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1181
Sustainable Agriculture: The Role of Biostimulants in Enhancing Crop Growth and Resilience
Published 2025-04-01“…Humic compounds modulate gene expression and activate antioxidant pathways to improve soil fertility and stress tolerance. …”
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1182
In vitro hair growth-promoting effects of araliadiol via the p38/PPAR-γ signaling pathway in human hair follicle stem cells and dermal papilla cells
Published 2024-12-01“…Specifically, it increased the protein expression of cyclin B1 and Ki67. In HHFSCs, it elevated the expression of hair growth-promoting factors, including CD34, vascular endothelial growth factor (VEGF), and angiopoietin-like 4. …”
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1183
The mevalonate pathway contributes to breast primary tumorigenesis and lung metastasis
Published 2025-01-01“…The mevalonate pathway plays an important role in breast cancer and other tumor types. However, many issues remain obscure as yet regarding its mechanism of regulation and action. …”
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1184
Assessing the effectiveness of preventing placenta-associated complications in patients with burdened obstetric history and circulating antiphospholipid antibodies
Published 2024-09-01“…The role of antiphospholipid antibody (APA) carriage in the pathogenesis of pregnancy failure is one of the most recently debated issues. To date, no unified therapeutic approach to immunotherapy of antiphospholipid syndrome (APS) in pregnancy exists. …”
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1185
Development and characterization of a novel immortalized human vaginal fibroblast cell line for advanced applications in reproductive health
Published 2025-04-01“…Abstract Background Reproductive health issues related to the vagina, face significant challenges due to the lack of standardized research models. …”
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1186
Emerging Roles of GDF15 in Metabolic and Cardiovascular Diseases
Published 2025-01-01“…This review summarizes the expression, distribution, structure, processing, and secretion of GDF15. …”
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1187
Temperature‐sensitive sodium beta‐glycerophosphate/chitosan hydrogel loaded with all‐trans retinoic acid regulates Pin1 to inhibit the formation of spinal cord injury‐induced rat g...
Published 2025-05-01“…Mechanistically, ATRA administration blocks the development of glial scars and the activation of the PI3K/AKT/CDK2 pathway by inhibiting Pin1 expression. This study suggests that combining ATRA with a hydrogel to target Pin1 expression may be a promising strategy for treating glial scar formation following SCI.…”
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1188
Neuroendocrine tumors of the digestive system: pathologic and molecular characteristics
Published 2015-06-01“…In the light of these criteria, current issues of the nomenclature, as well as systems of grading and staging are discussed. …”
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1189
(Un) Critical Pedagogy: Current Priorities and Prospects of Development
Published 2023-04-01“…It is substantiated that various forms of discrimination often arise in the educational setting due to the social or material status of the child's parents, and his/her racial or religious affiliation, that is, they are associated with the rejection of diversity and have an impact on the educational process and personal self-expression in society. The issue of criticality in education must be considered in the modern dimension: in school and student society, teaching and scientific activities, educational management, pedagogical imageology, intercultural education, etc. …”
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1190
The impact of alexithymia, anxiety, social pressure, and academic burnout on depression in Chinese university students: an analysis based on SEM
Published 2024-12-01“…Furthermore, the positive influence of academic burnout on anxiety and depression indicates that excessive academic burdens are significant sources of mental health issues for college students. This research offers new insights into understanding college students’ mental health issues, aiming to provide more comprehensive intervention strategies for their psychological well-being.…”
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1191
Dietary <i>Astragalus</i> Polysaccharides Can Improve the Immune Capacity and Reproductive Performance of the Lined Seahorse (<i>Hippocampus erectus</i>)
Published 2025-06-01“…However, in recent years, two new issues have gradually emerged in Chinese seahorse cultivation. …”
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1192
Fault Type Recognition and Localization Method for Grounding Electrode Line Based on Modulus Backward Traveling Wave
Published 2025-02-01“…To address the above issues, this paper adopts an active traveling wave injection method, and through analytical calculations, obtains the time-domain expression of the modulus-backward traveling wave at the measuring point at the first end of the ground electrode line after a single-line ground fault, a cross-line fault, a single-line open-circuit fault and a double-line open-circuit fault. …”
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1193
Wb5, a novel biomarker for monitoring efficacy and success of mass drug administration programs for Wuchereria bancrofti elimination.
Published 2025-05-01“…As current testing suffers from either sensitivity or specificity levels that fail to meet adopted target product profiles, additional targets that could be used as confirmatory tests or in multiplexed assays could overcome these issues. To this end, bioinformatic analyses coupled with stage-specific expression data for W. bancrofti (Wb) and/or B. malayi (Bm) resulted in the identification of 12 targets that were: 1) present in Wb and/or Bm; 2) had very little to no homology with proteins from other filariae; and 3) were enriched in the microfilarial or L3 stages. …”
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1194
5-Azacytidine-Induced Cardiomyocyte Differentiation of Very Small Embryonic-Like Stem Cells
Published 2020-01-01“…Due to the propensity of stem cells to form tumors, as well as ethical issues surrounding their use, the seed cells used in cardiac biological pacemakers have limitations. …”
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1195
MTFSR: Multitemporal and Spatial Feature Reconstruction Denoising Network for Remote Sensing Change Detection
Published 2025-01-01“…Meanwhile, a spatial attention mechanism and discrete cosine transform (DCT) are incorporated to further improve the spatial expression and frequency domain perception of the features. …”
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1196
Precise copper ion release and recovery in polycaprolactone nanofiber scaffold: an antibacterial and osteogenic synergistic strategy for guided bone regeneration
Published 2025-08-01“…IntroductionInfection control and bone regeneration remain major challenges in orthopedic therapy. To address these issues, we developed a multifunctional guided bone regeneration (GBR) nanofibrous material based on electrospun polycaprolactone (PCL). …”
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1197
Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics
Published 2025-03-01“…Here, we present a nonparametric statistical method, BEANIE, for differential expression of gene signatures between clinically relevant groups that addresses these issues. …”
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1198
Conceptual Framework of Energy-and-Ecology of Indoor Plant Lighting
Published 2018-12-01“…The author proposes to expand the range of issues considered in this field and highlight the energy-and-ecology of horticulture (EEH) as a scientific area located at the junction of power engineering and technical subjects, plant physiology, and ecology. …”
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1199
Human Amnion-Derived Mesenchymal Stem Cells Promote Osteogenic Differentiation in Human Bone Marrow Mesenchymal Stem Cells by Influencing the ERK1/2 Signaling Pathway
Published 2016-01-01“…Human amnion-derived mesenchymal stem cells (HAMSCs) are considered to be an important resource in the field of tissue engineering because of their anti-inflammatory properties and fewer ethical issues associated with their use compared with other sources of stem cells. …”
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1200
Basolateral Amygdala but Not Medial Prefrontal Cortex Contributes to Chronic Fluoxetine Treatments for PTSD Symptoms in Mice
Published 2020-01-01“…The Cg1, PrL, IL, and BLA were seemingly to increase c-Fos expression after footshock-induced PTSD symptoms in the situational reminder phase. …”
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