MicroRNA-22 inhibits proliferation and promotes differentiation of satellite cells in porcine skeletal muscle by Hong Quyen DANG, Gu-li XU, Lian-jie HOU, Jian XU, Guang-liang HONG, Chingyuan HU, Chong WANG

“…Improving meat quality and meat productivity is a long time issue in animal genetic breeding. MicroRNAs (miRNAs) are short non-coding RNAs that participate in various biological processes, such as muscle development and embryogenesis. miR-22 differentially expresses in embryonic and adult skeletal muscle. …”
Get full text

Dual targeting of BCMA and SLAMF7 with the CARtein system: chimeric antigen receptors with intein-mediated splicing elicit specific T cell activation against multiple myeloma by Noelia Moares, Noelia Moares, Pablo Gonzalez-Garcia, Pablo Gonzalez-Garcia, Wenjie Yi-He, Wenjie Yi-He, Juan P. Muñoz-Miranda, Juan P. Muñoz-Miranda, Antonio Gabucio, Antonio Gabucio, Rosa Luna-Espejo, Javier Ocaña-Cuesta, Ricardo Fernandez-Cisnal, Cecilia M. Fernandez-Ponce, Cecilia M. Fernandez-Ponce, Francisco Garcia-Cozar, Francisco Garcia-Cozar

“…However, several barriers continue to limit the overall effectiveness of this approach, such as high production costs, prolonged manufacturing timelines, safety issues, and the potential for tumor antigen escape due to selective therapeutic pressure. …”
Get full text

In vitro antibacterial efficacy of a novel chicken-derived Bacillus subtilis GX15 strain and its protective mechanisms in mice challenged by Salmonella enterica serovar typhymurium by Huili Bai, Yuying Liao, Jingshan Lu, Zhe Pei, Yangyan Yin, Chunxia Ma, Zhongwei Chen, Changting Li, Jun Li, Yu Gong, Ling Teng, Leping Wang, Zijuan Su, Hailan Chen, Hao Peng

“…Abstract Background The escalating issue of bacterial resistance, coupled with stringent restrictions on antibiotic use in many countries, has prompted the search for alternative strategies to combat bacterial infections. …”
Get full text

Ginsenoside Rb1 and berberine synergistically protect against type 2 diabetes mellitus via GDF15/HAMP pathway throughout the liver lobules: Insights from spatial transcriptomics an... by Rongfang Guo, Shuying Zhang, Anyao Li, Ping Zhang, Xin Peng, Xiaoyan Lu, Xiaohui Fan

“…Type 2 diabetes mellitus (T2DM) is a significant public health issue with high morbidity and mortality. Ginsenoside Rb1 (Rb1) and berberine (BBR), the main bioactive compounds of Panax ginseng and Coptis chinensis, respectively, are known for their hypoglycemic effects. …”
Get full text

Analysis of red blood cell transfusion reactions in China from 2018 to 2023 by PAN Bo, GUAN Xiaoyu, WANG Jue, PAN Yunlong, HE Liu, XU Haixia, JI Xin, TIAN Li, LI Ling, LIU Zhong

“…The demographic characteristics of patients who experienced transfusion reactions with different types of red blood cell preparations, the utilization of these preparations, and the differences of the composition ratios of transfusion reactions were analyzed. Count data were expressed as numbers (n) or percentages (%), and comparisons between groups were performed using the Chi-square test. …”
Get full text

A systematic review on domestic development of nursing-sensitive quality indicators for post-anesthesia care unit based on the structure-process-outcome model (国内基于结构-过程-结果模型的麻醉恢复室... by ZHANG Quyun (张屈云), ZHU Xinyan (朱欣艳)

“…方法 检索中国知网、万方数据库、中国生物医学数据库、维普数据库, 时限为建库至2023年11月18日, 通过NoteExpress软件进行文献去重, 制定纳入标准与排除标准。采用 NoteExpress提取文献资料, 根据纳入排除标准进行文献筛选。…”
Get full text

