The real-world analysis of adverse events with azacitidine: a pharmacovigilance study based on the FAERS and WHO-VigiAccess databases by Zhaorui Wang, Linlin Guo, Youfu He, Baiquan Zhang, Yang Wang, Juan Ding

“…These results may offer important vigilance information for clinicians and pharmacists when addressing safety issues associated with azacitidine.…”
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Multifunctional approach with LHRH-mediated PLGA nanoconjugate for site-specific codelivery of curcumin and BCL2 siRNA in mice lung cancer by Madhuchandra Lahan, Trideep Saikia, Kalpajit Dutta, Rinku Baishya, Alakesh Bharali, Sunayana Baruah, Rituraj Bharadwaj, Subhash Medhi, Bhanu P. Sahu

“…Abstract Background Lung cancer remains a leading cancer type, but current chemotherapy is limited by issues including poor drug delivery, toxicity, and resistance. …”
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Blind Recognition Algorithm of Multi-Carrier Composite Modulation Signal Based on Multi-Dimensional Time-Frequency Superimposed Spectrum by Shoubin Wang, Huan Li, Xiaolong Zhang, Hao Jiang, Lei Shen

“…Meanwhile, the dual-channel input mechanism enables collaborative expression of outer modulation time-frequency diagram and inner modulation dual spectrum features, ensuring tight integration of inner and outer characteristics while avoiding feature isolation issues in traditional multi-diagram concatenation methods. …”
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The Shengmai San Exerts Therapeutic Effects on Type 2 Diabetes by Modulating the PI3K/AKT/GSK3B Signaling Pathway by Shang H, Wang T, Pang D, Qi Y, Liu L, Wang Y, Gao Y

“…The mRNA and protein expression levels of genes related to the PI3K/AKT/GSK3B pathway were analyzed using qRT-PCR and Western blot.Results: There were 39 components found in SMS San by UPLC-Q-Orbitrap/MS. …”
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Anticryptosporidial action mechanisms of Launaea spinosa extracts in Cryptosporidium parvum experimentally infected mice in relation to its UHPLC-MS metabolite profile and biochemo... by Mai M Elghonemy, Mohamed G Sharaf El-Din, Dina Aboelsoued, Mohamed F Abdelhameed, Mohamed A El-Saied, Nagwa I Toaleb, Mohamed A Farag, Abdelsamed I Elshamy, Abdelbaset M Elgamal

“…Examination of colon tissue revealed that infected-treated mice with LS extracts exhibited a reduction in the expression of cleaved caspase-3, damage score, and degenerative changes. …”
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Transcriptome and Physiological Analysis Reveals the Mechanism of Abscisic Acid in Regulating Cadmium Uptake and Accumulation in the Hyperaccumulator <i>Phytolacca acinosa</i> Roxb... by Qin Xie, Wenting Xu, Qing Wang, Feihong Yao, Yachao Jiang, Haijia Cao, Wanhuang Lin

“…The results show that ABA treatment affected gene expression in <i>P. acinosa</i> roots under Cd stress. …”
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Réponses culturelles aux changements rapides de la nature by Thomas Heyd, Irène Dupuis

“…In view of the changes in climate that our society will face in the near future, issues related to vulnerability and resilience have become of paramount importance. …”
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Current status and future perspectives on consensus and controversies in advanced breast cancer for 2024 by WANG Xiaobo, WANG Tao

“…It also highlighted critical unresolved issues: no standard recommendations exist for post-CDK4/6 inhibitor therapy, though current evidence supports prioritizing targeted therapies for mutation-positive cases or ADC/endocrine therapies for mutation-negative scenarios. …”
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Inhibitory Effect and Potential Mechanism of Trans-2-Hexenal Treatment on Postharvest <i>Rhizopus</i> Rot of Peach Fruit by Xuanyi Cai, Wen Xiang, Liangyi Zhao, Ziao Liu, Ye Li, Yuan Zeng, Xinyan Shen, Yinqiu Bao, Yonghua Zheng, Peng Jin

“…Chemical control risks residue and resistance issues, demanding eco-friendly alternatives. This study elucidated the mechanism by which trans-2-hexenal (E2H) mitigated postharvest soft rot caused by <i>Rhizopus stolonifer</i> in peach (<i>Prunus persica</i> cv. …”
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Iron metabolism and preeclampsia: new insights from bioinformatics analysis by Xijiao Guo, Sha Li, Guoping Xiong

“…The diagnosis and prevention of PE remain urgent clinical issues that need to be addressed. Therefore, finding molecular diagnostic targets for PE through bioinformatics and machine learning methods is crucial for the diagnosis and prevention of patients with PE.Methods Data sets for PE were obtained from the GEO database, and gene differential expression analysis was conducted along with enrichment analysis annotations. …”
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Cellular characteristics and milk component productivity of primary bovine mammary cells for cell-cultured milk component production by Hyuk Cheol Kwon, Hyun Su Jung, Do Hyun Kim, Jong Hyeon Han, Sung Gu Han

