Experimental Study on Stress-Dependent Nonlinear Flow Behavior and Normalized Transmissivity of Real Rock Fracture Networks by Qian Yin, Hongwen Jing, Richeng Liu, Guowei Ma, Liyuan Yu, Haijian Su

“…The mechanism and quantitative descriptions of nonlinear fluid flow through rock fractures are difficult issues of high concern in underground engineering fields. …”
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Utilizing Microbial Inoculants to Alleviate Continuous Cropping Obstacles: Insights into the Metabolites and Transcriptomic Responses of <i>Pinellia ternata</i> by Xinyu Wang, Mohammad Murtaza Alami, Shuqi Gong, Qinglin Cheng, Chaoqun Chen, Xinghui Li, Shumei Zhong, Zhigang He, Dilin Chen, Shengqiu Feng, Shenghu Chen, Shaohua Shu

“…<b>Methods</b>: Soil samples from fields with and without continuous cropping issues were used to compare the effects of microbial inoculants on the secondary metabolism and gene expression of <i>P. ternata</i>. …”
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From the editors by Redakcja Czasopisma, Jan Grabowski

“… The present issue of “Holocaust. Studies and Materials” continues the tradition which started with the publication of our first volume, two years ago. …”
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Potential upscaling protocol establishment and wound healing bioactivity screening of exosomes isolated from canine adipose-derived mesenchymal stem cells by Yudith Violetta Pamulang, Saranyou Oontawee, Watchareewan Rodprasert, Irma Padeta, Noppadol Sa-Ard-lam, Rangsini Mahanonda, Thanaphum Osathanon, Poorichaya Somparn, Trairak Pisitkun, Chutirat Torsahakul, Chenphop Sawangmake

“…However, the clinical translation of exosome-based therapy was hindered due to issues regarding low productivity and the lack of efficient production protocol to obtain a clinically relevant exosome quantity. …”
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Chemical profile of Ficus lyrata bark extract and its therapeutic effect on non-alcoholic fatty liver disease via regulating oxidative stress, inflammation and hepatic lipogenesis by Amria Mamdouh Mousa, Rehab Fikry Taher, Nermin Mohamed El-Sammad, Esraa Aly Balabel, Elham Mohamed Youssef, Ahmed Hassan Afifi, Sahar Samir Abdel-Rahman, Nayera Anwar, Sherien Kamal Hassan

“…In conclusion, our findings suggested that F. lyrata bark could be a promising therapeutic agent against the health issues related to NAFLD.…”
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Oral Administration of Propolis and Lysozyme Combination Improves Feline Oral Health and Modulates Systemic Inflammatory and Oxidative Responses by Longjiao Wang, Qianqian Chen, Weiwei Wang, Hao Dong, Xiaohan Chang, Lishui Chen, Ran Wang, Yaoxing Chen, Pengjie Wang, Shuxing Chen, Wei Xiong, Yixuan Li

“…This study evaluated the efficacy of a dietary supplement combining propolis and lysozyme (PL) in mitigating feline oral health issues, based on a cohort of 24 cats divided equally into placebo, treatment, and healthy control groups (<i>n</i> = 8 per group). …”
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In situ treatment with a TLR9 agonist virus-like particle to promote immune responses against oral epithelial dysplasia progression by Yan Xu, Alexandra Mcmillan, Nikesh Gupta, Caitlin D. Lemke-Miltner, Aseel O. Rataan, Sudartip Areecheewakul, Divya S. Bhat, Emily A. Lanzel, Sean M. Geary, Andrean L. Simons, George J. Weiner, Aliasger K. Salem

“…Vidutolimod + ICB caused a significant decrease in Ki-67 expression by epithelial cells in the lesion area compared to untreated mice, implicating that this treatment regime may prevent lesion progression.…”
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MGA-related syndrome: A proposed novel disorder by Bobbi McGivern, Michelle M. Morrow, Erin Torti, Kirsty McWalter, Ingrid M. Wentzensen, Kristin G. Monaghan, Amanda Gerard, Laurie Robak, David Chitayat, Claire Botsford, Sarah Jurgensmeyer, Peter Leahy, Paul Kruszka

“…Summary: MGA (OMIM: 616061) encodes a dual-specificity transcription factor that regulates the expression of Max-network and T-box family target genes, important in embryogenesis. …”
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An ovalbumin-based hydrogel loaded with dendrobium polysaccharide for promoting wound healing while reducing inflammations by Ruiya Zhang, Lei Wang, Rongjia Zhang, Xinyi Zhang, Jianfei Huang, Xuemin Li, Bochu Wang, Shuguang Piao, Xiaorong Zhou, Run Meng

“…Development of a wound repair product that can effectively overcome the aforementioned issues at a relatively low cost would better meet the needs of patients. …”
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A novel CUL4B gene variant activating Wnt4/β-catenin signal pathway to karyotype 46, XY female with disorders of sex development by Chunlin Wang, Hong Chen, Qingqing Chen, Yangbin Qu, Ke Yuan, Li Liang, Qingfeng Yan