Unraveling the mechanisms of irAEs in endometrial cancer immunotherapy: insights from FAERS and scRNA-seq data by Lu Zhang, Mengjie Yang, Yiqian Zhang, Jianfa Lan, Qionghua Chen

“…Fatigue, product use issues, and diarrhea were the most reported Preferred Terms (PTs). …”
Get full text

SLC7A11 as a therapeutic target to attenuate phthalates-driven testosterone level decline in mice by Yi Zhao, Xue-Qi Wang, Rui-Qi Liu, Fu-Wei Jiang, Jia-Xin Wang, Ming-Shan Chen, Hao Zhang, Jia-Gen Cui, Yuan-Hang Chang, Jin-Long Li

“…As the primary metabolite of DEHP, mono-2-ethylhexyl phthalate (MEHP) triggered testosterone synthesis disorder accompanied by a decrease in the expression of solute carri1er family 7 member 11 (SLC7A11) protein. …”
Get full text

Maqâshid Revitalization in Global Era: Istidlâl Study from Text to Context by Mukti Tabrani

“…This paper attempts to describe <em>istidl</em><em>â</em><em>l</em> (extracting process of Islamic jurisprudence) on answering complexities of social issues and scrutinizing the classification of <em>Maqâshid</em> <em>s</em><em>yar</em><em>î`</em><em>ah</em>. …”
Get full text

DETECTION AND SYSTEMATIZATION OF SIGNS AND MARKERS OF MODIFICATIONS IN MEDIA CONTENT FOR THE DEVELOPMENT OF A METHODOLOGY TO ENHANCING CRITICAL THINKING IN THE ERA OF DEEPFAKES by Ганна Чемерис

“…The paper focuses on creating a comprehensive framework for detecting manipulated content and identifying indicators such as pixelization, unnatural expressions, etc. With attention to international and Ukrainian efforts, the work advocates for ongoing research adapted to evolving technologies to improve media literacy programs in combating emerging forms of misinformation. …”
Get full text

Using Social Media Data to Assess the Impact of Infertility on French Patients’ Quality of Life: Retrospective Observational Study by Mouna Mael-Ainin, Pierre-Emmanuel Bouet, Paméla Voillot, Joelle Malaab, Manissa Talmatkadi, Stéphane Schück, Nathalie Massin

“…The use of assisted reproductive technology (ART) for infertility issues has been steadily increasing in recent years, with in vitro fertilization being the most common type of ART. …”
Get full text

Acceptability and barriers of a GP–physiotherapist partnership in the diagnosis and management of COPD in primary care: A qualitative study by Lisa Pagano, Zoe McKeough, Sally L. Wootton, Andrew S. L. Chan, Sriram Mahadev, Nicholas Zwar, Deborah Pallavicini, Sarah Dennis

“…Abstract Introduction Chronic obstructive pulmonary disease (COPD) is commonly diagnosed and managed in primary care but there is evidence that this has been suboptimal, with low confidence expressed in providing interventions requiring behaviour change. …”
Get full text

Engineering thinking: Vectors of development in the context of the transformation of the scientific picture of the world by L. M. Andryukhina, B. N. Guzanov, S. V. Anakhov

“…Actively ongoing processes of technological transformation in the education system give rise to a situation of uncertainty, and the desire to respond to emerging challenges, most often, is expressed in disparate, local educational solutions, if they are not based on scientifically sound conceptual models of personnel training.Aim. …”
Get full text

¡Salimos a la plaza!, difundiendo al mundo lo aprendido y experimentado en materia de género desde el aula de primaria (We will go out to the square! we will open up to the world f... by Iñaki Arana Arrieta, Ainhoa Gómez-Pintado, Maria Teresa Vizcarra Morales

“…It can be concluded that the experience led them to become empowered in gender issues, fostering their growth as individuals and as active citizens, a feeling that was reinforced by the perception of support from their peers. …”
Get full text

