Calbindin 2 as a Novel Biomarker and Therapeutic Target for Abdominal Aortic Aneurysm: Integrative Analysis of Human Proteomes and Genetics by Yulin Bao, Jiayi Chen, Xudong Han, Ye He, Tongtong Yang, Xinying Shi, Jiawen Chen, Lingfeng Gu, Sibo Wang, Liping Xie, Hao Wang, Liansheng Wang

“…Background Abdominal aortic aneurysm (AAA) is a clinical life‐threatening issue. No pharmacological treatments are currently approved for the prevention and treatment of AAA. …”
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Hydroxyapatite-filled osteoinductive and piezoelectric nanofibers for bone tissue engineering by Frederico Barbosa, Fábio F. F. Garrudo, Paola S. Alberte, Leonor Resina, Marta S. Carvalho, Akhil Jain, Ana C. Marques, Francesc Estrany, Frankie J. Rawson, Carlos Aléman, Frederico Castelo Ferreira, João C. Silva

“…Given the current lack of optimized clinical techniques to adequately address this issue, bone tissue engineering (BTE) strategies focusing on the development of scaffolds for temporarily replacing damaged bone and supporting its regeneration process have been gaining interest. …”
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Investigating the response mechanisms of the intertidal seagrass Zostera japonica to increased UVB radiation through physiological, transcriptomic, and metabolomic analyses by Jiayi Xin, Song Xue, Hongzhen Wang, Xinqi Li, Yu Zang, Lei Liu, Xuexi Tang, Jun Chen

“…Global climate change has led to increased ultraviolet-B (UVB) radiation, which is now a major global environmental issue that poses significant threats to ecosystems. …”
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Antiproliferative and proapoptotic effects of extract on Burkitt lymphoma cell line by Patrizia Virdis, Rossana Migheli, Grazia Galleri, Silvia Fancello, Maria Piera L Cadoni, Giorgio Pintore, Giacomo Luigi Petretto, Irene Marchesi, Francesco Paolo Fiorentino, Alessandra di Francesco, Francesca Sanges, Luigi Bagella, Maria Rosaria Muroni, Claudio Fozza, Maria Rosaria De Miglio, Luigi Podda

“…Raji human cell line was treated with increasing Inula viscosa extract concentration for cytotoxicity screening and subsequent establishment of cell cycle arrest and apoptosis. Moreover, gene expression profiles were performed to identify molecular mechanisms involved in the anticancer activities of this medical plant. …”
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A Hidden Mark of a Troubled Past: Neuroimaging and Transcriptomic Analyses Reveal Interactive Effects of Maternal Immune Activation and Adolescent THC Exposure Suggestive of Increa... by Mario Moreno-Fernández, Víctor Luján, Shishir Baliyan, Celia Poza, Roberto Capellán, Natalia de las Heras-Martínez, Miguel Ángel Morcillo, Marta Oteo, Emilio Ambrosio, Marcos Ucha, Alejandro Higuera-Matas

“…Methods: To elucidate this issue, we utilized a rat model of maternal immune activation combined with exposure to increasing doses of Δ9-tetrahydrocannabinol during adolescence in both male and female rats. …”
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Effects of 1-Deoxynojirimycin Extracts of Mulberry Leaves on Oxidative Stress and the Function of the Intestinal Tract in Broilers Induced by H₂O₂ by Chengfeng Zhao, Mingzhu Wang, Tao Li, Dehui Li, Yuan Feng, Yuhua Wang, Liang Qu, Adileidys Ruiz Barcenas, Boris Ramos Serrano, Manman Shen, Weiguo Zhao

“…This study examined using 1-Deoxynojirimycin (DNJ) extracts from mulberry leaves as an antioxidant in broilers feed to combat this issue. We divided 240 broilers, aged 16 days, into six groups, including a control and groups exposed to oxidative stress through H₂O₂ injections, with different supplement levels of DNJ-E (40, 80, 120, and 160 mg/kg of the basal diet) lasting until the broilers reached 42 days old. …”
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Itaconate: A Nexus Metabolite Fueling <i>Leishmania</i> Survival Through Lipid Metabolism Modulation by Ayyoub Kihel, Hajar El Filaly, Dounia Darif, Aicha Assouab, Myriam Riyad, Imane Nait Irahal, Khadija Akarid

“…Using transcriptomic data from <i>L. major</i>-infected BMDMs, we assessed the expression dynamics of <i>Il1b</i> and <i>Acod1</i> and performed pathway enrichment analysis to determine the profile of genes co-expressed with <i>Acod1</i>. …”
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Economic burden attributable to high BMI-caused cancers: a global level analysis between 2002 and 2021 by Jiacheng Zheng, Laiang Yao, Katie Lei, Wanying Huang, Yi Jie Zhou Luo, Priscilla Hui–Xuan Tran, Aaron Guan, Yueyi Qiu, Yusuff Adebayo Adebisi, Don Lucero-Prisno Eliseo, Claire Chenwen Zhong, Martin C.S. Wong, Junjie Huang, Global Health Focus Epidemiology Group (GHFEG)