“…Despite the increasing demand for milk, there is a simultaneous growth in awareness regarding sustainable dairy farming and concerns about environmental issues. The concept of generating milk components without traditional dairy farming has been introduced through the utilization of bovine mammary cells. …”
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Microenvironment-responsive NIR-IIb multifunctional nanozyme platform for bacterial imaging and specialized anti-anaerobic bacteria periodontal therapy by Suai Lin, Tiehan Cui, Yuxin Jiang, Jialiang Xie, Da Zhong, Junkai Jiang, Dan Deng, Mengzhen Zhao, Chengzhou Xue, Shiyu Gan, Jiaxuan Qiu, Xiaolei Wang

“…This study aims to address these issues by developing a responsive near-infrared-IIb nanozyme system (DMUP), assembled from lanthanide-doped down-converted nanoparticles and multi-enzymatically active nanozyme. …”
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The seven deadly sins: measuring overvaluation of social media with the Plan-net 25 scale by Víctor Ciudad-Fernández, Alfredo Zarco-Alpuente, Tamara Escrivá-Martínez, Elena Gomis-Vicent, Begoña Espejo, Óscar Lecuona, José C. Perales, Olatz Lopez-Fernandez, Rosa Baños

“…Although linked to mental health issues such as depression, anxiety, and loneliness, the underlying mechanisms remain unclear. …”
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Integrative bioinformatics and machine learning identify iron metabolism genes MAP4, GPT, and HIRIP3 as diagnostic biomarkers and therapeutic targets in Alzheimer’s disease by Xiaoqiong An, Xiangguang Zeng, Zhenzhen Yi, Manni Cao, Yijia Wang, Wenfeng Yu, Wenfeng Yu, Zhenkui Ren, Zhenkui Ren

“…MAP4 and GPT were linked to Notch signaling and metabolic issues. In APP/PS1 mice, MAP4 decreased, while GPT and HIRIP3 increased.DiscussionThis analysis highlights these genes as diagnostic biomarkers and therapeutic targets, connecting iron balance, neuroinflammation, and metabolic problems in AD. …”
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Evaluating the efficacy and safety of bladder-sparing regimen with Disitamab Vedotin combined with Toripalimab and pelvic lymph node dissection in muscle-invasive bladder cancer pa... by Tianhang Lan, Yingying Zhu, Wenlong Zhong, Qihong Tan, Tianxin Lin, Jian Huang, Wang He

“…In order to address these issues, a secure and efficient bladder preservation program is desperately needed. …”
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Peculiarities of concluding an agreement on the transfer of property rights to a software by D. V. Tymoshenko Tymoshenko

“…It is noted that in recent years a lot of research has been carried out on contracts in the field of intellectual property law. However, many issues remain debatable and unsettled in the legislation of Ukraine. …”
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Biocides as drivers of antibiotic resistance: A critical review of environmental implications and public health risks by Mariana Sousa, Idalina Machado, Lúcia C. Simões, Manuel Simões

“…In this review, we conduct a critical assessment of four significant issues pertaining to this topic. Specifically, (i) the role of biocides in exerting selective pressure within the environmental resistome, thereby promoting the proliferation of resistant microbial populations and contributing to the global spread of antimicrobial resistance genes (ARGs); (ii) the role of biocides in triggering transient phenotypic adaptations in bacteria, including efflux pump overexpression, membrane alterations, and reduced porin expression, which often result in cross-resistance to multiple antibiotics; (iii) the capacity of biocides to disrupt bacteria and make the genetic content accessible, releasing DNA into the environment that remains intact under certain conditions, facilitating horizontal gene transfer and the spread of resistance determinants; (iv) the capacity of biocides to disrupt bacterial cells, releasing intact DNA into the environment and enhancing horizontal gene transfer of resistance determinants; and (iv) the selective interactions between biocides and bacterial biofilms in the environment, strengthening biofilm cohesion, inducing resistance mechanisms, and creating reservoirs for resistant microorganisms and ARG dissemination. …”
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Ontological Representation of the Structure and Vocabulary of Modern Greek on the Protégé Platform by Nikoletta Samaridi, Evangelos Papakitsos, Nikitas Karanikolas

“…One of the issues in Natural Language Processing (NLP) and Artificial Intelligence (AI) is language representation and modeling, aiming to manage its structure and find solutions to linguistic issues. …”
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Time-Course Renal and Pulmonary Injury Analysis and Bioinformatics Screening of Core Pathogenic Genes and Immune Cell Infiltration Patterns in a Sepsis by Apizi A, Li J, Kamilijiang P, Yang CB, Wang ZK, Chai RF, Yu ZX

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Comprehensive Analysis of the Role of Metabolic Features in Osteoporosis: A Multi-Omics Analysis by Chang S, Tao W, Shi P, Wu H, Liu H, Xu J, Chen J, Zhu J

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