Single-Cell Analysis Reveals Aspirin Restores Intervertebral Disc Integrity via Ferroptosis Regulation by Niu H, Qi H, Zhang P, Meng H, Liu N, Zhang D

“…Subtype identification, differential expression analysis, enrichment analysis, and cell proportion analysis were conducted to explore functional alterations in various nucleus pulposus cell (NPC) subpopulations. …”
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Chronic conditions patient’s perception of post-COVID-19 pandemic teleconsulting continuation in primary care clinics: a qualitative descriptive study by Yves Couturier, Marie-Ève Poitras, Gilles Gauthier, Vanessa T Vaillancourt, Marie-Dominique Poirier, Caroline Cormier, Sylvie Massé, Audrey Gendron, Megan L Oswick, Anaelle Morin, Patricia Blanchette, Andréanne Bernier

“…However, several issues must be addressed. Patients do and should contribute to the implementation of teleconsultation in primary care. …”
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A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma by Ruiling Xu, Sai Zhu, Wenchao Zhang, Haodong Xu, Chao Tu, Honghui Wang, Lu Wang, Na He, Tang Liu, Xiaoning Guo, Xiaolei Ren, Zhihong Li

“…Notably, the knockdown of ERCC6 and HNRNPM increased expression of full‐length BAX and reduced skipping of exon 2, thus promoting apoptosis. …”
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Expanding the phenotypic and genetic spectrum of GTPBP3 deficiency: findings from nine Chinese pedigrees by Yaojun Xie, Keyi Li, Li Yang, Xiaofei Zeng, Zhehui Chen, Xue Ma, Luyi Zhang, Yuwei Zhou, Liqin Jin, Yanling Yang, Xiaoting Lou

“…Re-expressing GTPBP3 variants in knockout cell lines further defined the pathogenicity of the novel variants. …”
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Study on Students’ Use of Foreign Words by Batbold Turbat, Jigmed Tserendorj

“…The influence of the development of a free society and globalization in the field of education is to some extent manifested by the use of foreign words in the students’ written and verbal expressions. The presence of different points of view that widespread use of foreign words may adversely affect the immunity of the Mongolian language leading to its destruction or have a positive influence enriching its vocabulary is one of the important issues of consideration. …”
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The Extract of <i>Larrea tridentata</i> Promotes the Synthesis of Silver Nanoparticles and Stimulates Immune Responses in <i>Penaeus vannamei</i> Against <i>Vibrio</i> spp., Causin... by Germán León-Valdez, Wenceslao Valenzuela-Quiñonez, Píndaro Álvarez-Ruiz, Carlos A. Soto-Robles, Eusebio Nava-Perez, Gabriela López-Cervantes, Magnolia Montoya-Mejía

“…Specific strains of <i>Vibrio parahaemolyticus</i> can cause Acute Hepatopancreatic Necrosis Disease (AHPND), a critical issue in shrimp aquaculture despite the application of several control strategies. …”
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Criteria for the normativity of interpretative legal acts in Russian judicial practice by E. V. Timoshina, A. A. Kraevsky

“…The authors identified that the courts consider that there are two ways in which an ANP can acquire normative properties: either through the expression of the will of the issuing authority or through actual application of an ANP. …”
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Home-based rehabilitation experience of children with congenital muscular torticollis: a qualitative study by Youqiong Lu, Lin Mo, Gefang Li, Dan Xiao, Chen Mu

“…Comprehensive physical therapy combined with home-based care intervention has been developed as well; However, certain issues persist in practical application, such as poor caregiver compliance, inability to adhere to rehabilitation in the long term, lack of disease - related knowledge, etc. …”
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GWAS and RNA-seq reveal novel loci and genes of low-nitrogen tolerance in cucumber (Cucumis sativus L.) by Huaxiang Wu, Huiming Yan, Bowen Li, Yike Han, Yike Han, Nan Liu, Mengyu Fan, Yahan Liu, Mingjie Lyu, Shengli Du, Shengli Du, Shengli Du, Aimin Wei, Aimin Wei

“…However, the prevalent issues of low nitrogen use efficiency (NUE) in cultivars and excessive fertilizer application have led to increased production costs and environmental burdens. …”
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Sexual and reproductive health from the perspective of patients with autoimmune rheumatic diseases in Mexico: a qualitative study by Dionicio Angel Galarza-Delgado, Ingris Peláez-Ballestas, Cassandra Michelle Skinner-Taylor, Lorena Perez-Barbosa, Abraham Yair Lujano-Negrete, Fanny Arévalo-Nieto, Maria Eugenia Corral-Trujillo, Andrea Aguilar-Leal, Génesis Guadalupe Sandoval-Torres, Cecilia Rodríguez-Ruiz, Melanie Gabriela Rios-Medina, Amaranta Manrique de Lara

“…First, participants expressed confusion and concern about the safety and effectiveness of contraceptive methods in the context of their disease and treatment. …”
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The Stress Response of Aphids to the Accumulation of Heavy Metals Along <i>Vicia faba</i> L. Under Cadmium Treatment by Yexin Xie, Shasha Wang, Sijing Wan, Liya Chen, Qintian Shen, Keting Zhao, Shiyu Tao, Wenjing Zhou, Xinyi Zhang, Xiaoling Tan, Binghua Xie, Bin Tang

