Self-Control, Rationality, Ethics, and Mutual Respect: A Dominican Poet Addresses His Audience and Calls Them to Reason. Ulrich Bonerius’s The Gemstone (1350) by Albrecht Classen

“…Nevertheless, the timeless value of fables finds particularly powerful expression in the collection of fables, Der Edelstein, by the Dominican Swiss-German poet Ulrich Bonerius (ca. 1350). …”
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Nanogene editing drug delivery systems in the treatment of liver fibrosis by Qun Wang, Siyu Jia, Zihan Wang, Hui Chen, Xinyi Jiang, Yan Li, Peng Ji, Peng Ji

“…Future studies need to address these issues further to explore the potential and application of liver fibrosis technologies in treating liver fibrosis.…”
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Design of an Early Prediction Model for Parkinson’s Disease Using Machine Learning by K. Velu, N. Jaisankar

“…In the initial phases of PD, individuals have trouble with speech and exhibit a slow rate of verbal expression. Dysphonia is seventy to ninety percent of persons with Parkinson’s disease report a speech impairment or modification in speech, and it serves as a preliminary indicator of the disease. …”
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Smart societies, gender and the 2030 spotlight - are we prepared? by Bissera ZANKOVA

“…Technology can help women and girls access new opportunities, means of expression and channels for participation. However, technological boom can also cause imbalances in the convergent environment. …”
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Private information in public spaces: Facial recognition in the times of smart urban governance by Juliana NOVAES

“…Results: As a result, this paper points to some of the issues that arise with the implementation of surveillance technologies in public services, such as the invasions of individuals’ rights of privacy and freedom of expression. …”
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Influence of the Power Generation Capacity of the Structural Parameters of a Piezoelectric Bimorph by Xiaochao Tian, Jinzhi Zhu, Zhicong Wang, Hu Wang, Yuze Sun, HaiGang Wang, Sida Zhang, Zhigang Yang

“…With the popularization of integrated circuits, MEMS, and portable electronic devices, chemical batteries have many disadvantages as the main energy supply method, such as large size, high quality, and limited energy supply life, requiring regular replacement, resulting in waste of materials, environmental pollution, and other issues. From the above reasons, energy harvesting technology plays an important role in improving the efficiency and life of electronic equipment. …”
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Knowing the Unknown: The Paradox of “The Absolute Unknown” From Fakhr al-Din al-Razi to Tashkoprizada by Harun Kuşlu

“…Upon this, both the statement of the paradox and the scholarly framework within which it came to be addressed were renewed. Rather than the issues surrounding the possibility of the acquisition of knowledge, the issue was centered in this framework on the structural relationship between the parts of knowledge (i.e., conception and assent ), and the impact such a relationship had on how the topics of logic came to be discussed. …”
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G3DC: A Gene-Graph-Guided Selective Deep Clustering Method for Single Cell RNA-seq Data by Shuqing He, Jicong Fan, Tianwei Yu

“…Single-cell RNA sequencing (scRNA-seq) technology measures the expression of thousands of genes at the cellular level. …”
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A myotropic AAV vector combined with skeletal muscle cis-regulatory elements improve glycogen clearance in mouse models of Pompe disease by P. Sellier, F. Collaud, Y. Krimi Benchekroun, V. Jimenez, X. Leon, N. Daniele, Q.H. Pham, J. El Andari, T. VandenDriessche, M.K. Chuah, D. Grimm, F. Bosch, F. Mingozzi, G. Ronzitti

“…However, increased muscle-specific expression led to a robust anti-hGAA immune response. …”
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RNA-Seq Identification of Peanut Callus-Specific Promoters and Evaluation of Base-Editing Efficiency by Lulu Xue, Han Liu, Huanhuan Zhao, Pengyu Qu, Xiaona Li, Xiaobo Wang, Bingyan Huang, Ziqi Sun, Suoyi Han, Xiaodong Dai, Wenzhao Dong, Lei Shi, Xinyou Zhang

“…To mitigate these issues in peanut (<i>Arachis hypogaea</i> L.), callus-specific promoters were screened to restrict Cas9 expression to the callus stage, minimizing its activity in regenerated plants. …”
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In vivo efficacy and safety of systemically administered serinol nucleic acid-modified antisense oligonucleotides in mouse kidney by Toshiki Tsuboi, Keita Hattori, Takuji Ishimoto, Kentaro Imai, Tomohito Doke, Junichiro Hagita, Jumpei Ariyoshi, Kazuhiro Furuhashi, Noritoshi Kato, Yasuhiko Ito, Yukiko Kamiya, Hiroyuki Asanuma, Shoichi Maruyama

