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Screening and Verification COPD-OSA Overlap Syndrome Core Genes Using Bioinformatics
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TMAO Induces Vascular Endothelial Cells Pyroptosis Through TET2-CYTB-ROS Pathway
Published 2025-07-01Get full text
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1564
Translational PK–PD model for in vivo CAR‐T‐cell therapy delivered using CAR mRNA‐loaded polymeric nanoparticle vector
Published 2024-12-01“…To address this issue, we have devised a translational pharmacokinetic–pharmacodynamic (PK–PD) model that characterizes the transient surface CAR expression following mRNA‐encapsulated NP administration, leveraging in vitro and in vivo data alongside critical binding kinetic parameters sourced from literature. …”
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The effects of the urotensin-II receptor antagonist palosuran treatment on the corpora cavernosa of streptozotocin-induced diabetic rats
Published 2025-01-01“…Although induction of diabetes did not change U-II expression in CC significantly, palosuran treatment reduced U-II expression in diabetic CC. …”
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Diagnostic significance of soluble adhesion molecules and costimulatory molecules of immune cells in the patients with ischemic heart disease
Published 2020-01-01“…Ischemic heart disease (IHD) represents significant medical issues, due to high prevalence of the disorder, permanent progressive course, being a leading cause of mortality. …”
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Dragon Fruit Peel (<i>Hylocereus undatus</i>) Modulates Hepatic Lipid Metabolism and Inflammation in a Rat Model of High-Fat, High-Fructose-Induced Metabolic Dysfunction
Published 2025-03-01“…Metabolic dysfunction and hepatic abnormalities, such as those associated with high-fat, high-fructose (HFHFr) diets, are major contributors to obesity-related health issues. The growing interest in sustainable dietary interventions has highlighted the potential of plant-based byproducts. …”
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Oral delivery of GLP-1 peptide using recombinant Lactobacillus gasseri for the treatment of type 2 diabetes mellitus
Published 2025-08-01“…The supernatants of LgsGPA cultures significantly upregulated the expression of PDX-1 and stimulated insulin release in Min6 cells. …”
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Real-time quantitative PCR method for assessing wheat cultivars for resistance to Zymoseptoria tritici
Published 2025-06-01“…However, there is little understanding of the growth dynamics of the causal fungus during the 14- to 18-day latent period between penetration and symptom expression, making it challenging to develop wheat cultivars resistant to Z. tritici. …”
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PPARγ Agonists in Adaptive Immunity: What Do Immune Disorders and Their Models Have to Tell Us?
Published 2013-01-01“…The present review addresses these issues by placing PPARγ agonists in the context of adaptive immune responses and the relation of the activation of these receptors with the expression of cytokines involved in adaptive immunity.…”
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Comprehensive benchmarking of genome editing quantification methods for plant applications
Published 2025-06-01“…Furthermore, we discuss the advantages and drawbacks of each technique, the issues faced during optimization and the solutions we devised. …”
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Mendelian randomization and transcriptomic analysis reveal a positive cause-and-effect relationship between Alzheimer's disease and colorectal cancer
Published 2025-01-01“…Background: This study addresses the complex multifactorial causes of Alzheimer's disease (AD) and colorectal cancer (CRC), two significant public health issues. Despite previous research, the precise relationship between AD and CRC remains unclear. …”
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Self-Care in Palliative Healthcare Professionals: A Qualitative Study
Published 2025-04-01“…<b>Background/Objectives</b>: Self-care strategies enhance well-being and facilitate coping with emotional distress, particularly for palliative care professionals dealing with end-of-life issues. This study aimed to explore self-care practices among healthcare professionals working in palliative care settings by analyzing their perceptions and reflections. …”
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Integrating Virtual Reality into Art Education: Enhancing Public Art and Environmental Literacy Among Technical High School Students
Published 2025-03-01“…The experimental group excelled in spatial expression, showing better understanding and interaction with spatial concepts. …”
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NUTRI-ONCOCARE: New integral nutrition care model to prevent and treat malnutrition in cancer patients
Published 2021-05-01“…<p><strong>Objective:</strong> The maximum expression of malnutrition in cancer patients is cancerous cachexia, always linked to an unfavorable prognosis. …”
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Infrared Small Target Detection Based on Weak Feature Enhancement and Target Adaptive Proliferation
Published 2025-01-01“…In addition, we introduced a target data self-adaptive proliferation strategy (DSAS) to address the imbalance of positive and negative samples, enhancing the generalization and expression capability of the detection datasets. Finally, we proposed a target-background joint loss to alleviate the imbalance issue and help the network converge smoothly. …”
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School as a Safe Space through Gender-Responsive Basic Education Policy
Published 2024-10-01“…There are gaps in policy implementation, and safety issues faced by LGBTQIA+ learners persist. Purpose. …”
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The Role of Convection and Size Effects in Microhotplate Heat Exchange: Semiconductor and Thermomagnetic Gas Sensors
Published 2025-04-01“…We analyzed convection issues in two groups of gas sensors: semiconductor and thermocatalytic (calorimetric) sensors and, on the other hand, in the oxygen sensors of the thermomagnetic type. …”
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Data standards for single‐cell RNA‐sequencing of paediatric cancer
Published 2025-01-01“…We urge data standards institutes and repositories, such as NCBI Gene Expression Omnibus (GEO) and European Genome‐Phenome Archive (EGA), to strictly enforce these standardised data practices.…”
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VERBAL NEOLEXEMS OF INDIVIDUAL AUTHOR’S IN THE NEWSPAPER LANGUAGE OF THE LATE 20th CENTURY: SEMANTICS AND WORD FORMATION
Published 2022-06-01“…Such formations enrich the semantics of the sentence, expand the associative connections with other lexemes, consequently the context acquires a unique meaning, which enhances the expressiveness of the whole utterance. Authorial verbs, adjectives and adverbs are always expressive and original. …”
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