Discovery and preclinical development of a therapeutically active nanobody-based chimeric antigen receptor targeting human CD22 by Scott McComb, Mehdi Arbabi-Ghahroudi, Kevin A. Hay, Brian A. Keller, Sharlene Faulkes, Michael Rutherford, Tina Nguyen, Alex Shepherd, Cunle Wu, Anne Marcil, Annie Aubry, Greg Hussack, Devanand M. Pinto, Shannon Ryan, Shalini Raphael, Henk van Faassen, Ahmed Zafer, Qin Zhu, Susanne Maclean, Anindita Chattopadhyay, Komal Gurnani, Rénald Gilbert, Christine Gadoury, Umar Iqbal, Dorothy Fatehi, Anna Jezierski, Jez Huang, Robert A. Pon, Mhairi Sigrist, Robert A. Holt, Brad H. Nelson, Harold Atkins, Natasha Kekre, Eric Yung, John Webb, Julie S. Nielsen, Risini D. Weeratna

Get full text

Exploring Qualitative Evidence Through a School-Based Intervention: Can Youth Be Empowered Through Writing? by Maria Farella, Ingrid Sladeczek, Danielle Groleau

“…Research indicates that in-school programs are more successful in addressing common mental health issues and promoting well-being. This evaluation study was performed on the Kids Write Network, an expressive writing intervention that aims to facilitate emotional expression and processing by encouraging individuals to address and reassess adverse life events through writing. …”
Get full text

Exploring Multifactorial Expressed Emotion among Caregivers of Bipolar Disorder Patients: Insights from a Pilot Study in Tamil Nadu, India by Vrinda Sankar Kala, Arul Saravanan Ramachandran, Manesh Muraleedharan, Alaka Omprakash Chandak, Girija Mahale

“…Background: Expressed emotion (EE) among caregivers of bipolar mood disorder patients has been identified as a risk factor for relapse. …”
Get full text

Antitumor power of oncolytic HSV engineered with IL-12 and IL-15 by Lei Zhang, Yanbin Zhu, Kunpeng Zheng, Xinyu Zhang, Chunxue Fu, Dan Wang, Xinqiang Zhang, Tong Wu, Shuxin Han, Zhenghai Ma

Get full text

Food Problem in Eastern Siberia Cities during First World War and Its Consideration at Congress of Cities Representatives in April 1916 by O. M. Dolidovich

“…It is reported that at the Congress of cities representatives of Eastern Siberia in Irkutsk, April 15-19, 1916 the issue of supplying the population with food was one of the main. …”
Get full text

Targeted expansion of cytotoxic T cells using IL-12 and CD137L supplementation enhances antitumor efficacy by Marta Sanz, Brendan T. Mann, Elyse K. McMahon, Alberto Bosque, Samuel Simmens, Natalia Soriano-Sarabia

“…Here, we show the in vitro expansion of cytotoxic Vδ2 T cells expressing CD16 and NKG2A enriched in granzyme B that displayed enhanced antitumor activity of up to 40% against leukemia and ovarian, breast, and lung cancer cells. …”
Get full text

Oncolytic adenovirus inhibits TNBC tumor growth/metastasis in mice by targeting TGFB and overexpressing GM-CSF by Nguyễn Thị Thanh Nhàn, Soon Cheon Shin, Beniamin Filimon, Yuefeng Yang, Zebin Hu, Bruce Brockstein, Weidong Xu

Get full text

TheraVision: Engineering platform technology for the development of oncolytic viruses based on herpes simplex virus type 1 by Christina Funk, Nadja Uhlig, Zsolt Ruzsics, Florentin Baur, Matthias Peindl, Sarah Nietzer, Karina Epting, Gabriele Vacun, Gudrun Dandekar, Catherine Botteron, Christian Werno, Thomas Grunwald, Susanne M. Bailer

Get full text

Intra-tumoral administration of CHST15 siRNA remodels tumor microenvironment and augments tumor-infiltrating T cells in pancreatic cancer by Juanjuan Ye, Futoshi Suizu, Keiko Yamakawa, Yuri Mukai, Hiroyuki Yoneyama, Jiro Kondo, Motohiko Kato, Akira Nishiyama, Naohisa Yahagi, Kyuichi Kadota

Get full text

Allele-specific depletion of GNAQQ209L via siRNA or an rAAV2-shRNA vector induces selective toxicity in GNAQQ209L uveal melanoma cells by Trace F. McCall, Emma J. Sawyer, Joshua Darnell, Matthew L. Hirsch, Jacquelyn J. Bower