“…The pollution of heavy metals in agricultural systems has become a serious issue of global concern. This study detected the bioaccumulation of cadmium (Cd) in broad beans and aphids through continuous exposure to varying concentrations of Cd pollution (0, 3.125, 6.25, 12.5, 25, 50 mg/L) and subsequently examined its effects on aphid energy metabolism and reproductive ability. …”
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Human Chondrocytes from Human Adipose Tissue-Derived Mesenchymal Stem Cells Seeded on a Dermal-Derived Collagen Matrix Sheet: Our Preliminary Results for a Ready to Go Biotechnolog... by Quan Tran Dang, Thao Duy Huynh, Francesco Inchingolo, Gianna Dipalma, Alessio Danilo Inchingolo, Stefania Cantore, Gregorio Paduanelli, Kieu Cao Diem Nguyen, Andrea Ballini, Ciro Gargiulo Isacco, Cong Toai Tran

“…The establishment of cartilage regenerative medicine is an important clinical issue, but the search for cell sources able to restore cartilage integrity proves to be challenging. …”
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First opinion practice electronic health records are a useful source of descriptions of medication errors by Eirini Petrou, Eirini Petrou, Heather Davies, Heather Davies, Maria Aoun, Alan D. Radford, David Singleton, David Singleton, Peter-John M. Noble, David R. Killick

“…BackgroundMedication error (MedE) is a leading global cause of harm in human healthcare with significance both in patient morbidity and mortality, and consequent legal and financial issues. Despite this, MedEs are a poorly explored area in veterinary medicine. …”
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The increasing doses of methotrexate pharmacokinetics after intravenous administration in rats - model selection by Rajšić Ivana, Pavlović Nebojša, Milijašević Boris, Vukmirović Saša, Spasić Dragan, Žigić Miodrag, Grahovac Nenad, Goločorbin-Kon Svetlana, Mikov Momir

“…Methotrexate (MTX) plays a significant role in the treatment of various diseases, but the toxicity remains the main issue of its use, especially when administered in high doses. …”
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Investigation of calonysterone and 20-hydroxyecdysone effects in high-fat, high-sugar diet-induced obesity rat model by Alaa AM. Osman, Dávid Laczkó, Máté Vágvölgyi, Adrienn Seres-Bokor, Anita Sztojkov-Ivanov, Kata Kira Kemény, Attila Hunyadi, Eszter Ducza

“…Overweight constitutes a significant health and social issue in developed nations globally. Conventional therapies such as lifestyle modification (nutrition and physical activity) have limited weight reduction. …”
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GEOMAPLEARN 1.2: detecting structures from geological maps with machine learning – the case of geological folds by D. Oakley, D. Oakley, C. Loiselet, T. Coowar, T. Coowar, V. Labbe, J.-P. Callot

“…For the unsupervised case, we use regular expression matching to identify map patterns suggestive of folds along lines crossing the map. …”
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HPV Vaccination Knowledge and Decision‐Making Among Adults 27 to 45 Years: A Large Online Survey by Matthew E. Lin, Oluwatobiloba Ayo‐Ajibola, Jun Yun, Tyler J. Gallagher, Carlos X. Castellanos, Jonathan D. West, Ian Kim, Sophia Chen, Niels C. Kokot, Tamara N. Chambers

“…The 27–45‐year group exhibited more knowledge of HPV's link to head and neck cancer and vaccine protection but expressed less concern about HPV infection (all p < 0.05). …”
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Facilitators and challenges in collaboration between public health units and faith-based organizations to promote COVID-19 vaccine confidence in Ontario by Kadidiatou Kadio, Denessia Blake-Hepburn, Melodie Yunju Song, Anna Karbasi, Elizabeth Estey Noad, Samiya Abdi, Nazia Peer, Shaza A. Fadel, Sara Allin, Anushka Ataullahjan, Erica Di Ruggiero

“…Some external challenges issues were related to the provincial level and the Ministry of Health, while others were related to FBOs. …”
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Ethical governance of clinical research on the brain–computer interface for mental disorders: a modified Delphi study by Qing Zhang, Zhen Wang, Jing Chen, Chen Zhang, Tianhong Zhang, Yifeng Xu, Haiqing Ji, Xingchao Wang, Pinan Liu

“…We conducted quantitative analysis of responses and agreements among experts to reveal the consensus and differences regarding the ethical governance of mental BCI research from a multidisciplinary perspective.Results The Delphi panel emphasised important concerns of ethical review practices and ethical principles within the BCI context, identified qualified and highly influential institutions and personnel in conducting and advancing clinical BCI research, and recognised prioritised aspects in the risk–benefit evaluation. Experts expressed diverse opinions on specific ethical concerns, including concerns about invasive technology, its impact on humanity and potential social consequences. …”
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Evaluating implementation preparedness for suicide screening and referral in a Nepali emergency department: A mixed-methods study by Anmol P Shrestha, Roshana Shrestha, Ajay Risal, Renu Shakya, Kripa Sigdel, Riya Bajracharya, Pratiksha Paudel, Divya Gumudavelly, Emilie Egger, Sophia Zhuang, Lakshmi Vijayakumar, Ashley Hagaman

“…Results Qualitatively, clinicians expressed hopelessness and reservations surrounding ED programs to prevent suicide given important system and social barriers. …”
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