CLEC3B as a Prognostic and Immunological Biomarker in Pan-Cancer: Multi-Omics Profiling and Validation in Pancreatic Cancer and Exosomes by Nan K, Zhang L, Peng Y, Huang J, Yin S, Zou Y, He K, Zhang M

Get full text

Histone deacetylase-2 inducer like theophylline has a potential to improve glucocorticoid responsiveness in severe uncontrolled asthma by reducing P-glycoprotein/MRP-1 by Ravi Mishra, Zia Hashim, Mansi Gupta, Rachna Chaturvedi, Harshit Singh, Alok Nath, Durga Prasanna Misra, Ajmal Khan, Mohit Kumar Rai, Shivani Srivastava, Saurabh Chaturvedi, Vikas Agarwal

Get full text

Investigating EFL Students’ Speaking Difficulties in Their Speaking for Social Objectives by Fikri Fuadi Azmy

“…Students can read more books in English for fun to help with vocabulary issues. Future researchers can look into the speaking issues faced by other EFL students in other remote areas of Kalimantan or other large Indonesian islands to see if they are similar to those revealed in this study. …”
Get full text

Interdisciplinary Teaching About Refugee and Migrant Policy and Experiences Using Simulation and Story by Emily Wierszewski, Roni Kay O'Dell

“…This data reveals the effectiveness of an interdisciplinary approach with regards to increased empathy, problem-solving strategies, and collaboration when teaching about complex issues like the refugee and migrant crisis. Using simulation and narrative teaching pedagogies to teach about migration and refugee issues and rights allows students the space to express their ideas, learn and understand the complexities of the issues, develop empathy, and challenge their own worldviews. …”
Get full text

Sentiment analysis and topic modeling in the context of scientific integrity: implications for teaching and research in higher education by GaoFeng Han, Fang Xia

“…The results obtained demonstrate that the public expresses significant concern and experiences significant negative emotions in relation to academic integrity issues, particularly on social media. …”
Get full text

The Relationship between the World of Archetypal Images and the World of Nature from the View of Allāma Tabataba'i and Sheikh Ishraq by Javad Parsā'i, Ahamad Shahgoli

“…The discussion of the relationship between the world of archetypal images and the world of nature is one of the important issues of Islamic philosophy. Sheikh Ishraq rejected the theory of the peripatetic (Aristotelians) about the materiality of imaginary forms and proposed the theory of the world of archetypal images to explain some other issues of his philosophy. …”
Get full text

« Cannot women hate as well as men? » : La haine au féminin dans The Tragedy of Mariam d’Elizabeth Cary et La Mariane de Tristan l’Hermite by Pauline Durin

“…Wives’ hatred towards their husbands transgresses a social, marital and political order. However, the expression of this passion on stage is quite theatrical, as it is both audible and visible, thus representing an aesthetic issue. …”
Get full text

Increased miR-132 level is associated with visual memory dysfunction in patients with depression by Liu Y, Yang X, Zhao L, Zhang J, Li T, Ma X

Get full text

Transforming growth factor-β1 and TGF-β2 act synergistically in the fibrotic pathway in oral submucous fibrosis: An immunohistochemical observation by Venkatesh Viswanath Kamath, Shruti Krishnamurthy, Krishnanand P Satelur, Komali Rajkumar

Get full text

Oser l’incertain. L’imputation des effets indésirables médicamenteux. by Anne-Chantal Hardy

“…After a description of collective and individual issues of the imputation process, the results of the study show the subtle or diverted forms in which ADRs are expressed: expected effects, drug toxicity or patient intolerance? …”
Get full text

WHY SCIENTIFIC RESEARCH OF A LECTURER IS THE «LAME HORSE» OF MODERN SCIENCE? by Maria A. Belyaeva

“…In particular, researches turn to promoters of themselves to solve financial and organizational issues of a scientific research and promotion of ratings. …”
Get full text

CD56-Positive NK Cells and CD138-Positive Plasma Cells in Basal Decidua of Term Placentas in Singleton Pregnancies After Assisted Reproductive Technology Treatment of Endometriosis... by Stipe Dumancic, Marinela Bakotin Jakovac, Marko Drazen Mimica, Sandra Zekic Tomas, Jelena Marusic

“…A eutopic endometrium in endometriosis shows altered immune responses, including abnormalities of NK cells and expression of plasma cells, related to reproductive issues. …”
Get full text

