Computationally Effective Gravity Inversion Allows for High-Resolution Regional Density Modeling of Earth's Crust with the Inclusion of the Topography Layer by Martyshko Pyotr, Byzov Denis, Chernoskutov Aleksandr

“…In this paper however, we will address those issues simultaneously, offering a complete and computationally effective method of recovering spherical density model of Earth's crust with the upper topography layer. …”
Get full text

School Leadership and the Civic Nationalist Turn: towards a typology of leadership styles employed by Head Teachers in their enactment of the Prevent Duty and the promotion of fund... by Hazel Bryan, Lynn Revell

“…The Windrush scandal of 2017 was an expression of this environment, and coupled with a resurgent nationalism, the UK voted to leave the EU.   …”
Get full text

Visual symbolism in 2D animated film on the traumatic impact of child abuse by Alisa Arindhani, Devi Kurniawati Homan, Jonata Witabora

“…Sexual violence remains a critical and pervasive issue in Indonesian society, affecting victims across diverse demographics and social backgrounds. …”
Get full text

Development of animal model for anterior open bite and mechanism of temporomandibular joint morphological change: an implication for MAC surgery by Yaosen Chen, Ikuo Yonemitsu, Risa Usumi-Fujita, Albert Chun-Shuo Huang, Shuntaro Iwaki, Koichi Fujita, Takashi Ono

“…Abstract Background Although mandibular autorotation concept (MAC) surgery is a novel technique for addressing long-term stability issues in patients with mandibular retrusion and open bite accompanied by temporomandibular joint osteoarthritis (TMJOA), studies on MAC surgery in animal models and its mechanisms are scarce. …”
Get full text

Targeting Replication Fork Processing Synergizes with PARP Inhibition to Potentiate Lethality in Homologous Recombination Proficient Ovarian Cancers by Ganesh Pai Bellare, Kshama Kundu, Papiya Dey, Krupa Thankam Philip, Nitish Chauhan, Muskan Sharma, Sankarsingh Kesharsingh Rajput, Birija Sankar Patro

“…Stilbenes are a privileged class of molecules, which include resveratrol, pterostilbene, piceatannol, etc, that modulate both replication processes and RAD51‐expression. In this investigation, by screening a small library of stilbenes, including in‐house synthesized molecules, trans‐4,4′‐dihydroxystilbene (DHS) was discovered as a potent natural agent, which downregulates RAD51 expression and HR repair (GFP‐reporter assay). …”
Get full text

Effect of sea salt on the fatty liver induced by a high fat diet by Saoraya Chanmuang, Ye-Jin Son, Quynh-An Nguyen, Dong-Shin Kim, Hyo-Kyoung Choi, Ji-Hye Song, Soo-Hyun Park, Madhuri Sangar, Kyung-Sik Ham, Sang-Mi Jo, Inhae Kang, Hyun-Jin Kim

“…Abstract High fat and salt intake link with various health issues, but the combined impact of high fat and salt, especially sea salt (SS) with minerals, on health are still not fully investigated. …”
Get full text

A pH‐Sensitive Nanosized Covalent–Organic Polymer for Enhanced Tumor Photodynamic Immunotherapy by Hypoxia Relief and STAT3 Inhibition by Lei Lei, Wenbin Dai, Jinchao Zhao, Angfeng Jiang, Haisheng Peng, Qiao Jin, Xiaojing Li, Zhe Tang

“…WP1066 effectively inhibits the expression of STAT3 and reduces PD‐L1 expression, thereby significantly inhibiting tumor immune escape and enhancing antitumor efficacy in a synergistic manner. …”
Get full text

Successful cryopreservation of marine invertebrates immune cells enables long-term studies of common octopus, Octopus vulgaris Cuvier 1797, hemocyte immune functions by María M. Costa, Estefania Paredes, Mercedes Peleteiro, Lucía Sánchez-Ruiloba, Francisco Gambón, Sonia Dios, Camino Gestal

“…Moreover, thawed acclimated cells exhibited a gene expression pattern comparable to fresh cells, as opposed to directly thawed cells. …”
Get full text

Antioxidant peptides from Lateolabrax japonicus to protect against oxidative stress injury in Drosophila melanogaster via biochemical and gut microbiota interaction assays by Chen Li, Lichan Li, Jing Cheng, Xu Chen, Mohamed A. Farag, Xixi Cai, Shaoyun Wang

