UDP-Glucose Ceramide Glucosyltransferase Inhibition, Immune Cell Mediation, and Endometriosis Risk: A Mendelian Randomization Study by Xue L, Zhang R, Chen J, Ge X, Chen J

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Unveiling the Therapeutic Potential of Baicalin in Intervertebral Disc Degeneration: Integrative Bulk and Single-Cell Transcriptome Analysis with Experimental Validation of PANopto... by Wang X, Gao S, Zhou D, Cai W, Lv J, Wei Z, Song C, Shan X, Liu Z

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Potential of Sivelestat for Pulmonary Arterial Hypertension Treatment: Network Pharmacology-Based Target Identification and Mechanistic Exploration by Deng X, Qiu P, Li X, Hu Y, Que Q, Zhang K, Deng T, Liu Y

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Exploring the Potential of Chaihu-Danggui Tang in Breast Cancer Treatment Based on Network Pharmacology, Molecular Docking, and Experimental Validation by Liu Y, Zhang J, Lai Y, Wu C, Liu D, Liang R, Chen G, Jiang X

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Prevalence and associated factors of suicidal behavior among adolescents in Bahir Dar City, Northwest Ethiopia. by Belete Birhan, Michael Beka, Habte Belete, Abdulbasit Sherfa, Gidey Rtbey

“…<h4>Background</h4>Suicide is a significant public health issue worldwide and the third leading cause of death among 15-19-year-olds. …”
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Ultrasonic Parameters as Biomarkers for Tumor Staging and Aggressiveness in Breast Cancer: Correlation with GP73 and miR-27a by Tao ZY, Rong R, Zhou LP

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Mechanisms of Hydromorphone-Mediated Protection Against Myocardial Ischemia-Reperfusion Injury via NLRP3 Inflammasome Inhibition by Zeng S, Xu W, Ren F, Xiong Q, Qing Q, Luo L, Song X, Tan Y, Huang Z, Zheng M

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Liposomal Nanoparticle Delivery of Ginkgo Flavone Glycosides Enhances SIRT1 Activation and Improves Diabetic Cardiomyopathy by Gao W, Chen R, Tong H, Wang Y, Liang L, Li Y, Yu H

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Association of Serum PSA, fPSA, and CEA Levels with Prognosis and Clinicopathological Characteristics in Prostate Cancer by Ahamed Y, Wu L, Baral S, Al-Raiyan AU, Sun W

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Cell Death-Related Genesets Activity Improved Clinical Concordance and Intrinsically Associated with Alterations in Ulcerative Colitis: Mucosal Healing at Molecular Depth by Li Y, Xie Y, Cao K, Zhai J, Luo S, Liu X, Pan Q, Chen Y

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De novo assembly of plasmodium interspersed repeat (pir) genes from Plasmodium vivax RNAseq data suggests geographic conservation of sub-family transcription by Timothy S. Little, Deirdre A. Cunningham, George K. Christophides, Adam James Reid, Jean Langhorne

“…Results To overcome the issue of hidden pir diversity from utilising a reference genome, we employed de novo transcriptome assembly to construct the pir ‘reference’ of different parasite isolates from published and novel RNAseq datasets. …”
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Percepción del alumnado sobre el uso del método AICLE en Educación Física: estudio de caso (Students’ perception of the use of CLIL method in Physical Education: A Case Study)... by Celina Salvador-García, Oscar Chiva-Bartoll, Juan José Vergaz Gallego

“…Results reinforce the current status of the issue, uncovering five categories according to students’ beliefs: fear for the language, motivation and participation in the subject, specific Physical Education learnings, improvement of oral expression, and magnitude of English language for their academic-professional future. …”
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Reactive Oxygen Species in Asthma: Regulators of Macrophage Polarization and Therapeutic Implications: A Narrative Review by Liu Y, Zhang M, Wang T, Zhang J

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Exploring the Impact of the Gut Microbiota/REV-ERB&amp;alpha;/NF-&amp;kappa;B Axis on the Circadian Rhythmicity of Gout Flares from a Chronobiological Perspective by Wang H, Liu M, Xie C, Zhao L, Wang H