Identifying Patients&amp;rsquo; Preference During Their Hospital Experience. A Sentiment and Topic Analysis of Patient-Experience Comments via Natural Language Techniques by Yuan J, Chen X, Yang C, Chen J, Han P, Zhang Y, Zhang Y

“…Jie Yuan,1,&amp;ast; Xiao Chen,2,&amp;ast; Chun Yang,3 JianYou Chen,3 PengFei Han,3 YuHong Zhang,2 YuXia Zhang2 1School of Nursing, Fudan University, Shanghai, 200032, People’s Republic of China; 2Department of Nursing, Zhongshan Hospital of Fudan University, Shanghai, 200032, People’s Republic of China; 3Department of Information, Zhongshan Hospital of Fudan University, Shanghai, 200032, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: YuXia Zhang, Department of Nursing, Zhongshan Hospital of Fudan University, Room 501, Building 5, Fenglin Road No. 180, Xuhui District, Shanghai, 200032, People’s Republic of China, Tel +86 13816881925, Email zhang.yx@aliyun.com YuHong Zhang, Department of Nursing, Zhongshan Hospital of Fudan University, Room 501, Building 5, Fenglin Road No. 180, Xuhui District, Shanghai, 200032, People’s Republic of China, Tel +86 13816881925, Email zhang.yuhong@zs-hospital.sh.cnBackground: Open-ended questions in patient experience surveys provide a valuable opportunity for people to express and discuss their authentic opinions. The analysis of free-text comments can add value to quantitative measures by offering information which matters most to patients and by providing detailed descriptions of the service issues that closed-ended items may not cover.Objective: To extract useful information from large amounts of free-text patient experience comments and to explore differences in patient satisfaction and loyalty between patients who provided negative comments and those who did not.Methods: We collected free-text comments on a broad, open-ended question in a cross-sectional patient satisfaction survey. …”
Get full text

Experiencias del estudiantado de la carrera de pedagogía en educación física con personas transgénero en su práctica profesional (Experiences of the students of the pedagogy career... by Elizabeth Flores Ferro, Krishna Badilla Carreño, Ángela Silva-Salse, Israel Llaupi Cornejo, Javiera Sereño Moreno, Montserrat Maldonado Cabezas, Yaime Silva Hernández, Rodrigo Gamboa Jiménez

“…In conclusion, prospective teachers express that there is no difference among students and that they do not employ different methodologies for transgender individuals. …”
Get full text

Estudios de violencia y conflicto: aproximación a un análisis transdisciplinar de la violencia política by Jairo Ernesto Sánchez

“…Finally, some partial conclusions about the body of work are expressed.   RESUMÉÉ Cet article aborde dans un premier temps une analyse de la violence et des conflits du point de vue des recherches pour la paix, et examine les causes des conflits contemporains et les principales perspectives des recherches ayant abordé ces questions. …”
Get full text

Application of Balint Intervention Groups in Professional Communication in Medical Science Education by Ali Moradi, Akram Sanagoo, Leila Jouybari

“…The members of the group take turns expressing their opinions on the topic, and finally, the group leader summarizes the opinions, and the final result is obtained (6). …”
Get full text

Thematic Analysis of Factors Influencing Helmet Non-Use among Motorcyclists in Gorgan by Vajihe Jalaeian Bakhshande, Seyes Rasoul Davoodi

“…Moreover, a sense of agency and empowerment in controlling their environment had driven some motorcyclists to forgo helmets as they sought to express their skills and individuality in this manner. …”
Get full text

“Get Well Enough to Make the Right Decision for Themselves”—Experiences and Perspectives of Clinicians Working with People with Serious Mental Illness and Their Substitute Decision... by Samuel Law, Vicky Stergiopoulos, Juveria Zaheer, Arash Nakhost

“…Clinicians’ unique understanding of this complex and nuanced intersection of patient care provides insight into the core issues of autonomy, duty to care and protect, advocacy, and emotional dynamics involved in this sector as a larger philosophical and social movement to abolish SDMs, as advocated by the Convention on the Rights of Persons with Disability (CRPD), is taking place. …”
Get full text