Get full text

Expression of matrix metalloproteinases 1, 2, 9, 12 in xenogenic tissues of epoxy-crosslinked bioprosthetic heart valves explanted due to dysfunction by A. E. Kostyunin, T. V. Glushkova

Get full text

Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. by Zhumur Ghosh, Kitchener D Wilson, Yi Wu, Shijun Hu, Thomas Quertermous, Joseph C Wu

“…Human induced pluripotent stem cells (hiPSCs) generated by de-differentiation of adult somatic cells offer potential solutions for the ethical issues surrounding human embryonic stem cells (hESCs), as well as their immunologic rejection after cellular transplantation. …”
Get full text

Unveiling the impact of bisphenol a exposure on gene expression and immune response in diabetic nephropathy through integrative toxicogenomics and molecular dynamics approaches by Yan Zhang, Shan Lu, Yijun Dong, Jin Shang

“…Abstract Background Bisphenol A (BPA) exposure has been implicated in various health issues, including diabetic nephropathy (DN). Understanding the molecular mechanisms underlying BPA-induced DN is crucial for developing effective therapeutic strategies. …”
Get full text

Passenger Flow Impact Analysis of Express/Local Train Operation Plans for Urban Rapid Rail Transit Line Based on VISUM Software by WANG Chaoyu, TANG Qing, CHEN Hongbing, HE Hongjie

“…To further optimize the operation plan, issues such as long intervals between express trains and inconvenient interchanges between express and local services should be addressed.…”
Get full text

VARIATION ET TRADUCTION: A LA RECHERCHE DE L’EQUIVALENCE FONCTIONNELLE by Olga INKOVA

“…The author addresses the problem of formal equivalence when translating a mainly expressive text focused on form. This issue is broached through the translation into French of Gogol’s novel “The Overcoat” and, more precisely, of the incoherent language of the main character of the novel, Akaki Akakievitch Bachmatchkine. …”
Get full text

Big data based metro crowd delivery system by Kun-fang ZHANG, Ming-ming LU, Lin ZHENG

“…In recent years,the demand for urban express delivery experiences fast growing.Several startup delivery corporations,such as iShansong,have provided the delivery services,which are promised to deliver a parcel within 1 or 3 hours in a city.However,since the quality of the promised services have not been fully quantitatively analyzed based on real data,it is quite often that couriers refuse to pick up delivery requests or the accepted parcels fail to be delivered on time.To address the above issue,a metro crowd-delivery system was proposed,which could utilize the historical records of metro passengers to analyze the quality of the delivery service and provide differential service within different period of time.The system not only meet the requirements of high delay requirements of the courier,but also as a city-wide express supplement.At the same time,a courier transit program was proposed.Experiments show that this transfer program is efficient.…”
Get full text

Effect of dietary zinc supplementation on the gastrointestinal microbiome and host gene expression in the Shank3B−/− mouse model of autism spectrum disorder by Giselle C. Wong, Giselle C. Wong, Yewon Jung, Yewon Jung, Kevin Lee, Kevin Lee, Chantelle Fourie, Chantelle Fourie, Kim M. Handley, Johanna M. Montgomery, Johanna M. Montgomery, Michael W. Taylor, Michael W. Taylor

“…This raises the potential of manipulating both dietary zinc and the gut microbiota itself to ameliorate ASD-related behaviours and associated gastrointestinal issues. These data broaden understanding of the gut microbiome in autism and pave the way towards potential microbial therapeutics for gastrointestinal problems in people with autism.…”
Get full text

FSTL-1 as a Novel Cardiokine of Cardiac Angiogenesis: A Systematic Review by Karisa P, Sylviana N, Fitria N, Setiawan S

Get full text

Lipid Nanoparticles Formulated with a Novel Cholesterol-Tailed Ionizable Lipid Markedly Increase mRNA Delivery Both in vitro and in vivo by Jeon JH, Zhu H, Qin J, Wang L, Mou S, Langston LK, Marasini R, Chen J, Xu R, Li S, Cui X

Get full text

MiRNA-130a promotes inflammation to accelerate atherosclerosis via the regulation of proliferator-activated receptor γ (PPARγ) expression by Fengtong Liu, Yali Liu, Yuqing Du, Youshan Li

Get full text