“…Abstract Background Karyotype 46, XY female disorders of sex development (46, XY female DSD) are congenital conditions due to irregular gonadal development or androgen synthesis or function issues. Genes significantly influence DSD; however, the underlying mechanisms remain unclear. …”
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Increasing Life Expectancy with Plant Polyphenols: Lessons from the Mediterranean and Japanese Diets by Marco Fiore, Anton B. Tonchev, Ruzha Z. Pancheva, Tetsumori Yamashima, Sabrina Venditti, Giampiero Ferraguti, Sergio Terracina

“…This work debates emerging evidence addressing issues of bioavailability, dosage optimization, and formulation technologies for polyphenol supplementation, also comparing differences and similarities with the vegan and vegetarian diets. …”
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Macrophage polarization in sarcoidosis by I. E. Malysheva, E. L. Tikhonovich, E. K. Oleinik, L. V. Topchieva, O. V. Balan

“…These two cell populations are characterized by the expression of different markers on their surface, which allow these cells to differentiate from each other. …”
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The effect of workplace environment on coal miners' gut microbiota in a mouse model by Lei Li, Lei Li, Mei Zhi, Mei Zhi, Siwei Wang, Siwei Wang, Siwei Wang, Jun Deng, Jun Deng, Qing Cai, Dayun Feng

“…The coal mine workplace environment is a significant factor in inducing occupational health issues, such as intestinal dysfunction in coal miners. …”
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Pediatricians’ Competence in Prevention, Risk Determination or Detection of Suicidal Behavior in Children: Cross-Sectional Survey Study by Anna Y. Basova, Marina A. Bebchuk, Natalia V. Ustinova, Leyla S. Namazova-Baranova, Kamilla E. Efendiyeva, Elena A. Vishneva

“…Child and adolescent suicides remain one of the most painful public issues. The COVID-19 pandemic has aggravated this topic as the number of suicides among children population has increased in this period. …”
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A new BWO-based RGB vegetation index and ensemble learning strategy for the pests and diseases monitoring of CCB trees using unmanned aerial vehicle by Keliang Hu, Keliang Hu, Junchen Liu, Hai Xiao, Qiangguo Zeng, Jun Liu, Jun Liu, Lei Zhang, Lei Zhang, Man Li, Man Li, Zhihui Wang, Zhihui Wang

“…To tackle the high cost and challenging data processing issues associated with traditional hyper-spectral/multi-spectral sensors, this method only relies on UAV visible light RGB bands. …”
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Identification of circulating tumor cells marker genes as prognostic signature in triple-negative breast cancer by Jia Hu, Kai-Ming Zhang, Xi Wang

“…The emergence of malignant progression, along with issues of drug resistance, poses substantial challenges in the clinical management of this disease. …”
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Media and information literacy to counter disinformation by Samy Abdel Raoof Tayia

“…The risks are connected to the reliability of information, privacy, safety and security issues, and potential abuse of media, the Internet and other information providers.…”
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Acute myeloid leukemia-derived bone marrow mesenchymal cells exhibit improved support for leukemic cell proliferation by Mariane Cristina do Nascimento, Diego A. Pereira-Martins, João Agostinho Machado-Neto, Eduardo M. Rego

“…Hypothesis and method: Nevertheless, currently unknown are the relevance of the spatial localization of AML cells relative to the BMMSCs and whether BMMSCs from patients with AML and healthy subjects have similar properties. To address these issues, we performed a differential gene expression analysis using RNA-sequencing data generated from healthy donors (HDs) and leukemic BMMSCs. …”
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Explainable Predictive Model for Suicidal Ideation During COVID-19: Social Media Discourse Study by Salah Bouktif, Akib Mohi Ud Din Khanday, Ali Ouni

“…This strategy enhances the comprehension and interpretation of suicidal ideation. Despite easy expression via social media, suicidal thoughts remain sensitive and complex to comprehend and detect. …”
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Exploring user experiences of clinicians engaged with the digital healthcare interventions across the referral and university teaching hospitals in Nigeria: a qualitative study by Uchechukwu Solomon Onyeabor, Okechukwu Onwuasoigwe, Wilfred Okwudili Okenwa, Thorsten Schaaf, Niels Pinkwart, Felix Balzer

“…This research was therefore designed and restricted to clinicians who had used these systems so as to explore their experiences with these systems and possibly unveil any challenges/limitations that can bedevil successful and sustainable acquisition of digital healthcare intervention programmes and projects across referral and university teaching hospitals in the Southeastern Region of Nigeria; and could also hamper any future implementations.MethodThis study was designed in a manner that allows the clinicians the liberty to conveniently express in writing (via comments) issues, challenges and concerns that they had perceived, encountered or experienced bedevilling electronic health record adoption and use across their care facilities. …”
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