“…At the gene level, LPH upregulated the expression of antioxidant-related Nrf2 genes while concurrently downregulated mTOR expression level. …”
Get full text

Topologically inferring active miRNA‐mediated subpathways toward precise cancer classification by directed random walk by Ziyu Ning, Chenchen Feng, Chao Song, Wei Liu, Desi Shang, Meng Li, Qiuyu Wang, Jianmei Zhao, Yuejuan Liu, Jiaxin Chen, Xiaoyang Yu, Jian Zhang, Chunquan Li

“…We then identified miRNAs with expression levels which were strongly inversely correlated with differentially expressed target genes in the GDPN. …”
Get full text

Serum-free endothelial cell culture medium for vascular smooth muscle cells sheet formation by Jing Yang, Xuheng Sun, Hongjing Jiang, Jiandong Li, Jierong Liang, Zhanyi Lin

“…However, concerns regarding immunogenicity and ethical issues, which are raised by the use of fetal bovine serum (FBS) in traditional culture systems, limit its potential for clinical translation. …”
Get full text

Stacking ensemble learning models diagnose pulmonary infections using host transcriptome data from metatranscriptomics by Tian Zhang, Ying Deng, Wentao Wang, Zhe Zhao, Yiling Wu, Haoqian Wang, Shutao Xia, Weifang Liao, Weijie Liao

“…To identify host gene expression signatures associated with infection, we screened characteristic genes from human metatranscriptomic data by comparing 70% of patients with confirmed infections vs. non-infections. …”
Get full text

Theoretical Simulation of Output Characteristics of an RTD-Fluxgate Sensor Under Sawtooth Wave Excitation by Haibo Guo, Na Pang, Xu Hu, Rui Wang, Guo Li, Fei Li

“…To address these issues, this paper proposed using a sawtooth wave as the excitation waveform for RTD-fluxgate sensors. …”
Get full text

Xiao Yao San mitigates corticosterone stimulation-induced hippocampal neuronal damage by inhibiting GR phosphorylation and nuclear translocation via FKBP4 involvement by Xuedi Kang, Ting Wang, Haiping Wan, Wenjun Fu, Songjun Lin

“…It downregulated FKBP51 expression and suppressed GR phosphorylation and nuclear translocation. …”
Get full text

Digital Culture of the Individual as a Factor in the Socio-Psychological Safety of the Digital Space by M. E. Kudryavtseva, A. V. Pryakhina

“…The legitimacy of the digital world as a different “mode of being” and a space for self-expression is recognized primarily by representatives of the younger age group, which is an alarming symptom. …”
Get full text

Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids by Cong-Yi Shen, Qi-Rong Zhou, Xiang Wu, Xin-Yu Han, Qin Zhang, Xiao Chen, Yu-Xiao Lai, Long Bai, Ying-Ying Jing, Jian-Hua Wang, Cheng-Long Wang, Zhen Geng, Jia-Can Su

“…Despite extensive research on biomaterials for cartilage repair in recent years, issues such as prolonged repair cycles and suboptimal outcomes persist. …”
Get full text

The injury effect of osteopontin in sepsis-associated lung injury by Qian Wang, Zhicai Yu, Zhixin Song, Xue Lu, Zhu Li, Dandan Pi, Jing Li, Feng Xu

“…Within the sepsis mouse model, there was a marked increase in OPN expression in the lung’s tissues compared to the sham group mice. …”
Get full text

Evidentiary Value of Reconciliation: Developing Professor Elena I. Nosyreva’s Ideas by Natalia S. Zvyagina, Egor S. Trezubov

“…The article examines the issues of evidentiary value of information obtained during conciliation procedures in civil law proceedings. …”
Get full text

Christianity, ‘supernatural’ beliefs and COVID-19 by E. Shoko

“… COVID-19 arguably had far-reaching implications for Christianity and the church as an institution. Issues around social distancing and lockdown directly impacted articulation and religious expression, while understanding of the pandemic and the virus were mediated through constructions of religio-spiritual beliefs. …”
Get full text

Drosophila Eye Gene Regulatory Network Inference Using BioGRNsemble: An Ensemble-of-Ensembles Machine Learning Approach by Abdul Jawad Mohammed, Amal Khalifa

“…Improving accuracy and comprehensiveness will require addressing these issues through hyperparameter fine-tuning, the development of alternative scoring mechanisms, and the incorporation of additional validation methods.…”
Get full text