“…However, their therapeutic application has been constrained by challenges such as instability, off-target effects, delivery issues, and immunogenic responses. Furthermore, their practical utility in treating kidney diseases remains unrealized. …”
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Fibrous dysplasia/McCune-Albright syndrome: state-of-the-art advances, pathogenesis, and basic/translational research by Biagio Palmisano, Camryn Berry, Alison Boyce, Julia F. Charles, Michael T. Collins, Alessandro Corsi, Fernando A. Fierro, Anne-Marie Heegaard, Hanne van der Heijden, Charles S. Hoffman, Chelsea Hopkins, Jaymin Upadhyay, Paul M. Wehn, Kelly L. Wentworth, Yingzi Yang, Xuefeng Zhao, Edward C. Hsiao, Mara Riminucci

“…In contrast, a detailed understanding of the cellular and molecular mechanisms that act downstream of the Gαs pathway to generate FD bone lesions and clinical expression thereof remain elusive. Multiple key issues remain to be addressed, including some questions that have recently emerged such as the interaction between mutated and non-mutated cells and the role of the latter in the development of the fibrotic tissue. …”
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Early stage of metabolic dysfunction associated steatotic liver disease disrupts circadian rhythm and induces neuroinflammation in rats by Paul-Henri Graindorge, Justine Paoli, Berivan Yildirim, Chloe Morel, Ameziane Herzine, Maud Collin, Isabelle Gallais, Stephane Boucard, Benoît Pouyatos, David Meyre, Dominique Lagadic-Gossmann, Odile Sergent, Henri Schroeder, Nathalie Grova

“…Associated brain disorders include sleep, cognitive issues, anxiety, and depression. While neurological complications in advanced MASLD are well documented, early cerebral manifestations remain largely unexplored. …”
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Arbuscular mycorrhizal fungi increase aleurone layer zinc concentration but reduce overall zinc bioavailability in rice grain by Thi Diem Nguyen, Na Sai, Alexander A. T. Johnson, Enzo Lombi, Euan Smith, Casey L. Doolette, Timothy R. Cavagnaro, Stephanie J. Watts‐Williams

“…Biofortification of rice with zinc (Zn) and iron (Fe) aims to combat the health issues associated with “hidden hunger”. Arbuscular mycorrhizal (AM) fungi have been explored for their potential to enhance Zn and Fe uptake in rice products. …”
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Probiotic Administration Contributes to the Improvement in Intestinal Dysregulation Induced by Allergic Contact Dermatitis by Eduardo Mendes, Evelyn Roxana Perez Umana, Daniel Di Pace Soares Penna, Fernando Augusto de Oliveira, Leandro Nascimento Lemos, Willian Rodrigues Ribeiro, Mateus Barbosa Casaro, Mariana Lazarini, Valéria Maia Oliveira, Caroline Marcantonio Ferreira

“…The findings suggest that probiotics could be a therapeutic strategy to prevent intestinal issues caused by skin diseases.…”
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Wharton’s jelly mesenchymal stromal cells derived from preterm umbilical cord reveal a hepatogenic potential by F. Timoneri, M. Lo Iacono, S. Corrao, G. Alberti, G. Amico, T. Corsello, P. G. Conaldi, Eleonora Russo, Eleonora Russo, G. La Rocca

“…Preterm umbilical cord (birth before 37 weeks of gestation) is generally considered a waste product, so its use does not affect ethical issues. Similarly to the full-term UC, it can be considered a valid source of WJ-MSCs, although little is known about their phenotype and differentiation capacity. …”
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The Development of Mabādī Subjects in the Classical Books on Uṣūl al-Fiqh by Yakup Dalmızrak

“…The jurists, on the other hand, kept their distance from transferring the issues of kalām to works on methodology but did not hesitate to express their thoughts on the subject when appropriate. …”
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Semiotic Visual Analysis of Avant-Garde Fashion Designs in Ghana by Noble Nkrumah-Abraham, Genevieve Adjei-Appoh, Francis Kwasi Selormey Amenakpor

“…The design samples gathered in the study addressed these concerns as well as other issues such as health, marriage, and politics among other socio-cultural concerns. …”
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Drawing as an experience. Knowledge, simulation and participation by Giuseppe Amoruso

“…The chapter, starting from the new social condition inspired by the learning society introduces issues and questions about the role of designers in the future. …”
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Poet Ahmet Çıtak’s Epics of Our Prime Minister and Makarios in the Context of the Relationship Between Literature and History by Adnan Boyunduruk

“…From the past to the present, minstrels and poets have expressed individual issues such as love, longing, affection, expatriation, as well as social issues such as flood, earthquake, famine, war and migration through their works. …”
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