“…Abstract Background Obesity and overweight are prevailing concerns in modern society, but high BMI shows an established correlation with the risk of cancers that impacts not only medical issues but also economic performance. This study analyzes the economic loss due to high BMI-caused cancers (HBCCs). …”
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Lower rate of mpox vaccination hesitancy and medical consultation among Chinese men who have sex with men living with HIV in comparison with those living without HIV: A national ob... by Min Zheng, Min Du, Guanghong Yang, Yongming Yao, Xiaohan Qian, Yuan Zhi, Lin Ma, Rui Tao, Zhilin Zhu, Feng Zhou, Siqi Dai, Jie Yang, Min Liu, Jue Liu

“…This anonymous cross-sectional study aimed to investigate the relationships between HIV infection and mpox-related focus issues among Chinese men who have sex with men (MSM). …”
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Non-exclusive breastfeeding is associated with pneumonia and asthma in under-five children: an umbrella review of systematic review and meta-analysis by Biruk Beletew Abate, Biruk Shalmeno Tusa, Ashenafi Kibret Sendekie, Freweyni Gebreegziabher Araya, Molla Azmeraw Bizuayehu, Getachew Tesfaw Walle, Tegene Atamenta Kitaw, Befkad Derese Tilahun, Addis Wondmagegn Alamaw, Alemu Birara Zemariam, Amare Kassaw, Ayelign Mengesha Kassie, Gizachew Yilak, Fassikaw Kebede Bizuneh, Berihun Dachew

“…Summary effect estimates were expressed using odds ratios (OR) with 95% confidence intervals (CI). …”
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Implant-Derived <i>S. aureus</i> Isolates Drive Strain-Specific Invasion Dynamics and Bioenergetic Alterations in Osteoblasts by Lei Song, Lea-Sophie Schwinn, Juliane Barthel, Vanessa Ketter, Philipp Lechler, Uwe Linne, Ardawan J. Rastan, Sebastian Vogt, Steffen Ruchholtz, Jürgen R. J. Paletta, Madeline Günther

“…<b>Methods and Results:</b> We found that the ability of <i>S. aureus</i> to adhere to osteoblasts depends on the isolate and was not associated with a single gene or expression pattern of characteristic adhesion proteins, and further, was not correlated with invasion. …”
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Cadmium targeting transcription factor EB to inhibit autophagy-lysosome function contributes to acute kidney injury by Peng-Fei Dong, Tian-Bin Liu, Kai Chen, Dan Li, Yue Li, Cai-Yu Lian, Zhen-Yong Wang, Lin Wang

“…Thus, in vivo and in vitro studies were conducted to clarify this issue. Methods and results: Data firstly showed that reduced TFEB expression and nuclear translocation were evident in Cd-induced AKI models, accompanied by autophagy-lysosome dysfunction. …”
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Stakeholder perspectives on the effects of environmental and socio-economic factors on children's health and learning: a qualitative study in Greater Manchester, England by Sarah Daniels, Hua Wei, Anne Clayson, Martie van Tongeren, Thomas Bannan, Melanie Carder, Luke Munford, Nicola Gartland

“…Participants also expressed concern over socio-economic factors affecting children's health and development, including deprivation, housing conditions, and access to green spaces. …”
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Non-formal encounters between Israeli families and African immigrant families foster lifelong learning competence by Michal Ganz Meishar

“…A few limited encounters may affect the author’s interpretation of the study data. In addition, expressions of “social desire” that may be expressed in interviews must be considered. …”
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THE BIBLE IN THE WORLD OF JENA ROMANTICISM by Galina V. Sinilo

“…One of the pressing issues of modern literary criticism is the identification of the links between fiction and the “axial” archetext of European culture and literature (more broadly, the culture of the Judeo-Christian area) – The Bible. …”
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The role of psycho-emotional factors in assessing the prognosis of different types of myocardial infarction by V. I. Kinash, V. V. Kashtalap, A. S. Vorobiev, I. A. Urvantseva, L. V. Kovalenko

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VISUAL LANGUAGE OF MULTIMODAL TEXT: PRAGMATICS OF COLOR (The Russian-Ukrainian War in the Covers of World Publications) by Maryna M. Zhovnir, Tetyana O. Leshchenko

“…The article raises issues closely related to interrelationships, interdependence and pragmatics of colors in multimodal texts. …”
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Demand, utilization, and supply of community smart senior care services for older people in China by Ruobing Fa, Shengxuan Jin, Peng Fan, Fengyuan Tang, Qian Jin, Changqing Wang

“…Objective Although smart senior care services offer numerous benefits, they have not yet gained widespread acceptance among the general populace, particularly seniors. Numerous related issues have surfaced, with the structural imbalance between supply and demand being most prominent. …”
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Design of the optimal groundwater quality monitoring network using a genetic algorithm based optimization approach by Somaye Janatrostami, Ali Salahi

“…Results and discussion: The results showed that the relative importance of each objective is expressed using the weighting coefficient, w. It was found that the solution of the optimization is very dependent on the selection of w. …”
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Inaugural Editorial by Rolf Rønning, Anne Marie Berg, Noralv Veggeland, Hans Wiggo Kristiansen, Inger Haug

“…In this issue, we present three original, peer-reviewed articles. …”
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