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N terminus and C terminus of Arabidopsis P4-ATPase AtALA1 facilitate the detoxification of the mycotoxin deoxynivalenol in wheat by Fanlong Wang, Mingliang Qiu, Lei Hou, Xianbi Li, Hui Ren, Jingxin Zhuo, Haoru Liu, Yujie Li, Yang Yang, Xingying Yan, Mi Zhang, Dan Jin, Ting Lan, Jianyan Zeng, Yanhua Fan, Yang Yuan, Zhengqiang Ma, Yan Pei

“…., deoxynivalenol (DON), that contaminate grains, leading to serious issues in food safety worldwide. Here, we demonstrate that expressing the Arabidopsis P4-ATPase flippase gene, AtALA1, significantly increases wheat resistance to FHB, while substantially reducing DON content in grains. …”
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Indolepropionic Acid Attenuates CFA-Induced Inflammatory Pain in Mice by Ao RF, Yong HR, Hu YT, Huang YS, Gao JW, Tu C, Zhuang JS, Zhong ZM

“…Behavioral assessments were conducted using the Von Frey test, cold or hot plate tests. The expression of pain-related transcripts, such as transient receptor potential vanilloid 1 (TRPV1) and calcitonin gene-related peptide (CGRP) was evaluated. …”
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Targeted degradation of sICOSL reverses cytotoxic T cells dysfunction by Zhenghao Wu, Peng Zheng, Ruobing Qi, Yunxiao Xiao, Zihan Xi, Lei Dai, Tao Chen, Qianheng Wang, Furong Zhang, Rong Wang, Zimei Tang, Xiangwang Zhao, Jie Tan, Jie Ming, Ping Lei, Chunping Liu, Tao Huang

“…Notably, certain chemotherapeutic drugs activate the histone methyltransferase Enhancer of zeste homolog 2 (EZH2), which in turn suppresses DPP4 expression. To address this issue, we have developed nanobody-DPP4 fusion proteins that can specifically degrade sICOSL, achieving substrate selectivity and tumor targeting. …”
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Addressing the environmental sustainability of plastics used in agriculture: a multi-actor perspective by Valentina E. Tartiu, Rachel Hurley, Cecilie Baann, Demetres Briassoulis, Evelia Schettini, Fabiana Convertino, Bernard Le Moine, Adalgisa Martinelli, Luc Vernet, Sissel B. Ranneklev, Violette Geissen, Esperanza Huerta Lwanga, Nicolas Beriot, Defu He, Richard H. Thompson, Giulia Carcasci, Luca Nizzetto

“…All stakeholders express concern for the environment. A ‘best practice’-based circular model was elaborated capturing these perspectives. …”
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A novel nanomedicine integrating ferroptosis and photothermal therapy, well-suitable for PD-L1-mediated immune checkpoint blockade by Yujun Bao, Guanghao Li, Siqi Li, Haishui Zhou, Ziqing Yang, Zhiqiang Wang, Rui Yan, Changhong Guo, Yingxue Jin

“…Moreover, the O2-generating ability induced by Fc-SS-Fe/Cu could reverse the hypoxic tumor microenvironment, and importantly, the expression of PD-L1 on tumor cell surfaces could be effectively downregulated by inhibiting the HIF-1α pathways, thereby augmenting the effect of anti-PD-L1 (αPD-L1) therapy. …”
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Multifunctional hydrogel promotes rotator cuff healing through anti-inflammation and vascularization by Bitao Wang, Yiyang Hou, Xi Shang, Yuxuan Zhou, Yubiao Yang, Zhenhan Li, Boyuan Ma, Zhi Zeng, Jinyu Chen, Cheng Tang, Jian Hao, Lianyong Wang, Xianhu Zhou

“…Additionally, it markedly enhances vascular endothelial growth factor (VEGF) expression, stimulating the proliferation and migration of human umbilical vein endothelial cells (HUVECs) to facilitate neovascularization. …”
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