolates and deepen the understanding of this public health issue. …”
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Surfaces and interfaces analysis on different carboxymethylation reaction time of anionic cellulose nanoparticles derived from oil palm biomass by Manimaran Mageswari, Norizan Mohd Nurazzi, Kassim Mohamad Haafiz Mohamad, Adam Mohd Ridhwan, Abdullah Norli, Faiz Norrrahim Mohd Nor

“…This process introduces anionic groups (−CH2COONa+) onto the CNP surface, producing anionic nanocellulose particles (ACNPs) that act as capping agents to enhance nanoparticle incorporation. …”
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Visual nutrition analysis: leveraging segmentation and regression for food nutrient estimation by Yaping Zhao, Yaping Zhao, Ping Zhu, Ping Zhu, Yizhang Jiang, Kaijian Xia, Kaijian Xia

“…Finally, the extracted features were processed through several fully connected layers to obtain predictions for the weight, calories, fat, carbohydrates, and protein content.Results and discussionOur model achieved an outstanding average percentage mean absolute error (PMAE) of 17.06% for these components. …”
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Use of digital data from open sources during the investigation of criminal offenses: certain aspects by Basysta I., Havrylyuk L., Hutnyk A., Khytra A.

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A quantitative analysis on policies of China’s fuel cell electric vehicle industry by Zhensen Ding, Lingjun Song, Haifeng Fang, Zhanhui Yao, Jia Wang

“…Moreover, most existing research is based on qualitative analysis, which falls short in tackling this issue. This study developed a policy evaluation model that combines the analytic hierarchy process and content analysis (AHP-CA) to assess the differences between ideal and actual policy distributions, grounded in AHP and CA theories. …”
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The impact of future changes in climate variables and groundwater abstraction on basin-scale groundwater availability by S. R. Rusli, S. R. Rusli, V. F. Bense, S. M. T. Mustafa, A. H. Weerts, A. H. Weerts

“…The results of this study are expected to show and inform responsible parties in operational water management about the issue of the impact of projected climate forcing and anthropogenic activity on future groundwater status.…”
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Automated interpretation of deep learning-based water quality assessment system for enhanced environmental management decisions by Javed Mallick, Saeed Alqadhi, Majed Alsubih, Mohamed Fatahalla Mohamed Ahmed, Hazem Ghassan Abdo

“…Abstract Water quality assessment is a critical issue in the Aseer region of Saudi Arabia, where environmental and anthropogenic factors pose a major challenge to both drinking water and irrigation systems. …”
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Experience of the Varicella Vaccine Introduction into Regional Vaccination Shedule of the Russian Federation by M. A. Baryshev, O. P. Chernyavskaya, T. S. Saltykova

“…Materials for the study were: Form № 2 «Information about infectious and parasitic diseases» for 2007–2017; State reports «On the state of sanitary and epidemiological welfare of the population in the Russian Federation» for 2016, 2017; scientific publications on the studied issue in Russian and English. The program «Microsoft Excel» was used to process the research data. …”
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Recent advances in CO2 adsorption using aerogel materials: A review by Salem A. Bahadi, Ahmed H. Hassan, Sagheer A. Onaizi

“…The rapidly increasing concentration of carbon dioxide (CO2) in the atmosphere, primarily due to industrial processes and fossil fuel combustion, presents a serious environmental challenge. …”
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A Proposal for Rapid Assessment of Long-Distance Oil and Gas Pipelines After Earthquakes by Hongyuan Jing, Liang Huang, Hua Liu, Weijun Jiang, Qinglu Deng, Ruiqing Niu

“…These pipelines are susceptible to a range of safety concerns, exacerbated by the increasing frequency of strong earthquakes in recent years. To address this issue, a comprehensive risk investigation framework has been proposed for long-distance oil and gas pipelines following seismic events. …”
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