Liposomal Lactoferrin Reduces Brain Neuroinflammation in Rats and Alleviates Jetlag and Improves Sleep Quality After Long-Haul Travel by Shoko Uesaki, Masanori Yamato, Atsushi Ishikado, Yutaka Suekawa, Yasuhisa Tamura, Yosky Kataoka

“…This triggers neuroinflammation and can result in health issues including depression, dementia, lifestyle-related diseases, and industrial accidents. …”
Get full text

Comprehensive approaches to design efficient gRNA for SDN1-CRISPR/Cas9 genome editing in wheat by Tushadri Singh, Tushadri Singh, H. M. Mamrutha, Rajender Singh, J. P. Jaiswal, Zeenat Wadhwa, Rakesh Kumar, Omvir Singh, O. P. Ahlawat, Ratan Tiwari

“…By virtue of wheat being a hexaploid crop and having a large genome size with repetitive DNA, a tailor-made strategy for designing the gRNA is crucial.ResultThe manuscript explains the comprehensive strategies and methods for efficient gRNA designing by considering the physical and structural expression of the target gene in the genome and explains the on-target and off-target effects of gRNA for its precise editing through the CRISPR/Cas9-mediated SDN1 method of genome editing in wheat.ConclusionThe present manuscript is first of its kind to address the holistic approach, starting from efficient gene selection, gRNA designing, and post-gRNA designing issues like gRNA stability, binding efficiency, and functionality for SDN1-CRISPR/Cas9 genome editing in wheat. …”
Get full text

Mitigation of P. gingivalis-exacerbated intestinal inflammation by paeoniflorin through alteration of the gut microbiota by Ru Qu, Ming Li, Ping Li, Ying Song, Biao Dong, Juan Liu, Xuan Mo, Zhenjiang Zech Xu, Xiaochang Huang

“…Furthermore, P. gingivalis increased the population of Th17 cells in the spleen and upregulated the expression of pro-inflammatory cytokines in mice. Additionally, P. gingivalis aggravated the gut microbiota dysbiosis by reducing the beneficial bacteria like S24-7. …”
Get full text

Building Surface Defect Detection Based on Improved YOLOv8 by Xiaoxia Lin, Yingzhou Meng, Lin Sun, Xiaodong Yang, Chunwei Leng, Yan Li, Zhenyu Niu, Weihao Gong, Xinyue Xiao

“…This module minimizes irrelevant features and redundant information and enhances the salient feature expression of cracks, delamination, and other defects, improving feature utilization. …”
Get full text

Gibberellin action‐based strategies show promise in the control of Striga—A major threat to global agriculture by Jiazheng Chen, Ikuo Takahashi, Masatoshi Nakajima, Tadao Asami

“…This study demonstrates the potential of quantitative endogenous gibberellin control for Striga management, providing valuable insights for alleviating food security issues.…”
Get full text

Papillomavirus-like particles as vectors for ex vivo gene therapy of the skin by Francesco Diversi, Juliette Dabin, Elisa Mazza, Mirko Rinaldin, Fernanda de Castro Reis, Jamie A. Hackett, Paul A. Heppenstall

“…However, because these vectors integrate their cargo into the genome, safety issues arise when utilizing them to deliver gene-editing nucleases. …”
Get full text

Exploring a Novel Anti-Inflammatory Therapy for Diabetic Retinopathy Based on Glyco-Zeolitic-Imidazolate Frameworks by Elena Díaz-Paredes, Francisco Martín-Loro, Rocío Rodríguez-Marín, Laura Gómez-Jaramillo, Elena M. Sánchez-Fernández, Carolina Carrillo-Carrión, Ana I. Arroba

“…<b>Background/Objectives:</b> Diabetic retinopathy is an ocular disease caused by changes in the expression of inflammatory mediators and increased oxidative stress in the retina and is the leading cause of vision loss in diabetic patients. …”
Get full text

DNA Origami‐Based CD44‐Targeted Therapy Silences Stat3 Enhances Cartilage Regeneration and Alleviates Osteoarthritis Progression by Qi Lv, Xiang Zhao, Songsong Teng, Xinmeng Jin, Ying Zhou, Yueyang Sun, Hao Pei, Zuoqin Yan, Chunhui Ma

“…However, the efficient and targeted delivery of siRNA remains a major challenge due to issues with tissue specificity and degradation in vivo. …”
Get full text