Showing 1,561 - 1,580 results of 5,025 for search 'issues expression', query time: 0.10s Refine Results
  1. 1561
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  4. 1564

    Translational PK–PD model for in vivo CAR‐T‐cell therapy delivered using CAR mRNA‐loaded polymeric nanoparticle vector by Se Jin Kim, Ganesh M. Mugundu, Aman P. Singh

    Published 2024-12-01
    “…To address this issue, we have devised a translational pharmacokinetic–pharmacodynamic (PK–PD) model that characterizes the transient surface CAR expression following mRNA‐encapsulated NP administration, leveraging in vitro and in vivo data alongside critical binding kinetic parameters sourced from literature. …”
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  5. 1565

    The effects of the urotensin-II receptor antagonist palosuran treatment on the corpora cavernosa of streptozotocin-induced diabetic rats by Murat Olukman, Cenk Can, Sibel Ülker, Yiğit Uyanikgil, Türker Çavuşoğlu, Neslihan Düzenli, Deniz Coşkunsever, Fatma G. Kozcu

    Published 2025-01-01
    “…Although induction of diabetes did not change U-II expression in CC significantly, palosuran treatment reduced U-II expression in diabetic CC. …”
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  6. 1566

    Diagnostic significance of soluble adhesion molecules and costimulatory molecules of immune cells in the patients with ischemic heart disease by A. V. Logatkina, I. V. Terekhov, S. S. Bondar, V. S. Nikiforov

    Published 2020-01-01
    “…Ischemic heart disease (IHD) represents significant medical issues, due to high prevalence of the disorder, permanent progressive course, being a leading cause of mortality. …”
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  7. 1567

    Dragon Fruit Peel (<i>Hylocereus undatus</i>) Modulates Hepatic Lipid Metabolism and Inflammation in a Rat Model of High-Fat, High-Fructose-Induced Metabolic Dysfunction by Siriwan Chumroenvidhayakul, Thavaree Thilavech, Mahinda Yapa Abeywardena, Michael Conlon, Julie Dallimore, Michael Adams, Beverly Muhlhausler, Sirichai Adisakwattana

    Published 2025-03-01
    “…Metabolic dysfunction and hepatic abnormalities, such as those associated with high-fat, high-fructose (HFHFr) diets, are major contributors to obesity-related health issues. The growing interest in sustainable dietary interventions has highlighted the potential of plant-based byproducts. …”
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  8. 1568

    Oral delivery of GLP-1 peptide using recombinant Lactobacillus gasseri for the treatment of type 2 diabetes mellitus by Zhiqiang Ke, Qianqian Ma, Xiaonan Ye, Yan Jin, Yanlin Wang, Xinyuan Zhao, Zhengding Su

    Published 2025-08-01
    “…The supernatants of LgsGPA cultures significantly upregulated the expression of PDX-1 and stimulated insulin release in Min6 cells. …”
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  9. 1569

    Real-time quantitative PCR method for assessing wheat cultivars for resistance to Zymoseptoria tritici by Tika B. Adhikari, Boovaraghan Balaji, Stephen B. Goodwin

    Published 2025-06-01
    “…However, there is little understanding of the growth dynamics of the causal fungus during the 14- to 18-day latent period between penetration and symptom expression, making it challenging to develop wheat cultivars resistant to Z. tritici. …”
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  10. 1570

    PPARγ Agonists in Adaptive Immunity: What Do Immune Disorders and Their Models Have to Tell Us? by Laurindo Ferreira da Rocha Junior, Andréa Tavares Dantas, Ângela Luzia Branco Pinto Duarte, Moacyr Jesus Barreto de Melo Rego, Ivan da Rocha Pitta, Maira Galdino da Rocha Pitta

    Published 2013-01-01
    “…The present review addresses these issues by placing PPARγ agonists in the context of adaptive immune responses and the relation of the activation of these receptors with the expression of cytokines involved in adaptive immunity.…”
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  11. 1571

    Comprehensive benchmarking of genome editing quantification methods for plant applications by Zheng Gong, Yan Zhang, Di Xia, Sohye Yoon, Peter Alexander Crisp, José Ramón Botella

    Published 2025-06-01
    “…Furthermore, we discuss the advantages and drawbacks of each technique, the issues faced during optimization and the solutions we devised. …”
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  12. 1572

    Mendelian randomization and transcriptomic analysis reveal a positive cause-and-effect relationship between Alzheimer's disease and colorectal cancer by Wei Du, Xueming Xia, Qiheng Gou, Yan Qiu

    Published 2025-01-01
    “…Background: This study addresses the complex multifactorial causes of Alzheimer's disease (AD) and colorectal cancer (CRC), two significant public health issues. Despite previous research, the precise relationship between AD and CRC remains unclear. …”
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  13. 1573

    Self-Care in Palliative Healthcare Professionals: A Qualitative Study by Andrea Bovero, Maria Federica Spada, Alessandra Loreta Cito, Alexa Victoria Pidinchedda, Chiara Tosi, Sara Carletto

    Published 2025-04-01
    “…<b>Background/Objectives</b>: Self-care strategies enhance well-being and facilitate coping with emotional distress, particularly for palliative care professionals dealing with end-of-life issues. This study aimed to explore self-care practices among healthcare professionals working in palliative care settings by analyzing their perceptions and reflections. …”
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  14. 1574

    Integrating Virtual Reality into Art Education: Enhancing Public Art and Environmental Literacy Among Technical High School Students by Chin-Wen Liao, Cheng-Chia Wang, I-Chi Wang, En-Shiuh Lin, Bo-Siang Chen, Wei-Lun Huang, Wei-Sho Ho

    Published 2025-03-01
    “…The experimental group excelled in spatial expression, showing better understanding and interaction with spatial concepts. …”
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  15. 1575

    NUTRI-ONCOCARE: New integral nutrition care model to prevent and treat malnutrition in cancer patients by Mariola Sirvent-Ochando, Ana Murcia-Lopez, Cristina Sangrador-Pelluz, Sara Espla, Margarita Garrido-Siles, Jimena Abiles

    Published 2021-05-01
    “…<p><strong>Objective:</strong> The maximum expression of malnutrition in cancer patients is cancerous cachexia, always linked to an unfavorable prognosis. …”
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  16. 1576

    Infrared Small Target Detection Based on Weak Feature Enhancement and Target Adaptive Proliferation by Xiaoyu Xu, Weida Zhan, Yichun Jiang, Depeng Zhu, Yu Chen, Jinxin Guo, Ziqiang Hao, Deng Han

    Published 2025-01-01
    “…In addition, we introduced a target data self-adaptive proliferation strategy (DSAS) to address the imbalance of positive and negative samples, enhancing the generalization and expression capability of the detection datasets. Finally, we proposed a target-background joint loss to alleviate the imbalance issue and help the network converge smoothly. …”
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  17. 1577

    School as a Safe Space through Gender-Responsive Basic Education Policy by Gemar B. Mori

    Published 2024-10-01
    “…There are gaps in policy implementation, and safety issues faced by LGBTQIA+ learners persist. Purpose. …”
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  18. 1578

    The Role of Convection and Size Effects in Microhotplate Heat Exchange: Semiconductor and Thermomagnetic Gas Sensors by Alexey Vasiliev, Alexey Shaposhnik, Oleg Kul, Artem Mokrushin

    Published 2025-04-01
    “…We analyzed convection issues in two groups of gas sensors: semiconductor and thermocatalytic (calorimetric) sensors and, on the other hand, in the oxygen sensors of the thermomagnetic type. …”
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  19. 1579

    Data standards for single‐cell RNA‐sequencing of paediatric cancer by Xiaohan Xu, John Saxon, Megan Sioe Fei Soon, Colin YC Lee, Zewen Kelvin Tuong

    Published 2025-01-01
    “…We urge data standards institutes and repositories, such as NCBI Gene Expression Omnibus (GEO) and European Genome‐Phenome Archive (EGA), to strictly enforce these standardised data practices.…”
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  20. 1580

    VERBAL NEOLEXEMS OF INDIVIDUAL AUTHOR’S IN THE NEWSPAPER LANGUAGE OF THE LATE 20th CENTURY: SEMANTICS AND WORD FORMATION by Olena M. Turchak

    Published 2022-06-01
    “…Such formations enrich the semantics of the sentence, expand the associative connections with other lexemes, consequently the context acquires a unique meaning, which enhances the expressiveness of the whole utterance. Authorial verbs, adjectives and adverbs are always expressive and original. …”
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